Sleep as a fundamental property of neuronal assemblies
Open accessAbstract
Sleep is vital to cognitive performance, productivity, health and well-being. Earlier theories of sleep presumed that it occurred at the level of the whole organism and that it was governed by central control mechanisms. However, evidence now indicates that sleep might be regulated at a more local level in the brain: it seems to be a fundamental property of neuronal networks and is dependent on prior activity in each network. Such local-network sleep might be initiated by metabolically driven changes in the production of sleep-regulatory substances. We discuss a mathematical model which illustrates that the sleep-like states of individual cortical columns can be synchronized through humoral and electrical connections, and that whole-organism sleep occurs as an emergent property of local-network interactions.
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Encoding of information during waking enhances subsequent SWA in specific brain regions.
“in demonstrating that the encoding of information during waking enhances subsequent SWA in specific brain regions, these studies provide compelling evidence that SWA is regulated locally in addition to its global regulation by brain stem and diencephalic structures (672, 859, 975, 1267).”
From About Sleep's Role in Memory (2013) · cites this paper as [672]
Section III, “Sleep Depends on Past Activity” (page unavailable), reports that regions disproportionately stimulated during waking show enhanced EEG delta power during subsequent NREM sleep. This supports the regional SWA finding, but the passage describes stimulation and prior use, not specifically the encoding of information. (LLM, conf=0.82)
Experimental — accuracy not yet measuredSWA is regulated locally in addition to its global regulation by brain stem and diencephalic structures.
“these studies provide compelling evidence that SWA is regulated locally in addition to its global regulation by brain stem and diencephalic structures (672, 859, 975, 1267).”
From About Sleep's Role in Memory (2013) · cites this paper as [672]
The pro-inflammatory acting cytokines IFN-γ, IL-2, IL-6, IL-15, and IL-18 have NREM sleep-promoting actions in animal models.
“the pro-inflammatory acting cytokines IFN-γ, IL-2, IL-6, IL-15, and IL-18 have NREM sleep-promoting actions in animal models (238, 306, 307, 309).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [306]
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Cites
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
Affective Neuroscience: The Foundations of Human and Animal Emotions
Panksepp, J. (1998) · doi:10.1093/oso/9780195096736.001.0001 · Cited by 4,428 · see citing works
Self-citationExcitatory and Inhibitory Interactions in Localized Populations of Model Neurons
Wilson, H. R., & Cowan, J. D. (1972) · Biophysical Journal · doi:10.1016/s0006-3495(72)86068-5 · Cited by 3,579 · see citing works
Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804 · see citing works
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588 · see citing works
Synaptic plasticity: taming the beast
Abbott, L. F., & Nelson, S. B. (2000) · Nature Neuroscience · doi:10.1038/81453 · Cited by 2,263 · see citing works
Sleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151 · see citing works
Synchronization of Pulse-Coupled Biological Oscillators
Mirollo, R. E., & Strogatz, S. H. (1990) · SIAM Journal on Applied Mathematics · doi:10.1137/0150098 · Cited by 2,078 · see citing works
Huber, R., Felice Ghilardi, M., Massimini, M., & Tononi, G. (2004) · Nature · doi:10.1038/nature02663 · Cited by 1,854 · see citing works
Synaptic scaling mediated by glial TNF-α
Stellwagen, D., & Malenka, R. C. (2006) · Nature · doi:10.1038/nature04671 · Cited by 1,715 · see citing works
Physiology and Pathophysiology of Purinergic Neurotransmission
Burnstock, G. (2007) · Physiological Reviews · doi:10.1152/physrev.00043.2006 · Cited by 1,579 · see citing works
Control of Synaptic Strength by Glial TNFα
Beattie, E. C., Stellwagen, D., Morishita, W., Bresnahan, J. C., Ha, B. K., Von Zastrow, M., Beattie, M. S., & Malenka, R. C. (2002) · Science · doi:10.1126/science.1067859 · Cited by 1,344 · see citing works
Biogenic Amines and the States of Sleep
Jouvet, M. (1969) · Science · doi:10.1126/science.163.3862.32 · Cited by 1,284 · see citing works
Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study
Braun, A. (1997) · Brain · doi:10.1093/brain/120.7.1173 · Cited by 1,268 · see citing works
The role of sleep in learning and memory
Maquet, P. (2001) · Science · doi:10.1126/science.1062856 · Cited by 1,177 · see citing works
Clues to the functions of mammalian sleep
Siegel, J. M. (2005) · Nature · doi:10.1038/nature04285 · Cited by 1,040 · see citing works
The P2X7 Receptor: A Key Player in IL-1 Processing and Release
Ferrari, D., Pizzirani, C., Adinolfi, E., Lemoli, R. M., Curti, A., Idzko, M., Panther, E., & Di Virgilio, F. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.3877 · Cited by 1,025 · see citing works
Crick, F., & Mitchison, G. (1983) · Nature · doi:10.1038/304111a0 · Cited by 865 · see citing works
The neurotrophin hypothesis for synaptic plasticity
Schinder, A. F. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01672-6 · Cited by 729 · see citing works
Astrocyte-Derived ATP Induces Vesicle Shedding and IL-1β Release from Microglia
Bianco, F., Pravettoni, E., Colombo, A., Schenk, U., Möller, T., Matteoli, M., & Verderio, C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7268 · Cited by 596 · see citing works
Adenosine and sleep–wake regulation
Basheer, R., Strecker, R. E., Thakkar, M. M., & McCarley, R. W. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.06.004 · Cited by 589 · see citing works
Arm immobilization causes cortical plastic changes and locally decreases sleep slow wave activity
Huber, R., Ghilardi, M. F., Massimini, M., Ferrarelli, F., Riedner, B. A., Peterson, M. J., & Tononi, G. (2006) · Nature Neuroscience · doi:10.1038/nn1758 · Cited by 579 · see citing works
Sleep Enhances Plasticity in the Developing Visual Cortex
Frank, M. G., Issa, N. P., & Stryker, M. P. (2001) · Neuron · doi:10.1016/s0896-6273(01)00279-3 · Cited by 523 · see citing works
The corticothalamic system in sleep
Steriade, M. (2003) · Frontiers in bioscience · doi:10.2741/1043 · Cited by 504 · see citing works
Model of Thalamocortical Slow-Wave Sleep Oscillations and Transitions to Activated States
Bazhenov, M., Timofeev, I., Steriade, M., & B, T. J. S. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08691.2002 · Cited by 457 · see citing works
Extracellular ATP Triggers Tumor Necrosis Factor‐α Release from Rat Microglia
Hide, I., Tanaka, M., Inoue, A., Nakajima, K., Kohsaka, S., Inoue, K., & Nakata, Y. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750965.x · Cited by 447 · see citing works
Kaneko, M., Stellwagen, D., Malenka, R. C., & Stryker, M. P. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.023 · Cited by 405 · see citing works
Effect of unilateral somatosensory stimulation prior to sleep on the sleep EEG in humans
KATTLER, H., DIJK, D., & BORBÉLY, A. A. (1994) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1994.tb00123.x · Cited by 401 · see citing works
Suzuki, T., Hide, I., Ido, K., Kohsaka, S., Inoue, K., & Nakata, Y. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3792-03.2004 · Cited by 394 · see citing works
Insights from studying human sleep disorders
Mahowald, M. W., & Schenck, C. H. (2005) · Nature · doi:10.1038/nature04287 · Cited by 330 · see citing works
Biochemical regulation of non-rapid-eye-movement sleep
Krueger, J. M. (2003) · Frontiers in Bioscience · doi:10.2741/1033 · Cited by 329 · see citing works
Self-citationA neuronal group theory of sleep function
Krueger, J. M., & Obál, F. (1993) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1993.tb00064.x · Cited by 314 · see citing works
Self-citationInterhemispheric asymmetry of the electroencephalographic sleep patterns in dolphins
Mukhametov, L. M., Supin, A., & Polyakova, I. G. (1977) · Brain Research · doi:10.1016/0006-8993(77)90835-6 · Cited by 301 · see citing works
Sleep deprivation-induced reduction in cortical functional response to serial subtraction
Drummond, S. P. A., Brown, G. G., Stricker, J. L., Buxton, R. B., Wong, E. C., & Gillin, J. C. (1999) · NeuroReport · doi:10.1097/00001756-199912160-00004 · Cited by 285 · see citing works
Links between the innate immune system and sleep
Majde, J. A., & Krueger, J. M. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.08.005 · Cited by 277 · see citing works
Self-citationA functional role for REM sleep in brain maturation.
Marks, G. A., Shaffery, J., Oksenberg, A., Speciale, S., & Roffwarg, H. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00018-o · Cited by 276 · see citing works
Spindle frequency activity in the sleep EEG: individual differences and topographical distribution
Werth, E., Achermann, P., Dijk, D., & Borbély, A. A. (1997) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/s0013-4694(97)00070-9 · Cited by 260 · see citing works
Endogenous sleep-promoting substances and sleep regulation
Borbely, A. A., & Tobler, I. (1989) · Physiological Reviews · doi:10.1152/physrev.1989.69.2.605 · Cited by 259 · see citing works
Identification of a population of sleep-active cerebral cortex neurons
Gerashchenko, D., Wisor, J. P., Burns, D., Reh, R. K., Shiromani, P. J., Sakurai, T., de la Iglesia, H. O., & Kilduff, T. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803125105 · Cited by 207 · see citing works
Koch, C. (2004) · Caltech Magazine (California Institute of Technology) · Cited by 203 · see citing works
Vyazovskiy, V., Borbély, A. A., & Tobler, I. (2000) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2000.00230.x · Cited by 203 · see citing works
Suprachiasmatic nucleus in sleep–wake regulation
Moore, R. Y. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2007.10.003 · Cited by 202 · see citing works
Caffeine Reduces Low-Frequency Delta Activity in the Human Sleep EEG
Landolt, H. (1995) · Neuropsychopharmacology · doi:10.1016/0893-133x(94)00079-f · Cited by 198 · see citing works
Asavathiratham, C., Roy, S., Lesieutre, B. C., et al. (2001) · IEEE Control Systems · doi:10.1109/37.969135 · Cited by 184 · see citing works
Self-citationRhythmic electrical activity from isolated cerebral cortex
Kristiansen, K., & Courtois, G. (1949) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(49)90191-1 · Cited by 172 · see citing works
Diem, R., Meyer, R., Weishaupt, J. H., & Bähr, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-06-02058.2001 · Cited by 164 · see citing works
Purinergic signaling and microglia
Färber, K., & Kettenmann, H. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0064-7 · Cited by 163 · see citing works
Interleukin-1 beta modulates AMPA receptor expression and phosphorylation in hippocampal neurons
Lai, A. Y., Swayze, R. D., El-Husseini, A., & Song, C. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.03.001 · Cited by 162 · see citing works
Local functional state differences between rat cortical columns
Rector, D. M., Topchiy, I., Carter, K. M., & Rojas, M. J. (2005) · Brain Research · doi:10.1016/j.brainres.2005.04.002 · Cited by 159 · see citing works
Self-citationInhibition of nitric oxide synthesis inhibits rat sleep
Kapás, L., Fang, J., & Krueger, J. M. (1994) · Brain Research · doi:10.1016/0006-8993(94)91969-0 · Cited by 133 · see citing works
Self-citationKrueger, J. M., Rector, D. M., & Churchill, L. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.03.003 · Cited by 127 · see citing works
Self-citationInteraction Between Sleep and the Immune Response in Drosophila: A Role for the NFκB Relish
Williams, J. A., Sathyanarayanan, S., Hendricks, J. C., & Sehgal, A. (2007) · Sleep · doi:10.1093/sleep/30.4.389 · Cited by 126 · see citing works
Evidence for asynchronous development of sleep in cortical areas
Pigarev, I. N., Nothdurft, H., & Kästner, S. (1997) · Neuroreport · doi:10.1097/00001756-199707280-00027 · Cited by 125 · see citing works
Brain organization and sleep function
Krueger, J. M., Obál, F., Kapás, L., & Fang, J. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00015-l · Cited by 120 · see citing works
Self-citationRegional Cerebral Metabolic Correlates of WASO During NREM Sleep in Insomnia
Nofzinger, E. A., Nissen, C., Germain, A., Moul, D., Hall, M., Price, J. C., Miewald, J. M., & Buysse, D. J. (2006) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26592 · Cited by 114 · see citing works
Alam, M. N., McGinty, D., Bashir, T., Kumar, S., Imeri, L., Opp, M. R., & Szymusiak, R. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03469.x · Cited by 108 · see citing works
Experience-dependent slow-wave sleep development
Miyamoto, H., Katagiri, H., & Hensch, T. K. (2003) · Nature Neuroscience · doi:10.1038/nn1064 · Cited by 102 · see citing works
Manfridi, A., Brambilla, D., Bianchi, S., Mariotti, M., Opp, M. R., & Imeri, L. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02836.x · Cited by 101 · see citing works
Cellular mechanisms of burst firing‐mediated long‐term depression in rat neocortical pyramidal cells
Czarnecki, A., Birtoli, B., & Ulrich, D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.123588 · Cited by 99 · see citing works
Krueger, J. M. (2003) · Frontiers in bioscience · doi:10.2741/1031 · Cited by 94 · see citing works
Self-citationChurchill, L., Rector, D. M., Yasuda, K., Fix, C. F., Rojas, M. J., Yasuda, T., & Krueger, J. M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.066 · Cited by 93 · see citing works
Self-citationState-specific asymmetries in EEG slow wave activity induced by local application of TNFα
Yoshida, H., Peterfi, Z., García‐García, F., Kirkpatrick, R. J., Yasuda, T., & Krueger, J. M. (2004) · Brain Research · doi:10.1016/j.brainres.2004.02.055 · Cited by 90 · see citing works
Self-citationYu, Z., Cheng, G., Wen, X., Wu, G. D., Lee, W.-T., & Pleasure, D. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0530 · Cited by 79 · see citing works
De, A., Krueger, J. M., & Simasko, S. M. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02997-4 · Cited by 73 · see citing works
Self-citationTabarean, I. V., Korn, H., & Bartfai, T. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.05.007 · Cited by 71 · see citing works
GHRH and IL1β increase cytoplasmic Ca2+ levels in cultured hypothalamic GABAergic neurons
De, A., Churchill, L., Obál, F., Simasko, S. M., & Krueger, J. M. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03157-8 · Cited by 70 · see citing works
Self-citationThe organization and regulation of sleep
Koella, W. P. (1984) · Cellular and Molecular Life Sciences · doi:10.1007/bf01952538 · Cited by 69 · see citing works
Yasuda, T., Yoshida, H., García‐García, F., Kay, D. B., & Krueger, J. M. (2005) · SLEEP · doi:10.1093/sleep/28.2.177 · Cited by 68 · see citing works
Self-citationKawada, H., Niwano, S., Niwano, H., Yumoto, Y., Wakisaka, Y., Yuge, M., Kawahara, K., & Izumi, T. (2006) · Circulation Journal · doi:10.1253/circj.70.605 · Cited by 66 · see citing works
Sleep and dynamic stabilization of neural circuitry: A review and synthesis
Kavanau, J. L. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90082-5 · Cited by 66 · see citing works
Unilateral Eye Closure and Interhemispheric EEG Asymmetry during Sleep in the Pigeon (Columba livia)
Rattenborg, N. C., Amlaner, C. J., & Lima, S. L. (2001) · Brain Behavior and Evolution · doi:10.1159/000057573 · Cited by 62 · see citing works
[Neuromediators and hypnogenic factors].
Jouvet, M. (1984) · PubMed · Cited by 61 · see citing works
Sarro, G. D., Gareri, P., Sinopoli, V. A., David, E., & Rotiroti, D. (1997) · Life Sciences · doi:10.1016/s0024-3205(96)00692-3 · Cited by 60 · see citing works
井上, 昌. (1989) · CRC Press eBooks · Cited by 59 · see citing works
A network model for activity-dependent sleep regulation
Roy, S., Krueger, J. M., Rector, D. M., & Wan, Y. (2008) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2008.03.033 · Cited by 56 · see citing works
Self-citationTNFα siRNA Reduces Brain TNF and EEG Delta Wave Activity in Rats
Taishi, P., Churchill, L., Wang, M., Kay, D., Davis, C. J., Guan, X., De, A., Yasuda, T., Liao, F., & Krueger, J. (2007) · Brain Research · doi:10.1016/j.brainres.2007.04.072 · Cited by 54 · see citing works
Self-citationBrandt, J. A., Churchill, L., Guan, Z., Fang, J., Chen, L., & Krueger, J. M. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02149-7 · Cited by 52 · see citing works
Self-citationTNFα induces a protein kinase C-dependent reduction in astroglial K+ conductance
Köller, H., Allert, N., Oel, D., et al. (1998) · Neuroreport · doi:10.1097/00001756-199805110-00023 · Cited by 50 · see citing works
Acute actions of tumor necrosis factor-α on intracellular Ca2+ and K+ currents in human microglia
McLarnon, J. G., Franciosi, S., Wang, X., Bae, J.-H., Choi, H. B., & Kim, S. U. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00119-1 · Cited by 45 · see citing works
Biochemical regulation of sleep
Monnier, M., & Gaillard, J. (1980) · Cellular and Molecular Life Sciences · doi:10.1007/bf02003946 · Cited by 44 · see citing works
Hypothalamic neuronal responses to cytokines.
Shibata, M. (1990) · PubMed Central · Cited by 43 · see citing works
Yasuda, K., Churchill, L., Yasuda, T., Blindheim, K., Falter, M., & Krueger, J. M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.11.051 · Cited by 37 · see citing works
Self-citationState-dependent effects of light-dark cycle on somatosensory and visual cortex EEG in rats
Yasuda, T., Yasuda, K., Brown, R. A., & Krueger, J. M. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00112.2005 · Cited by 34 · see citing works
Self-citationInterhemispheric asymmetry of human sleep EEG in response to selective slow-wave sleep deprivation.
Ferrara, M., Gennaro, L. D., Curcio, G., Cristiani, R., & Bertini, M. (2002) · Behavioral Neuroscience · doi:10.1037//0735-7044.116.6.976 · Cited by 33 · see citing works
Cytokine mRNA induction by interleukin-1β or tumor necrosis factor α in vitro and in vivo
Taishi, P., Churchill, L., De, A., Obál, F., & Krueger, J. M. (2008) · Brain Research · doi:10.1016/j.brainres.2008.05.067 · Cited by 33 · see citing works
Self-citationDe, A., Krueger, J. M., & Simasko, S. M. (2005) · Brain Research · doi:10.1016/j.brainres.2005.06.044 · Cited by 32 · see citing works
Self-citationInhibition of tumor necrosis factor prevents warming-induced sleep responses in rabbits
Takahashi, S., & Krueger, J. M. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.4.r1325 · Cited by 30 · see citing works
Self-citationChurchill, L., Yasuda, K., Yasuda, T., Blindheim, K., Falter, M., García‐García, F., & Krueger, J. M. (2005) · Brain Research · doi:10.1016/j.brainres.2005.06.052 · Cited by 28 · see citing works
Self-citationInterhemispheric asymmetry of human sleep EEG in response to selective slow-wave sleep deprivation.
Ferrara, M., Gennaro, L. D., Curcio, G., et al. (2002) · Behavioral Neuroscience · doi:10.1037/0735-7044.116.6.976 · Cited by 28 · see citing works
Jajoo, S., Mukherjea, D., Pingle, S. C., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.096255 · Cited by 27 · see citing works
Rapid impact of ?-amyloid on Paxillin in a neural cell line
Berg, M. M., Krafft, G. A., & Klein, W. L. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19971215)50:6 · Cited by 26 · see citing works
Growth hormone-releasing hormone: cerebral cortical sleep-related EEG actions and expression
Szentirmai, É., Yasuda, T., Taishi, P., Wang, M., Churchill, L., Bohnet, S. G., Magrath, P., Kacsoh, B. Z., Jimenez, L., & Krueger, J. M. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00237.2007 · Cited by 26 · see citing works
Self-citationZolovick, A. J., Stern, W. C., Panksepp, J., et al. (1973) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(73)90053-1 · Cited by 22 · see citing works
Self-citationSleep EEG dynamics in rat barrel cortex associated with sensory deprivation
Iwasaki, N., Karashima, A., Tamakawa, Y., Katayama, N., & Nakao, M. (2004) · Neuroreport · doi:10.1097/00001756-200412030-00026 · Cited by 19 · see citing works
Inhibition of glycolytic metabolism and sleep-waking states in cats
Panksepp, J., Jalowiec, J. E., Zolovick, A. J., et al. (1973) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(73)90065-8 · Cited by 18 · see citing works
Self-citationMonocular-unihemispheric sleep and visual discrimination learning in the domestic chick
Mascetti, G. G., Rugger, M., Vallortígara, G., & Bobbo, D. (2006) · Experimental Brain Research · doi:10.1007/s00221-006-0595-3 · Cited by 16 · see citing works
The Effect of Unilateral Somatosensory Stimulation on Hemispheric Asymmetries During Slow Wave Sleep
Cottone, L. A., Adamo, D. S., & Squires, N. K. (2004) · SLEEP · doi:10.1093/sleep/27.1.63 · Cited by 14 · see citing works
Obál, F., & Krueger, J. M. (2005) · IMPERIAL COLLEGE PRESS eBooks · doi:10.1142/9781860947186_0002 · Cited by 8 · see citing works
Self-citationEvoked Optical Response Under Wake, Sleep, and Anesthetized States
Schei, J. L., Foust, A. J., Rojas, M. J., et al. (2008) · Biomedical optics · doi:10.1364/biomed.2008.bme5 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [35]Jouvet M Neuromediateurs et facteurs hypnogenes Rev Neurol (Paris) 140 389 400 1984 6147008
- [89]Panksepp J 1998 Affective Neuroscience Oxford University Press New York
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Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · see citing works
“Contributions of glia cells to the regulation of Ca(2) concentrations and excitability in neighboring neurons are likely (30, 31, 506, 672).”
BackgroundControl of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477 · see citing works
An opportunity cost model of subjective effort and task performance
Kurzban, R., Duckworth, A., Kable, J. W., & Myers, J. (2013) · Behavioral and Brain Sciences · doi:10.1017/s0140525x12003196 · Cited by 1,381 · see citing works
The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479 · see citing works
“They can activate the immune system through binding to respective PRRs, which likely leads to systemic increases of sleep regulatory substances, such as TNF and IL-1 (303, 305).”
BackgroundEffects of sleep deprivation on cognition
Killgore, W. D. S. (2010) · Progress in Brain Research · doi:10.1016/b978-0-444-53702-7.00007-5 · Cited by 1,421 · see citing works
Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
Wulff, K., Gatti, S., Wettstein, J. G., & Foster, R. G. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2868 · Cited by 1,055 · see citing works
Vyazovskiy, V. V., Olcese, U., Hanlon, E. C., Nir, Y., Cirelli, C., & Tononi, G. (2011) · Nature · doi:10.1038/nature10009 · Cited by 865 · see citing works
How (and why) the immune system makes us sleep
Imeri, L., & Opp, M. R. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2576 · Cited by 710 · see citing works
Möller-Levet, C. S., Archer, S. N., Bucca, G., Laing, E. E., Slak, A., Kabiljo, R., Lo, J. C. Y., Santhi, N., von Schantz, M., Smith, C. P., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217154110 · Cited by 576 · see citing works
Sleep Spindles in Humans: Insights from Intracranial EEG and Unit Recordings
Andrillon, T., Nir, Y., Staba, R. J., Ferrarelli, F., Cirelli, C., Tononi, G., & Fried, I. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2604-11.2011 · Cited by 504 · see citing works
Sleep, circadian rhythm, and gut microbiota
Matenchuk, B. A., Mandhane, P. J., & Kozyrskyj, A. L. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101340 · Cited by 495 · see citing works
Sleep viewed as a state of adaptive inactivity
Siegel, J. M. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2697 · Cited by 468 · see citing works
Sleep function: Toward elucidating an enigma
Krueger, J. M., Frank, M. G., Wisor, J. P., & Roy, S. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.08.005 · Cited by 440 · see citing works
Self-citationThe slow (<1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillators
Crunelli, V., & Hughes, S. W. (2010) · Nature Neuroscience · doi:10.1038/nn.2445 · Cited by 435 · see citing works
Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive
Eban-Rothschild, A., Appelbaum, L., & de Lecea, L. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.294 · Cited by 282 · see citing works
Schmidt, M. H. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.08.001 · Cited by 291 · see citing works
Effects of sleep deprivation on dissociated components of executive functioning
Tucker, A. M., Whitney, P., Belenky, G., Hinson, J. M., & Van Dongen, H. P. (2010) · SLEEP · doi:10.1093/sleep/33.1.47 · Cited by 287 · see citing works
Self-citationSomnambulism: clinical aspects and pathophysiological hypotheses
Zadra, A., Desautels, A., Petit, D., & Montplaisir, J. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70322-8 · Cited by 229 · see citing works
Prostaglandin D2 and sleep/wake regulation
Urade, Y., & Hayaishi, O. (2011) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.08.003 · Cited by 200 · see citing works
Marshall, L., Kirov, R., Brade, J., Mölle, M., & Born, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016905 · Cited by 188 · see citing works
Genetic analysis in the Collaborative Cross breeding population
Philip, V. M., Sokoloff, G., Ackert-Bicknell, C. L., Striz, M., Branstetter, L., Beckmann, M. A., Spence, J. S., Jackson, B. L., Galloway, L. D., Barker, P., et al. (2011) · Genome Research · doi:10.1101/gr.113886.110 · Cited by 168 · see citing works
Adenosine, caffeine, and sleep–wake regulation: state of the science and perspectives
Reichert, C. F., Deboer, T., & Landolt, H. (2022) · Journal of Sleep Research · doi:10.1111/jsr.13597 · Cited by 183 · see citing works
“The accumulation of adenosine, but also other sleep promoting substances (Krueger et al., 2008), may therefore reduce the activity of wake promoting areas and, in this way, disinhibit sleep promoting areas.”
BackgroundSkeldon, A. C., Derks, G., & Dijk, D.-J. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.05.011 · Cited by 165 · see citing works
Chee, M. W. L., & Tan, J. C. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.02.031 · Cited by 168 · see citing works
NREM and REM Sleep: Complementary Roles in Recovery after Wakefulness
Vyazovskiy, V. V., & Delogu, A. (2014) · The Neuroscientist · doi:10.1177/1073858413518152 · Cited by 169 · see citing works
Biochemical Regulation of Sleep and Sleep Biomarkers
Clinton, J. M., Davis, C. J., Zielinski, M. R., Jewett, K. A., & Krueger, J. M. (2011) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.1360 · Cited by 159 · see citing works
Self-citationExploring the Effects of Problematic Internet Use on Adolescent Sleep: A Systematic Review
Kokka, I., Mourikis, I., Nicolaides, N. C., Darviri, C., Chrousos, G. P., Kanaka-Gantenbein, C., & Bacopoulou, F. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18020760 · Cited by 152 · see citing works
Kristensson, K., Nygård, M., Bertini, G., & Bentivoglio, M. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.12.001 · Cited by 140 · see citing works
A role for clock genes in sleep homeostasis
Franken, P. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.05.002 · Cited by 125 · see citing works
Involvement of cytokines in slow wave sleep
Krueger, J. M., Clinton, J. M., Winters, B. D., Zielinski, M. R., Taishi, P., Jewett, K. A., & Davis, C. J. (2011) · Progress in Brain Research · doi:10.1016/b978-0-444-53839-0.00003-x · Cited by 126 · see citing works
Self-citationSleep and the functional connectome
Picchioni, D., Duyn, J. H., & Horovitz, S. G. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.067 · Cited by 115 · see citing works
Krueger, J. M., & Opp, M. R. (2016) · International Review of Neurobiology · doi:10.1016/bs.irn.2016.07.003 · Cited by 120 · see citing works
Self-citationSleep function: current questions and new approaches
Vassalli, A., & Dijk, D. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06767.x · Cited by 110 · see citing works
Homeostatic and circadian contribution to EEG and molecular state variables of sleep regulation
Curie, T., Mongrain, V., Dorsaz, S., Mang, G. M., Emmenegger, Y., & Franken, P. (2013) · SLEEP · doi:10.5665/sleep.2440 · Cited by 94 · see citing works
Nobili, L., De Gennaro, L., Proserpio, P., Moroni, F., Sarasso, S., Pigorini, A., De Carli, F., & Ferrara, M. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59427-3.00013-7 · Cited by 100 · see citing works
Regulation of neuron-astrocyte metabolic coupling across the sleep-wake cycle
Petit, J.-M., & Magistretti, P. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.007 · Cited by 92 · see citing works
Elmenhorst, D., Elmenhorst, E.-M., Hennecke, E., Kroll, T., Matusch, A., Aeschbach, D., & Bauer, A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614677114 · Cited by 92 · see citing works
Chee, M. W. L., Goh, C. S. F., Namburi, P., Parimal, S., Seidl, K. N., & Kastner, S. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.06.058 · Cited by 81 · see citing works
Neuropeptidergic control of sleep and wakefulness
Richter, C., Woods, I. G., & Schier, A. F. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150447 · Cited by 75 · see citing works
REM sleep is associated with distinct global cortical dynamics and controlled by occipital cortex
Wang, Z., Fei, X., Liu, X., Wang, Y., Hu, Y., Peng, W., Wang, Y.-W., Zhang, S., & Xu, M. (2022) · Nature Communications · doi:10.1038/s41467-022-34720-9 · Cited by 73 · see citing works
Januszko, P., Niemcewicz, S., Gajda, T., Wołyńczyk-Gmaj, D., Piotrowska, A. J., Gmaj, B., Piotrowski, T., & Szelenberger, W. (2016) · Clinical Neurophysiology · doi:10.1016/j.clinph.2015.01.014 · Cited by 74 · see citing works
Removal of Synaptic Ca <sup>2+</sup> -Permeable AMPA Receptors during Sleep
Lanté, F., Toledo-Salas, J.-C., Ondrejcak, T., Rowan, M. J., & Ulrich, D. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3210-10.2011 · Cited by 74 · see citing works
Stereotypic wheel running decreases cortical activity in mice
Fisher, S. P., Cui, N., McKillop, L. E., Gemignani, J., Bannerman, D. M., Oliver, P. L., Peirson, S. N., & Vyazovskiy, V. V. (2016) · Nature Communications · doi:10.1038/ncomms13138 · Cited by 70 · see citing works
“…that sleep has properties of an activity-dependent process, whereby it is initiated at the level of local neuronal networks, which were more active during prior waking, and then progressively encompasses larger areas of the brain, before eventually precipitating global behavioural sleep 15–17 .”
McKenna, B. S., & Eyler, L. T. (2012) · Clinical Psychology Review · doi:10.1016/j.cpr.2012.07.003 · Cited by 69 · see citing works
Cipolli, C., Ferrara, M., De Gennaro, L., & Plazzi, G. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.07.005 · Cited by 67 · see citing works
Neuroscience-driven discovery and development of sleep therapeutics
Dresler, M., Spoormaker, V. I., Beitinger, P., Czisch, M., Kimura, M., Steiger, A., & Holsboer, F. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.10.012 · Cited by 63 · see citing works
Yoon, S. Y. R., Jain, U. R., & Shapiro, C. M. (2013) · Sleep Medicine · doi:10.1016/j.sleep.2013.03.003 · Cited by 57 · see citing works
Dimitrov, S., Besedovsky, L., Born, J., & Lange, T. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.11.017 · Cited by 56 · see citing works
Faraguna, U., Nelson, A., Vyazovskiy, V. V., Cirelli, C., & Tononi, G. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq041 · Cited by 54 · see citing works
Sleep stage dynamics in neocortex and hippocampus
Durán, E., Oyanedel, C. N., Niethard, N., Inostroza, M., & Born, J. (2018) · Sleep · doi:10.1093/sleep/zsy060 · Cited by 52 · see citing works
Confusional arousals during non-rapid eye movement sleep: evidence from intracerebral recordings
Flamand, M., Boudet, S., Lopes, R., Vignal, J.-P., Reyns, N., Charley-Monaca, C., Peter-Derex, L., & Szurhaj, W. (2018) · Sleep · doi:10.1093/sleep/zsy139 · Cited by 41 · see citing works
Schmidt, E.-M., Linz, B., Diekelmann, S., Besedovsky, L., Lange, T., & Born, J. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.11.012 · Cited by 41 · see citing works
Night shift schedule alters endogenous regulation of circulating cytokines
Liu, P. Y., Irwin, M. R., Krueger, J. M., Gaddameedhi, S., & Van Dongen, H. P. A. (2021) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2021.100063 · Cited by 33 · see citing works
Self-citationRegional variability in intracerebral properties of NREM to REM sleep transitions in humans
Peter-Derex, L., von Ellenrieder, N., van Rosmalen, F., Hall, J., Dubeau, F., Gotman, J., & Frauscher, B. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2300387120 · Cited by 26 · see citing works
Fifel, K., Piggins, H., & Deboer, T. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.02.005 · Cited by 30 · see citing works
Chee, M. W. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2014.10.003 · Cited by 27 · see citing works
Sato, N., Marui, S., Ozaki, M., & Nagashima, K. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.05.024 · Cited by 11 · see citing works
- Authors
- Krueger, J. M., Rector, D. M., Roy, S., Van Dongen, H. P. A., Belenky, G., & Panksepp, J.
- Affiliations
- Washington State University (US)
- Washington State University Spokane (US)
- Corresponding author
- Krueger, James M.
- Venue
- Nature Reviews Neuroscience
- Published
- 2008-11-05
- Volume
- 9
- Issue
- 12
- Pages
- 910-919
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC2586424
- OpenAlex
- W2086969201
- Cited by
- 596
- References
- 100
- Citations by year
- 2026: 11 · 2025: 30 · 2024: 26 · 2023: 16 · 2022: 25 · 2021: 29 · 2020: 20 · 2019: 38 · 2018: 32 · 2017: 36 · 2016: 28 · 2015: 32 · 2014: 40 · 2013: 57 · 2012: 48
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- W. M. Keck Foundation
- National Institutes of Health
- National Institute of Mental Health (MH71830, R01MH071830)
- National Institute of Neurological Disorders and Stroke (NS-31453, NS-25378, R01NS031453, R01NS025378)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep regulation, cell assemblies, cortical columns, sleep-like state, neuronal synchronization
- MeSH terms
- Brain, Humans, Models, Biological, Nerve Net, Synaptic Transmission, Neurons, Sleep
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