Review article: evidence for the role of gut microbiota in irritable bowel syndrome and its potential influence on therapeutic targets
Abstract
Summary: Background: Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disease with a substantial social and economic burden. Treatment options remain limited and research on the aetiology and pathophysiology of this multifactorial disease is ongoing. Aim: To discuss the potential role of gut microbiota in the pathophysiology of IBS and to identify possible interactions with pathophysiologic targets in IBS. Methods: Articles were identified via a PubMed database search [‘irritable bowel syndrome’ AND (anti‐bacterial OR antibiotic OR flora OR microbiota OR microflora OR probiotic)]. English‐language articles were screened for relevance. Full review of publications for the relevant studies was conducted, including additional publications that were identified from individual article reference lists. Results: The role of gut microbiota in IBS is supported by varying lines of evidence from animal and human studies. For example, post‐infectious IBS in humans is well documented. In addition, certain probiotics and nonsystemic antibiotics appear to be efficacious in the treatment of IBS. Mechanisms involved in improving IBS symptoms likely go beyond mere changes in the composition of the gut microbiota, and accumulating animal data support the interplay of microbiota with other IBS targets, such as the gut–brain axis, visceral hypersensitivity, mucosal inflammation and motility. Conclusion: The role of the gut microbiota is still being elucidated; however, it appears to be one of several important factors that contributes to the aetiology and pathophysiology of the irritable bowel syndrome.
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Gastrointestinal flora disorder, mild mucosal inflammation, chronic immune activation, changes in intestinal permeability, and psychosocial factors are implicated in IBS.
“Yet, gastrointestinal flora disorder, mild mucosal inflammation, chronic immune activation, changes in intestinal permeability, and psychosocial factors are implicated in IBS [4,15,16,17].”
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- Authors
- DuPont, H. L.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- DuPont, H. L.
- ORCID
- DuPont, H. L.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2014-03-25
- Volume
- 39
- Issue
- 10
- Pages
- 1033-1042
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W1981417697
- Cited by
- 171
- References
- 92
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 7 · 2023: 10 · 2022: 14 · 2021: 11 · 2020: 11 · 2019: 13 · 2018: 19 · 2017: 19 · 2016: 24 · 2015: 26 · 2014: 9
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- irritable bowel syndrome, gut microbiota, probiotics, post-infectious IBS, gut-brain axis, visceral hypersensitivity, mucosal inflammation, gastrointestinal motility, therapeutic target
- MeSH terms
- Animals, Anti-Bacterial Agents, Humans, Probiotics, Irritable Bowel Syndrome, Molecular Targeted Therapy, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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