Immunosenescence and immunecheckpoint inhibitors in non-small cell lung cancer patients: Does age really matter?
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Immunotherapy has dramatically changed the therapeutic scenario in non-small cell lung cancer (NSCLC), extending overall survival, with a favorable safety profile. However, there is still a gap of knowledge about the efficacy of immune checkpoint inhibitors (ICIs) in elderly patients. Data from randomized clinical trials testing ICIs are conflicting and often lack adequate statistical power. Although two large meta-analyses suggested an absence of a significant survival benefit in patients older than 75years, expanded access programs and retrospective cohort studies of ICIs in the real-life setting, showed comparable survival outcomes and safety profiles between older and younger patients. In this complex scenario, a further unresolved issue is the potential correlation between older age and immunotherapy primary resistance, a phenomenon probably linked to the continuous and progressive remodeling of immune functions with ageing, known as immunosenescence. Defining the role of ICIs in elderly NSCLC patients and exploring the molecular mechanisms underlying a possible lack of benefit or even accelerated tumor growth during immunotherapy are two major challenges for future research in this field of cancer treatment. In this review, we describe the major hallmarks of immunosenescence and we summarize the existing clinical data of ICIs in elderly NSCLC patients.
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Immunosenescence may affect the response to blocking antibody therapy in patients with non-small cell lung cancer.
“Immunosenescence may affect the response to blocking antibody therapy in patients with non-small cell lung cancer [152].”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [152]
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- Authors
- Ferrara, R., Mezquita, L., Auclin, E., Chaput, N., & Besse, B.
- Affiliations
- Institut Gustave Roussy (FR)
- Université Paris-Sud (FR)
- Corresponding author
- Besse, Benjamin
- Venue
- Cancer Treatment Reviews
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 60
- Pages
- 60-68
- ISSN
- 0305-7372 (ISSN-L)
- OpenAlex
- W2745874962
- Cited by
- 163
- References
- 74
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 12 · 2023: 25 · 2022: 17 · 2021: 18 · 2020: 27 · 2019: 18 · 2018: 23 · 2017: 1 · 2016: 1
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cancer Treatment Reviews (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
- Keywords
- immunosenescence, immune checkpoint inhibitors, non-small cell lung cancer, elderly patients, immunotherapy resistance, age as prognostic factor, survival outcomes, immunotherapy safety, real-world evidence
- MeSH terms
- Antineoplastic Agents, Carcinoma, Non-Small-Cell Lung, Humans, Immunity, Cellular, Immunotherapy, Lung Neoplasms, Molecular Targeted Therapy, Cell Cycle Checkpoints
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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