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Immune signaling as a node of interaction between systems that sex-specifically develop during puberty and adolescence
Open accessAbstract
Adolescence is pivotal for neural and behavioral development across species. During this period, maturation occurs in several biological systems, the most well-recognized being activation of the hypothalamic-pituitary-gonadal axis marking pubertal onset. Increasing comparative studies of sex differences have enriched our understanding of systems integration during neurodevelopment. In recent years, immune signaling has emerged as a key node of interaction between a variety of biological signaling processes. Herein, we review the age- and sex-specific changes that occur in neural, hypothalamic-pituitary, and microbiome systems during adolescence. We then describe how immune signaling interacts with these systems, and review recent preclinical evidence indicating that immune signaling may play a central role in integrating changes in their typical and atypical development during adolescence. Finally, we discuss the translational relevance of these preclinical studies to human health and wellness.
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“it is increasingly recognized to be evolutionarily conserved, with animal species also showing distinct markers of an adolescent state [35–40].”
From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [37]
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Petrican, R., Fornito, A., & Boyland, E. J. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.06.023 · Cited by 14
Adolescent social isolation induces sex-specific behavioral and neural alterations
Albanese, N. C., Poggini, S., Reccagni, A., Barezzi, C., Salciccia, C., Poleggi, A., & Branchi, I. (2024) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2024.107264 · Cited by 10
Metadata
- Authors
- Granata, L., Gildawie, K. R., Ismail, N., Brenhouse, H. C., & Kopec, A. M.
- Affiliations
- Northeastern University (US)
- Tufts University (US)
- University of Ottawa (CA)
- Albany Medical College (US)
- Corresponding author
- Kopec, Ashley M.
- Venue
- Developmental Cognitive Neuroscience
- Publisher
- Elsevier BV
- Published
- 2022-10
- Volume
- 57
- Pages
- 101143
- ISSN
- 1878-9293 (ISSN-L)
- PMC
- PMC9357835
- OpenAlex
- W4289527871
- Cited by
- 15
- References
- 300
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 6
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Developmental Cognitive Neuroscience (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (R03AG07011)
- Natural Sciences and Engineering Research Council of Canada
- National Institute on Aging (R03AG070111)
- National Institute of Mental Health (R01MH127850)
- National Institute on Drug Abuse (R01DA052889)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- immune signaling, adolescence, puberty, sex differences, hypothalamic-pituitary-gonadal axis, microbiome, brain development, system integration, hypothalamic-pituitary axis, atypical development
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