Disease Management of Dairy Calves and Heifers
Open accessAbstract
This article focuses on the most important diseases of dairy calves and heifers and presents clinical approaches that can improve detection, diagnosis, and treatment of herd-based problems. A systematic herd investigation strategy is pivotal to define the problems, understand important risk factors, develop a plan, and make recommendations for disease management accurately. A review of records, colostrum and feeding routines, housing and bedding management, routine procedures, vaccination, and treatment protocols begins the investigation and determines which diagnostic procedures and testing strategies are most useful. Disease management is most effective when the problem source is well defined and the exposure can be limited, calf immunity can be enhanced, or a combination of both. Screening examinations performed regularly or done at strategic time points improves detection of disease, can be used to monitor treatment outcomes, and can avoid disease outbreaks.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Multiple scoring systems have been developed and evaluated across various environmental conditions to bring uniformity to BRD case definitions.
“To bring uniformity to BRD case definitions, multiple scoring systems have been developed and evaluated across various environmental conditions [61,64].”
From Strategies for Bovine Respiratory Disease (BRD) Diagnosis and Prognosis: A Comprehensive Overview (2024) · cites this paper as [61]
The section ‘Solving respiratory disease problems of calves and heifers’ (page unavailable) describes a respiratory scoring tool, a disease threshold validated against bronchoalveolar fluid findings, and a related approach for group pens. It does not say that multiple scoring systems were developed and evaluated across various environmental conditions. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Omidbakhsh, N., & Sattar, S. A. (2006) · American Journal of Infection Control · doi:10.1016/j.ajic.2005.06.002 · Cited by 161 · see citing works
Flagged first, then by citations
Research works printed but not linked: 37
- [2]Tyler J.W. Hancock D.D. Thorne J.G. Partitioning the mortality risk associated with inadequate passive transfer of colostral immunoglobulins in dairy calves J Vet Intern Med 13 1999 335 337 10449225
- [4]Svensson C. Linder A. Olsson S.O. Mortality in Swedish dairy calves and replacement heifers J Dairy Sci 89 2006 4769 4777 17106108
- [5]Agerholm J.S. Basse A. Krogh H.V. Abortion and calf mortality in Danish cattle herds Acta Vet Scand 34 1993 371 377 8147289 PMC8112523
- [6]Virtala A.M. Mechor G.D. Gröhn Y.T. Morbidity from nonrespiratory diseases and mortality in dairy heifers during the first three months of life J Am Vet Med Assoc 208 1996 2043 2046 8707681
- [7]Karzes J. Dairy replacement programs: cost and analysis. In: Dairy calves and heifers: integrating biology and management. NRAES Conference. Syracuse (NY); 2005. p. 10–23.
- [8]Tozer P.R. Heinrichs A.J. What affects the costs of raising replacement dairy heifers: a multiple component analysis J Dairy Sci 84 2001 1836 1844 11518308
- [9]Wolf C.A. Custom dairy heifer grower industry characteristics and contract terms J Dairy Sci 86 2003 3016 3022 14507039
- [10]Hall G.A. Reynolds D.J. Parsons K.R. Pathology of calves with diarrhoea in southern Britain Res Vet Sci 45 1988 240 250 3194595 PMC7130561
- [11]Garber L.P. Salman M.D. Hurd H.S. Potential risk factors for Cryptosporidium infection in dairy calves J Am Vet Med Assoc 205 1994 86 91 7928557
- [12]Lucchelli A. Lance S.E. Bartlett P.B. Prevalence of bovine group A rotavirus shedding among dairy calves in Ohio Am J Vet Res 53 2 1992 169 174 1315490
- [13]Hoet A.E. Smiley J. Thomas C. Association of enteric shedding of bovine torovirus (Breda virus) and other enteropathogens with diarrhea in veal calves Am J Vet Res 64 4 2003 485 490 12693541
- [14]Theil K.W. McCloskey C.M. Rotavirus shedding in feces of gnotobiotic calves orally inoculated with a commercial rotavirus-coronavirus vaccine J Vet Diagn Invest 7 4 1995 427 432 8580160
- [15]Nielsen L.R. Toft N. Ersbøll A.K. Evaluation of an indirect serum ELISA and a bacteriological faecal culture test for diagnosis of Salmonella serotype Dublin in cattle using latent class models J Appl Microbiol 96 2004 311 319 14723692
- [16]Pelan-Mattocks L.S. Kehrli M.E. Casey T.A. Fecal shedding of coliform bacteria during the peripartum period in dairy cows Am J Vet Res 61 12 2000 1636 1638 11131612
- [17]Panivivat R. Kegley E.B. Penninton J.A. Growth performance and health of dairy calves bedded with different types of materials J Dairy Sci 87 2004 3736 3745 15483157 PMC7190087
- [18]Zehner M.M. Farnsworth R.J. Appleman R.D. Growth of environmental mastitis pathogens in various bedding materials J Dairy Sci 69 1986 1932 1941 3528251
- [19]Hogan J.S. Smith K.L. Todhunter D.A. Bacterial counts associated with recycled newspaper bedding J Dairy Sci 73 7 1990 1756 1761 2229587
- [20]Cobbold R.N. Rice D.H. Davis M.A. Long-term persistence of multi-drug resistant Salmonella enterica serovar Newport in two dairy herds J Am Vet Med Assoc 228 4 2006 585 591 16478439
- [22]Quilez J. Sanchez-Acedo C. Avendaño C. Efficacy of two peroxygen-based disinfectants for inactivation of Cryptosporidium parvum oocysts Appl Environ Microbiol 71 5 2005 2479 2483 15870337 PMC1087572
- [24]Patterson G. Morley P.S. Blehm K.D. Efficacy of directed misting application of a peroxygen disinfectant for environmental decontamination of a veterinary hospital J Am Vet Med Assoc 227 4 2005 597 602 16117069
- [25]Hardman P.M. Wathes C.M. Wray C. Transmission of salmonellae among calves penned individually Vet Rec 129 15 1991 327 329 1750173
- [26]Naylor J.M. Oral electrolyte therapy Vet Clin North Am Food Anim Pract 15 3 1999 487 504 10573808
- [27]Berchtold J. Intravenous fluid therapy of calves Vet Clin North Am Food Anim Pract 15 3 1999 505 531 10573809 PMC7135553
- [28]Quigley J.D. Wolfe T.A. Elsasser T.H. Effects of additional milk replacer feeding on calf health, growth and selected blood metabolites in calves J Dairy Sci 89 2006 207 216 16357284 PMC7164769
- [29]Constable P.D. Antimicrobial use in the treatment of calf diarrhea J Vet Intern Med 18 2004 8 17 14765726 PMC7197454
- [30]Berge A.C.B. Lindeque P. Moore D.A. A clinical trial evaluating prophylactic and therapeutic antibiotic use on health and performance of preweaned calves J Dairy Sci 88 2005 2166 2177 15905446
- [31]Fecteau M.-E. House J.K. Kotarski S.F. Efficacy of ceftiofur for treatment of experimental salmonellosis in neonatal calves Am J Vet Res 64 2003 918 925 12856779
- [32]Weigler B.J. Hird D.W. Sischo W.M. Veterinary and nonveterinary costs of disease in 29 California dairies participating in the National Animal Health Monitoring System from 1988 to 1989 J Am Vet Med Assoc 196 12 1990 1945 1949 2365618
- [33]Donavan G.A. Dohoo I.R. Montgomery D.M. Calf and disease factors affecting growth in female Holstein calves in Florida, USA Prev Vet Med 33 1–4 1998 1 10 9500160
- [34]Waltner-Toews D. Martin S.W. Meek A.H. The effect of early calfhood health status on survivorship and age at first calving Can J Vet Res 50 3 1986 314 317 3742366 PMC1255219
- [35]Warnick L.D. Erb H.N. White M.E. The relationship of calfhood morbidity with survival after calving in 25 New York Holstein herds Prev Vet Med 31 3–4 1997 263 273 9234450
- [36]Virtala A.M. Mechor G.D. Grohn Y.T. Epidemiologic and pathologic characteristics of respiratory tract disease in dairy heifers during the first three months of life J Am Vet Med Assoc 208 12 1996 2035 2042 8707680
- [37]Lago A. McGuirk S.M. Bennett T.B. Calf respiratory disease and pen microenvironments in naturally ventilated calf barns in winter J Dairy Sci 89 2006 4014 4025 16960078
- [38]McGuirk SM. Troubleshooting dairy calf pneumonia problems. Proceedings of the Twenty fifth Annual ACVIM Forum. Seattle, Washington, June 6–9, 2007.
- [39]DeRosa D.C. Mechor G.D. Staats J.J. Comparison of Pasteurella spp. simultaneously isolated from nasal and transtracheal swabs from cattle with clinical signs of bovine respiratory disease J Clin Microbiol 38 1 2000 327 332 10618110 PMC88718
- [40]ter Laak E.A. Noordergraaf J.H. Boomsluiter E. The nasal mycoplasmal flora of healthy calves and cows Zentralbl Veterinarmed B 39 8 1992 610 616 1462726
- [41]Zimmerman A.D. Boots R.E. Valli J.L. Evaluation of protection against virulent bovine viral diarrhea virus type 2 in calves that had maternal antibodies and were vaccinated with a modified-live vaccine J Am Vet Med Assoc 228 11 2006 1757 1761 16740078
Cited by
Sorted by citations
Love, W. J., Lehenbauer, T. W., Kass, P. H., Van Eenennaam, A. L., & Aly, S. S. (2014) · PeerJ · doi:10.7717/peerj.238 · Cited by 228 · see citing works
Silage review: Foodborne pathogens in silage and their mitigation by silage additives
Queiroz, O. C. M., Ogunade, I. M., Weinberg, Z., & Adesogan, A. T. (2018) · Journal of Dairy Science · doi:10.3168/jds.2017-13901 · Cited by 213 · see citing works
On-Farm Use of Ultrasonography for Bovine Respiratory Disease
Ollivett, T. L., & Buczinski, S. (2016) · Veterinary Clinics of North America: Food Animal Practice · doi:10.1016/j.cvfa.2015.09.001 · Cited by 177 · see citing works
Risk factors associated with mortality at a milk-fed veal calf facility: A prospective cohort study
Renaud, D. L., Duffield, T. F., LeBlanc, S. J., Ferguson, S., Haley, D. B., & Kelton, D. F. (2018) · Journal of Dairy Science · doi:10.3168/jds.2017-13581 · Cited by 118 · see citing works
Dunn, T. R., Ollivett, T. L., Renaud, D. L., Leslie, K. E., LeBlanc, S. J., Duffield, T. F., & Kelton, D. F. (2018) · Journal of Dairy Science · doi:10.3168/jds.2017-13870 · Cited by 102 · see citing works
Bovine Respiratory Disease Diagnosis
Buczinski, S., & Pardon, B. (2020) · Veterinary Clinics of North America: Food Animal Practice · doi:10.1016/j.cvfa.2020.03.004 · Cited by 89 · see citing works
Strategies for Bovine Respiratory Disease (BRD) Diagnosis and Prognosis: A Comprehensive Overview
Kamel, M. S., Davidson, J. L., & Verma, M. S. (2024) · Animals · doi:10.3390/ani14040627 · Cited by 76 · see citing works
“…with bacterial pathogens can trigger an acute phase response characterized by a swift emergence of systemic symptoms, such as fever, loss of appetite, lethargy, and respiratory issues including nasal discharge, coughing, rapid breathing (tachypnea), and difficulty breathing (dyspnea) [61].”
BackgroundMethodJoshi, V., Gupta, V. K., Bhanuprakash, A. G., Mandal, R. S. K., Dimri, U., & Ajith, Y. (2018) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.01.001 · Cited by 75 · see citing works
Renaud, D. L., Duffield, T. F., LeBlanc, S. J., Haley, D. B., & Kelton, D. F. (2018) · Journal of Dairy Science · doi:10.3168/jds.2017-14042 · Cited by 70 · see citing works
Welfare of cattle during transport
(AHAW), E. P. O. A. H. A. W., Nielsen, S. S., Alvarez, J., Bicout, D. J., Calistri, P., Canali, E., Drewe, J. A., Garin‐Bastuji, B., Gonzales Rojas, J. L., Gortázar Schmidt, C., et al. (2022) · EFSA Journal · doi:10.2903/j.efsa.2022.7442 · Cited by 64 · see citing works
Adams, E. A., & Buczinski, S. (2016) · Journal of Dairy Science · doi:10.3168/jds.2015-10260 · Cited by 58 · see citing works
Scott, K., Kelton, D. F., Duffield, T. F., & Renaud, D. L. (2019) · Journal of Dairy Science · doi:10.3168/jds.2019-16829 · Cited by 52 · see citing works
Ferraro, S., Fecteau, G., Dubuc, J., Francoz, D., Rousseau, M., Roy, J.-P., & Buczinski, S. (2021) · Journal of Dairy Science · doi:10.3168/jds.2020-19471 · Cited by 51 · see citing works
Cramer, M. C., & Stanton, A. L. (2015) · Journal of Dairy Science · doi:10.3168/jds.2015-9534 · Cited by 49 · see citing works
Buczinski, S., Borris, M. E., & Dubuc, J. (2018) · Journal of Dairy Science · doi:10.3168/jds.2017-13459 · Cited by 49 · see citing works
Renaud, D. L., Overton, M. W., Kelton, D. F., LeBlanc, S. J., Dhuyvetter, K. C., & Duffield, T. F. (2018) · Journal of Dairy Science · doi:10.3168/jds.2018-14960 · Cited by 44 · see citing works
Buczinski, S., Fecteau, G., Dubuc, J., & Francoz, D. (2018) · Preventive Veterinary Medicine · doi:10.1016/j.prevetmed.2018.05.004 · Cited by 43 · see citing works
“Various systemic clinical signs (fever, depression, anorexia) and respiratory signs (nasal discharge, tachypnea, dyspnea, cough, etc…) characterize the classical BRD presentation (McGuirk, 2008).”
BackgroundMethodInfluentialCramer, M. C., Ollivett, T. L., & Stanton, A. L. (2016) · Journal of Dairy Science · doi:10.3168/jds.2015-10207 · Cited by 43 · see citing works
Abdallah, A., Hewson, J., Francoz, D., Selim, H., & Buczinski, S. (2016) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.13975 · Cited by 39 · see citing works
Buczinski, S., Faure, C., Jolivet, S., & Abdallah, A. (2016) · New Zealand Veterinary Journal · doi:10.1080/00480169.2016.1153439 · Cited by 39 · see citing works
Berman, J., Francoz, D., Abdallah, A., Dufour, S., & Buczinski, S. (2021) · Journal of Dairy Science · doi:10.3168/jds.2021-20503 · Cited by 30 · see citing works
Bovine Respiratory Disease Considerations in Young Dairy Calves
Cummings, D. B., Meyer, N. F., & Step, D. L. (2022) · Veterinary Clinics of North America: Food Animal Practice · doi:10.1016/j.cvfa.2021.11.007 · Cited by 30 · see citing works
Early Detection of Respiratory Diseases in Calves by Use of an Ear-Attached Accelerometer
Ramezani Gardaloud, N., Guse, C., Lidauer, L., Steininger, A., Kickinger, F., Öhlschuster, M., Auer, W., Iwersen, M., Drillich, M., & Klein-Jöbstl, D. (2022) · Animals · doi:10.3390/ani12091093 · Cited by 24 · see citing works
Predictive Modeling of Bovine Respiratory Disease Outcomes in Feedlot Cattle: A Narrative Review
Wisnieski, L., Amrine, D. E., & Renter, D. G. (2021) · Livestock Science · doi:10.1016/j.livsci.2021.104666 · Cited by 23 · see citing works
Short communication: Calf cleanliness does not predict diarrhea upon arrival at a veal calf facility
Graham, A. N., Renaud, D. L., Duffield, T. F., & Kelton, D. F. (2018) · Journal of Dairy Science · doi:10.3168/jds.2017-14113 · Cited by 19 · see citing works
Buczinski, S., Boccardo, A., & Pravettoni, D. (2021) · Animals · doi:10.3390/ani11113244 · Cited by 15 · see citing works
Behavior Assessment and Applications for BRD Diagnosis: Preweaned Dairy Calves
Cramer, C., & Ollivett, T. L. (2020) · Animal Health Research Reviews · doi:10.1017/s1466252320000213 · Cited by 15 · see citing works
Condition of bob veal calves on arrival at an abattoir in Ohio
England, Z. A., Maggard, H. L., Fisher, A. D., Roadknight, N. W., & Pempek, J. A. (2023) · Animal Welfare · doi:10.1017/awf.2022.8 · Cited by 15 · see citing works
Bajus, A., Creutzinger, K. C., Cantor, M. C., Wilms, J. N., Gomez Nieto, D. E., Steele, M. A., Kelton, D. F., & Renaud, D. L. (2024) · Journal of Dairy Science · doi:10.3168/jds.2023-23973 · Cited by 8 · see citing works
Pisoni, L., Devant, M., Bassols, A. M., Saco, Y., Pato, R., Pujols, J., & Marti, S. (2023) · Journal of Dairy Science · doi:10.3168/jds.2023-23374 · Cited by 6 · see citing works
- Authors
- McGuirk, S. M.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- McGuirk, Sheila M.
- Venue
- Veterinary Clinics of North America: Food Animal Practice
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 24
- Issue
- 1
- Pages
- 139-153
- ISSN
- 0749-0720 (ISSN-L)
- PMC
- PMC7135781
- OpenAlex
- W2024547860
- Cited by
- 629
- References
- 1
- Citations by year
- 2026: 38 · 2025: 72 · 2024: 52 · 2023: 59 · 2022: 58 · 2021: 76 · 2020: 56 · 2019: 48 · 2018: 35 · 2017: 44 · 2016: 29 · 2015: 18 · 2014: 19 · 2013: 11 · 2012: 4
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Veterinary Clinics of North America Food Animal Practice (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Animal health and immunology
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Animal Disease Management and Epidemiology
- Keywords
- dairy calves, heifers, calf diseases, disease management, colostrum, calf feeding, vaccination, treatment protocols, screening test, calf immunity, risk factors, outbreak
- MeSH terms
- Animals, Animals, Newborn, Cattle, Cattle Diseases, Dairying, Female, Health Status, Population Surveillance, Risk Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review