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Cited by 82Substance Abuse Treatment and OutcomesGambling Behavior and TreatmentsOpioid Use Disorder Treatment

Shared and specific associations of substance use disorders on adverse outcomes: A national prospective study

Franco, Silvia, Olfson, Mark, Wall, Melanie M., Wang, Shuai, Hoertel, Nicolas, Blanco, Carlos·2019·Drug and Alcohol Dependence
DOI 10.1016/j.drugalcdep.2019.03.003
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Abstract

Background and aims Substance use disorders (SUD) frequently co-occur and are associated with numerous adverse outcomes and lower quality of life. The goal of this study was to examine whether the associations of SUD with adverse outcomes occur through a shared liability or are disorder-specific even after taking into account their frequent co-occurrence.Basic procedures Data were drawn from the National Epidemiological Survey on Alcohol and Related Conditions. The association between nine SUDs assessed at Wave 1 (2001-2002) and a broad range of outcomes (divorce/separation, violence, unemployment, financial crisis, legal problems, problems with a neighbor, friend, or relative, and quality of life) at Wave 2 (2005-2005) were estimated separately and simultaneously using a latent variable model to account for their co-occurrence and identify potential disorder-specific effects.Main findings SUD at Wave 1 were associated with increased prevalence of all adverse outcomes at Wave 2 (p < .05). With the exception of nicotine dependence and tranquilizer use disorder, we found no specific associations of any SUD with any adverse outcome. Rather, associations occurred primarily through the latent variable representing the shared effects of the different SUDs.Conclusions and relevance Our findings underscore the importance of adopting dimensional approaches to model the co-occurrence of SUD. Because SUD increases the risk of adverse outcomes mainly through a general predisposition representing mechanisms shared across SUD rather than through drug-specific mechanisms, this dimension should be considered as a therapeutic target to substantially advance prevention of adverse outcomes caused by SUD.

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Authors
Franco, S., Olfson, M., Wall, M. M., Wang, S., Hoertel, N., & Blanco, C.
Affiliations
  • New York State Psychiatric Institute (US)
  • Inserm (FR)
  • National Institute on Drug Abuse (US)
ORCID
Venue
Drug and Alcohol Dependence
Publisher
Elsevier BV
Published
2019-08
Volume
201
Pages
212-219
ISSN
0376-8716 (ISSN-L)
DOI
10.1016/j.drugalcdep.2019.03.003
OpenAlex
W2940496841
Cited by
82
References
69
Citations by year
2026: 4 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 49 · 2019: 3
FWCI
11.61
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Drug and Alcohol Dependence (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • NIH (DA019606, MH076051, MH082773)
  • New York State Psychiatric Institute
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Keywords
substance use disorders, adverse outcomes, shared liability, latent variable models, divorce and separation, violence, unemployment, financial crisis, legal issues, quality of life, nicotine dependence, dimensional approach, prevention
MeSH terms
Exposure to Violence, Adolescent, Adult, Female, Humans, Male, Personality Disorders, Prospective Studies, Quality of Life, Surveys and Questionnaires, Socioeconomic Factors, United States, Comorbidity, Prevalence, Marital Status, Substance-Related Disorders

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