RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3
Open accessAbstract
Receptor-interacting protein kinase (RIPK)-1 is involved in RIPK3-dependent and -independent signaling pathways leading to cell death and/or inflammation. Genetic ablation of ripk1 causes postnatal lethality, which was not prevented by deletion of ripk3, caspase-8, or fadd. However, animals that lack RIPK1, RIPK3, and either caspase-8 or FADD survived weaning and matured normally. RIPK1 functions in vitro to limit caspase-8-dependent, TNFR-induced apoptosis, and animals lacking RIPK1, RIPK3, and TNFR1 survive to adulthood. The role of RIPK3 in promoting lethality in ripk1(-/-) mice suggests that RIPK3 activation is inhibited by RIPK1 postbirth. Whereas TNFR-induced RIPK3-dependent necroptosis requires RIPK1, cells lacking RIPK1 were sensitized to necroptosis triggered by poly I:C or interferons. Disruption of TLR (TRIF) or type I interferon (IFNAR) signaling delayed lethality in ripk1(-/-)tnfr1(-/-) mice. These results clarify the complex roles for RIPK1 in postnatal life and provide insights into the regulation of FADD-caspase-8 and RIPK3-MLKL signaling by RIPK1.
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Ripk1−/− genotype causes perinatal lethality, which cannot be prevented by ablation of Ripk3, Casp8, or Fadd alone, but can be rescued by co-deletion of Ripk3 and Casp8, Fadd or Tnfrsf1a.
“Thus, in contrast to Ripk3−/− mice that are viable and fertile, the Ripk1−/− genotype causes perinatal lethality [482], which cannot be prevented by the ablation of Ripk3, Casp8, or Fadd alone, but can be rescued by the co-deletion of Ripk3 and Casp8, Fadd or Tnfrsf1a [482 499–501].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [482]
Tnfrsf1a−/−Ripk1−/−Ripk3−/− mice develop into adulthood, suggesting existence of additional RIPK3 activators.
“However, Tnfrsf1a−/−Ripk1−/−Ripk3−/− mice develop into adulthood, suggesting the existence of additional RIPK3 activators [482].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [482]
Ripk1−/− cells are more sensitive to necroptosis induced by polyI:C or type I IFN.
“Moreover, Ripk1−/− cells are more sensitive to necroptosis induced by polyI:C or type I IFN [482].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [482]
Lethality imposed to mice by Ripk1−/−Tnfrsf1a−/− genotype is delayed (but not prevented) by co-deletion of Ticam1 or Ifnar1.
“Genetic studies demonstrate that the lethality imposed to mice by the Ripk1−/−Tnfrsf1a−/− genotype is delayed (but not prevented) by the co-deletion of Ticam1 or Ifnar1 [482].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [482]
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Phycocyanin: Anti-inflammatory effect and mechanism
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- Authors
- Dillon, C. P., Weinlich, R., Rodriguez, D. A., Cripps, J. G., Quarato, G., Gurung, P., Verbist, K. C., Brewer, T. L., Llambi, F., Gong, Y.-N., Janke, L. J., Kelliher, M. A., Kanneganti, T.-D., & Green, D. R.
- Affiliations
- St. Jude Children's Research Hospital (US)
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Green, Douglas R.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 157
- Issue
- 5
- Pages
- 1189-1202
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4068710
- OpenAlex
- W1987186266
- Cited by
- 562
- References
- 52
- Citations by year
- 2026: 23 · 2025: 46 · 2024: 30 · 2023: 32 · 2022: 46 · 2021: 53 · 2020: 52 · 2019: 50 · 2018: 48 · 2017: 39 · 2016: 69 · 2015: 42 · 2014: 32
- FWCI
- 24.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA169291, CA169291, P30CA021765)
- National Institute of Allergy and Infectious Diseases (R01AI044828, AI44828, R01AI075118)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- RIPK1, RIPK3, caspase-8, FADD, postnatal lethality, necroptosis, apoptosis, TNFR1 signaling, MLKL, type I interferon signaling, TRIF, IFNAR, poly(I:C), inflammation, cell death regulation
- MeSH terms
- Animals, Animals, Newborn, Embryo, Mammalian, Fibroblasts, Genes, Lethal, Inflammation, Interferons, Mice, Inbred C57BL, Cell Death, Apoptosis, Adaptor Proteins, Vesicular Transport, Receptors, Tumor Necrosis Factor, Type I, Tumor Necrosis Factors, Mice, Caspase 8, Fas-Associated Death Domain Protein, Receptor-Interacting Protein Serine-Threonine Kinases
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