The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Short-Wavelength Light Sensitivity of Circadian, Pupillary, and Visual Awareness in Humans Lacking an Outer Retina
Open accessAbstract
As the ear has dual functions for audition and balance, the eye has a dual role in detecting light for a wide range of behavioral and physiological functions separate from sight. These responses are driven primarily by stimulation of photosensitive retinal ganglion cells (pRGCs) that are most sensitive to short-wavelength ( approximately 480 nm) blue light and remain functional in the absence of rods and cones. We examined the spectral sensitivity of non-image-forming responses in two profoundly blind subjects lacking functional rods and cones (one male, 56 yr old; one female, 87 yr old). In the male subject, we found that short-wavelength light preferentially suppressed melatonin, reset the circadian pacemaker, and directly enhanced alertness compared to 555 nm exposure, which is the peak sensitivity of the photopic visual system. In an action spectrum for pupillary constriction, the female subject exhibited a peak spectral sensitivity (lambda(max)) of 480 nm, matching that of the pRGCs but not that of the rods and cones. This subject was also able to correctly report a threshold short-wavelength stimulus ( approximately 480 nm) but not other wavelengths. Collectively these data show that pRGCs contribute to both circadian physiology and rudimentary visual awareness in humans and challenge the assumption that rod- and cone-based photoreception mediate all "visual" responses to light.
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Cites
Phototransduction by retinal ganglion cells that set the circadian clock
Berson, D. M., Dunn, F. A., & Takao, M. (2002) · Science · doi:10.1126/science.1067262 · Cited by 3,629
Action Spectrum for Melatonin Regulation in Humans: Evidence for a Novel Circadian Photoreceptor
Brainard, G. C., Hanifin, J. P., Greeson, J. M., Byrne, B., Glickman, G., Gerner, E., & Rollag, M. D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06405.2001 · Cited by 1,930
Self-citationDacey, D. M., Liao, H.-W., Peterson, B. B., Robinson, F. R., Smith, V. C., Pokorny, J., Yau, K.-W., & Gamlin, P. D. (2005) · Nature · doi:10.1038/nature03387 · Cited by 1,333
Thapan, K., Arendt, J., & Skene, D. J. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.t01-1-00261.x · Cited by 1,320
Hattar, S., Lucas, R. J., Mrosovsky, N., Thompson, S., Douglas, R. H., Hankins, M. W., Lem, J., Biel, M., Hofmann, F., Foster, R. G., et al. (2003) · Nature · doi:10.1038/nature01761 · Cited by 1,245
Zeitzer, J. M., Dijk, D., Kronauer, R. E., Brown, E. N., & Czeisler, C. A. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00695.x · Cited by 1,175
Self-citationIn search of the visual pigment template
GOVARDOVSKII, V. I., FYHRQUIST, N., REUTER, T., KUZMIN, D. G., & DONNER, K. (2000) · Visual Neuroscience · doi:10.1017/s0952523800174036 · Cited by 1,055
Central projections of melanopsin‐expressing retinal ganglion cells in the mouse
Hattar, S., Kumar, M., Park, A., Tong, P., Tung, J., Yau, K., & Berson, D. M. (2006) · Journal of Comparative Neurology · doi:10.1002/cne.20970 · Cited by 996
Cajochen, C., Münch, M., Kobialka, S., Kräuchi, K., Steiner, R., Oelhafen, P., Orgül, S., & Wirz-Justice, A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0957 · Cited by 939
Regulation of Mammalian Circadian Behavior by Non-rod, Non-cone, Ocular Photoreceptors
Freedman, M. S., Lucas, R. J., Soni, B., von Schantz, M., Muñoz, M., David-Gray, Z., & Foster, R. (1999) · Science · doi:10.1126/science.284.5413.502 · Cited by 848
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Measuring and using light in the melanopsin age
Lucas, R. J., Peirson, S. N., Berson, D. M., Brown, T. M., Cooper, H. M., Czeisler, C. A., Figueiro, M. G., Gamlin, P. D., Lockley, S. W., O’Hagan, J. B., et al. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2013.10.004 · Cited by 1,278
Self-citationThe Circadian Clock and Human Health
Roenneberg, T., & Merrow, M. (2016) · Current Biology · doi:10.1016/j.cub.2016.04.011 · Cited by 1,004
Brown, T. M., Brainard, G. C., Cajochen, C., Czeisler, C. A., Hanifin, J. P., Lockley, S. W., Lucas, R. J., Münch, M., O’Hagan, J. B., Peirson, S. N., et al. (2022) · PLOS Biology · doi:10.1371/journal.pbio.3001571 · Cited by 659
Self-citationAberrant light directly impairs mood and learning through melanopsin-expressing neurons
LeGates, T. A., Altimus, C. M., Wang, H., Lee, H.-K., Yang, S., Zhao, H., Kirkwood, A., Weber, E. T., & Hattar, S. (2012) · Nature · doi:10.1038/nature11673 · Cited by 577
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Vandewalle, G., Maquet, P., & Dijk, D.-J. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2009.07.004 · Cited by 556
Metadata
- Authors
- Zaidi, F. H., Hull, J. T., Peirson, S. N., Wulff, K., Aeschbach, D., Gooley, J. J., Brainard, G. C., Gregory-Evans, K., Rizzo, J. F., Czeisler, C. A., Foster, R. G., Moseley, M. J., & Lockley, S. W.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 17
- Issue
- 24
- Pages
- 2122-2128
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2165727733
- Cited by
- 366
- References
- 46
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Zaidi, F. H., Hull, J. T., Peirson, S. N., Wulff, K., Aeschbach, D., Gooley, J. J., Brainard, G. C., Gregory-Evans, K., Rizzo, J. F., Czeisler, C. A., Foster, R. G., Moseley, M. J., & Lockley, S. W. (2007). Short-Wavelength Light Sensitivity of Circadian, Pupillary, and Visual Awareness in Humans Lacking an Outer Retina. Current Biology. https://doi.org/10.1016/j.cub.2007.11.034
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
