The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Neuronal Expression of p53 Dominant-Negative Proteins in Adult Drosophila melanogaster Extends Life Span
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Again, however, controversy obfuscates the picture because both pro-aging and anti-aging roles have been reported in disparate mouse models that express elevated levels of p53 (Arum and Johnson, 2007; Bauer et al., 2005; Matheu et al., 2008).”
From p53 at a glance (2010) · cites this paper as Bauer et al., 2005
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
p53 mutant mice that display early ageing-associated phenotypes
Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., et al. (2002) · Nature · doi:10.1038/415045a · Cited by 1,459 · cited 2×
“Mice with increased expression of the 24 kDa or 44 kDa forms of p53 are resistant to tumor formation, but unexpectedly have a shortened life span with premature development of a number of phenotypes associated with aging [1, 2].”
BackgroundDoes p53 affect organismal aging?
Donehower, L. A. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10104 · Cited by 155
Differential patterns of apoptosis in response to aging in Drosophila
Zheng, J., Edelman, S. W., Tharmarajah, G., Walker, D. W., Pletcher, S. D., & Seroude, L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503374102 · Cited by 100
Research works printed but not linked: 22
- Maier, 2004, Modulation of mammalian life span by the short isoform of p53, Genes Dev., 18, 306, 10.1101/gad.1162404 · DOI · Paper page
- Campisi, 2002, Between Scylla and Charybdis: p53 links tumor suppression and aging, Mech. Ageing Dev., 123, 567, 10.1016/S0047-6374(02)00006-4 · DOI · Paper page
- van Heemst, 2005, Variation in the human TP53 gene affects old age survival and cancer mortality, Exp. Gerontol., 40, 11, 10.1016/j.exger.2004.10.001 · DOI · Paper page
- Nordstrom, 2000, Guardian ancestry: fly p53 and damage-inducible apoptosis, Cell Death Differ., 7, 1035, 10.1038/sj.cdd.4400766 · DOI
- Wolkow, 2002, Life span: getting the signal from the nervous system, Trends Neurosci., 25, 212, 10.1016/S0166-2236(02)02133-1 · DOI
- Brand, 1993, Targeted gene expression as a means of altering cell fates and generating dominant phenotypes, Development, 118, 401, 10.1242/dev.118.2.401 · DOI · Paper page
- Brodsky, 2000, Drosophila p53 binds a damage response element at the reaper locus, Cell, 101, 103, 10.1016/S0092-8674(00)80627-3 · DOI · Paper page
- Osterwalder, 2001, A conditional tissue-specific transgene expression system using inducible GAL4, Proc. Natl. Acad. Sci. USA, 98, 12596, 10.1073/pnas.221303298 · DOI · Paper page
- Roman, 2001, P[Switch], a system for spatial and temporal control of gene expression in Drosophila melanogaster, Proc. Natl. Acad. Sci. USA, 98, 12602, 10.1073/pnas.221303998 · DOI · Paper page
- Rogina, 2004, Sir2 mediates longevity in the fly through a pathway related to calorie restriction, Proc. Natl. Acad. Sci. USA, 101, 15998, 10.1073/pnas.0404184101 · DOI · Paper page
- Wang, 2004, Multiple-stress analysis for isolation of Drosophila longevity genes, Proc. Natl. Acad. Sci. USA, 101, 12610, 10.1073/pnas.0404648101 · DOI · Paper page
- Johnson, 2002, Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease, J. Inherit. Metab. Dis., 25, 197, 10.1023/A:1015677828407 · DOI · Paper page
- Li, 2001, Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures, Cancer Res., 61, 428
- Partridge, 1997, The effects of reproduction on longevity and fertility in male Drosophila melanogaster, J. Insect Physiol., 43, 501, 10.1016/S0022-1910(97)00014-0 · DOI
- Marden, 2003, Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies, Proc. Natl. Acad. Sci. USA, 100, 3369, 10.1073/pnas.0634985100 · DOI · Paper page
- Mair, 2003, Demography of dietary restriction and death in Drosophila, Science, 301, 1731, 10.1126/science.1086016 · DOI · Paper page
- Bross, 2005, Behavioral, physical, and demographic changes in Drosophila populations through dietary restriction, Aging Cell, 10.1111/j.1474-9726.2005.00181.x · DOI · Paper page
- Igaki, 2000, Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death, Proc. Natl. Acad. Sci. USA, 97, 662, 10.1073/pnas.97.2.662 · DOI
- Jin, 2000, Identification and characterization of a p53 homologue in Drosophila melanogaster, Proc. Natl. Acad. Sci. USA, 97, 7301, 10.1073/pnas.97.13.7301 · DOI · Paper page
- Ollmann, 2000, Drosophila p53 is a structural and functional homolog of the tumor suppressor p53, Cell, 101, 91, 10.1016/S0092-8674(00)80626-1 · DOI · Paper page
- Sogame, 2003, Drosophila p53 preserves genomic stability by regulating cell death, Proc. Natl. Acad. Sci. USA, 100, 4696, 10.1073/pnas.0736384100 · DOI · Paper page
- Kirkwood, 2002, p53 and ageing: too much of a good thing?, Bioessays, 24, 577, 10.1002/bies.10111 · DOI
Cited by
Blinded by the Light: The Growing Complexity of p53
Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163
Vousden, K. H., & Lane, D. P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2147 · Cited by 2,272
Yankner, B. A., Lu, T., & Loerch, P. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.2.010506.092044 · Cited by 677
Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila
Sykiotis, G. P., & Bohmann, D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.12.002 · Cited by 660
Greer, E. L., & Brunet, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00459.x · Cited by 572
Metadata
- Authors
- Bauer, J. H., Poon, P. C., Glatt-Deeley, H., Abrams, J. M., & Helfand, S. L.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2005-11
- Volume
- 15
- Issue
- 22
- Pages
- 2063-2068
- ISSN
- 0960-9822
- Cited by
- 100
- References
- 3
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2846 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Neuronal Expression of p53 Dominant-Negative Proteins in Adult Drosophila melanogaster Extends Life Span. https://app.cochat.ai/papers/10.1016/j.cub.2005.10.051
- The paper
- Bauer, J. H., Poon, P. C., Glatt-Deeley, H., Abrams, J. M., & Helfand, S. L. (2005). Neuronal Expression of p53 Dominant-Negative Proteins in Adult Drosophila melanogaster Extends Life Span. Current Biology. https://doi.org/10.1016/j.cub.2005.10.051
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.