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Social reward-conditioned place preference: A model revealing an interaction between cocaine and social context rewards in rats
Open accessAbstract
A recent thrust in drug abuse research is the influence of social interactions on drug effects. Therefore, the present study examined conditioned place preference (CPP) as a model for assessing interactions between drug and social rewards in adolescent rats. Parameters for establishing social reward-CPP were examined, including the number of conditioning sessions/day (1 or 2), the total number of sessions (2, 8, or 16), and the duration of sessions (10 or 30 min). Subsequently, the effects of cocaine or dextromethorphan on social reward-CPP and play behavior were examined. The results demonstrate that social reward-CPP (i.e., preference shift for an environment paired previously with a rat) was similar using either 1 or 2 conditioning sessions/day and either 10 or 30 min sessions; however, social reward-CPP increased as the number of social pairings increased. Additionally, a low dose of cocaine (2 mg/kg, IP) and a low number of social pairings (2 pairings) failed to produce CPP when examined alone, but together produced a robust CPP, demonstrating an interaction between these rewards. The non-rewarding drug, dextromethorphan (30 mg/kg, IP), failed to enhance social reward-CPP, suggesting that drug-enhanced social reward-CPP is specific to rewarding drugs. Surprisingly, there was no relationship between play behaviors and preference shift in drug-naïve animals. Furthermore, cocaine inhibited play behavior despite enhancing social reward-CPP, suggesting that aspects of social interaction other than play behavior likely contribute to social reward. The findings have important implications for understanding the influence of social context on cocaine reward during adolescence.
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“Positive social stimuli act as a natural reward; rodents demonstrate conditioned preferences for places previously paired with a social partner (Douglas et al. 2004; Thiele et al. 2008), and in humans, positive social signs such as smiling faces activate reward circuitry (Tsukiura and Cabeza 2008).”
From Effects of MDMA on sociability and neural response to social threat and social reward (2009) · cites this paper as Thiele et al. 2008
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“socio-emotional stimuli influencing salience of rewarding stimuli”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Thiel et al, 2008
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Metadata
- Authors
- Thiel, K. J., Okun, A. C., & Neisewander, J. L.
- Affiliations
- Arizona State University (US)
- Corresponding author
- Neisewander, Janet L.
- Venue
- Drug and Alcohol Dependence
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 96
- Issue
- 3
- Pages
- 202-212
- ISSN
- 0376-8716 (ISSN-L)
- PMC
- PMC2488154
- OpenAlex
- W2004813278
- Cited by
- 164
- References
- 72
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 12 · 2022: 8 · 2021: 7 · 2020: 11 · 2019: 4 · 2018: 12 · 2017: 5 · 2016: 16 · 2015: 14 · 2014: 10 · 2013: 17 · 2012: 12
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Drug and Alcohol Dependence (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (DA011064, F31DA023746, F31DA02746, R21DA023123, R01DA011064)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- social reward, conditioned place preference, cocaine, dextromethorphan, social environment, adolescent rats, play behavior, cocaine reward
- MeSH terms
- Animals, Behavior, Animal, Choice Behavior, Cocaine, Conditioning, Classical, Conditioning, Operant, Extinction, Psychological, Models, Biological, Motor Activity, Reward, Social Behavior, Social Environment, Spatial Behavior, Rats, Sprague-Dawley, Substance-Related Disorders, Rats
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