Cited by 1,142Protist diversity and phylogenyMitochondrial Function and PathologyAutophagy in Disease and Therapy

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The Origin and Diversification of Mitochondria

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Roger, Andrew J., Muñoz-Gómez, Sergio A., Kamikawa, Ryoma·2017·Current Biology

DOI 10.1016/j.cub.2017.09.015

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Abstract

Mitochondria are best known for their role in the generation of ATP by aerobic respiration. Yet, research in the past half century has shown that they perform a much larger suite of functions and that these functions can vary substantially among diverse eukaryotic lineages. Despite this diversity, all mitochondria derive from a common ancestral organelle that originated from the integration of an endosymbiotic alphaproteobacterium into a host cell related to Asgard Archaea. The transition from endosymbiotic bacterium to permanent organelle entailed a massive number of evolutionary changes including the origins of hundreds of new genes and a protein import system, insertion of membrane transporters, integration of metabolism and reproduction, genome reduction, endosymbiotic gene transfer, lateral gene transfer and the retargeting of proteins. These changes occurred incrementally as the endosymbiont and the host became integrated. Although many insights into this transition have been gained, controversy persists regarding the nature of the original endosymbiont, its initial interactions with the host and the timing of its integration relative to the origin of other features of eukaryote cells. Since the establishment of the organelle, proteins have been gained, lost, transferred and retargeted as mitochondria have specialized into the spectrum of functional types seen across the eukaryotic tree of life.

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Authors: Roger, A. J., Muñoz-Gómez, S. A., & Kamikawa, R.
Affiliations: Dalhousie University (CA)
Kyoto University (JP)
Corresponding author: Roger, Andrew J.
ORCID: Roger, Andrew J.
Muñoz-Gómez, Sergio A.
Kamikawa, Ryoma
Venue: Current Biology
Publisher: Elsevier BV
Published: 2017-11
Volume: 27
Issue: 21
Pages: R1177-R1192
ISSN: 0960-9822 (ISSN-L)
DOI: 10.1016/j.cub.2017.09.015
OpenAlex: W2767078779
Semantic Scholar: 7bb03e08dc50f88f426d6ec3ad173e496c036fb5
Cited by: 1,142
References: 130
Citations by year: 2026: 124 · 2025: 141 · 2024: 164 · 2023: 172 · 2022: 165 · 2021: 162 · 2020: 113 · 2019: 62 · 2018: 37 · 2017: 2
FWCI: 5.47
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 370 d)
Locations: Current Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Japan Society for the Promotion of Science (15H05606, 15K14591)
Topics: Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Protist diversity and phylogeny
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: mitochondrial origin, endosymbiotic origin of mitochondria, Alphaproteobacteria, Asgard archaea, endosymbiotic gene transfer, horizontal gene transfer, membrane transporters, eukaryotic evolution, aerobic respiration
MeSH terms: Adenosine Triphosphate, Eukaryotic Cells, Biological Evolution, Mitochondria, Symbiosis, Alphaproteobacteria, Protein Transport, Membrane Transport Proteins, Genome, Mitochondrial

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The Origin and Diversification of Mitochondria

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