The DOI matches its Crossref record; 146 of the 146 references it cites were found in a registry or an index.
Mechanisms of Cardiac Regeneration
Open accessAbstract
Adult humans fail to regenerate their hearts following injury, and this failure to regenerate myocardium is a leading cause of heart failure and death worldwide. Although all adult mammals appear to lack significant cardiac regeneration potential, some vertebrates can regenerate myocardium throughout life. In addition, new studies indicate that mammals have cardiac regeneration potential during development and very soon after birth. The mechanisms of heart regeneration among model organisms, including neonatal mice, appear remarkably similar. Orchestrated waves of inflammation, matrix deposition and remodeling, and cardiomyocyte proliferation are commonly seen in heart regeneration models. Understanding why adult mammals develop extensive scarring instead of regeneration is a crucial goal for regenerative biology.
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Citations
Cites
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Cited by
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(2019) · doi:10.1007/978-3-030-13864-6 · Cited by 32
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Metadata
- Authors
- Uygur, A., & Lee, R. T.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 36
- Issue
- 4
- Pages
- 362-374
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2279233812
- Cited by
- 286
- References
- 146
- FWCI
- 15.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
