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Kibra Is a Regulator of the Salvador/Warts/Hippo Signaling Network
Open accessAbstract
The Salvador (Sav)/Warts (Wts)/Hippo (Hpo) (SWH) network controls tissue growth by inhibiting cell proliferation and promoting apoptosis. The core of the pathway consists of a MST and LATS family kinase cascade that ultimately phosphorylates and inactivates the YAP/Yorkie (Yki) transcription coactivator. The FERM domain proteins Merlin (Mer) and Expanded (Ex) represent one mode of upstream regulation controlling pathway activity. Here, we identify Kibra as a member of the SWH network. Kibra, which colocalizes and associates with Mer and Ex, also promotes the Mer/Ex association. Furthermore, the Kibra/Mer association is conserved in human cells. Finally, Kibra complexes with Wts and kibra depletion in tissue culture cells induces a marked reduction in Yki phosphorylation without affecting the Yki/Wts interaction. We suggest that Kibra is part of an apical scaffold that promotes SWH pathway activity.
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Citations
Cites
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Metadata
- Authors
- Genevet, A., Wehr, M. C., Brain, R., Thompson, B. J., & Tapon, N.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 18
- Issue
- 2
- Pages
- 300-308
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2002116477
- Cited by
- 402
- References
- 1
- FWCI
- 17.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
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