Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome
Abstract
BACKGROUND: The profile of intestinal organic acids in irritable bowel syndrome (IBS) and its correlation with gastrointestinal (GI) symptoms are not clear. We hypothesized in this study that altered GI microbiota contribute to IBS symptoms through increased levels of organic acids. METHODS: Subjects were 26 IBS patients and 26 age- and sex-matched controls. Fecal samples were collected for microbiota analysis using quantitative real-time polymerase chain reaction and culture methods, and the determination of organic acid levels using high-performance liquid chromatography. Abdominal gas was quantified by image analyses of abdominal X-ray films. Subjects completed a questionnaire for GI symptoms, quality of life (QOL) and negative emotion. KEY RESULTS: Irritable bowel syndrome patients showed significantly higher counts of Veillonella (P = 0.046) and Lactobacillus (P = 0.031) than controls. They also expressed significantly higher levels of acetic acid (P = 0.049), propionic acid (P = 0.025) and total organic acids (P = 0.014) than controls. The quantity of bowel gas was not significantly different between controls and IBS patients. Finally, IBS patients with high acetic acid or propionic acid levels presented with significantly worse GI symptoms, QOL and negative emotions than those with low acetic acid or propionic acid levels or controls. CONCLUSIONS & INFERENCES: These results support the hypothesis that both fecal microbiota and organic acids are altered in IBS patients. A combination of Veillonella and Lactobacillus is known to produce acetic and propionic acid. High levels of acetic and propionic acid may associate with abdominal symptoms, impaired QOL and negative emotions in IBS.
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An altered fermentation process, with an increase in faecal short chain fatty acids and their producing bacteria, has been described in IBS; the highest levels being related to the severest symptoms.
“An altered fermentation process, with an increase in faecal SCFA and their producing bacteria, has been described; the highest levels being related to the severest symptoms [63] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [63]
Acetic and propionic acid-producing bacteria, such as Veionella and Lactobacilli spp, have been reported in IBS patients.
“acetic and propionic acid-producing bacteria (i.e., Veionella and Lactobacilli spp) have been reported in IBS patients [51]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [51]
Fecal concentrations of SCFAs in IBS patients differ only slightly in comparison to healthy subjects.
“fecal concentrations of SCFAs in IBS patients differ only slightly in comparison to healthy subjects [51,240]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [51]
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- Authors
- tana, C., umesaki, Y., imaoka, A., handa, T., kanazawa, M., & fukudo, S.
- Affiliations
- Tohoku University (JP)
- Yakult Central Institute (JP)
- Corresponding author
- fukudo, s.
- ORCID
- umesaki, y.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2009-11
- Volume
- 22
- Issue
- 5
- Pages
- 512-9, e114
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W1974577714
- Cited by
- 474
- References
- 45
- Citations by year
- 2026: 6 · 2025: 21 · 2024: 30 · 2023: 19 · 2022: 35 · 2021: 38 · 2020: 31 · 2019: 34 · 2018: 27 · 2017: 29 · 2016: 39 · 2015: 32 · 2014: 38 · 2013: 29 · 2012: 23
- FWCI
- 23.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Keywords
- irritable bowel syndrome, gut microbiota, organic acids, acetic acid, propionic acid, Veillonella, Lactobacillus, gastrointestinal symptoms, quality of life, negative emotions, abdominal gas, fecal microbiota
- MeSH terms
- Adult, Analysis of Variance, Chromatography, High Pressure Liquid, DNA, Bacterial, Feces, Female, Humans, Immunoenzyme Techniques, Lactobacillus, Male, Propionates, Quality of Life, Surveys and Questionnaires, Severity of Illness Index, Veillonella, Case-Control Studies, Statistics, Nonparametric, Acetic Acid, Reverse Transcriptase Polymerase Chain Reaction, Irritable Bowel Syndrome, Metagenome
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