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Cited by 293Cannabis and Cannabinoid ResearchSubstance Abuse Treatment and OutcomesGambling Behavior and Treatments

Gender differences in cannabis use disorders: Results from the National Epidemiologic Survey of Alcohol and Related Conditions

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Khan, Sharaf S., Secades-Villa, Roberto, Okuda, Mayumi, Wang, Shuai, Pérez-Fuentes, Gabriela, Kerridge, Bradley T., Blanco, Carlos·2013·Drug and Alcohol Dependence
DOI 10.1016/j.drugalcdep.2012.10.015PMC PMC3586748
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Abstract

Background To examine gender differences among individuals diagnosed with DSM-IV lifetime cannabis use disorder (CUD).Methods A nationally representative sample of U.S. adults aged 18 years or older that were diagnosed with lifetime CUD (n=3297): Men (n=2080), Women (n=1217). Data were drawn from the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC, n=43,093). The survey response rate was 81%.Results Nearly all individuals with CUD had a psychiatric comorbidity (95.6% of men, 94.1% of women). Men with lifetime CUD were more likely than women to be diagnosed with any psychiatric disorder, any substance use disorder and antisocial personality disorder, whereas women with CUD had more mood and anxiety disorders. After adjusting for gender differences in sociodemographic correlates and the prevalence of psychiatric disorders in the general population, women with CUD were at greater risk for externalizing disorders. Men with CUD met more criteria for cannabis abuse, had longer episodes of CUD, smoked more joints, and were older at remission when compared to women with CUD. Women experienced telescoping to CUD. Treatment-seeking rates were very low for both genders, and there were no gender differences in types of services used or reasons for not seeking treatment.Conclusions There are important gender differences in the clinical characteristics and psychiatric comorbidities among individuals with CUD.

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  • Patterns of comorbidity vary between men and women: men are more likely to have multiple SUDs, while women tend to have greater rates of mood, anxiety and eating disorders in addition to a SUD.

    “Patterns of comorbidity also vary between men and women: men are more likely to have multiple SUDs, while women tend to have greater rates of mood, anxiety and eating dis orders in addition to a SUD 330,333 .”

    From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [333]

    Results §3.2 and the Discussion report that, among people with cannabis use disorder, men had higher rates of other substance use disorders, while women had higher rates of comorbid mood and anxiety disorders. The claim extends this pattern to SUDs generally, and the passages do not support its added assertion about eating disorders. (LLM, conf=0.88)

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  • For many, although not all, substances, women progress more rapidly from use to SUD.

    “This is particularly concerning because, for many (although not all) substances, women progress more rapidly from use to SUD 332,333 .”

    From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [333]

    The Discussion (page unavailable) reports that women progressed faster from first cannabis use to cannabis use disorder. It also reports accelerated progression to alcohol dependence in some treatment samples, but notes that this may not occur in general-population samples. The paper does not establish the claim across “many” substances. (LLM, conf=0.84)

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Research works printed but not linked: 2

  1. Australian Institute of Health and Welfare Alcohol and other drug treatment services in Australia: findings from the National Minimum Data Set 2001-02. 16 Bulletin No 10 AIHW cat no AUS 40 2003 Australian Institute of Health and Welfare, Canberra 1 2
  2. Substance Abuse and Mental Health Services Administration Treatment Episode Data Set (TEDS) 1996–2006. National Admissions to Substance Abuse Treatment Services Office of Applied Studies (Ed.), DASIS Series: S- 43 DHHS Publication No (SMA) 08-4347 2008 Rockville, MD SAMHSA

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Authors
Khan, S. S., Secades-Villa, R., Okuda, M., Wang, S., Pérez-Fuentes, G., Kerridge, B. T., & Blanco, C.
Affiliations
  • New York State Psychiatric Institute (US)
  • University of Maryland, College Park (US)
ORCID
Venue
Drug and Alcohol Dependence
Publisher
Elsevier BV
Published
2013-06
Volume
130
Issue
1-3
Pages
101-108
ISSN
0376-8716 (ISSN-L)
DOI
10.1016/j.drugalcdep.2012.10.015
PMC
PMC3586748
OpenAlex
W2030628632
Cited by
293
References
87
Citations by year
2026: 24 · 2025: 26 · 2024: 22 · 2023: 32 · 2022: 25 · 2021: 33 · 2020: 29 · 2019: 16 · 2018: 17 · 2017: 24 · 2016: 19 · 2015: 14 · 2014: 8 · 2013: 3
FWCI
5.87
Type
journal article
Language
en
Open access
Licence
Locations
  • Drug and Alcohol Dependence (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • National Institutes of Health (CA133050, DA019606, DA020783-S4, DA023200, DA023973)
  • National Institute on Drug Abuse
  • National Institute on Alcohol Abuse and Alcoholism
  • New York State Psychiatric Institute
  • Ministerio de Educación, Cultura y Deporte (PR2010-0501)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
Keywords
cannabis use disorder, gender differences, psychiatric comorbidity, substance use disorders, antisocial personality disorder, mood disorders, anxiety disorders, treatment seeking, telescoping, externalizing disorders, NESARC
MeSH terms
Adolescent, Alcoholism, Mental Disorders, Marijuana Abuse, Female, Health Surveys, Humans, Male, Sex Characteristics, United States, Young Adult

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