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The Hippo Pathway Regulates Wnt/β-Catenin Signaling
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Cites
Basu, S., Totty, N. F., Irwin, M. S., Sudol, M., & Downward, J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(02)00776-1 · Cited by 843
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
Chan, E. H. Y., Nousiainen, M., Chalamalasetty, R. B., Schäfer, A., Nigg, E. A., & Silljé, H. H. W. (2005) · Oncogene · doi:10.1038/sj.onc.1208445 · Cited by 584
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity
Wallingford, J. B., & Habas, R. (2005) · Development · doi:10.1242/dev.02068 · Cited by 509
Kif3a constrains β-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms
Corbit, K. C., Shyer, A. E., Dowdle, W. E., Gaulden, J., Singla, V., & Reiter, J. F. (2008) · Nature Cell Biology · doi:10.1038/ncb1670 · Cited by 509
Cited by
Zhan, T., Rindtorff, N., & Boutros, M. (2017) · Oncogene · doi:10.1038/onc.2016.304 · Cited by 2,626
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
Liu, J., Xiao, Q., Xiao, J., Niu, C., Li, Y., Zhang, X., Zhou, Z., Shu, G., & Yin, G. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00762-6 · Cited by 2,519
YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response
Azzolin, L., Panciera, T., Soligo, S., Enzo, E., Bicciato, S., Dupont, S., Bresolin, S., Frasson, C., Basso, G., Guzzardo, V., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.013 · Cited by 1,094
YAP/TAZ upstream signals and downstream responses
Totaro, A., Panciera, T., & Piccolo, S. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0142-z · Cited by 1,086
Transduction of mechanical and cytoskeletal cues by YAP and TAZ
Halder, G., Dupont, S., & Piccolo, S. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3416 · Cited by 985
Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine
Dey, A., Varelas, X., & Guan, K.-L. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0070-z · Cited by 860
Self-citationβ-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis
Rosenbluh, J., Nijhawan, D., Cox, A. G., Li, X., Neal, J. T., Schafer, E. J., Zack, T. I., Wang, X., Tsherniak, A., Schinzel, A. C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.11.026 · Cited by 757
E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components
Kim, N.-G., Koh, E., Chen, X., & Gumbiner, B. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103345108 · Cited by 698
The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease
Varelas, X. (2014) · Development · doi:10.1242/dev.102376 · Cited by 665
Self-citationYap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer
Gregorieff, A., Liu, Y., Inanlou, M. R., Khomchuk, Y., & Wrana, J. L. (2015) · Nature · doi:10.1038/nature15382 · Cited by 648
Self-citationXin, M., Kim, Y., Sutherland, L. B., Qi, X., McAnally, J., Schwartz, R. J., Richardson, J. A., Bassel-Duby, R., & Olson, E. N. (2011) · Science Signaling · doi:10.1126/scisignal.2002278 · Cited by 548
Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy
Li, Q., Geng, S., Luo, H., Wang, W., Mo, Y.-Q., Luo, Q., Wang, L., Song, G.-B., Sheng, J.-P., & Xu, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01953-7 · Cited by 546
Restriction of intestinal stem cell expansion and the regenerative response by YAP
Barry, E. R., Morikawa, T., Butler, B. L., Shrestha, K., de la Rosa, R., Yan, K. S., Fuchs, C. S., Magness, S. T., Smits, R., Ogino, S., et al. (2013) · Nature · doi:10.1038/nature11693 · Cited by 543
Role of TAZ as Mediator of Wnt Signaling
Azzolin, L., Zanconato, F., Bresolin, S., Forcato, M., Basso, G., Bicciato, S., Cordenonsi, M., & Piccolo, S. (2012) · Cell · doi:10.1016/j.cell.2012.11.027 · Cited by 493
Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction
Dupont, S. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.10.034 · Cited by 449
Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning
Perrimon, N., Pitsouli, C., & Shilo, B.-Z. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005975 · Cited by 391
Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy
Song, P., Gao, Z., Bao, Y., Chen, L., Huang, Y., Liu, Y., Dong, Q., & Wei, X. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01563-4 · Cited by 382
YAP/TAZ functions and their regulation at a glance
Pocaterra, A., Romani, P., & Dupont, S. (2020) · Journal of Cell Science · doi:10.1242/jcs.230425 · Cited by 367
WNT signalling in prostate cancer
Murillo-Garzón, V., & Kypta, R. (2017) · Nature Reviews Urology · doi:10.1038/nrurol.2017.144 · Cited by 361
The Hippo-YAP signaling pathway and contact inhibition of growth
Gumbiner, B. M., & Kim, N.-G. (2014) · Journal of Cell Science · doi:10.1242/jcs.140103 · Cited by 339
Mechanisms that link the oncogenic epithelial–mesenchymal transition to suppression of anoikis
Frisch, S. M., Schaller, M., & Cieply, B. (2013) · Journal of Cell Science · doi:10.1242/jcs.120907 · Cited by 295
Pan, J.-X., Xiong, L., Zhao, K., Zeng, P., Wang, B., Tang, F.-L., Sun, D., Guo, H.-H., Yang, X., Cui, S., et al. (2018) · Bone Research · doi:10.1038/s41413-018-0018-7 · Cited by 282
Lin, C.-W., Chang, Y.-L., Chang, Y.-C., Lin, J.-C., Chen, C.-C., Pan, S.-H., Wu, C.-T., Chen, H.-Y., Yang, S.-C., Hong, T.-M., et al. (2013) · Nature Communications · doi:10.1038/ncomms2876 · Cited by 281
Konsavage, W. M., Kyler, S. L., Rennoll, S. A., Jin, G., & Yochum, G. S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.327767 · Cited by 279
YAP and TAZ Regulate Skin Wound Healing
Lee, M.-J., Byun, M. R., Furutani-Seiki, M., Hong, J.-H., & Jung, H.-S. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.339 · Cited by 253
Barry, E. R., & Camargo, F. D. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.12.006 · Cited by 214
SOX2 Regulates YAP1 to Maintain Stemness and Determine Cell Fate in the Osteo-Adipo Lineage
Seo, E., Basu-Roy, U., Gunaratne, P. H., Coarfa, C., Lim, D.-S., Basilico, C., & Mansukhani, A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.029 · Cited by 216
“Several points of crosstalk between the Hippo and Wnt pathways in both the cytoplasm and nucleus were recently reported (Heallen et al., 2011; Imajo et al., 2012; Varelas et al., 2010).”
BackgroundInsights into recent findings and clinical application of YAP and TAZ in cancer
Franklin, J. M., Wu, Z., & Guan, K.-L. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-023-00579-1 · Cited by 213
Li, Q., Sun, Y., Jarugumilli, G. K., Liu, S., Dang, K., Cotton, J. L., Xiol, J., Chan, P. Y., DeRan, M., Ma, L., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.03.002 · Cited by 180
Vlashi, R., Zhang, X., Wu, M., & Chen, G. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2022.07.011 · Cited by 165
Are Wnt/β-Catenin and PI3K/AKT/mTORC1 Distinct Pathways in Colorectal Cancer?
Prossomariti, A., Piazzi, G., Alquati, C., & Ricciardiello, L. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.04.007 · Cited by 155
Modularity in the Hippo signaling pathway
Sudol, M., & Harvey, K. F. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.05.010 · Cited by 149
The Hippo Pathway Effectors TAZ/YAP Regulate Dicer Expression and MicroRNA Biogenesis through Let-7
Chaulk, S. G., Lattanzi, V. J., Hiemer, S. E., Fahlman, R. P., & Varelas, X. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.c113.529362 · Cited by 101
Self-citationA feed forward loop enforces YAP/TAZ signaling during tumorigenesis
Gill, M. K., Christova, T., Zhang, Y. Y., Gregorieff, A., Zhang, L., Narimatsu, M., Song, S., Xiong, S., Couzens, A. L., Tong, J., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05939-2 · Cited by 95
Self-citationIntersection of Hippo/YAP and Wnt/β-catenin signaling pathways
Konsavage, W. M., & Yochum, G. S. (2013) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gms084 · Cited by 94
Nuclear signaling from cadherin adhesion complexes
McCrea, P. D., Maher, M. T., & Gottardi, C. J. (2015) · Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2014.11.018 · Cited by 85
Lats2 Modulates Adipocyte Proliferation and Differentiation via Hippo Signaling
An, Y., Kang, Q., Zhao, Y., Hu, X., & Li, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072042 · Cited by 71
Label-free quantitative proteomic analysis of the YAP/TAZ interactome
Kohli, P., Bartram, M. P., Habbig, S., Pahmeyer, C., Lamkemeyer, T., Benzing, T., Schermer, B., & Rinschen, M. M. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00339.2013 · Cited by 61
Burcklé, C., Gaudé, H.-M., Vesque, C., Silbermann, F., Salomon, R., Jeanpierre, C., Antignac, C., Saunier, S., & Schneider-Maunoury, S. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr164 · Cited by 59
Lin, A. Y. T., & Pearson, B. J. (2014) · Development · doi:10.1242/dev.101915 · Cited by 57
Borgal, L., Habbig, S., Hatzold, J., Liebau, M. C., Dafinger, C., Sacarea, I., Hammerschmidt, M., Benzing, T., & Schermer, B. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.385658 · Cited by 56
Regulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins
Morthorst, S. K., Christensen, S. T., & Pedersen, L. B. (2018) · The FEBS Journal · doi:10.1111/febs.14583 · Cited by 49
Metadata
- Authors
- Varelas, X., Miller, B. W., Sopko, R., Song, S., Gregorieff, A., Fellouse, F. A., Sakuma, R., Pawson, T., Hunziker, W., McNeill, H., Wrana, J. L., & Attisano, L.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 18
- Issue
- 4
- Pages
- 579-591
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2007916618
- Cited by
- 569
- References
- 4
- FWCI
- 17.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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