Altered molecular signature of intestinal microbiota in irritable bowel syndrome patients compared with healthy controls: A systematic review and meta-analysis
Abstract
Background Many studies have reported significant changes in intestinal microbiota in irritable bowel syndrome (IBS) patients based on quantitative real-time PCR analysis. Aims We aimed to review the alterations in intestinal microbiota. Methods An online search up to June 9, 2016, was conducted. This systematic review and meta-analysis included differential expression of intestinal microbiota in patients with IBS versus healthy controls (HCs) and subgroup analysis. We assessed the quality of the included studies using an original assessment tool. Results A total of 13 articles involving 360 IBS patients and 268 healthy controls were included. The quality assessment scores for these articles ranged from 5 to 8. Significant differences in expression in IBS patients were observed for Lactobacillus (SMD=-0.85, P<0.001, I 2=28%), Bifidobacterium (SMD=-1.17, P<0.001, I 2=79.3%), and Faecalibacterium prausnitzii (SMD=-1.05, P<0.001, I 2=0.0%) but not Bacteroides-Prevotella group, Escherichia coli or other genera or species. Subgroup analysis showed that diarrhea-predominant IBS patients had significantly different expression of Lactobacillus (SMD=-1.81, P<0.001) and Bifidobacterium (SMD=-1.45, P<0.001). Conclusion Down-regulation of bacterial colonization including Lactobacillus, Bifidobacterium and F. prausnitzii was observed in IBS patients, particularly in diarrhea-predominant IBS (IBS-D). Microbiota changes participate in the pathogenesis of IBS and may underlie the efficacy of probiotic supplements.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some studies reported that the number of Bifidobacteria and Lactobacilli in the feces of IBS patients was less than that of normal subjects, whereas other studies reported that the number was greater.
“Some studies have reported that the number of Bifidobacteria and Lactobacilli in the feces of IBS patients was less than that of normal subjects, whereas other studies reported that the number was greater than that of normal subjects [8,9,10,11,12,13,14].”
Cites
An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
Jeffery, I. B., O'Toole, P. W., Öhman, L., Claesson, M. J., Deane, J., Quigley, E. M. M., & Simrén, M. (2012) · Gut · doi:10.1136/gutjnl-2011-301501 · Cited by 835 · see citing works
Malinen, E., Rinttila, T., Kajander, K., Matto, J., Kassinen, A., Krogius, L., Saarela, M., Korpela, R., & Palva, A. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40312.x · Cited by 699 · see citing works
tana, C., umesaki, Y., imaoka, A., handa, T., kanazawa, M., & fukudo, S. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01427.x · Cited by 474 · see citing works
Duboc, H., Rainteau, D., Rajca, S., Humbert, L., Farabos, D., Maubert, M., Grondin, V., Jouet, P., Bouhassira, D., Seksik, P., et al. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01893.x · Cited by 256 · see citing works
Carroll, I. M., Chang, Y.-H., Park, J., Sartor, R. B., & Ringel, Y. (2010) · Gut Pathogens · doi:10.1186/1757-4749-2-19 · Cited by 203 · see citing works
DuPont, H. L. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12728 · Cited by 171 · see citing works
Sundin, J., Rangel, I., Fuentes, S., Heikamp‐de Jong, I., Hultgren‐Hörnquist, E., de Vos, W. M., & Brummer, R. J. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13055 · Cited by 164 · see citing works
Dulon, S., Leduc, D., Cottrell, G. S., D'Alayer, J., Hansen, K. K., Bunnett, N. W., Hollenberg, M. D., Pidard, D., & Chignard, M. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2004-0274oc · Cited by 139 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
ACG Clinical Guideline: Management of Irritable Bowel Syndrome
Lacy, B. E., Pimentel, M., Brenner, D. M., Chey, W. D., Keefer, L. A., Long, M. D., & Moshiree, B. (2021) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001036 · Cited by 893 · see citing works
Precup, G., & Vodnar, D.-C. (2019) · British Journal of Nutrition · doi:10.1017/s0007114519000680 · Cited by 378 · see citing works
The food-gut axis: lactic acid bacteria and their link to food, the gut microbiome and human health
De Filippis, F., Pasolli, E., & Ercolini, D. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa015 · Cited by 303 · see citing works
Castro-Bravo, N., Wells, J. M., Margolles, A., & Ruas-Madiedo, P. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02426 · Cited by 284 · see citing works
The Link between Gut Dysbiosis and Neuroinflammation in Parkinson’s Disease
Baizabal-Carvallo, J. F., & Alonso-Juarez, M. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.02.030 · Cited by 130 · see citing works
Fukui, H., Xu, X., & Miwa, H. (2018) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm18071 · Cited by 128 · see citing works
Sohail, M. U., Yassine, H. M., Sohail, A., & Thani, A. A. A. (2019) · Review of Diabetic Studies · doi:10.1900/rds.2019.15.35 · Cited by 128 · see citing works
Quigley, E. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7010006 · Cited by 109 · see citing works
Qi-Xiang, M., Yang, F., Ze-Hua, H., Nuo-Ming, Y., Rui-Long, W., Bin-Qiang, X., Jun-Jie, F., Chun-Lan, H., & Yue, Z. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2112882 · Cited by 112 · see citing works
Huang, H. L., Chen, H. T., Luo, Q. L., Xu, H. M., He, J., Li, Y. Q., Zhou, Y. L., Yao, F., Nie, Y. Q., & Zhou, Y. J. (2019) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12756 · Cited by 89 · see citing works
Creedon, A. C., Hung, E. S., Berry, S. E., & Whelan, K. (2020) · Nutrients · doi:10.3390/nu12082347 · Cited by 75 · see citing works
Shang, X., E, F.-F., Guo, K.-L., Li, Y.-F., Zhao, H.-L., Wang, Y., Chen, N., Nian, T., Yang, C.-Q., Yang, K.-H., et al. (2022) · Nutrients · doi:10.3390/nu14122482 · Cited by 41 · see citing works
Kemppinen, A., Howell, C., Allgar, V., Dodd, M., Gregson, J., Knowles, C., McLaughlin, J., Pandya, P., Whorwell, P., Markaryan, E., et al. (2020) · Trials · doi:10.1186/s13063-020-4069-x · Cited by 14 · see citing works
- Authors
- Liu, H.-N., Wu, H., Chen, Y.-Z., Chen, Y.-J., Shen, X.-Z., & Liu, T.-T.
- Affiliations
- Fudan University (CN)
- Corresponding author
- Liu, Hai-Ning
- Wu, Hao
- Chen, Yu-Zhuo
- ORCID
- Venue
- Digestive and Liver Disease
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 49
- Issue
- 4
- Pages
- 331-337
- ISSN
- 1590-8658 (ISSN-L)
- OpenAlex
- W2574577991
- Cited by
- 254
- References
- 8
- Citations by year
- 2026: 16 · 2025: 19 · 2024: 25 · 2023: 39 · 2022: 29 · 2021: 34 · 2020: 35 · 2019: 32 · 2018: 23 · 2017: 2
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Digestive and Liver Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- irritable bowel syndrome, gut microbiota, Lactobacillus, Bifidobacterium, Faecalibacterium prausnitzii, diarrhea-predominant irritable bowel syndrome, bacterial colonization, probiotics, gut dysbiosis
- MeSH terms
- Gastrointestinal Microbiome, Bacteria, Diarrhea, DNA, Bacterial, Feces, Humans, Down-Regulation, Probiotics, Irritable Bowel Syndrome, Real-Time Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
