The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
A neurobiological model of insomnia
Open accessAbstract
Insomnia is a common clinical condition resulting in significant costs and morbidity. Previous models of insomnia focusing on psychological and behavioral processes are useful clinically, but lack neurobiological specificity. We propose an insomnia model based on basic and clinical neuroscience findings, and hypothesize that insomnia results from persistent activity in wake-promoting neural structures during NREM sleep. The simultaneous occurrence of sleeping and waking neural activity helps to explain clinical phenomenology and treatment effects in insomnia.
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Citations
Cites
Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804
Psychological and behavioral treatment of insomnia: update of the recent evidence (1998-2004)
Morin, C. M., Bootzin, R. R., Buysse, D. J., Edinger, J. D., Espie, C. A., & Lichstein, K. L. (2006) · Sleep · doi:10.1093/sleep/29.11.1398 · Cited by 1,345
Self-citationA behavioral perspective on insomnia treatment
Spielman, A. J., Caruso, L. S., & Glovinsky, P. B. (1987) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(18)30532-x · Cited by 1,261
Psychophysiological insomnia: the behavioural model and a neurocognitive perspective
PERLIS, M. L., GILES, D. E., MENDELSON, W. B., BOOTZIN, R. R., & WYATT, J. K. (1997) · Journal of Sleep Research · doi:10.1046/j.1365-2869.1997.00045.x · Cited by 795 · cited 1×
“Finally, the neurocognitive model [15] builds on the diathesis-stress (3-P) model described above, but integrates neurobiological and neurophysiological observations.”
MethodFunctional Neuroimaging Evidence for Hyperarousal in Insomnia
Nofzinger, E. A., Buysse, D. J., Germain, A., Price, J. C., Miewald, J. M., & Kupfer, D. J. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.2126 · Cited by 752 · cited 1×
“) These studies show smaller differences between wakefulness and early NREM sleep in insomnia patients compared to controls in medial temporal cortex, thalamus, anterior cingulate, and brainstem arousal centers [34].”
Self-citationSleep as a fundamental property of neuronal assemblies
Krueger, J. M., Rector, D. M., Roy, S., Van Dongen, H. P. A., Belenky, G., & Panksepp, J. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2521 · Cited by 596
Espie, C. A., Broomfield, N. M., MacMahon, K. M. A., Macphee, L. M., & Taylor, L. M. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2006.03.002 · Cited by 532
The Natural History of Insomnia: A Population-Based 3-Year Longitudinal Study
Morin, C. M., Bélanger, L., LeBlanc, M., Ivers, H., Savard, J., Espie, C. A., Mérette, C., Baillargeon, L., & Grégoire, J.-P. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2008.610 · Cited by 498 · cited 1×
“Insomnia is often a chronic condition: Longitudinal studies indicate that approximately 2/3 of individuals have symptoms which persist for at least one year [3].”
BackgroundWhat is self-specific? Theoretical investigation and critical review of neuroimaging results
Legrand, D., & Ruby, P. (2009) · Psychological Review · doi:10.1037/a0014172 · Cited by 470 · cited 1×
“It is thought to play a central role in modulation of conscious processes, awareness, mental representations of the self, and inferential processing of context-related information [36,37].”
BackgroundEffect of unilateral somatosensory stimulation prior to sleep on the sleep EEG in humans
KATTLER, H., DIJK, D., & BORBÉLY, A. A. (1994) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1994.tb00123.x · Cited by 401
Regional Cerebral Metabolic Correlates of WASO During NREM Sleep in Insomnia
Nofzinger, E. A., Nissen, C., Germain, A., Moul, D., Hall, M., Price, J. C., Miewald, J. M., & Buysse, D. J. (2006) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26592 · Cited by 114
Self-citationDe Gennaro, L., Fratello, F., Marzano, C., Moroni, F., Curcio, G., Tempesta, D., Pellicciari, M. C., Pirulli, C., Ferrara, M., & Rossini, P. M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002483 · Cited by 60
Cited by
Kalmbach, D. A., Anderson, J. R., & Drake, C. L. (2018) · Journal of Sleep Research · doi:10.1111/jsr.12710 · Cited by 620
“…the neurobiology of sleep disturbance and insomnia (please refer to reviews by Baglioni et al., 2010; Basta et al., 2007; Bonnet & Arand, 2010; Buysse et al., 2012; Harvey et al., 2014; Palagini et al., 2014; Riemann et al., 2010, 2015; and Vgontzas et al., 2013 for in-depth analysis in this…”
BackgroundOlaithe, M., Bucks, R. S., Hillman, D. R., & Eastwood, P. R. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2017.03.005 · Cited by 350
Harvey, A. G., Bélanger, L., Talbot, L., Eidelman, P., Beaulieu-Bonneau, S., Fortier-Brochu, É., Ivers, H., Lamy, M., Hein, K., Soehner, A. M., et al. (2014) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0036606 · Cited by 215
Mitchell, L. J., Bisdounis, L., Ballesio, A., Omlin, X., & Kyle, S. D. (2019) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2019.06.002 · Cited by 171
Insomnia Disorder and Brain’s Default-Mode Network
Marques, D. R., Gomes, A. A., Caetano, G., & Castelo-Branco, M. (2018) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-018-0861-3 · Cited by 112
Metadata
- Authors
- Buysse, D. J., Germain, A., Hall, M., Monk, T. H., & Nofzinger, E. A.
- Venue
- Drug Discovery Today: Disease Models
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 8
- Issue
- 4
- Pages
- 129-137
- ISSN
- 1740-6757 (ISSN-L)
- OpenAlex
- W2082538973
- Cited by
- 179
- References
- 12
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
