The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Cadherin Switch during EMT in Neural Crest Cells Leads to Contact Inhibition of Locomotion via Repolarization of Forces
Open accessAbstract
Contact inhibition of locomotion (CIL) is the process through which cells move away from each other after cell-cell contact, and it contributes to malignant invasion and developmental migration. Various cell types exhibit CIL, whereas others remain in contact after collision and may form stable junctions. To investigate what determines this differential behavior, we study neural crest cells, a migratory stem cell population whose invasiveness has been likened to cancer metastasis. By comparing pre-migratory and migratory neural crest cells, we show that the switch from E- to N-cadherin during EMT is essential for acquisition of CIL behavior. Loss of E-cadherin leads to repolarization of protrusions, via p120 and Rac1, resulting in a redistribution of forces from intercellular tension to cell-matrix adhesions, which break down the cadherin junction. These data provide insight into the balance of physical forces that contributes to CIL in cells in vivo.
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Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics
Grashoff, C., Hoffman, B. D., Brenner, M. D., Zhou, R., Parsons, M., Yang, M. T., McLean, M. A., Sligar, S. G., Chen, C. S., Ha, T., et al. (2010) · Nature · doi:10.1038/nature09198 · Cited by 1,541
Self-citationStresses at the Cell-to-Substrate Interface during Locomotion of Fibroblasts
Dembo, M., & Wang, Y.-L. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77386-8 · Cited by 1,287
A genetically encoded photoactivatable Rac controls the motility of living cells
Wu, Y. I., Frey, D., Lungu, O. I., Jaehrig, A., Schlichting, I., Kuhlman, B., & Hahn, K. M. (2009) · Nature · doi:10.1038/nature08241 · Cited by 1,083
Wheelock, M. J., Shintani, Y., Maeda, M., Fukumoto, Y., & Johnson, K. R. (2008) · Journal of Cell Science · doi:10.1242/jcs.000455 · Cited by 767
Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cells
Wang, N., Tolić-Nørrelykke, I. M., Chen, J., Mijailovich, S. M., Butler, J. P., Fredberg, J. J., & Stamenović, D. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00269.2001 · Cited by 669
Contact inhibition of locomotion in vivo controls neural crest directional migration
Carmona-Fontaine, C., Matthews, H. K., Kuriyama, S., Moreno, M., Dunn, G. A., Parsons, M., Stern, C. D., & Mayor, R. (2008) · Nature · doi:10.1038/nature07441 · Cited by 613
Self-citationSpatial organization of the extracellular matrix regulates cell–cell junction positioning
Tseng, Q., Duchemin-Pelletier, E., Deshiere, A., Balland, M., Guillou, H., Filhol, O., & Théry, M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106377109 · Cited by 594
Itoh, R. E., Kurokawa, K., Ohba, Y., Yoshizaki, H., Mochizuki, N., & Matsuda, M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.18.6582-6591.2002 · Cited by 577
P120 Catenin Regulates the Actin Cytoskeleton via Rho Family Gtpases
Noren, N. K., Liu, B. P., Burridge, K., & Kreft, B. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.3.567 · Cited by 576
The surface properties of cancer cells: a review.
Abercrombie, M., & AMBROSE, E. J. (1962) · PubMed · Cited by 572
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Yang, J., Antin, P., Berx, G., Blanpain, C., Brabletz, T., Bronner, M., Campbell, K., Cano, A., Casanova, J., Christofori, G., et al. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0237-9 · Cited by 2,226
Self-citationLabernadie, A., Kato, T., Brugués, A., Serra-Picamal, X., Derzsi, S., Arwert, E., Weston, A., González-Tarragó, V., Elosegui-Artola, A., Albertazzi, L., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3478 · Cited by 747
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Friedl, P., & Mayor, R. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a029199 · Cited by 357
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Katsuno, Y., & Derynck, R. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.02.028 · Cited by 187
Localized EMT reprograms glial progenitors to promote spinal cord repair
Klatt Shaw, D., Saraswathy, V. M., Zhou, L., McAdow, A. R., Burris, B., Butka, E., Morris, S. A., Dietmann, S., & Mokalled, M. H. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.01.017 · Cited by 70
Herdy, J., Schafer, S., Kim, Y., Ansari, Z., Zangwill, D., Ku, M., Paquola, A., Lee, H., Mertens, J., & Gage, F. H. (2019) · eLife · doi:10.7554/elife.41356 · Cited by 64
Regulation of cell polarity by cell adhesion receptors
Ebnet, K., Kummer, D., Steinbacher, T., Singh, A., Nakayama, M., & Matis, M. (2018) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2017.07.032 · Cited by 52
Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts
Deb Roy, A., Yin, T., Choudhary, S., Rodionov, V., Pilbeam, C. C., & Wu, Y. I. (2017) · Nature Communications · doi:10.1038/ncomms15831 · Cited by 44
Metadata
- Authors
- Scarpa, E., Szabó, A., Bibonne, A., Theveneau, E., Parsons, M., & Mayor, R.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 34
- Issue
- 4
- Pages
- 421-434
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W1921522108
- Cited by
- 279
- References
- 49
- FWCI
- 15.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
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