Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance

Role of YAP/TAZ in mechanotransduction

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Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280

In Vivo Imaging of Embryonic Vascular Development Using Transgenic Zebrafish

Lawson, N. D., & Weinstein, B. M. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0711 · Cited by 2,151

The Biology of YAP/TAZ: Hippo Signaling and Beyond

Piccolo, S., Dupont, S., & Cordenonsi, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00005.2014 · Cited by 1,802

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

Cermak, T., Doyle, E. L., Christian, M., Wang, L., Zhang, Y., Schmidt, C., Baller, J. A., Somia, N. V., Bogdanove, A. J., & Voytas, D. F. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr218 · Cited by 1,787

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

Aragona, M., Panciera, T., Manfrin, A., Giulitti, S., Michielin, F., Elvassore, N., Dupont, S., & Piccolo, S. (2013) · Cell · doi:10.1016/j.cell.2013.07.042 · Cited by 1,651

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

Calvo, F., Ege, N., Grande-Garcia, A., Hooper, S., Jenkins, R. P., Chaudhry, S. I., Harrington, K., Williamson, P., Moeendarbary, E., Charras, G., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2756 · Cited by 1,478

Genetic compensation induced by deleterious mutations but not gene knockdowns

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The Hippo pathway: regulators and regulations.

Yu, F.-X., & Guan, K.-L. (2013) · Genes & Development · doi:10.1101/gad.210773.112 · Cited by 1,231

Mechanotransduction in vascular physiology and atherogenesis

Hahn, C., & Schwartz, M. A. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2596 · Cited by 1,211

Molecular control of endothelial cell behaviour during blood vessel morphogenesis

Herbert, S. P., & Stainier, D. Y. R. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3176 · Cited by 1,042

Hippo pathway regulation by cell morphology and stress fibers

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Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish

Kok, F. O., Shin, M., Ni, C.-W., Gupta, A., Grosse, A. S., van Impel, A., Kirchmaier, B. C., Peterson-Maduro, J., Kourkoulis, G., Male, I., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2014.11.018 · Cited by 755

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

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Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

Feng, X., Degese, M. S., Iglesias-Bartolome, R., Vaque, J. P., Molinolo, A. A., Rodrigues, M., Zaidi, M. R., Ksander, B. R., Merlino, G., Sodhi, A., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.016 · Cited by 563

Dynamics of endothelial cell behavior in sprouting angiogenesis

Eilken, H. M., & Adams, R. H. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.08.010 · Cited by 561

Genetic dissection of neural circuits by Tol2 transposon-mediated Gal4 gene and enhancer trapping in zebrafish

Asakawa, K., Suster, M. L., Mizusawa, K., Nagayoshi, S., Kotani, T., Urasaki, A., Kishimoto, Y., Hibi, M., & Kawakami, K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704963105 · Cited by 560

Mechanical strain induces E-cadherin–dependent Yap1 and β-catenin activation to drive cell cycle entry

Benham-Pyle, B. W., Pruitt, B. L., & Nelson, W. J. (2015) · Science · doi:10.1126/science.aaa4559 · Cited by 534

Vascular remodeling of the mouse yolk sac requires hemodynamic force

Lucitti, J. L., Jones, E. A. V., Huang, C., Chen, J., Fraser, S. E., & Dickinson, M. E. (2007) · Development · doi:10.1242/dev.02883 · Cited by 483

Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis

Wang, K.-C., Yeh, Y.-T., Nguyen, P., Limqueco, E., Lopez, J., Thorossian, S., Guan, K.-L., Li, Y.-S. J., & Chien, S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613121113 · Cited by 471

Defects in Yolk Sac Vasculogenesis, Chorioallantoic Fusion, and Embryonic Axis Elongation in Mice with Targeted Disruption of Yap65

Morin-Kensicki, E. M., Boone, B. N., Howell, M., Stonebraker, J. R., Teed, J., Alb, J. G., Magnuson, T. R., O'Neal, W., & Milgram, S. L. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.1.77-87.2006 · Cited by 429

Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling

Ota, M., & Sasaki, H. (2008) · Development · doi:10.1242/dev.027151 · Cited by 391

Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin

Chan, S. W., Lim, C. J., Chong, Y. F., Pobbati, A. V., Huang, C., & Hong, W. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.c110.212621 · Cited by 386

Coordinating cell behaviour during blood vessel formation

Geudens, I., & Gerhardt, H. (2011) · Development · doi:10.1242/dev.062323 · Cited by 376

A small-molecule inhibitor of skeletal muscle myosin II

Cheung, A., Dantzig, J. A., Hollingworth, S., Baylor, S. M., Goldman, Y. E., Mitchison, T. J., & Straight, A. F. (2002) · Nature Cell Biology · doi:10.1038/ncb734 · Cited by 342

Cyclic stretching of soft substrates induces spreading and growth

Cui, Y., Hameed, F. M., Yang, B., Lee, K., Pan, C. Q., Park, S., & Sheetz, M. (2015) · Nature Communications · doi:10.1038/ncomms7333 · Cited by 320

Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression

Franco, C. A., Jones, M. L., Bernabeu, M. O., Geudens, I., Mathivet, T., Rosa, A., Lopes, F. M., Lima, A. P., Ragab, A., Collins, R. T., et al. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002125 · Cited by 295

Angiomotin-like Proteins Associate with and Negatively Regulate YAP1

Wang, W., Huang, J., & Chen, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.c110.205401 · Cited by 269

YAP is essential for tissue tension to ensure vertebrate 3D body shape

Porazinski, S., Wang, H., Asaoka, Y., Behrndt, M., Miyamoto, T., Morita, H., Hata, S., Sasaki, T., Krens, S. F. G., Osada, Y., et al. (2015) · Nature · doi:10.1038/nature14215 · Cited by 261

Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia☆

Langheinrich, U., Vacun, G., & Wagner, T. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.07.012 · Cited by 259

Haemodynamics-Driven Developmental Pruning of Brain Vasculature in Zebrafish

Chen, Q., Jiang, L., Li, C., Hu, D., Bu, J.-W., Cai, D., & Du, J.-L. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001374 · Cited by 250

Distinct Cellular Mechanisms of Blood Vessel Fusion in the Zebrafish Embryo

Herwig, L., Blum, Y., Krudewig, A., Ellertsdottir, E., Lenard, A., Belting, H.-G., & Affolter, M. (2011) · Current Biology · doi:10.1016/j.cub.2011.10.016 · Cited by 248

Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2

Choi, H.-J., Zhang, H., Park, H., Choi, K.-S., Lee, H.-W., Agrawal, V., Kim, Y.-M., & Kwon, Y.-G. (2015) · Nature Communications · doi:10.1038/ncomms7943 · Cited by 245

Regulation of YAP by Mechanical Strain through Jnk and Hippo Signaling

Codelia, V. A., Sun, G., & Irvine, K. D. (2014) · Current Biology · doi:10.1016/j.cub.2014.07.034 · Cited by 237

FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature

Sabine, A., Bovay, E., Demir, C. S., Kimura, W., Jaquet, M., Agalarov, Y., Zangger, N., Scallan, J. P., Graber, W., Gulpinar, E., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80454 · Cited by 237

Protein kinases of the Hippo pathway: Regulation and substrates

Avruch, J., Zhou, D., Fitamant, J., Bardeesy, N., Mou, F., & Barrufet, L. R. (2012) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2012.07.002 · Cited by 228

Cell behaviors and dynamics during angiogenesis

Betz, C., Lenard, A., Belting, H.-G., & Affolter, M. (2016) · Development · doi:10.1242/dev.135616 · Cited by 215

Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis

Wang, Y., Kaiser, M. S., Larson, J. D., Nasevicius, A., Clark, K. J., Wadman, S. A., Roberg-Perez, S. E., Ekker, S. C., Hackett, P. B., McGrail, M., et al. (2010) · Development · doi:10.1242/dev.048785 · Cited by 211

Arterial-venous network formation during brain vascularization involves hemodynamic regulation of chemokine signaling

Bussmann, J., Wolfe, S. A., & Siekmann, A. F. (2011) · Development · doi:10.1242/dev.059881 · Cited by 207

Angiomotins link F-actin architecture to Hippo pathway signaling

Mana-Capelli, S., Paramasivam, M., Dutta, S., & McCollum, D. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-11-0701 · Cited by 206

Flow detection and calcium signalling in vascular endothelial cells

Ando, J., & Yamamoto, K. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt084 · Cited by 203

A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription

Bao, Y., Nakagawa, K., Yang, Z., Ikeda, M., Withanage, K., Ishigami-Yuasa, M., Okuno, Y., Hata, S., Nishina, H., & Hata, Y. (2011) · Journal of Biochemistry · doi:10.1093/jb/mvr063 · Cited by 172

Semaphorin-PlexinD1 Signaling Limits Angiogenic Potential via the VEGF Decoy Receptor sFlt1

Zygmunt, T., Gay, C. M., Blondelle, J., Singh, M. K., Flaherty, K. M., Means, P. C., Herwig, L., Krudewig, A., Belting, H.-G., Affolter, M., et al. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.06.033 · Cited by 168

Fluid flows and forces in development: functions, features and biophysical principles

Freund, J. B., Goetz, J. G., Hill, K. L., & Vermot, J. (2012) · Development · doi:10.1242/dev.073593 · Cited by 156

MAGI-1 Is Required for Rap1 Activation upon Cell-Cell Contact and for Enhancement of Vascular Endothelial Cadherin-mediated Cell Adhesion

Sakurai, A., Fukuhara, S., Yamagishi, A., Sako, K., Kamioka, Y., Masuda, M., Nakaoka, Y., & Mochizuki, N. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-07-0647 · Cited by 152

Endothelial Signaling in Kidney Morphogenesis

Serluca, F. C., Drummond, I. A. S., & Fishman, M. C. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00694-2 · Cited by 151

Yap and Taz regulate retinal pigment epithelial cell fate

Miesfeld, J. B., Gestri, G., Clark, B. S., Flinn, M. A., Poole, R. J., Bader, J. R., Besharse, J. C., Wilson, S. W., & Link, B. A. (2015) · Development · doi:10.1242/dev.119008 · Cited by 143

A relationship between apoptosis and flow during programmed capillary regression is revealed by vital analysis

Meeson, A. P., Palmer, M. A. J., Calfon, M. A., & Lang, R. A. (1996) · Development · doi:10.1242/dev.122.12.3929 · Cited by 139

Stable Vascular Connections and Remodeling Require Full Expression of VE-Cadherin in Zebrafish Embryos

Montero‐Balaguer, M., Swirsding, K., Orsenigo, F., Cotelli, F., Mione, M., & Dejana, E. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005772 · Cited by 127

p130‐Angiomotin associates to actin and controls endothelial cell shape

Ernkvist, M., Aase, K., Ukomadu, C., Wohlschlegel, J., Blackman, R., Veitonmäki, N., Bratt, A., Dutta, A., & Holmgren, L. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05216.x · Cited by 120

Involvement of cell surface ATP synthase in flow-induced ATP release by vascular endothelial cells

Yamamoto, K., Shimizu, N., Obi, S., Kumagaya, S., Taketani, Y., Kamiya, A., & Ando, J. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01385.2006 · Cited by 110

Endothelial Ca2+ oscillations reflect VEGFR signaling-regulated angiogenic capacity in vivo

Yokota, Y., Nakajima, H., Wakayama, Y., Muto, A., Kawakami, K., Fukuhara, S., & Mochizuki, N. (2015) · eLife · doi:10.7554/elife.08817 · Cited by 107

S1P-Yap1 Signaling Regulates Endoderm Formation Required for Cardiac Precursor Cell Migration in Zebrafish

Fukui, H., Terai, K., Nakajima, H., Chiba, A., Fukuhara, S., & Mochizuki, N. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.08.014 · Cited by 70

Amotl2a interacts with the Hippo effector Yap1 and the Wnt/β-catenin effector Lef1 to control tissue size in zebrafish

Agarwala, S., Duquesne, S., Liu, K., Böhm, A., Grimm, L., Link, S., König, S., Eimer, S., Ronneberger, O., & Lecaudey, V. (2015) · eLife · doi:10.7554/elife.08201 · Cited by 51

Yap/Taz transcriptional activity in endothelial cells promotes intramembranous ossification via the BMP pathway

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The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 signaling in zebrafish

Kwon, H.-B., Fukuhara, S., Asakawa, K., Ando, K., Kashiwada, T., Kawakami, K., Hibi, M., Kwon, Y., Kim, K.-W., Alitalo, K. K., et al. (2013) · Development · doi:10.1242/dev.091702 · Cited by 40

Osteocrin, a peptide secreted from the heart and other tissues, contributes to cranial osteogenesis and chondrogenesis in zebrafish

Chiba, A., Watanabe‐Takano, H., Terai, K., Fukui, H., Miyazaki, T., Uemura, M., Hashimoto, H., Hibi, M., Fukuhara, S., & Mochizuki, N. (2016) · Development · doi:10.1242/dev.143354 · Cited by 36

Comparative expression of zebrafish lats1 and lats2 and their implication in gastrulation movements

Chen, C., Sun, Y., Pei, D., & Zhu, Z. (2009) · Developmental Dynamics · doi:10.1002/dvdy.22105 · Cited by 13

Force triggers YAP nuclear entry by regulating transport across nuclear pores

Elosegui-Artola, A., Andreu, I., Beedle, A. E. M., Lezamiz, A., Uroz, M., Kosmalska, A. J., Oria, R., Kechagia, J. Z., Rico-Lastres, P., Le Roux, A.-L., et al. (2017) · Cell · doi:10.1016/j.cell.2017.10.008 · Cited by 1,491

Mechanobiology of YAP and TAZ in physiology and disease

Panciera, T., Azzolin, L., Cordenonsi, M., & Piccolo, S. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.87 · Cited by 1,461

The Hippo Pathway: Biology and Pathophysiology

Ma, S., Meng, Z., Chen, R., & Guan, K.-L. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111829 · Cited by 1,387

YAP/TAZ upstream signals and downstream responses

Totaro, A., Panciera, T., & Piccolo, S. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0142-z · Cited by 1,086

Role of Extracellular Matrix in Development and Cancer Progression

Walker, C., Mojares, E., & Del Río Hernández, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103028 · Cited by 1,084