Cited by 338DNA Repair MechanismsEffects of Radiation ExposureGenomics and Chromatin Dynamics

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Assembly and function of DNA double-strand break repair foci in mammalian cells

Bekker-Jensen, Simon, Mailand, Niels·2010·DNA Repair

DOI 10.1016/j.dnarep.2010.09.010

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Abstract

DNA double-strand breaks (DSBs) are among the most cytotoxic types of DNA damage, which if left unrepaired can lead to mutations or gross chromosomal aberrations, and promote the onset of diseases associated with genomic instability such as cancer. One of the most discernible hallmarks of the cellular response to DSBs is the accumulation and local concentration of a plethora of DNA damage signaling and repair proteins in the vicinity of the lesion, initiated by ATM-mediated phosphorylation of H2AX (γ-H2AX) and culminating in the generation of distinct nuclear compartments, so-called Ionizing Radiation-Induced Foci (IRIF). The assembly of proteins at the DSB-flanking chromatin occurs in a highly ordered and strictly hierarchical fashion. To a large extent, this is achieved by regulation of protein-protein interactions triggered by a variety of post-translational modifications including phosphorylation, ubiquitylation, SUMOylation, and acetylation. Over the last decade, insight into the identity of proteins residing in IRIF and the molecular underpinnings of their retention at these structures has been vastly expanded. Despite such advances, however, our understanding of the biological relevance of such DNA repair foci still remains limited. In this review, we focus on recent discoveries on the mechanisms that govern the formation of IRIF, and discuss the implications of such findings in light of our understanding of the physiological importance of these structures.

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Authors: Bekker-Jensen, S., & Mailand, N.
Affiliations: University of Copenhagen (DK)
Corresponding author: Mailand, Niels
ORCID: Mailand, Niels
Venue: DNA Repair
Publisher: Elsevier BV
Published: 2010-12
Volume: 9
Issue: 12
Pages: 1219-1228
ISSN: 1568-7856 (ISSN-L)
1568-7864
DOI: 10.1016/j.dnarep.2010.09.010
OpenAlex: W1999541392
Cited by: 338
References: 112
Citations by year: 2026: 5 · 2025: 9 · 2024: 6 · 2023: 8 · 2022: 11 · 2021: 17 · 2020: 16 · 2019: 14 · 2018: 16 · 2017: 24 · 2016: 21 · 2015: 33 · 2014: 45 · 2013: 36 · 2012: 45
FWCI: 3.17
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: DNA repair (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: Lundbeckfonden
Novo Nordisk Fonden
Kræftens Bekæmpelse
Sundhed og Sygdom, Det Frie Forskningsråd
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: DNA double-strand break repair, ionizing radiation-induced foci, DNA damage signaling, γH2AX, protein-protein interaction, post-translational modification, ubiquitination, SUMOylation, acetylation, chromatin assembly, genomic instability, mammalian cells
MeSH terms: Tumor Suppressor p53-Binding Protein 1, Animals, Cell Nucleus, Chromatin, DNA Repair, DNA-Binding Proteins, Histones, Humans, Nuclear Proteins, Phosphorylation, Protein Processing, Post-Translational, Trans-Activators, Cell Cycle Proteins, BRCA1 Protein, Guanine Nucleotide Exchange Factors, Genomic Instability, Ubiquitin-Protein Ligases, Multiprotein Complexes, Intracellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing, DNA Breaks, Double-Stranded, Ubiquitination

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Assembly and function of DNA double-strand break repair foci in mammalian cells

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