Interactions of Surface Exopolysaccharides from Bifidobacterium and Lactobacillus within the Intestinal Environment

Castro-Bravo, Nuria; Wells, Jerry M.; Margolles, Abelardo; Ruas-Madiedo, Patricia

doi:10.3389/fmicb.2018.02426

Cited by 285Probiotics and Fermented FoodsPolysaccharides Composition and ApplicationsGut microbiota and health

Interactions of Surface Exopolysaccharides from Bifidobacterium and Lactobacillus within the Intestinal Environment

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Castro-Bravo, Nuria, Wells, Jerry M., Margolles, Abelardo, Ruas-Madiedo, Patricia·2018·Frontiers in Microbiology

DOI 10.3389/fmicb.2018.02426PMC PMC6193118

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Abstract

Exopolysaccharides (EPS) are surface carbohydrate polymers present in most bacteria acting as a protective surface layer but also interacting with the surrounding environment. This review discusses the roles of EPS synthesised by strains of Lactobacillus and Bifidobacterium, many of them with probiotic characteristics, in the intestinal environment. Current knowledge on genetics and biosynthesis pathways of EPS in lactic acid bacteria and bifidobacteria, as well as the development of genetic tools, has created possibilities to elucidate the interplay between EPS and host intestinal mucosa. These include the microbiota that inhabits this ecological niche and the host cells. Several carbohydrate recognition receptors located in the intestinal epithelium could be involved in the interaction with bacterial EPS and modulation of immune response; however, little is known about the receptors recognizing EPS from lactobacilli or bifidobacteria and the triggered response. On the contrary, it has been clearly demonstrated that EPS play a relevant role in the persistence of the producing bacteria in the intestinal tract. Indeed, some authors postulate that some of the beneficial actions of EPS-producing probiotics could be related to the formation of a biofilm layer protecting the host against injury, for example by pathogens or their toxins. Nevertheless, the in vivo formation of biofilms by probiotics has not been proved to date. Finally, EPS produced by probiotic strains are also able to interact with the intestinal microbiota that populates the gut. In fact, some of these polymers can be used as carbohydrate fermentable source by some gut commensals thus being putatively involved in the release of bacterial metabolites that exert positive benefits for the host. In spite of the increasing knowledge about the role that these surface molecules play in the interaction of probiotic bacteria with the gut mucosal actors, both intestinal receptors and microbiota, the challenging issue is to demonstrate the functionality of EPS in vivo, which will open an avenue of opportunities for the application of EPS-producing probiotics to improve health.

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HePS contain from three to eight repeating units made up of two or more monosaccharides and can present molecular modifications including acetylations, pyruvylations and phosphorylations.
“HePS contain from three to eight repeating units made up of two or more monosaccharides (e.g., rhamnose, fructose, galactose or glucose); they can present some molecular modifications, including acetylations, pyruvylations and phosphorylations [10].”
From Lactic Acid Bacteria Exopolysaccharides Producers: A Sustainable Tool for Functional Foods (2021) · cites this paper as [10]
The “Genetics and synthesis of EPS” section says HePS have repeating units containing mainly glucose, galactose and rhamnose, and mentions N-acetylated sugars. It reports three to nine monomers per repeating unit, not three to eight repeating units; it does not identify fructose as a HePS component or report pyruvylation and phosphorylation. Page numbers are unavailable in our copy. (LLM, conf=0.88)
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Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works
Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics
Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., et al. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.75 · Cited by 5,634 · see citing works
The Treatment-Naive Microbiome in New-Onset Crohn’s Disease
Gevers, D., Kugathasan, S., Denson, L. A., Vázquez-Baeza, Y., Van Treuren, W., Ren, B., Schwager, E., Knights, D., Song, S. J., Yassour, M., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.005 · Cited by 3,220 · see citing works
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910 · see citing works
Prebiotic effects: metabolic and health benefits
Roberfroid, M. B., Gibson, G. R., Hoyles, L., McCartney, A. L., Rastall, R. A., Rowland, I. R., Wolvers, D. A. W., Watzl, B., Szajewska, H., Stahl, B., et al. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003363 · Cited by 2,098 · see citing works
The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota
Milani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., Mahony, J., Belzer, C., Delgado Palacio, S., Arboleya Montes, S., Mancabelli, L., et al. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00036-17 · Cited by 1,950 · see citing works
Identification of DC-SIGN, a Novel Dendritic Cell–Specific ICAM-3 Receptor that Supports Primary Immune Responses
Geijtenbeek, T. B. H., Torensma, R., van Vliet, S. J., van Duijnhoven, G. C. F., Adema, G. J., van Kooyk, Y., & Figdor, C. G. (2000) · Cell · doi:10.1016/s0092-8674(00)80693-5 · Cited by 1,701 · see citing works
The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
Round, J. L., Lee, S. M., Li, J., Tran, G., Jabri, B., Chatila, T. A., & Mazmanian, S. K. (2011) · Science · doi:10.1126/science.1206095 · Cited by 1,604 · see citing works
Analysis of <i>Fusobacterium</i> persistence and antibiotic response in colorectal cancer
Bullman, S., Pedamallu, C. S., Sicinska, E., Clancy, T. E., Zhang, X., Cai, D., Neuberg, D., Huang, K., Guevara, F., Nelson, T., et al. (2017) · Science · doi:10.1126/science.aal5240 · Cited by 1,574 · see citing works
Signalling through C-type lectin receptors: shaping immune responses
Geijtenbeek, T. B. H., & Gringhuis, S. I. (2009) · Nature reviews. Immunology · doi:10.1038/nri2569 · Cited by 1,380 · see citing works
Probiotics, gut microbiota, and their influence on host health and disease
Sánchez, B., Delgado, S., Blanco‐Míguez, A., Lourenço, A., Gueimonde, M., & Margolles, A. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600240 · Cited by 1,104 · see citing works
Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function
Geijtenbeek, T. B. H., van Vliet, S. J., Koppel, E. A., Sánchez‐Hernández, M., Vandenbroucke‐Grauls, C. M. J. E., Appelmelk, B. J., & van Kooyk, Y. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20021229 · Cited by 1,058 · see citing works
The vocabulary of microbiome research: a proposal
Marchesi, J., & Ravel, J. (2015) · Microbiome · doi:10.1186/s40168-015-0094-5 · Cited by 1,016 · see citing works
Bacterial polymers: biosynthesis, modifications and applications
Rehm, B. H. A. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2354 · Cited by 899 · see citing works
Bacterial Exopolysaccharide mediated heavy metal removal: A Review on biosynthesis, mechanism and remediation strategies
Gupta, P., & Diwan, B. (2016) · Biotechnology Reports · doi:10.1016/j.btre.2016.12.006 · Cited by 864 · see citing works
Advances in bacterial exopolysaccharides: from production to Biotechnological applications
Freitas, F., Alves, V. D., & Reis, M. A. M. (2011) · Trends in Biotechnology · doi:10.1016/j.tibtech.2011.03.008 · Cited by 804 · see citing works
C-type lectins in immunity and homeostasis
Brown, G. D., Willment, J. A., & Whitehead, L. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0004-8 · Cited by 747 · see citing works
Bacterial exopolysaccharides: biosynthesis pathways and engineering strategies
Schmid, J., Sieber, V., & Rehm, B. H. A. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00496 · Cited by 616 · see citing works
Microbial Exopolysaccharides: Main Examples of Synthesis, Excretion, Genetics and Extraction
Donot, F., Fontana, A., Baccou, J. C., & Schorr-Galindo, S. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.08.083 · Cited by 605 · see citing works
Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection
Fanning, S., Hall, L. J., Cronin, M. A., Zomer, A., MacSharry, J. A., Goulding, D., Motherway, M. O., Shanahan, F., Nally, K., Dougan, G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115621109 · Cited by 564 · see citing works
A catalog of the mouse gut metagenome
Xiao, L., Feng, Q., Liang, S., Sonne, S. B., Xia, Z., Qiu, X., Li, X., Long, H., Zhang, J., Zhang, D., et al. (2015) · Nature Biotechnology · doi:10.1038/nbt.3353 · Cited by 514 · see citing works
New Perspectives for Lactobacilli Exopolysaccharides
Badel, S., Bernardi, T., & Michaud, P. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2010.08.011 · Cited by 497 · see citing works
Structure-Function Relationships of Glucansucrase and Fructansucrase Enzymes from Lactic Acid Bacteria
van Hijum, S. A. F. T., Kralj, S., Ozimek, L. K., Dijkhuizen, L., & van Geel-Schutten, I. H. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.70.1.157-176.2006 · Cited by 466 · see citing works
Immunomodulatory mechanisms of lactobacilli
Wells, J. M. (2011) · Microbial Cell Factories · doi:10.1186/1475-2859-10-s1-s17 · Cited by 431 · see citing works
A diet low in FODMAPs reduces symptoms in patients with irritable bowel syndrome and a probiotic restores bifidobacterium species: a randomized controlled trial
Staudacher, H. M., Lomer, M. C. E., Farquharson, F. M., Louis, P., Fava, F., Franciosi, E., Scholz, M., Tuohy, K. M., Lindsay, J. O., Irving, P. M., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.06.010 · Cited by 430 · see citing works
Bacterial biogeography of the human digestive tract
Stearns, J. C., Lynch, M. D. J., Senadheera, D. B., Tenenbaum, H. C., Goldberg, M. B., Cvitkovitch, D. G., Croitoru, K., Moreno‐Hagelsieb, G., & Neufeld, J. D. (2011) · Scientific Reports · doi:10.1038/srep00170 · Cited by 399 · see citing works
A journey through the lectin pathway of complement— MBL and beyond
Garred, P., Genster, N., Pilely, K., Bayarri‐Olmos, R., Rosbjerg, A., Ma, Y. J., & Skjoedt, M. (2016) · Immunological Reviews · doi:10.1111/imr.12468 · Cited by 399 · see citing works
Exopolysaccharides Produced by Lactic Acid Bacteria: From Health-Promoting Benefits to Stress Tolerance Mechanisms
Caggianiello, G., Kleerebezem, M., & Spano, G. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7471-2 · Cited by 396 · see citing works
Recent Developments in the Biosynthesis and Applications of Heteropolysaccharides from Lactic Acid Bacteria
De Vuyst, L., De Vin, F., Vaningelgem, F., & Degeest, B. (2001) · International Dairy Journal · doi:10.1016/s0958-6946(01)00114-5 · Cited by 391 · see citing works
Production, Properties, and Industrial Food Application of Lactic Acid Bacteria-Derived Exopolysaccharides
Zannini, E., Waters, D. M., Coffey, A., & Arendt, E. K. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-7172-2 · Cited by 371 · see citing works
Lactic acid bacteria and bifidobacteria with potential to design natural biofunctional health-promoting dairy foods
Linares, D. M., Gómez, C., Renes, E., Fresno, J. M., Tornadijo, M. E., Ross, R. P., & Stanton, C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00846 · Cited by 335 · see citing works
Helicobacter pylori Modulates the T Helper Cell 1/T Helper Cell 2 Balance through Phase-variable Interaction between Lipopolysaccharide and DC-SIGN
Bergman, M. P., Engering, A. J., Smits, H. H., van Vliet, S. J., Bodegraven, A. A. V., Wirth, H.-P., Kapsenberg, M. L., Vandenbroucke‐Grauls, C. M. J. E., van Kooyk, Y., & Appelmelk, B. J. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041061 · Cited by 332 · see citing works
Present and future medical applications of microbial exopolysaccharides
Moscovici, M. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01012 · Cited by 331 · see citing works
Polysaccharide Production by Lactic Acid Bacteria: From Genes to Industrial Applications
Zeidan, A. A., Poulsen, V. K., Janzen, T., Buldo, P., Derkx, P. M. F., Øregaard, G., & Neves, A. R. (2017) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux017 · Cited by 326 · see citing works
Pivotal Roles of the Outer Membrane Polysaccharide Export and Polysaccharide Copolymerase Protein Families in Export of Extracellular Polysaccharides in Gram-Negative Bacteria
Cuthbertson, L., Mainprize, I. L., Naismith, J. H., & Whitfield, C. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00024-08 · Cited by 301 · see citing works
Identification of probiotic effector molecules: present state and future perspectives
Lebeer, S., Bron, P. A., Marco, M. L., van Pijkeren, J., Motherway, M. O., Hill, C., Pot, B., Roos, S., & Klaenhammer, T. R. (2017) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2017.10.007 · Cited by 295 · see citing works
The Role of Bacterial Polysaccharide Capsules as Virulence Factors
Moxon, E. R., & Kroll, J. S. (1990) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-74694-9_4 · Cited by 289 · see citing works
Glycointeractions in bacterial pathogenesis
Poole, J., Day, C. J., von Itzstein, M., Paton, J. C., & Jennings, M. P. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0007-2 · Cited by 273 · see citing works
Identification of a Gene Cluster for the Biosynthesis of a Long, Galactose-Rich Exopolysaccharide in Lactobacillus rhamnosus GG and Functional Analysis of the Priming Glycosyltransferase
Lebeer, S., Verhoeven, T. L. A., Francius, G., Schoofs, G., Lambrichts, I., Dufrêne, Y. F., Vanderleyden, J., & Keersmaecker, S. C. J. D. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.02919-08 · Cited by 271 · see citing works
Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-α production
Meyer‐Wentrup, F. A. G., Benítez‐Ribas, D., Tacken, P. J., Punt, C. J. A., Figdor, C. G., de Vries, I. J. M., & Adema, G. J. (2008) · Blood · doi:10.1182/blood-2007-03-081398 · Cited by 268 · see citing works
C-type lectins: their network and roles in pathogen recognition and immunity
Mayer, S., Raulf, M., & Lepenies, B. (2016) · Histochemistry and Cell Biology · doi:10.1007/s00418-016-1523-7 · Cited by 257 · see citing works
Altered molecular signature of intestinal microbiota in irritable bowel syndrome patients compared with healthy controls: A systematic review and meta-analysis
Liu, H.-N., Wu, H., Chen, Y.-Z., Chen, Y.-J., Shen, X.-Z., & Liu, T.-T. (2017) · Digestive and Liver Disease · doi:10.1016/j.dld.2017.01.142 · Cited by 254 · see citing works
In vivo characterization of Lactobacillus johnsonii FI9785 for use as a defined competitive exclusion agent against bacterial pathogens in poultry
Ragione, R. M. L., Narbad, A., Gasson, M. J., & Woodward, M. J. (2004) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2004.01474.x · Cited by 252 · see citing works
Exopolysaccharides Produced by Probiotic Strains Modify the Adhesion of Probiotics and Enteropathogens to Human Intestinal Mucus
Ruas‐Madiedo, P., Gueimonde, M., Margollés, A., Reyes‐Gavilán, C. G. D. L., & Salminen, S. (2006) · Journal of Food Protection · doi:10.4315/0362-028x-69.8.2011 · Cited by 241 · see citing works
Production, purification and structural characterization of an exopolysaccharide produced by a probiotic Lactobacillus plantarum MTCC 9510
Ismail, B., & Nampoothiri, K. M. (2010) · Archives of Microbiology · doi:10.1007/s00203-010-0636-y · Cited by 241 · see citing works
Influence of exopolysaccharides on the structure, texture, stability and sensory properties of yoghurt and related products
Mende, S., Rohm, H., & Jaros, D. (2015) · International Dairy Journal · doi:10.1016/j.idairyj.2015.08.002 · Cited by 238 · see citing works
Metabolism by bifidobacteria and lactic acid bacteria of polysaccharides from wheat and rye, and exopolysaccharides produced by Lactobacillus sanfranciscensis
Korakli, M., Gänzle, M. G., & Vogel, R. F. (2002) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2002.01607.x · Cited by 237 · see citing works
In vivo imaging and tracking of host–microbiota interactions via metabolic labeling of gut anaerobic bacteria
Geva‐Zatorsky, N., Álvarez, D., Hudak, J. E., Reading, N. C., Ertürk-Hasdemir, D., Dasgupta, S., von Andrian, U. H., & Kasper, D. L. (2015) · Nature Medicine · doi:10.1038/nm.3929 · Cited by 236 · see citing works
Multivariate modelling of faecal bacterial profiles of patients with IBS predicts responsiveness to a diet low in FODMAPs
Bennet, S. M. P., Böhn, L., Störsrud, S., Liljebo, T., Collin, L., Lindfors, P., Törnblom, H., Öhman, L., & Simrén, M. (2018) · Gut · doi:10.1136/gutjnl-2016-313128 · Cited by 225 · see citing works
Sugar-Coated: Exopolysaccharide Producing Lactic Acid Bacteria for Food and Human Health Applications
Ryan, P. M., Ross, R. P., Fitzgerald, G. F., Caplice, N. M., & Stanton, C. (2015) · Food & Function · doi:10.1039/c4fo00529e · Cited by 221 · see citing works
Exopolysaccharides from Sourdough Lactic Acid Bacteria
Galle, S., & Arendt, E. K. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.617474 · Cited by 219 · see citing works
Impact of the exopolysaccharide layer on biofilms, adhesion and resistance to stress in Lactobacillus johnsonii FI9785
Dertli̇, E., Mayer, M. J., & Narbad, A. (2015) · BMC Microbiology · doi:10.1186/s12866-015-0347-2 · Cited by 216 · see citing works
Genomic Overview and Biological Functions of Exopolysaccharide Biosynthesis in Bifidobacterium spp
Hidalgo-Cantabrana, C., Sánchez, B., Milani, C., Ventura, M., Margollés, A., & Ruas‐Madiedo, P. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.02977-13 · Cited by 216 · see citing works
In Vitro Study of Prebiotic Properties of Levan-Type Exopolysaccharides from Lactobacilli and Non-Digestible Carbohydrates Using Denaturing Gradient Gel Electrophoresis
Bello, F. D., Walter, J., Hertel, C., & Hammes, W. P. (2001) · Systematic and Applied Microbiology · doi:10.1078/0723-2020-00033 · Cited by 214 · see citing works
Glucan synthesis in the genus Lactobacillus: isolation and characterization of glucansucrase genes, enzymes and glucan products from six different strains
Kralj, S., van Geel-Schutten, G. H., Dondorff, M. M. G., Kirsanovs, S., van der Maarel, M. J. E. C., & Dijkhuizen, L. (2004) · Microbiology · doi:10.1099/mic.0.27321-0 · Cited by 213 · see citing works
Biopolymers from Lactic Acid Bacteria. Novel Applications in Foods and Beverages
Torino, M. I., Font de Valdez, G., & Mozzi, F. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00834 · Cited by 201 · see citing works
C-Type Lectin-Like Receptors of the Dectin-1 Cluster: Ligands and Signaling Pathways
Plato, A., Willment, J. A., & Brown, G. D. (2013) · International Reviews of Immunology · doi:10.3109/08830185.2013.777065 · Cited by 201 · see citing works
Immune Modulation Capability of Exopolysaccharides Synthesised by Lactic Acid Bacteria and Bifidobacteria
Hidalgo-Cantabrana, C., López, P., Gueimonde, M., Reyes‐Gavilán, C. G. D. L., Suárez, A., Margollés, A., & Ruas‐Madiedo, P. (2012) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-012-9110-2 · Cited by 192 · see citing works
Exopolysaccharides Produced by Lactic Acid Bacteria and Bifidobacteria as Fermentable Substrates by the Intestinal Microbiota
Salazar, N., Gueimonde, M., de los Reyes-Gavilán, C. G., & Ruas-Madiedo, P. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.770728 · Cited by 188 · see citing works
Exopolysaccharides of Lactobacillus rhamnosus GG form a protective shield against innate immune factors in the intestine
Lebeer, S., Claes, I. J. J., Verhoeven, T. L. A., Vanderleyden, J., & Keersmaecker, S. C. J. D. (2010) · Microbial Biotechnology · doi:10.1111/j.1751-7915.2010.00199.x · Cited by 179 · see citing works
Identification of Genes Associated with the Long-Gut-Persistence Phenotype of the Probiotic Lactobacillus johnsonii Strain NCC533 Using a Combination of Genomics and Transcriptome Analysis
Denou, E., Pridmore, R. D., Berger, B. W., Panoff, J.-M., Arigoni, F., & Brüssow, H. (2008) · Journal of Bacteriology · doi:10.1128/jb.01637-07 · Cited by 179 · see citing works
Exopolysaccharides produced by Bifidobacterium longum IPLA E44 and Bifidobacterium animalis subsp. lactis IPLA R1 modify the composition and metabolic activity of human faecal microbiota in pH-controlled batch cultures
Salazar, N., Ruas-Madiedo, P., Kolida, S., Collins, M., Rastall, R., Gibson, G., & de los Reyes-Gavilán, C. G. (2009) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2009.08.017 · Cited by 168 · see citing works
Recent insights in microbial exopolysaccharide biosynthesis and engineering strategies
Schmid, J. (2018) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2018.01.005 · Cited by 163 · see citing works
Elucidating the gut microbiome of ulcerative colitis: bifidobacteria as novel microbial biomarkers
Duranti, S., Gaiani, F., Mancabelli, L., Milani, C., Grandi, A., Bolchi, A., Santoni, A., Lugli, G. A., Ferrario, C., Mangifesta, M., et al. (2016) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiw191 · Cited by 159 · see citing works
Exploring the human microbiome from multiple perspectives: factors altering its composition and function
Rojo, D., Méndez–García, C., Raczkowska, B. A., Bargiela, R., Moyá, A., Ferrer, M., & Barbas, C. (2016) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuw046 · Cited by 159 · see citing works
DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine production
Meyer‐Wentrup, F. A. G., Cambi, A., Joosten, B., Looman, M. W. G., de Vries, I. J. M., Figdor, C. G., & Adema, G. J. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0608352 · Cited by 155 · see citing works
A Novel Rhamnose-Rich Hetero-exopolysaccharide Isolated from Lactobacillus paracasei DG Activates THP-1 Human Monocytic Cells
Balzaretti, S., Taverniti, V., Guglielmetti, S., Fiore, W., Minuzzo, M., Ngehnyuiy, N. H., Ngere, J. B., Sadiq, S., Humphreys, P. N., & Laws, A. P. (2016) · Applied and Environmental Microbiology · doi:10.1128/aem.02702-16 · Cited by 148 · see citing works
Immunoregulatory Effects Triggered by Lactic Acid Bacteria Exopolysaccharides: New Insights into Molecular Interactions with Host Cells
Laiño, J., Villena, J., Kanmani, P., & Kitazawa, H. (2016) · Microorganisms · doi:10.3390/microorganisms4030027 · Cited by 144 · see citing works
A novel purified Lactobacillus acidophilus 20079 exopolysaccharide, LA-EPS-20079, molecularly regulates both apoptotic and NF-κB inflammatory pathways in human colon cancer
El-Deeb, N., Yassin, A. M., Al-Madboly, L. A., & El-Hawiet, A. M. (2018) · Microbial Cell Factories · doi:10.1186/s12934-018-0877-z · Cited by 144 · see citing works
Bacterial Polysaccharides - Current Innovations and Future Trends
Ullrich, M. S. (2009) · Caister Academic Press eBooks · doi:10.13140/2.1.1992.0321 · Cited by 142 · see citing works
Faecalibacterium prausnitzii Strain HTF-F and Its Extracellular Polymeric Matrix Attenuate Clinical Parameters in DSS-Induced Colitis
Rossi, O., Khan, M. T., Schwarzer, M., Hudcovic, T., Šrůtková, D., Duncan, S. H., Stolte, E. H., Kozáková, H., Flint, H. J., Samsom, J. N., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123013 · Cited by 141 · see citing works
Structural Characterization and Anticancer Activity of Cell-Bound Exopolysaccharide from Lactobacillus helveticus MB2-1
Li, W., Xia, X., Tang, W., Ji, J., Rui, X., Chen, X., Jiang, M., Zhou, J., Zhang, Q., & Dong, M. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b01086 · Cited by 140 · see citing works
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Dertli, E., Colquhoun, I. J., Gunning, A. P., Bongaerts, R. J., Le Gall, G., Bonev, B. B., Mayer, M. J., & Narbad, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.507418 · Cited by 134 · see citing works
Bifidobacterium exopolysaccharides fermented by human microbiota
Salazar, N., Fernández, M., Hernández-Barranco, A., Ruas-Madiedo, P., & Reyes-Gavilán, C. D. L. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.00325-08 · Cited by 134 · see citing works
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Sims, I. M., Frese, S. A., Walter, J., Loach, D. M., Wilson, M., Appleyard, K., Eason, J. R., Livingston, M. K., Baird, M. A., Cook, G. M., et al. (2011) · The ISME Journal · doi:10.1038/ismej.2010.201 · Cited by 123 · see citing works
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Structure–function relationships of family GH70 glucansucrase and 4,6-α-glucanotransferase enzymes, and their evolutionary relationships with family GH13 enzymes
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Human intestinal epithelial cells respond to β‐glucans via Dectin‐1 and Syk
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Dols‐Lafargue, M., Lee, H. Y., Marrec, C. L., Heyraud, A., Chambat, G., & Lonvaud‐Funel, A. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.00673-08 · Cited by 103 · see citing works
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Werning, M. L., Ibarburu, I., Dueñas, M. T., Irastorza, A., Navas, J., & López, P. (2006) · Journal of Food Protection · doi:10.4315/0362-028x-69.1.161 · Cited by 97 · see citing works
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EPS-SJ Exopolisaccharide Produced by the Strain Lactobacillus paracasei subsp. paracasei BGSJ2-8 Is Involved in Adhesion to Epithelial Intestinal Cells and Decrease on E. coli Association to Caco-2 Cells
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Biodegradability of Food-Associated Extracellular Polysaccharides
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Exopolysaccharides produced byLactobacillussp.: Biosynthesis and applications
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Genetic and biochemical characterization of exopolysaccharide biosynthesis by Lactobacillus delbrueckii subsp. bulgaricus
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Wachi, S., Kanmani, P., Tomosada, Y., Kobayashi, H., Yuri, T., Egusa, S., Shimazu, T., Suda, Y., Aso, H., Sugawara, M., et al. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400218 · Cited by 87 · see citing works
The collectins CL-L1, CL-K1 and CL-P1, and their roles in complement and innate immunity
Hansen, S., Ohtani, K., Roy, N., & Wakamiya, N. (2016) · Immunobiology · doi:10.1016/j.imbio.2016.05.012 · Cited by 86 · see citing works
Factors Influencing Autoaggregation and Aggregation of Lactobacillus delbrueckii subsp. bulgaricus Isolated from Handmade Yogurt
Aslım, B., Onal, D., & Beyatlı, Y. (2007) · Journal of Food Protection · doi:10.4315/0362-028x-70.1.223 · Cited by 80 · see citing works
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Donnarumma, G., Molinaro, A., Cimini, D., De Castro, C., Valli, V., De Gregorio, V., De Rosa, M., & Schiraldi, C. (2014) · BMC Microbiology · doi:10.1186/1471-2180-14-137 · Cited by 76 · see citing works
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Li, W., Tang, W., Ji, J., Xia, X., Rui, X., Chen, X., Jiang, M., Zhou, J., & Dong, M. (2015) · Carbohydrate Research · doi:10.1016/j.carres.2014.12.014 · Cited by 72 · see citing works
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Horn, N., Wegmann, U., Dertli̇, E., Mulholland, F., Collins, S. R. A., Waldron, K. W., Bongaerts, R. J., Mayer, M. J., & Narbad, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059957 · Cited by 72 · see citing works
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Ríos-Covián, D., Cuesta, I., Álvarez-Buylla, J. R., Ruas‐Madiedo, P., Gueimonde, M., & Reyes‐Gavilán, C. G. D. L. (2016) · BMC Microbiology · doi:10.1186/s12866-016-0773-9 · Cited by 68 · see citing works
Safety and intestinal microbiota modulation by the exopolysaccharide-producing strains Bifidobacterium animalis IPLA R1 and Bifidobacterium longum IPLA E44 orally administered to Wistar rats
Salazar, N., Binetti, A., Gueimonde, M., Alonso, A., Garrido, P., González del Rey, C., González, C., Ruas-Madiedo, P., & de los Reyes-Gavilán, C. G. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.10.016 · Cited by 67 · see citing works
Self-citation
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Górska, S., Jachymek, W., Rybka, J., Strus, M., Heczko, P. B., & Gamian, A. (2009) · Carbohydrate Research · doi:10.1016/j.carres.2009.09.015 · Cited by 64 · see citing works
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Rodríguez-Carvajal, M. Á., Sánchez, J.-I., Campelo, A. B., Martı́nez, B., Rodrı́guez, A., & Serrano, A. M. G. (2008) · Carbohydrate Research · doi:10.1016/j.carres.2008.08.028 · Cited by 46 · see citing works
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Tahoun, A. A. E., Masutani, H., El-Sharkawy, H., Gillespie, T., Honda, R. P., Kuwata, K., Inagaki, M., Yabe, T., Nomura, I., & Suzuki, T. (2017) · Gut Pathogens · doi:10.1186/s13099-017-0177-x · Cited by 45 · see citing works
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Structural studies of the exopolysaccharide consisting of a nonasaccharide repeating unit isolated from Lactobacillus rhamnosus KL37B
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Biosynthesis of O-antigen chains and assembly
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Reid, A. N., & Szymanski, C. M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374546-0.00020-1 · Cited by 25 · see citing works
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- Leuconostoc and Its Use in Dairy Technology
Hemme, D. (2012) · CRC Press eBooks · doi:10.1201/b12084-9 · Cited by 11 · see citing works
Biological Activities and Applications of Bifidobacterial Exopolysaccharides: From the Bacteria and Host Perspective
Castro-Bravo, N., Sánchez, B., Margollés, A., & Ruas‐Madiedo, P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805060-6.00010-7 · Cited by 10 · see citing works

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Ruas-Madiedo P. Sánchez B. Hidalgo-Cantabrana C. Margolles A. Law A. (2012). Exopolysaccharides from lactic acid bacteria and bifidobacteria, in Handbook of Animal-Based Fermented Food and Beverage Technology, eds Hui Y. H. Evranuz E. O. (Boca Raton, FL: CRC Press, Taylor & Francis Group), 125– 151.

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“, rhamnose, fructose, galactose or glucose); they can present some molecular modifications, including acetylations, pyruvylations and phosphorylations [10].”
Background
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Combination of probiotics with different functions alleviate DSS-induced colitis by regulating intestinal microbiota, IL-10, and barrier function
Wang, Y., Xie, Q., Zhang, Y., Ma, W., Ning, K., Xiang, J., Cui, J., & Xiang, H. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10259-6 · Cited by 144 · see citing works
Molecules Produced by Probiotics and Intestinal Microorganisms with Immunomodulatory Activity
Delgado, S., Sánchez, B., Margollés, A., Ruas‐Madiedo, P., & Ruíz, L. (2020) · Nutrients · doi:10.3390/nu12020391 · Cited by 139 · see citing works
Lactic acid bacteria-derived exopolysaccharide: Formation, immunomodulatory ability, health effects, and structure-function relationship
Zhang, J., Xiao, Y., Wang, H., Zhang, H., Chen, W., & Lu, W. (2023) · Microbiological Research · doi:10.1016/j.micres.2023.127432 · Cited by 140 · see citing works
Biological Functions of Exopolysaccharides from Lactic Acid Bacteria and Their Potential Benefits for Humans and Farmed Animals
Werning, M. L., Hernández-Alcántara, A. M., Ruiz, M. J., Soto, L. P., Dueñas, M. T., López, P., & Frizzo, L. S. (2022) · Foods · doi:10.3390/foods11091284 · Cited by 126 · see citing works
Molecular and Cellular Mechanisms Influenced by Postbiotics
Jastrząb, R., Graczyk, D., & Siedlecki, P. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413475 · Cited by 121 · see citing works
The biological activities of postbiotics in gastrointestinal disorders
Abbasi, A., Rad, A. H., Ghasempour, Z., Sabahi, S., Kafil, H. S., Hasannezhad, P., Saadat, Y. R., & Shahbazi, N. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1895061 · Cited by 114 · see citing works
Exopolysaccharide Isolated from Lactobacillus plantarum L-14 Has Anti-Inflammatory Effects via the Toll-Like Receptor 4 Pathway in LPS-Induced RAW 264.7 Cells
Kwon, M., Lee, J., Park, S., Kwon, O.-H., Seo, J., & Roh, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239283 · Cited by 100 · see citing works
Diversity of non-starter lactic acid bacteria in autochthonous dairy products from Western Balkan Countries - Technological and probiotic properties
Terzić-Vidojević, A., Veljović, K., Tolinački, M., Živković, M., Lukić, J., Lozo, J., Fira, Đ., Jovčić, B., Strahinić, I., Begović, J., et al. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109494 · Cited by 99 · see citing works
Effect of intrapartum antibiotics on the intestinal microbiota of infants: a systematic review
Zimmermann, P., & Curtis, N. C. (2019) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2018-316659 · Cited by 97 · see citing works
Adhesion mechanisms of lactic acid bacteria: conventional and novel approaches for testing
Alp, D., & Kuleaşan, H. (2019) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-019-2730-x · Cited by 98 · see citing works
Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation
Zeng, W., Shen, J., Bo, T., Peng, L., Xu, H., Nasser, M. I., Zhuang, Q., & Zhao, M. (2019) · Journal of Immunology Research · doi:10.1155/2019/1603758 · Cited by 89 · see citing works
Health-Promoting Properties of Lacticaseibacillus paracasei: A Focus on Kefir Isolates and Exopolysaccharide-Producing Strains
Bengoa, A. A., Dardis, C., Garrote, G. L., & Abraham, A. G. (2021) · Foods · doi:10.3390/foods10102239 · Cited by 80 · see citing works
Comparative Analysis of Lactobacillus gasseri and Lactobacillus crispatus Isolated From Human Urogenital and Gastrointestinal Tracts
Pan, M., Hidalgo-Cantabrana, C., Goh, Y. J., Sanozky-Dawes, R., & Barrangou, R. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.03146 · Cited by 79 · see citing works
Horizon scanning the application of probiotics for wildlife
Garcías-Bonet, N., Roik, A., Tierney, B. T., García, F. C., Villela, H., Dungan, A. M., Quigley, K. M., Sweet, M. J., Berg, G., Gram, L., et al. (2023) · Trends in Microbiology · doi:10.1016/j.tim.2023.08.012 · Cited by 78 · see citing works
The Bifidogenic Effect Revisited—Ecology and Health Perspectives of Bifidobacterial Colonization in Early Life
Kumar, H., Collado, M. C., Wopereis, H., Salminen, S., Knol, J., & Roeselers, G. (2020) · Microorganisms · doi:10.3390/microorganisms8121855 · Cited by 80 · see citing works
Proteomic profile of extracellular vesicles released by Lactiplantibacillus plantarum BGAN8 and their internalization by non-polarized HT29 cell line
Bajić, S. S., Cañas, M.-A., Tolinački, M., Badı́a, J., Sánchez, B., Golić, N., Margollés, A., Baldomà, L., & Ruas‐Madiedo, P. (2020) · Scientific Reports · doi:10.1038/s41598-020-78920-z · Cited by 75 · see citing works
Biopolymers Produced by Lactic Acid Bacteria: Characterization and Food Application
Nicolescu, C. M., Bumbac, M., Buruleanu, C. L., Popescu, E. C., Stănescu, S. G., Georgescu, A. A., & Toma, S. M. (2023) · Polymers · doi:10.3390/polym15061539 · Cited by 74 · see citing works
Antibacterial potential of a novel Lactobacillus casei strain isolated from Chinese northeast sauerkraut and the antibiofilm activity of its exopolysaccharides
Xu, X., Peng, Q., Zhang, Y., Tian, D., Zhang, P., Ying, H., Ma, L., Día, V. P., Qiao, Y., & Shi, B. (2020) · Food & Function · doi:10.1039/d0fo00905a · Cited by 71 · see citing works
Whole-Genome Sequencing, Phylogenetic and Genomic Analysis of Lactiplantibacillus pentosus L33, a Potential Probiotic Strain Isolated From Fermented Sausages
Stergiou, O. S., Tegopoulos, K., Kiousi, D. E., Tsifintaris, M., Papageorgiou, A. C., Tassou, C. C., Chorianopoulos, N., Kolovos, P., & Galanis, Α. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.746659 · Cited by 71 · see citing works
Roseburia intestinalis ‐derived extracellular vesicles ameliorate colitis by modulating intestinal barrier, microbiome, and inflammatory responses
Han, H. S., Hwang, S., Choi, K. Y., Hitayezu, E., Mabwi, H. A., Enkhbayar, A., Song, D., Kim, M., Park, J. S., Park, Y., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12487 · Cited by 71 · see citing works
Cell Walls and Membranes of Actinobacteria
Rahlwes, K. C., Sparks, I. L., & Morita, Y. S. (2019) · Subcellular Biochemistry · doi:10.1007/978-3-030-18768-2_13 · Cited by 65 · see citing works
Exopolysaccharides from lactic acid bacteria, as an alternative to antibiotics, on regulation of intestinal health and the immune system
Yang, S., Xu, X., Peng, Q., Ma, L., Qiao, Y., & Shi, B. (2023) · Animal nutrition · doi:10.1016/j.aninu.2023.02.004 · Cited by 65 · see citing works
Shaping the Infant Microbiome With Non-digestible Carbohydrates
Verkhnyatskaya, S. A., Ferrari, M. D. L., de Vos, P., & Walvoort, M. T. C. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00343 · Cited by 64 · see citing works
Prospects of kefiran as a food-derived biopolymer for agri-food and biomedical applications
Tan, K. X., Chamundeswari, V. N., & Loo, S. C. J. (2020) · RSC Advances · doi:10.1039/d0ra02810j · Cited by 64 · see citing works
Probiotics alter biofilm formation and the transcription of Porphyromonas gingivalis virulence-associated genes
Ishikawa, K. H., Mita, D., Kawamoto, D., Nicoli, J. R., Albuquerque‐Souza, E., Simionato, M. R. L., & Mayer, M. P. A. (2020) · Journal of Oral Microbiology · doi:10.1080/20002297.2020.1805553 · Cited by 63 · see citing works
Mesona chinensis Benth Polysaccharides Alleviate DSS‐Induced Ulcerative Colitis via Inhibiting of TLR4/MAPK/NF‐κB Signaling Pathways and Modulating Intestinal Microbiota
Lu, H., Shen, M., Chen, T., Yu, Y., Chen, Y., Yu, Q., Chen, X., & Xie, J. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200047 · Cited by 63 · see citing works
Modulating the Microbiome for Crohn’s Disease Treatment
Gowen, R., Gamal, A., Martino, L. D., McCormick, T. S., & Ghannoum, M. A. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.01.017 · Cited by 65 · see citing works
Protective effect of exopolysaccharide fraction from Bacillus subtilis against dextran sulfate sodium-induced colitis through maintenance of intestinal barrier and suppression of inflammatory responses
Chung, K., Shin, J., Lee, J.-H., Park, S.-E., Han, H.-S., Rhee, Y. K., Cho, C., Hong, H., & Lee, K. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.02.186 · Cited by 62 · see citing works
Exploring the Links between Diet and Inflammation: Dairy Foods as Case Studies
Hess, J., Stephensen, C. B., Kratz, M., & Bolling, B. W. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab108 · Cited by 62 · see citing works
Biofilm-based delivery approaches and specific enrichment strategies of probiotics in the human gut
Gao, J., Sadiq, F. A., Zheng, Y., Zhao, J., He, G., & Sang, Y. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2126274 · Cited by 60 · see citing works
Lactobacillus fermentum: Could EPS production ability be responsible for functional properties?
Ale, E. C., Rojas, M. F., Reinheimer, J. A., & Binetti, A. G. (2020) · Food Microbiology · doi:10.1016/j.fm.2020.103465 · Cited by 61 · see citing works
Potential Probiotic Properties of Exopolysaccharide-Producing Lacticaseibacillus paracasei EPS DA-BACS and Prebiotic Activity of Its Exopolysaccharide
Lee, M.-G., Joeng, H., Shin, J., Kim, S., Lee, C., Song, Y.-B., Lee, B.-H., Park, H.-G., Lee, T., Jiang, H.-H., et al. (2022) · Microorganisms · doi:10.3390/microorganisms10122431 · Cited by 59 · see citing works
Babies, Bugs, and Barriers: Dietary Modulation of Intestinal Barrier Function in Early Life
Wells, J. M., Gao, Y., de Groot, N., Vonk, M. M., Ulfman, L. H., & van Neerven, R. J. J. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-122221-103916 · Cited by 58 · see citing works
Genetic and Biochemical Characterization of an Exopolysaccharide With in vitro Antitumoral Activity Produced by Lactobacillus fermentum YL-11
Wei, Y., Li, F., Li, L., Huang, L., & Li, Q. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02898 · Cited by 59 · see citing works
Functional bacterial cultures for dairy applications: Towards improving safety, quality, nutritional and health benefit aspects
González‐González, F., Delgado, S., Ruíz, L., Margollés, A., & Ruas‐Madiedo, P. (2022) · Journal of Applied Microbiology · doi:10.1111/jam.15510 · Cited by 58 · see citing works
Postbiotics as the key mediators of the gut microbiota-host interactions
Ozma, M. A., Abbasi, A., Akrami, S., Lahouty, M., Shahbazi, N., Ganbarov, K., Pagliano, P., Sabahi, S., Köse, Ş., Yousefi, M., et al. (2022) · Infezioni in Medicina · doi:10.53854/liim-3002-3 · Cited by 57 · see citing works
Effects of dietary inactivated probiotics on growth performance and immune responses of weaned pigs
Kang, J., Lee, J. J., Cho, J. H., Choe, J., Kyoung, H., Kim, S. H., Kim, H. B., & Song, M. (2021) · Journal of Animal Science and Technology · doi:10.5187/jast.2021.e44 · Cited by 56 · see citing works
Recent advances in understanding of multifaceted changes in the vaginal microenvironment: implications in vaginal health and therapeutics
Das, S., Bhattacharjee, M. J., Mukherjee, A. K., & Khan, M. R. (2023) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2022.2049696 · Cited by 51 · see citing works
Whole-Genome Sequencing of Lactobacillus helveticus D75 and D76 Confirms Safety and Probiotic Potential
Toropov, V., Demyanova, E. V., Шалаева, О. Н., Sitkin, S. I., & Vakhitov, T. (2020) · Microorganisms · doi:10.3390/microorganisms8030329 · Cited by 50 · see citing works
The role of probiotic exopolysaccharides in adhesion to mucin in different gastrointestinal conditions
Lu, Y., Han, S., Zhang, S., Wang, K., Lv, L., McClements, D. J., Xiao, H., Berglund, B., Yao, M., & Li, L. (2022) · Current Research in Food Science · doi:10.1016/j.crfs.2022.02.015 · Cited by 50 · see citing works
Exopolysaccharide-producing lactic acid bacteria isolated from traditional Algerian dairy products and their application for skim-milk fermentations
Bachtarzi, N., Kharroub, K., & Ruas‐Madiedo, P. (2019) · LWT · doi:10.1016/j.lwt.2019.03.005 · Cited by 44 · see citing works
Dextran from human feces-derived Weissella cibaria facilitates intestinal mucosal barrier function by modulating gut bacteria and propionate levels
Zhao, H., Abbas, S., Ren, J., Huang, H., Song, Y., Su, X., Wu, Q., Ma, Y., Tang, H., Gao, Y., et al. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.123300 · Cited by 40 · see citing works
Removal of Cr(VI) by magnetic iron oxide nanoparticles synthesized from extracellular polymeric substances of chromium resistant acid-tolerant bacterium Lysinibacillus sphaericus RTA-01
Kumar, H., Sinha, S. K., Goud, V. V., & Das, S. (2019) · Journal of Environmental Health Science and Engineering · doi:10.1007/s40201-019-00415-5 · Cited by 40 · see citing works
Exopolysaccharides from vaginal lactobacilli modulate microbial biofilms
Giordani, B., Naldi, M., Croatti, V., Parolin, C., Uzunoğlu, Ü. E., Bartolini, M., & Vitali, B. (2023) · Microbial Cell Factories · doi:10.1186/s12934-023-02053-x · Cited by 40 · see citing works
Exploring probiotic effector molecules and their mode of action in gut–immune interactions
Lee, C., Hyun, K., Kim, G.-C., Im, S., & Kwon, H. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad046 · Cited by 39 · see citing works
Bifidobacterium exopolysaccharides: new insights into engineering strategies, physicochemical functions, and immunomodulatory effects on host health
Sadeghi, M., Haghshenas, B., & Nami, Y. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1396308 · Cited by 40 · see citing works
Production, Characterization and Immunomodulatory Activity of an Extracellular Polysaccharide from Rhodotorula mucilaginosa YL-1 Isolated from Sea Salt Field
Li, H., Huang, L., Zhang, Y., & Yan, Y. (2020) · Marine Drugs · doi:10.3390/md18120595 · Cited by 39 · see citing works
Bifidobacterium breve Exopolysaccharide Blocks Dendritic Cell Maturation and Activation of CD4+ T Cells
Hickey, A., Stamou, P., Udayan, S., Ramón-Vázquez, A., Esteban-Torres, M., Bottacini, F., Woznicki, J. A., Hughes, O., Melgar, S., Ventura, M., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.653587 · Cited by 40 · see citing works
Postbiotics as potential new therapeutic agents for sepsis
Lou, X., Xue, J., Shao, R., Mo, C., Wang, F., & Chen, G. (2023) · Burns & Trauma · doi:10.1093/burnst/tkad022 · Cited by 38 · see citing works
The Immunomodulatory Properties of β-2,6 Fructans: A Comprehensive Review
Young, I. D., Latousakis, D., & Juge, N. (2021) · Nutrients · doi:10.3390/nu13041309 · Cited by 38 · see citing works
Health promoting benefits of postbiotics produced by lactic acid bacteria: Exopolysaccharide
Gezginç, Y., Erdem, T. K., Tatar, H. D., Ayman, S., Ganiyusufoğlu, E., & Dayısoylu, K. S. (2022) · Biotech Studies · doi:10.38042/biotechstudies.1159166 · Cited by 38 · see citing works
Lyophilized alginate-based microspheres containing Lactobacillus fermentum D12, an exopolysaccharides producer, contribute to the strain’s functionality in vitro
Butorac, K., Novak, J., Bellich, B., Terán, L. C., Banić, M., Pavunc, A. L., Zjalić, S., Cescutti, P., Šušković, J., & Kos, B. (2021) · Microbial Cell Factories · doi:10.1186/s12934-021-01575-6 · Cited by 37 · see citing works
Systematic Review of Probiotics and Their Potential for Developing Functional Nondairy Foods
Alemán, R. S., & Yadav, A. (2023) · Applied Microbiology · doi:10.3390/applmicrobiol4010004 · Cited by 41 · see citing works
Bifidobacterium breve UCC2003 Exopolysaccharide Modulates the Early Life Microbiota by Acting as a Potential Dietary Substrate
Puengel, D., Treveil, A., Dalby, M. J., Caim, S., Colquhoun, I. J., Booth, C., Ketskemety, J., Korcsmaros, T. D., van Sinderen, D., Lawson, M. A., et al. (2020) · Nutrients · doi:10.3390/nu12040948 · Cited by 37 · see citing works
Selection of Exopolysaccharide-Producing Lactobacillus Plantarum (Lactiplantibacillus Plantarum) Isolated from Algerian Fermented Foods for the Manufacture of Skim-Milk Fermented Products
Bachtarzi, N., Speciale, I., Kharroub, K., Castro, C. D., Ruíz, L., & Ruas‐Madiedo, P. (2020) · Microorganisms · doi:10.3390/microorganisms8081101 · Cited by 37 · see citing works
The effects of exopolysaccharides and exopolysaccharide-producing Lactobacillus on the intestinal microbiome of zebrafish (Danio rerio)
Ma, C., Guo, H., Chang, H., Huang, S. W., Jiang, S., Huo, D., Zhang, J., & Zhu, X. (2020) · BMC Microbiology · doi:10.1186/s12866-020-01990-6 · Cited by 35 · see citing works
The Exopolysaccharide of Lactobacillus fermentum UCO-979C Is Partially Involved in Its Immunomodulatory Effect and Its Ability to Improve the Resistance against Helicobacter pylori Infection
Garcia-Castillo, V., Marcial, G., Albarracín, L., Tomokiyo, M., Clua, P., Takahashi, H., Kitazawa, H., Garcia-Cancino, A., & Villena, J. (2020) · Microorganisms · doi:10.3390/microorganisms8040479 · Cited by 34 · see citing works
The Influence of the Degree of Thermal Inactivation of Probiotic Lactic Acid Bacteria and Their Postbiotics on Aggregation and Adhesion Inhibition of Selected Pathogens
Karbowiak, M., Gałek, M., Szydłowska, A., & Zielińska, D. (2022) · Pathogens · doi:10.3390/pathogens11111260 · Cited by 35 · see citing works
Probiotic Supplementation is Associated with Increased Antioxidant Capacity and Copper Chelation in C. difficile-Infected Fecal Water
Gaisawat, M. B., Iskandar, M. M., MacPherson, C. W., Tompkins, T. A., & Kubow, S. J. (2019) · Nutrients · doi:10.3390/nu11092007 · Cited by 34 · see citing works
Synergistic Effects of Heat-Killed Kefir Paraprobiotics and Flavonoid-Rich Prebiotics on Western Diet-Induced Obesity
Seo, K., Jeong, J., & Kim, H. (2020) · Nutrients · doi:10.3390/nu12082465 · Cited by 34 · see citing works
Konjac oligosaccharides attenuate DSS-induced ulcerative colitis in mice: mechanistic insights
Xia, P., Hou, T., Ma, M., Li, S., Jin, H., Luo, X., Li, J., Geng, F., & Li, B. (2022) · Food & Function · doi:10.1039/d1fo04004a · Cited by 33 · see citing works
Sheep Milk Symbiotic Ice Cream: Effect of Inulin and Apple Fiber on the Survival of Five Probiotic Bacterial Strains during Simulated In Vitro Digestion Conditions
Kowalczyk, M., Znamirowska, A., Buniowska, M., & Pawlos, M. (2022) · Nutrients · doi:10.3390/nu14214454 · Cited by 33 · see citing works
Advances in Research on the Relationship between Vaginal Microbiota and Adverse Pregnancy Outcomes and Gynecological Diseases
Zhao, F., Hu, X., & Ying, C. (2023) · Microorganisms · doi:10.3390/microorganisms11040991 · Cited by 33 · see citing works
Structural analysis and prebiotic activity of exopolysaccharide produced by probiotic strain Bifidobacterium bifidum EPS DA-LAIM
Kang, M. J., Jeong, H., Kim, S., Shin, J., Song, Y., Lee, B.-H., Park, H.-G., Lee, T.-H., Jiang, H.-H., Han, Y.-S., et al. (2023) · Food Science and Biotechnology · doi:10.1007/s10068-022-01213-w · Cited by 31 · see citing works
Effects of compound probiotics and aflatoxin-degradation enzyme on alleviating aflatoxin-induced cytotoxicity in chicken embryo primary intestinal epithelium, liver and kidney cells
Guo, H., Chang, J., Wang, P., Yin, Q., Liu, C., Xu, X., Dang, X.-W., Hu, X., & Wang, Q. (2021) · AMB Express · doi:10.1186/s13568-021-01196-7 · Cited by 30 · see citing works
Plasmid-encoded glycosyltransferase operon is responsible for exopolysaccharide production, cell aggregation, and bile resistance in a probiotic strain, Lactobacillus brevis KB290
Fukao, M., Zendo, T., Inoue, T., Nakayama, J., Suzuki, S., Fukaya, T., Yajima, N., & Sonomoto, K. (2019) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2019.04.008 · Cited by 29 · see citing works
Metabolic Response of Faecalibacterium prausnitzii to Cell-Free Supernatants from Lactic Acid Bacteria
Lebas, M., Garault, P., Carrillo, D., Codoñer, F. M., & Derrien, M. (2020) · Microorganisms · doi:10.3390/microorganisms8101528 · Cited by 29 · see citing works
Heat-killed endophytic bacterium induces robust plant defense responses against important pathogens
Portieles, R., Xu, H., Yue, Q., Zhao, L., Zhang, D., Du, L., Gao, X., Gao, J., González, N. P., Santos, R., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-91837-5 · Cited by 27 · see citing works
Effect of Heat-Killed Lactobacillus casei DKGF7 on a Rat Model of Irritable Bowel Syndrome
Seong, G., Lee, S., Min, Y. W., Jang, Y. S., Kim, H. S., Kim, E.-J., Park, S., Kim, C.-H., & Chang, D. K. (2021) · Nutrients · doi:10.3390/nu13020568 · Cited by 28 · see citing works
Outside the Cell Surface: Encoding the Role of Exopolysaccharide Producing Rhizobacteria to Boost the Drought Tolerance in Plants
Mandal, M., Chatterjee, S., & Majumdar, S. (2022) · Advances in Science, Technology & Innovation/Advances in science, technology & innovation · doi:10.1007/978-3-030-95365-2_18 · Cited by 28 · see citing works
Exopolysaccharide from Lactobacillus rhamnosus KL37 Inhibits T Cell-dependent Immune Response in Mice
Nowak, B., Śróttek, M., Ciszek‐Lenda, M., Skałkowska, A., Gamian, A., Górska, S., & Marcinkiewicz, J. (2020) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-020-00581-7 · Cited by 27 · see citing works
Phenotypic features and analysis of genes supporting probiotic action unravel underlying perspectives of Bacillus velezensis VTX9 as a potential feed additive for swine
Quach, N. T., Vu, T. H. N., Nguyen, N. A., Nguyen, V. T., Bui, T. L., Chu‐Ky, S., Le, L. T., Hoang, H., Ngo, C. C., Le, T. T. M., et al. (2021) · Annals of Microbiology · doi:10.1186/s13213-021-01646-4 · Cited by 27 · see citing works
The modulation and mechanism of probiotic-derived polysaccharide capsules on the immune response in allergic diseases
Yang, J., Kuang, H., Li, N., Hamdy, A. M., & Song, J. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2062294 · Cited by 26 · see citing works
κ-Selenocarrageenan Oligosaccharides Prepared by Deep-Sea Enzyme Alleviate Inflammatory Responses and Modulate Gut Microbiota in Ulcerative Colitis Mice
Wang, K., Qin, L., Cao, J., Zhang, L., Liu, M., Qu, C., & Miao, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054672 · Cited by 26 · see citing works
Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage Polarization
Zhang, D., Pan, Z.-Y., Yu, X., Chen, Y., Gao, C.-H., Yang, Y.-T., Jiang, X., Li, N., & Pan, J. (2019) · Journal of Immunology Research · doi:10.1155/2019/4657928 · Cited by 25 · see citing works
Genome Sequence and Assessment of Safety and Potential Probiotic Traits of Lactobacillus johnsonii CNCM I-4884
Boucard, A.-S., Florent, I., Polack, B., Langella, P., & Bermúdez‐Humarán, L. G. (2022) · Microorganisms · doi:10.3390/microorganisms10020273 · Cited by 24 · see citing works
In silico genomic analysis of the potential probiotic Lactiplantibacillus pentosus CF2-10N reveals promising beneficial effects with health promoting properties
Abriouel, H., Manetsberger, J., Gómez, N. C., & Benomar, N. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.989824 · Cited by 24 · see citing works
Macrophage cytokine responses to commensal Gram-positive Lactobacillus salivarius strains are TLR2-independent and Myd88-dependent
Udayan, S., Buttó, L. F., Rossini, V., Velmurugan, J., Martínez‐López, M., Sancho, D., Melgar, S., O’Toole, P. W., & Nally, K. (2021) · Scientific Reports · doi:10.1038/s41598-021-85347-7 · Cited by 23 · see citing works
Horizontally Acquired Polysaccharide-Synthetic Gene Cluster From Weissella cibaria Boosts the Probiotic Property of Lactiplantibacillus plantarum
Gao, Y.-Q., Niu, M., Yu, X., Bao, T., Wu, Z., & Zhao, X. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.692957 · Cited by 23 · see citing works
In vitro evaluation of probiotic properties of Lactobacillus acidophilus AD125 and antagonism against Escherichia coli O157:H7 adhesion to Caco-2 cell
Xing, T., Bian, X., Ma, C., Yang, Y., Liu, X., Wang, Y., Fan, J., & Zhang, N. (2023) · Food & Function · doi:10.1039/d2fo03200g · Cited by 23 · see citing works
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Fanning, S., Hall, L. J., Cronin, M. A., Zomer, A., MacSharry, J. A., Goulding, D., Motherway, M. O., Shanahan, F., Nally, K., Dougan, G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115621109 · Cited by 564 · see citing works
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Fanning, S., Hall, L. J., & van Sinderen, D. (2012) · Gut Microbes · doi:10.4161/gmic.20630 · Cited by 82 · see citing works

Authors: Castro-Bravo, N., Wells, J. M., Margolles, A., & Ruas-Madiedo, P.
Affiliations: Consejo Superior de Investigaciones Científicas (ES)
Wageningen University & Research (NL)
ORCID: Wells, Jerry M.
Venue: Frontiers in Microbiology
Publisher: Frontiers Media SA
Published: 2018-10-11
Volume: 9
Pages: 2426-2426
ISSN: 1664-302X (ISSN-L)
DOI: 10.3389/fmicb.2018.02426
PMC: PMC6193118
OpenAlex: W2897944860
Cited by: 284
References: 134
Citations by year: 2026: 37 · 2025: 49 · 2024: 26 · 2023: 38 · 2022: 37 · 2021: 37 · 2020: 40 · 2019: 19
FWCI: 2.52
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Frontiers in Microbiology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion, cc-by)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by-nc-sa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
Funders: Ministerio de Economía, Industria y Competitividad, Gobierno de España (AGL2015-64901-R)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: exopolysaccharides, Bifidobacterium, Lactobacillus, probiotics, intestinal mucosa, gut microbiota, biofilm formation, exopolysaccharide biosynthesis, host-microbe interactions, immunomodulation, lactic acid bacteria, gut commensals

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Interactions of Surface Exopolysaccharides from Bifidobacterium and Lactobacillus within the Intestinal Environment

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