Altered faecal and mucosal microbial composition in post‐infectious irritable bowel syndrome patients correlates with mucosal lymphocyte phenotypes and psychological distress
Open accessAbstract
BACKGROUND: A subset of irritable bowel syndrome (IBS) patients, denoted post-infectious IBS (PI-IBS), develop symptoms after an enteric infection. Bacterial dysbiosis and mucosal inflammation have been proposed to be involved in the pathophysiology of this entity. AIM: To characterise the mucosal and faecal microbiota in PI-IBS, general IBS and healthy controls, and to investigate associations between the microbiota and the mucosal immune system. METHODS: Mucosal biopsies and faeces were collected from 13 PI-IBS patients, 19 general IBS patients and 16 healthy controls. Global bacterial composition was determined by generating 16S rRNA amplicons that were examined by phylogenetic microarray hybridisation, principal component and redundancy analysis. We correlated previously reported lymphocyte proportions with the microbiota. RESULTS: Faecal microbiota composition of PI-IBS patients differed significantly from both general IBS patients and healthy controls (P < 0.02). Both mucosal (P < 0.01) and faecal (P = 0.05) microbial diversity were reduced in PI-IBS compared to healthy controls. In the intraepithelial lymphocytes the previously published proportion of CD8(+) CD45RA(+) was negatively correlated with mucosal microbial diversity (P < 0.005). The previously published number of lamina propria lymphocytes was negatively correlated with mucosal microbial diversity (P < 0.05). Faecal microbial diversity was significantly negatively correlated with the Hospital Anxiety and Depression scale (P < 0.05). CONCLUSIONS: We present data that distinguishes the intestinal microbiota of PI-IBS patients from that of both general IBS patients and HC. The microbial composition is significantly associated with the HADs score and alterations in lymphocyte subsets proportions.
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Small intestinal bacterial overgrowth has also been implicated, but its role is controversial due, in large part, to limitations of available diagnostic tests, such as glucose and lactulose breath tests and culture of jejunal aspirates.
“Small intestinal bacterial overgrowth (SIBO), has also been implicated, 44 but its role is controversial due, in large part, to limitations of available diagnostic tests, such as glucose and lactulose breath tests 45 and culture of jejunal aspirates. 46”
From Irritable bowel syndrome (2020) · cites this paper as [44]
Citation 44 is attached to the assertion that SIBO has been implicated in IBS. The Introduction and Discussion discuss altered faecal and colonic mucosal microbiota in IBS, but do not address small-intestinal bacterial overgrowth. Searches for SIBO and bacterial overgrowth found no passage supporting that specific assertion; the diagnostic-test claims have separate citations. (LLM, conf=0.76)
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- Authors
- Sundin, J., Rangel, I., Fuentes, S., Heikamp‐de Jong, I., Hultgren‐Hörnquist, E., de Vos, W. M., & Brummer, R. J.
- Affiliations
- Örebro University (SE)
- Wageningen University & Research (NL)
- Department of Microbiology Wageningen University Wageningen The Netherlands
- School of Health and Medical Sciences Örebro University Örebro Sweden
- Corresponding author
- Sundin, J.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2014-12-18
- Volume
- 41
- Issue
- 4
- Pages
- 342-351
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2014561129
- Cited by
- 164
- References
- 33
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 9 · 2023: 10 · 2022: 27 · 2021: 19 · 2020: 12 · 2019: 13 · 2018: 21 · 2017: 18 · 2016: 18 · 2015: 9
- FWCI
- 15.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Gravity grant (SIAM)
- Medical Faculty, Örebro University
- Spinoza award
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- post-infectious irritable bowel syndrome, irritable bowel syndrome, gut microbiota, fecal microbiota, intestinal mucosa, microbial diversity, bacterial dysbiosis, intraepithelial lymphocytes, lamina propria lymphocytes, mucosal immune system, psychological distress, anxiety, depression, gastrointestinal infections
- MeSH terms
- Adult, Feces, Female, Gastritis, Humans, Intestinal Mucosa, Intestines, Male, Middle Aged, Phenotype, RNA, Ribosomal, 16S, Body Mass Index, Lymphocyte Subsets, Irritable Bowel Syndrome, Microbiota
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