Fluvastatin potentiates the activity of caspofungin against Aspergillus fumigatus in vitro

Natesan, Suganthini Krishnan; Chandrasekar, Pranatharthi H.; Alangaden, George J.; Manavathu, Elias K.

doi:10.1016/j.diagmicrobio.2007.10.015

Cited by 32Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Plant Pathogen Control

Fluvastatin potentiates the activity of caspofungin against Aspergillus fumigatus in vitro

Natesan, Suganthini Krishnan, Chandrasekar, Pranatharthi H., Alangaden, George J., Manavathu, Elias K.·2008·Diagnostic Microbiology and Infectious Disease

DOI 10.1016/j.diagmicrobio.2007.10.015

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Abstract

Statins (anticholesterol drugs) inhibit HMG-CoA reductase, which is a key rate-limiting enzyme in the synthesis of sterols in fungi. We therefore investigated the in vitro inhibitory activity of various statins against Aspergillus fumigatus alone and in combination with antifungal drugs. Fresh conidial suspensions from 10 clinical isolates of A. fumigatus were obtained. The MIC and minimum fungicidal concentration (MFC) were determined by the Clinical and Laboratory Standards Institute M-38A protocol and the fungicidal activity by time-kill study. Fluvastatin (FST) showed good activity (MIC, 2 mg/L; MFC, 4 mg/L) against A. fumigatus; other statins had no activity (MIC > or = 256 mg/L). FST enhanced the activity of caspofungin (CFG) against A. fumigatus; subinhibitory concentrations of FST in combination with CFG showed >99.9% killing of A. fumigatus conidia, whereas either drug alone showed poor activity at subinhibitory concentrations. FST potentiated the antifungal activity of CFG but displayed no specific interaction with voriconazole or amphotericin B.

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Synergistic and/or additive interaction of AMB, caspofungin, VCZ, and primycin with FLV on growth reduction of Aspergillus fumigatus was demonstrated.
“Synergistic and/or additive interaction of AMB, caspofungin, VCZ, PN with FLV on the growth reduction of Aspergillus fumigatus was demonstrated [28,37] .”
From Statins as antifungal agents (2011) · cites this paper as [37]

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Authors: Natesan, S. K., Chandrasekar, P. H., Alangaden, G. J., & Manavathu, E. K.
Affiliations: Wayne State University (US)
ORCID: Chandrasekar, Pranatharthi H.
Alangaden, George J.
Venue: Diagnostic Microbiology and Infectious Disease
Publisher: Elsevier BV
Published: 2008-04
Volume: 60
Issue: 4
Pages: 369-373
ISSN: 0732-8893 (ISSN-L)
DOI: 10.1016/j.diagmicrobio.2007.10.015
OpenAlex: W2170180955
Semantic Scholar: 50486028b020cde1e920abe45c284c580612036e
Cited by: 32
References: 36
Citations by year: 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 4 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 3
FWCI: 1.26
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Diagnostic Microbiology and Infectious Disease (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
Keywords: fluvastatin, caspofungin, Aspergillus fumigatus, statins, antifungal synergy, combination antifungal therapy, HMG-CoA reductase inhibition, voriconazole, amphotericin B, invasive aspergillosis
MeSH terms: Caspofungin, Fluvastatin, Antifungal Agents, Aspergillus fumigatus, Drug Synergism, Fatty Acids, Monounsaturated, Humans, Indoles, Microbial Sensitivity Tests, Colony Count, Microbial, Microbial Viability, Echinocandins, Lipopeptides

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Fluvastatin potentiates the activity of caspofungin against Aspergillus fumigatus in vitro

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