The DOI matches its Crossref record; 69 of the 71 references it cites were found in a registry or an index; 22 of the 43 sources its claims cite were checked for support.
Adverse childhood experiences (ACEs) and substance use disorder (SUD): A scoping review
Open accessAbstract
BACKGROUND The long-term negative effects of adverse childhood experiences (ACEs) and their impact on physical and mental health has been widely studied. However, research about the relationship between ACEs and substance use disorder (SUD) diagnosis in adolescence and adulthood is still scarce. Therefore, this scoping review was conducted to collect the existing research findings to explore the relationship between the experience of ACEs and the diagnosis of SUD later in life. METHODS The PsycINFO, Medline, Scopus, Web of Science, and Cochrane Library databases were searched. After identifying the records based on eligibility and exclusion criteria, 12 studies were finally selected for inclusion. RESULTS Most of the studies were conducted in the USA with adult male and female participants. All studies were cross-sectional in nature and assessed ACEs retrospectively. The main conclusions of the studies were that there is a higher prevalence of ACEs in the population with SUD than in the general population, and a positive association between ACEs and the development and severity of SUD in adolescence and adulthood. CONCLUSIONS It is difficult to make comparisons between studies and to draw solid conclusions because of the lack of standardized criteria for evaluating ACEs and due to the heterogeneity in the substance types examined. More research is needed to fully elucidate the underlying mechanism of the relationship between ACEs and SUD.
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Claims the paper makes
12 Own method · 8 Own result · 7 Partly supported · 7 No basis given · 6 Supported · 5 Sources not found · 4 Supported so far · 4 No full text of the sources · 3 Own interpretation · accuracy not yet measured
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“In this sense, some of the studies have linked specific types of ACEs with an increased risk of SUD (Fuller-Thomson et al., 2016;Gomez et al., 2018;Kiburi et al., 2018;Levenson, 2016).”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 4. Discussion
What the sources say
- Not checked — no full text of the sourcecites Fuller-Thomson et al., 2016 source
- Not checked — no full text of the sourcecites Gomez et al., 2018 source
- Partly supportedcites Kiburi et al., 2018 sourceExperimental — accuracy not yet measured
The Discussion links specific ACEs to greater substance use: emotional abuse to tobacco use and physical abuse to current cannabis use. But this study examined associations among patients who already had substance use disorders, so its findings do not establish an increased risk of developing a disorder. (LLM, conf=0.84)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“In fact, people in treatment for an addiction have a higher prevalence of ACEs than the general population.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 1. Introduction
What the sources say
- Not checked — no full text of the sourcecites Chandler et al., 2018 source
- Partly supportedcites Philogene-Khalid et al., 2020 sourceExperimental — accuracy not yet measured
The Discussion says people with substance use disorders experience ACEs at a disproportionate frequency, and the Results report that 91% of this study’s participants had at least one ACE. But the Methods describe participants recruited during medical hospitalization, not people in addiction treatment, and the paper does not directly compare their ACE prevalence with that of the general population. No page numbers were available in our copy. (LLM, conf=0.87)
- Partly supportedcites Stein et al., 2017 sourceExperimental — accuracy not yet measured
The Discussion reports that people with opioid use disorder entering a detoxification program had substantially higher ACE scores than those in general-population studies; nearly half had four or more ACEs, versus 15.5% in one community-based study. This supports the comparison for the study sample, but not the broader claim about people in treatment for any addiction. (LLM, conf=0.87)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“The relationship between ACEs and subsequent SUD development might be partially mediated by a coping mechanism or a self-mediation strategy throughout which victims deal with their feelings associated with childhood maltreatment (Huang et al., 2011).”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 4. Discussion
What the sources say
- Partly supportedcites Huang et al., 2011 sourceExperimental — accuracy not yet measured
The Discussion proposes that substance use may be a coping or self-medication strategy for feelings associated with childhood maltreatment. But the Limitations section says the study did not investigate drug abuse or dependence in young adulthood, so it does not establish this mechanism for subsequent SUD development. (LLM, conf=0.88)
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Partly supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Recent research has suggested that protective factors moderate the effects of ACEs buffering their negative outcomes (Crouch et al., 2019;Liu et al., 2020;Moore & Ramirez, 2016).”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 4. Discussion
What the sources say
- Supportedcites Crouch et al., 2019 source
The Discussion states that the study provides evidence that protective factors moderate the relationship between ACEs and negative health outcomes. It also describes an adult who made a child feel safe and protected as a particularly important protective factor; the paper frames this as a suggested, rather than definitive, effect. (LLM, conf=0.94)
- Not checked — no full text of the sourcecites Liu et al., 2020 source
- Not checked — no full text of the sourcecites Moore & Ramirez, 2016 source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Thus, having a history of ACEs might increase the risk of developing SUD (Buckingham & Daniolos, 2013;Dube et al., 2002;Khoury et al., 2010;Wendland et al., 2017).”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 1. Introduction
What the sources say
- Not checked — no full text of the sourcecites Buckingham & Daniolos, 2013 source
- Not checked — no full text of the sourcecites Dube et al., 2002 source
- Supportedcites Khoury et al., 2010 source
The Introduction (Comorbidity of PTSD and Substance Use Disorder; page not provided) explicitly says early traumatic experience may increase the risk of SUDs. The Discussion also reports an association between childhood abuse and substance use, consistent with the claim's cautious wording. (LLM, conf=0.94)
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Moreover, various studies have found that this risk has a cumulative effect; as the number of ACEs increases, the risk for SUD during life also increases (Dube et al., 2003;LeTendre & Reed, 2017).”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 1. Introduction
What the sources say
- Partly supportedcites Dube et al., 2003 sourceExperimental — accuracy not yet measured
The ACE Score and Serious Drug Use Problems (p. 8) reports a dose-response relationship between ACE count and ever having drug problems or being addicted to drugs. This supports the cumulative, lifetime aspect of the claim, but the paper examines illicit-drug outcomes rather than substance use disorder broadly or a formal SUD diagnosis. (LLM, conf=0.84)
- Supportedcites LeTendre & Reed, 2017 source
The Discussion reports that, after adjustment for covariates, each one-unit increase in the adverse childhood experience scale was associated with at least 34% higher odds of an adult substance use disorder. The Results sections describe this association for lifetime diagnoses of alcohol, cannabis, and other drug use disorders. (LLM, conf=0.94)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Partly supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Two studies reported a positive relation between the presence of SUD with an earlier onset of substance use (Gomez et al., 2018;Stein et al., 2017).”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 4. Discussion
What the sources say
- Not checked — no full text of the sourcecites Gomez et al., 2018 source
- Partly supportedcites Stein et al., 2017 sourceExperimental — accuracy not yet measured
The Introduction (page unavailable) states that people who initiate drug use earlier are more likely to develop drug dependence problems, supporting the general association. But the Methods and Results (page unavailable) show that Stein et al. studied the association between adverse childhood experiences and age of opioid initiation among people with opioid use disorder; they did not compare onset ages by the presence or absence of SUD. (LLM, conf=0.85)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Four of the included studies have evidenced the cumulative effect of ACEs on the diagnosis of SUD (Gomez et al., 2018;LeTendre & Reed, 2017;Levenson, 2016;Shin et al., 2018), which was already demonstrated in previous research (Dube et al., 2003).”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 4. Discussion
What the sources say
- Not checked — no full text of the sourcecites Gomez et al., 2018 source
- Supportedcites LeTendre & Reed, 2017 source
The Discussion reports that the risk of a clinically diagnosed substance use disorder increased with the number of adverse childhood experiences. This supports citing LeTendre and Reed as one of the studies finding a cumulative association; it does not establish what the other three cited studies found. (LLM, conf=0.93)
- Not checked — no full text of the sourcecites Levenson, 2016 source
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Among patients with addiction problems, the rates of having suffered at least one ACE ranges from 85.4% to 100% (Chandler et al., 2018;Philogene-Khalid et al., 2020;Stein et al., 2017).”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 1. Introduction
What the sources say
- Not checked — no full text of the sourcecites Chandler et al., 2018 source
- Supportedcites Philogene-Khalid et al., 2020 source
The Results (Adverse Childhood Experiences) report that 91% of participants had at least one ACE. These were medical inpatients with substance use disorders, and 91% falls within the cited range of 85.4% to 100%. (LLM, conf=0.91)
- Supportedcites Stein et al., 2017 source
Section 3.2 (ACE Distribution) reports that 36.8% of participants had 1–3 ACEs and 48.6% had four or more, totaling the cited 85.4%. Stein et al. thus supports the lower end of the range; the sentence also cites other studies for the range as a whole. (LLM, conf=0.90)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Every source the paper cites for this claim was checked and supports it.
In the paper
“Different patterns of exposure to ACEs may be associated with specific substance use outcomes.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > Additional information
What the sources say
- Supportedcites Shin et al., 2018 source
The Conclusion states the claim directly: different patterns of ACE exposure may be associated with specific substance-use outcomes. The Discussion also reports different substance-use risks across ACE exposure classes. (LLM, conf=0.95)
hedgedcorrelationaln = 336- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
- Probably not a substantial claim. 15
- It may state two separate claims as one. 18
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Moreover, to adjust the methodology to the guidelines for conducting and publishing scoping reviews, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) was used, and a 22-item checklist to follow the recommendations in each phase of the process was considered (Tricco et al., 2018).”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 2. Method
What the sources say
- Partly supportedcites Tricco et al., 2018 sourceExperimental — accuracy not yet measured
Section 3.7 identifies PRISMA-ScR as a checklist with 20 items plus two optional items, supporting the cited checklist's identification and count. The Introduction distinguishes guidance for conducting scoping reviews from PRISMA-ScR's purpose as a reporting guideline; it does not present the checklist as recommendations for conducting each phase of a review. The source also cannot verify the citing authors' statement that they used it. (LLM, conf=0.86)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
- Partly supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“These findings are consistent with research that has supported the relationship between ACEs and further negative health consequences in the general population (Buckingham & Daniolos, 2013;Cicchetti & Handley, 2019;Felitti et al., 1998;Hughes et al., 2017).”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 4. Discussion
What the sources say
- Not checked — no full text of the sourcecites Buckingham & Daniolos, 2013 source
- Partly supportedcites Cicchetti & Handley, 2019 sourceExperimental — accuracy not yet measured
Section 7 (Allostatic load; page unavailable) links childhood maltreatment to later emotional and physical difficulties, including depression, substance use, inflammation, and cardiovascular disease. The paper supports the relationship for child maltreatment, but the cited passages do not establish it for ACEs broadly in the general population. (LLM, conf=0.84)
- Supportedcites Felitti et al., 1998 source
The Discussion reports a graded relationship between adverse childhood experiences and adult disease conditions, poor self-rated health, and health risk factors. The study was conducted in a primary-care setting, and the claim describes a relationship rather than asserting causation. (LLM, conf=0.90)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
Every source the paper cites for this claim was checked and supports it.
In the paper
“In this study, the scoping review methodology proposed by Arksey and O'Malley (2005) and Levac et al. (2010) was used.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 2. Method
What the sources say
- Supportedcites Arksey and O'Malley (2005) source
The Abstract says Arksey and O’Malley outline a framework for conducting a scoping study. The Methodological framework section sets out its five stages, supporting the citation’s identification of their proposed methodology. This source cannot establish whether the citing study used it, but that is the citing authors’ own statement. (LLM, conf=0.94)
- Supportedcites Levac et al. (2010) source
The Abstract (Discussion) says Levac et al. propose recommendations that clarify and enhance each stage of Arksey and O’Malley’s scoping-study framework. The citation therefore identifies a source of the methodology the citing study says it used; our copy cannot verify the citing study’s actual use of it. (LLM, conf=0.94)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“The High/Multiple ACEs group was significantly associated with increased alcohol-related problems and with tobacco use in young adulthood compared to the Low ACE group.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > Additional information
What the sources say
- Supportedcites Shin et al., 2018 source
The Results report that, compared with the Low ACEs class, the High/Multiple ACEs class had significantly more alcohol-related problems (β = .27, p < .001) and a significantly higher likelihood of current tobacco use in young adulthood (OR = 3.27, p < .05). (LLM, conf=0.95)
plaincorrelationaln = 336- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“Having experienced ACEs was associated with a higher likelihood of a past-year AUD and TUD diagnosis.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > Additional information
What the sources say
- Supportedcites Rhee et al., 2019 source
The Results section reports that, among older adults, experiencing ACEs was associated with higher likelihood of both a past-year alcohol use disorder diagnosis (aOR 1.76) and a past-year tobacco use disorder diagnosis (aOR 1.45). (LLM, conf=0.95)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“One study (8.3%) was carried out with an adolescent population, and the rest were conducted with adult participants (91.7%; n = 11).”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 3.2. Characteristics of the Included Studies
plainn = 11- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The main conclusions of the studies were that there is a higher prevalence of ACEs in the population with SUD than in the general population, and a positive association between ACEs and the development and severity of SUD in adolescence and adulthood.”
- Also stated in: § 3.5. Association Between ACEs and SUD · plain
“The 12 studies revealed either a positive association between the presence of ACEs and an SUD diagnosis or a higher prevalence of ACEs among people in treatment for SUD than in the general population.”
- Also stated in: § 4. Discussion · plain
“All the studies reported either a positive association between ACEs and a later diagnosis of SUD or a higher prevalence of ACEs among people in treatment for SUD than in the general population.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > Abstract
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Also stated in: § 3.5. Association Between ACEs and SUD · plain
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“The number (between three and 13) and the types of ACEs that have been evaluated in the studies are extremely diverse, which leads to the impossibility of comparing results and obtaining homogeneous conclusions.”
- Also stated in: § Abstract · plain
“It is difficult to make comparisons between studies and to draw solid conclusions because of the lack of standardized criteria for evaluating ACEs and due to the heterogeneity in the substance types examined.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 4. Discussion
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Also stated in: § Abstract · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“12 studies were finally selected for inclusion.”
- Also stated in: § 3.1. Study Selection · plain
“Twelve studies were finally eligible for inclusion.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > Abstract
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Also stated in: § 3.1. Study Selection · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The sample sizes ranged from 30 to 21,554 participants, with ages ranging from 15 to 85 years.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > PLACE TABLE 2 HERE
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Additionally, Fuller-Thomson et al. (2016) concluded that SUD was more strongly associated with the more invasive forms of direct violence in childhood, such as sexual and physical abuse, than with witnessing domestic violence.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 4. Discussion
What the sources say
- Not checked — no full text of the sourcecites Fuller-Thomson et al., 2016 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The majority of the studies included both men and women (83.3%; n = 10); two studies (16.7%) included only men, and none of them included only women.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 3.2. Characteristics of the Included Studies
plainn = 10- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“All studies were crosssectional in nature and assessed ACEs retrospectively.”
- Also stated in: § 3.2. Characteristics of the Included Studies · plain
“All of the studies were cross-sectional and retrospectively assessed ACE.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > Abstract
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Also stated in: § 3.2. Characteristics of the Included Studies · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Most of the studies were carried out in the United States (66.7%; n = 8), followed by Asia (16.7%; n = 2), Canada (8.3%; n = 1), and Africa (8.3%; n = 1) (Table 2).”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 3.2. Characteristics of the Included Studies
plainn = 8- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Exposure to household dysfunction was associated with a 2-fold increased risk of SUD, but exposure to abuse was not significantly associated.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 5. Conclusion
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: unclear — It is unclear why the paper says it holds.
It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Number of ACEs was positively associated with the severity of recent drug use and negatively associated with age of drug initiation.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 5. Conclusion
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Discrepancies between reviewers were resolved by discussions between reviewers until a consensus was reached.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 2.4. Study Selection and Data Abstraction
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The search strategy and the systematic search of the literature were developed with the help of an experienced information technician along with input from the project team.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 2.3. Search Strategy and Information Sources
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The protocol of this scoping review was registered on the Open Science Framework (OSF; https://osf.io/wfycs)prior to searching for relevant studies.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 2.1. Protocol and Registration
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“All of them were published between 2016 and 2020, which means that this is an emerging research focus, and the findings are still inconclusive.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 4. Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“At level 1 of screening, two independent reviewers of the research team reviewed the titles and abstracts of all the papers obtained from the electronic database search.At level 2 of screening, the full texts of the papers were reviewed.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 2.4. Study Selection and Data Abstraction
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Interrater reliability for the 123 results obtained in level 1 of screening and the six results in level 2 of screening was calculated by Cohen's kappa.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 2.4. Study Selection and Data Abstraction
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, the lack of a unique criterion for assessing ACEs across studies indicates that the results should be interpreted cautiously.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 4. Discussion
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The interrater reliability (Cohen's kappa statistic) for level 1 of screening was 0.98, and that for level 2 of screening was 1.00.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 3.1. Study Selection
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The retrospective design of the 12 studies to self-report ACEs could have underreported these experiences and biased the results of each study and of this scoping review.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 4.1. Limitations
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Finally, none of the studies were conducted in a European country, leading to the impossibility of comparing results with this region.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > 4.1. Limitations
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Early adversities are associated with SUD risk in later adulthood, although only for some ACE classes.”
§ Adverse Childhood Experiences (ACEs) and Substance Use Disorder (SUD): A Scoping Review > Additional information
What the sources say
- Not matchedcites Kim et al., 2019
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Not matched
The authors state this as an assumption.
Recruiting a sample from an addiction treatment programme assumes the presence of an SUD diagnosis.
“and/or to carry out the study recruiting a sample from an addiction treatment programme (which assumes the presence of a diagnosis).”
The paper relies on this without support.
The prevalence of ACEs among people in treatment for SUD is high.
“Due to the high prevalence of ACEs among people in treatment for SUD, it is crucial to continue evaluating the mediating mechanisms between specific types of ACEs and SUD diagnoses and the course of these patients in SUD treatment.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“In line with international data, another research [9] also supported the observation that ACEs are more prevalent among individuals with substance use disorders (SUD) than in the general population.”
From The link of adverse childhood experiences and attachment to maladaptive personality traits in adults diagnosed with substance use disorder (2025) · cites this paper as [9]
The cited source says what the claim attributes to it.
In the citing paper
“These frequencies are consistent with previous studies documenting elevated rates of childhood adversity among individuals with SUD [3, 5, 9].”
From The link of adverse childhood experiences and attachment to maladaptive personality traits in adults diagnosed with substance use disorder (2025) · cites this paper as [9]
Citations
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PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation
Tricco, A. C., Lillie, E., Zarin, W., O'Brien, K. K., Colquhoun, H., Levac, D., Moher, D., Peters, M. D. J., Horsley, T., Weeks, L., et al. (2018) · Annals of Internal Medicine · doi:10.7326/m18-0850 · Cited by 43,565
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“Those who used different types of ACEs than the original study (Felitti et al., 1998) added experiences such as bullying, community violence, collective violence/war, economic adversity, property victimization, or exposure to gang violence [7-10].”
BackgroundResultScoping studies: advancing the methodology
Levac, D., Colquhoun, H., & O'Brien, K. K. (2010) · Implementation Science · doi:10.1186/1748-5908-5-69 · Cited by 15,268
Measuring Intrafamily Conflict and Violence: The Conflict Tactics (CT) Scales
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“ACEs are important to examine not only due to their high prevalence but also because these experiences have an impact on the development and health of those who have experienced them (Ford et al., 2014; Hughes et al., 2017).”
BackgroundResult
Cited by
Sorted by citations
Adverse Childhood Experiences and Adult Mental Health Outcomes
Daníelsdóttir, H. B., Aspelund, T., Shen, Q., Halldorsdottir, T., Jakobsdóttir, J., Song, H., Lu, D., Kuja-Halkola, R., Larsson, H., Fall, K., et al. (2024) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2024.0039 · Cited by 266
Tzouvara, V., Kupdere, P., Wilson, K., Matthews, L., Simpson, A., & Foye, U. (2023) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2023.106092 · Cited by 205
Lin, C., Cousins, S. J., Zhu, Y., Clingan, S. E., Mooney, L. J., Kan, E., Wu, F., & Hser, Y. (2024) · Journal of Substance Use and Addiction Treatment · doi:10.1016/j.josat.2024.209484 · Cited by 91
“Additionally, a scoping review by Leza and colleagues revealed that adverse childhood experiences, such as violence, abuse, neglect, separation, and substance use/mental illness of family members, were positively associated with SUD in adolescents and adulthood (Leza et al., 2021).”
BackgroundIntimate partner violence, substance use, and health comorbidities among women: A narrative review
Mehr, J. B., Bennett, E. R., Price, J. L., de Souza, N. L., Buckman, J. F., Wilde, E. A., Tate, D. F., Marshall, A. D., Dams-O’Connor, K., & Esopenko, C. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.1028375 · Cited by 81
“Finally, it is noteworthy that adverse childhood experiences (ACEs) including childhood physical and sexual abuse, adversity, and a family history of (or witness to) IPV are associated with increased risk for IPV exposure in adulthood as well as increased risk for substance use (LeTendre and Reed, 2017; CDC, 2018; Cur…”
BackgroundAssociations between adverse childhood experiences and substance use: A meta-analysis
Zhu, J., Racine, N. M., Devereux, C., Hodgins, D. C., & Madigan, S. L. (2023) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2023.106431 · Cited by 63
Grummitt, L., Barrett, E., Kelly, E., & Newton, N. (2022) · Substance Abuse and Rehabilitation · doi:10.2147/sar.s341818 · Cited by 45
“They show graded associations with alcohol and other drug outcomes, including early onset, heavy use, and disorder.(29,30)”
BackgroundInfluentialFernandes, G., Spiers, A. D. V., Vaidya, N., Zhang, Y., Sharma, E., Holla, B., Heron, J., Hickman, M., Murthy, P., Chakrabarti, A., et al. (2021) · BMC Public Health · doi:10.1186/s12889-021-11892-5 · Cited by 55
Broekhof, R., Nordahl, H. M., Tanum, L., & Selvik, S. G. (2023) · Addictive Behaviors Reports · doi:10.1016/j.abrep.2023.100488 · Cited by 57
Ertanir, B., Cobb, C. L., Unger, J. B., Celada-Dalton, T., West, A. E., Zeledon, I., Perazzo, P. A., Cano, M. Á., Rosiers, S. E. D., Duque, M., et al. (2023) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-022-01016-x · Cited by 38
“The cumulative logic underlying ACEs – where greater severity and chronicity of ACEs pre - dict worse mental and physical health outcomes (Leza et al., 2021; Wiss et al., 2020 ) – would be applied to crisis-migration-related ACEs as well, such that greater numbers of crisis-migration-related ACEs –…”
BackgroundZhen‐Duan, J., Colombo, D., & Álvarez, K. (2023) · American Journal of Public Health · doi:10.2105/ajph.2023.307220 · Cited by 37
Adverse Childhood Experiences and Subjective Cognitive Decline in the US
Brown, M. J., Kaur, A., James, T. A., Avalos, C., Addo, P. N. O., Crouch, E. L., & Hill, N. L. (2021) · Journal of Applied Gerontology · doi:10.1177/07334648211058718 · Cited by 34
“…2013); HIV/STIs (Brown et al., 2017); depression (Brown et al., 2017; Brown, Perera, et al., 2015; Dagnino et al., 2020), substance abuse (Brown et al., 2017; Brown, Perera, et al., 2015; Leza et al., 2021), and posttraumatic stress disorder (PTSD) (Brown et al., 2017; Brown, Perera, et al., 2015).”
Sasaki, N., Watanabe, K., Kanamori, Y., Tabuchi, T., Fujiwara, T., & Nishi, D. (2024) · Scientific Reports · doi:10.1038/s41598-024-62634-7 · Cited by 30
Substance use disorder and lifetime suicidal behaviour: A scoping review
Leza, L., Haro, B., López-Goñi, J. J., & Fernández‐Montalvo, J. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115830 · Cited by 31
“…treatment presents an opportunity to address not only substance use problems but also associated issues like adverse childhood experiences (Leza et al., 2021), intimate partner violence (Fern ´ andez--Montalvo, Arteaga, et al., 2019), and trauma intervention (L ´ opez-Go ˜ ni et al.,…”
BackgroundSelf-citationZhang, Z., Wang, W., Yuan, X., Wang, X., Luo, Y., Dou, L., Zhang, L., & Wu, M. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115832 · Cited by 25
Lin, H., He, G., Zheng, H., & Ai, J. (2024) · Computers in Human Behavior · doi:10.1016/j.chb.2024.108484 · Cited by 25
Hall, O. T., Teater, J. E., Rood, K. M., Phan, K. L., & Clauw, D. J. (2022) · PAIN Reports · doi:10.1097/pr9.0000000000001016 · Cited by 26
“Early life adversity increases the risk of both CS and OUD.(44,59,70,82,88,101) Polymorphisms of the mu-opioid receptor gene OPRM1may predispose individuals to CS and OUD.”
BackgroundGraupensperger, S. A., Kilmer, J. R., Olson, D. C. D., & Linkenbach, J. (2022) · Journal of Community Health · doi:10.1007/s10900-022-01155-8 · Cited by 22
“Adverse childhood experiences have consistently shown to be a risk factor for substance use behaviors during adolescence and adulthood (see review [20].”
BackgroundLi, J., Sun, Q., Zhang, H., Li, B., Zhang, C., Zhao, Y., & Lu, J. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.10.140 · Cited by 22
Attention Deficit Hyperactivity Disorder and Substance Use Disorder: A Narrative Review
Srichawla, B. S., Telles, C. C., Schweitzer, M., & Darwish, B. (2022) · Cureus · doi:10.7759/cureus.24068 · Cited by 25
“However, more research is needed on this hypothesis [17,18].”
BackgroundNoel, M., Abbs, E., Suen, L. W., Samuel, L., Dobbins, S. K., Geier, M., & Soran, C. S. (2023) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000001154 · Cited by 23
Regmi, S., Kedia, S., Ahuja, N. A., Lee, G., Entwistle, C., & Dillon, P. (2023) · Trauma Violence & Abuse · doi:10.1177/15248380231205821 · Cited by 20
“Recent studies indicate that ACEs are a significant predictor of the tendency to use substances such as alcohol and tobacco (Leza et al., 2021); they are also associated with greater odds of prescription opioid misuse (Tang et al., 2020; Winstanley et al., 2020) and non-medical prescription opioid…”
BackgroundGilgoff, R., Mengelkoch, S., Elbers, J. M., Kotz, K. J., Radin, A. S., Pasumarthi, I., Murthy, R., Sindher, S., Harris, N. B., & Slavich, G. M. (2024) · Stress · doi:10.1080/10253890.2024.2327333 · Cited by 21
“…risk for addictions including smoking, alcohol, drugs, gambling, and food (Birnie et al., 2020; Hanson et al., 2021; Hendrikse et al., 2022; leza et al., 2021; lokshina et al., 2021; wiss et al., 2020), which have been described as “self-medication” and “self-soothing” coping behaviors in…”
BackgroundAdverse childhood experiences and substance use among university students: a systematic review
Schwartz, A. N., Arsandaux, J., Montagni, I., Meschke, L. L., Galéra, C., & Tzourio, C. (2022) · Journal of Substance Use · doi:10.1080/14659891.2022.2114389 · Cited by 21
“Early life experiences have been related to the risk of SU (Leza et al., 2021).”
BackgroundMethodMantsch, J. R. (2022) · Addiction Neuroscience · doi:10.1016/j.addicn.2022.100038 · Cited by 22
“Early-life trauma and adversity are key determinants of SUD risk and severity later in life [282].”
BackgroundEarly life influences on the development of food addiction in college attending young adults
Wattick, R. A., Olfert, M. D., Claydon, E. A., Hagedorn, R. L., Barr, M. L., & Brode, C. S. (2023) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-023-01546-3 · Cited by 20
“ACEs have also been shown to lead to adulthood SUD [18, 19].”
BackgroundIllicit drug use in university students in the UK and Ireland: a PRISMA-guided scoping review
Boden, M., & Day, E. (2023) · Substance Abuse Treatment Prevention and Policy · doi:10.1186/s13011-023-00526-1 · Cited by 22
“For example, a developing evidence base suggests that there is a positive association between adverse childhood experiences (ACEs) and the development of substance use disorder in adolescence and adulthood [55].”
BackgroundCorradin, O., Sallari, R. C., Hoang, A. T., Kassim, B. S., Hutta, G. B., Cuoto, L., Quach, B. C., Lovrenert, K., Hays, C., Gryder, B. E., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01477-y · Cited by 19
“ELA is an increasingly recognized contributor to many public health crises [47].”
Donovan, A., Assari, S., Grella, C. E., Shaheen, M. A., Richter, L., & Friedman, T. C. (2024) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2024.101121 · Cited by 21
“Adverse childhood experiences (ACE) (Giano et al., 2021; Leza et al., 2021), early childhood adversity (ECA) (Shonkoff et al., 2021), early life adversity (ELA) (Hoffman et al., 2019), and early life stress (ELS) (Campbell et al., 2022; King et al., 2020) are terms that have been used to describe…”
BackgroundAdverse childhood experiences and the substance use behaviors of Latinx youth
Grest, C. V., Cederbaum, J. A., Lee, J. O., & Unger, J. B. (2021) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2021.108936 · Cited by 20
Swimmer, K. R., & Sandelich, S. (2023) · Emergency Medicine Clinics of North America · doi:10.1016/j.emc.2023.06.023 · Cited by 20
The relationship between parental adverse childhood experiences and parenting behaviors
Wattanatchariya, K., Narkpongphun, A., & Kawilapat, S. (2024) · Acta Psychologica · doi:10.1016/j.actpsy.2024.104166 · Cited by 19
Lortye, S. A., Will, J. P., Rameckers, S. A., Marquenie, L. A., Goudriaan, A. E., Arntz, A. R., & de Waal, M. M. (2024) · European Journal of Psychotraumatology · doi:10.1080/20008066.2024.2367179 · Cited by 21
“Within treatment-seeking SUD patients, CM rates in both men and woman are higher than in the general population (Belfrage et al., 2023), with the occurrence of adverse childhood experience ranging from >70% to 100% (Leza et al., 2021; Tang et al., 2021).”
BackgroundAbufarsakh, B., Okoli, C. T. C., Darville, A. K., Williams, L. B., Garcia, A. R., & Martin, C. A. (2023) · Addictive Behaviors · doi:10.1016/j.addbeh.2023.107948 · Cited by 19
Ortiz, R., Kershaw, K. N., Zhao, S., Kline, D., Brock, G. N., Jaffee, S. R., Golden, S. H., Ogedegbe, G. G., Carroll, J., Seeman, T. E., et al. (2024) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.122.009794 · Cited by 17
“39 It is also possible that household challenges (eg, disor-ganization) and family environment (eg, poor physical and mental health of caregivers) may be more likely to impact habits experienced and learned by children.”
BackgroundMolina, G., & Whittaker, A. (2022) · Drug and Alcohol Dependence Reports · doi:10.1016/j.dadr.2022.100028 · Cited by 22
Weiss, N. H., Goncharenko, S., Forkus, S. R., Ferguson, J. J., & Yang, M. (2023) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2023.05.027 · Cited by 15
Estrada-Darley, I., Chen, P. G., McBain, R. K., Alvarado, G., Engel, C. C., Malika, N. M., Kim, D., Machtinger, E. L., McCaw, B. R., Thyne, S. M., et al. (2023) · Journal of Pediatric Health Care · doi:10.1016/j.pedhc.2023.06.005 · Cited by 16
Conradt, E. D., Camerota, M., Maylott, S. E., & Lester, B. M. (2023) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13761 · Cited by 18
Remmers, M. C. C., Reijs, R. P., & Hoebe, C. J. P. A. (2024) · Scandinavian Journal of Public Health · doi:10.1177/14034948241260105 · Cited by 21
Early life adversity: Epigenetic regulation underlying drug addiction susceptibility
Winter, J. J., Rodríguez-Acevedo, K. L., Dittrich, M., & Heller, E. A. (2023) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2023.103825 · Cited by 19
“Childhood and adolescence are critical periods for the impact of early life adversity, which is associated with early initiation of drug use and increased risk of overdose (Leza et al., 2021; Stein et al., 2017; Trujillo et al., 2019).”
Koolschijn, M., Janković, M., & Bogaerts, S. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1128020 · Cited by 15
Heerde, J. A., Merrin, G. J., Le, V. T., Toumbourou, J. W., & Bailey, J. A. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20031711 · Cited by 15
“As one example, a large body of research has identified disparities in substance use across the life course among individuals who experience social marginalization and vulnerability, such as people experiencing homelessness [39], those who have experienced ACEs [15,40], people who have had contact with the justice sys…”
BackgroundBochicchio, L. A., Porsch, L., Zollweg, S. S., Matthews, A. K., & Hughes, T. L. (2023) · Trauma Violence & Abuse · doi:10.1177/15248380231162973 · Cited by 14
“For example, in their scoping review of studies of adults in the general population, Leza et al. (2021) found a consistent, positive relationship between ACEs and substance use.”
BackgroundGovender, T., Vidal‐Ribas, P., Yu, J., Haynie, D. L., Augustin, D., & Gilman, S. E. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.10.085 · Cited by 13
Adverse Childhood Experiences among a Sample of Youth Living with HIV in the Deep South
Chenneville, T., Drake, H., Cario, A., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19159740 · Cited by 11
“This is consistent with findings from a systematic review, which documented that ACEs are common among people and correlated with substance use diagnoses [22].”
ResultPrevalence of Childhood Trauma in a Community-Based Mental Health Clinic
Sucich, J. T., Breitbart, V., Williams, S. Z., Sanichar, N., Candelaria-Arce, E., Frankle, W. G., & Davison-Duffy, S. (2023) · Community Mental Health Journal · doi:10.1007/s10597-023-01094-1 · Cited by 11
“Emotional abuse and neglect are associated with adult depression (Mandelli et al., 2015), while a diverse number of ACEs are associated with opioid use disorders (Evans et al., 2020) and alcohol dependence (Leza et al., 2021).”
BackgroundChang, H., Chen, C., Lu, M., Jou, S., Santos, V. H. J., & Goh, K. K. (2023) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2023.106579 · Cited by 12
Jones, A. A., Brant, K., Bishop, R. E., Strong-Jones, S., & Kreager, D. A. (2024) · Journal of Substance Use and Addiction Treatment · doi:10.1016/j.josat.2024.209587 · Cited by 15
Parental and own substance use disorder: The intersection of gender and early adversity
van Draanen, J., & Aneshensel, C. S. (2022) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2022.109393 · Cited by 11
Kurtzman, E. T., & Greene, J. (2021) · Substance Use & Misuse · doi:10.1080/10826084.2021.2002905 · Cited by 11
“While studies have found this same relationship between ACEs and substance use and substance use disorders (Leza et al., 2021; Substance Abuse and Mental Health Services Administration [SAMHSA], Center for the Application of Prevention Technologies (CAPT), 2018), few studies have examined the…”
BackgroundGonçalves, P. D., Duarte, C. S., Corbeil, T., Ramos-Olazagasti, M. A., Sussman, T. J., Talati, A., Alegria, M. M., CANINO, G. J., Bird, H., & Martins, S. S. (2023) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2023.04.010 · Cited by 10
Ko, C.-H., Lu, Y.-C., Lee, C.-H., & Liao, Y. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1382646 · Cited by 12
“As ACEs may predispose individuals to addiction in adulthood (18, 19), it is imperative to comprehend how these early life experiences induce addiction.”
BackgroundOnohuean, H., & Oosthuizen, F. (2025) · PLoS ONE · doi:10.1371/journal.pone.0317036 · Cited by 10
“…Africa Looking at the age variability in our findings, the years spent in high school and traditional universities, differs [129,130] and there is a positive correlation between adolescence, adult-hood and the emergence of substance use disorders due to adverse childhood experiences (ACEs) [131].”
The Legacy of Troubled Childhoods: Adverse Childhood Experiences, Sleep, and Delinquency
Tomlinson, T. A., Mears, D., Stults, B. J., Meldrum, R. C., Turanovic, J., & Young, J. T. N. (2022) · Crime & Delinquency · doi:10.1177/00111287221083961 · Cited by 9
“…poor educational and occupational outcomes (Crouch, Radcliff et al., 2019; Giovanelli et al., 2016; Jimenez et al., 2016; Topitzes et al., 2016), substance use (Dube et al., 2003; Leza et al., 2021; Mersky et al., 2013), and mental illness (Fuller-Thomson et al., 2016; Sheffler et al., 2020).”
BackgroundChildhood Adversity and Adolescent Smartphone Use Across Sexual Orientation and Gender Expression
Zheng, X., Jiang, W., Peng, S., Liu, Q., He, Y., Huang, C., Hua, Y., Lu, C., & Guo, L. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.6448 · Cited by 12
Butt, M. M., Watson, R. J., Rohner, R. P., & Malik, F. D. (2022) · Journal of Child and Family Studies · doi:10.1007/s10826-022-02323-z · Cited by 10
“…has found that parenting quality is one of the most important childhood predictors of later-life behavioral problems such as SUD (Arteaga et al., 2010; Bertrand et al., 2013; Hoffman 2015; Krohn et al., 2019; Leza et al., 2021; Mak and Iacovou 2019; Sitnick et al., 2014; Zucker et al., 2008).”
BackgroundExpanded Adverse Childhood Experiences (ACEs) and Adult Cannabis Use: A Latent Class Analysis
Smith, D. C., Garthe, R. C., Lee, A., Kim, S., Thebaud, M., & Kovacevic, L. (2023) · Cannabis · doi:10.26828/cannabis/2023.01.005 · Cited by 9
“A recent scoping review (k =12) found elevated ACEs among those with substance use disorders (SUD; Leza et al., 2021).”
Associations between Configurations of Childhood Adversity and Adult Mental Health Disorder Outcomes
Kamis, C., Lynch, S. M., & Copeland, W. (2023) · Society and Mental Health · doi:10.1177/21568693231197746 · Cited by 11
“For example, through individual therapies and trauma-informed care associated with mental health disorders (Leza et al. 2021).”
BackgroundInfluentialAdverse childhood experiences as precursors to cannabis use in adulthood: A systematic review
Collazos, K. S. G., Havanur, A., Santis, J. P. D., Baral, A., & Vidot, D. C. (2024) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2024.106889 · Cited by 9
Co-occurring experiences of traumatic events and substance use among young people
Kihas, I., Barrett, E. L., Teesson, M., Touyz, S. W., Newton, N. C., & Mills, K. L. (2024) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2024.107003 · Cited by 9
The genetic architecture of substance use and its diverse correlations with mental health traits
Wormington, B., Thorp, J. G., Gerring, Z. F., Scott, J. G., Akóṣílè, W., & Derks, E. M. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.116200 · Cited by 10
Lee, W., Fang, S., Chen, Y., Liu, H., Huang, M., & McKetin, R. (2021) · Addictive Behaviors · doi:10.1016/j.addbeh.2021.107060 · Cited by 10
The Prevalence of Comorbidities and Substance Use Disorder
Kress, C. B., & Schlesinger, S. (2023) · Nursing Clinics of North America · doi:10.1016/j.cnur.2023.02.007 · Cited by 13
Basting, E. J., Medenblik, A. M., Eberwein, J. D., Garner, A. R., Shorey, R. C., & Stuart, G. L. (2024) · Journal of Traumatic Stress · doi:10.1002/jts.23079 · Cited by 8
Türkmen, C., Tan, H., Gerhardt, S., Bougelet, E., Bernardo, M., Machunze, N., Grauduszus, Y., Sicorello, M., Demirakça, T., Kiefer, F., et al. (2024) · Addiction Biology · doi:10.1111/adb.13438 · Cited by 9
“10 More recently, Broekhof et al 11 have presented longitudinal evidence that adults with any history of ACE are approximately four times more likely to develop an SUD, confirming previous retrospective findings.”
ResultKeator, D. B., Salgado, F., Madigan, C., Murray, S., Norris, S., & Amen, D. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1401745 · Cited by 9
“There is support in the literature for this alternative interpretation by studies showing that ACEs are associated with increased drug abuse (55 – 57).”
Moore, C. R., & Stoddard, S. A. (2024) · Journal of School Health · doi:10.1111/josh.13527 · Cited by 8
Harada, T., Kanamori, S., Baba, T., Takano, A., Nomura, K., Villaroman, A., Rey, F., Peralta, J., & Shirasaka, T. (2023) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2023.110924 · Cited by 8
Trauma and mental health in Pacific Islanders
Subica, A. M., Soakai, L., Tukumoeatu, A., Johnson, T., & Aitaoto, N. (2024) · International Journal of Social Psychiatry · doi:10.1177/00207640241236109 · Cited by 8
“…with or anesthetize the negative cognitions, affective states, and neurobiological pathologies triggered by trauma (Khantzian, 1997; Schimmenti et al., 2022), leading to worsened substance use, substance use disorders, and personal and community harms (Cicchetti & Handley, 2019; Leza et al., 2021).”
BackgroundMorton, S., Curran, M. A., & O'Gorman, M. B. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.892849 · Cited by 7
Examining the pathways from adverse childhood experiences to substance use
Azagba, S., Ebling, T., & Korkmaz, A. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.10.090 · Cited by 7
Altikriti, S., Semenza, D. C., Testa, A. M., Jackson, D. B., & Anestis, M. D. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.12.030 · Cited by 8
Sgro, M., Kodila, Z. N., Salberg, S., Li, C. N., Smith, M. J., Freeman, J., Vlassopoulos, E., Harris, S., Shultz, S. R., Yamakawa, G. R., et al. (2024) · Journal of Pain · doi:10.1016/j.jpain.2024.104762 · Cited by 7
Sabawoon, A., Nesheim-Case, R., Keyes, K. M., Karam, E. G., & Kovess–Masféty, V. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06677-8 · Cited by 7
“Further there is a higher prevalence of adverse childhood experiences (ACEs) in populations with SUD than in those without reported ACEs, and a positive association between ACEs and the development and severity of SUD in adolescence and adulthood [7].”
Roller, K. M., Snow, W., Grapa, J., Hernández, M., Consoli, A. J., Pineda, B. S., & Andrade, E. (2023) · Journal of the National Hispanic Medical Association · doi:10.59867/nhma0202 · Cited by 7
Schnarrs, P. W., Bond, M. A., Stone, A. L., Salcido, R., Young, L. E., Dean, J. A., & Grigsby, T. J. (2022) · AIDS and Behavior · doi:10.1007/s10461-022-03690-w · Cited by 7
“While much is known about the deleterious effects of ACEs exposure on psychological [29, 30], behavioral [31], and physiological [32, 33], health outcomes in adulthood, there is considerably less research examining the impact of ACEs exposure on health screening behaviors, such as HIV testing.”
BackgroundMagin, Z. E., Park, C. L., Burke, J. D., & Infurna, F. J. (2024) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001282 · Cited by 6
Fabio, R. A., Centorrino, R., Caprì, T., Mento, C., & Picciotto, G. (2024) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-024-10048-y · Cited by 8
“…with the research conducted on predominantly American samples (Anda et al., 2006; Beilharz et al., 2020; Bunting et al., 2023; Hyland et al., 2019; Leza et al., 2021; Majer et al., 2010; Tzouvara et al., 2023; Windle et al., 2018; Wu et al., 2018), reveal some distinct differences that may be…”
Morgan, M. H. C., Coe, J. L., Kranzler, E. C., et al. (2024) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2024.107066 · Cited by 6
A Prospective Study of Adverse Childhood Experiences and Illicit Drug Use in Adulthood
Kaufman-Parks, A. M., Longmore, M. A., Manning, W. D., & Giordano, P. C. (2024) · Journal of Human Services · doi:10.52678/001c.117729 · Cited by 9
The Influence of Family on Gambling Behaviours: A Rapid Review of Emergent Literature
Smith, J. R., Wright, S., Dighton, G., Dymond, S., & Torrance, J. (2025) · International Journal of Mental Health and Addiction · doi:10.1007/s11469-025-01505-2 · Cited by 10
“This approach enabled examination of complete trajectories from childhood family dynamics to adult gambling behaviours and has been adopted in similar reviews focusing on substance use (Leza et al., 2021; Sebalo et al., 2023)”
Qeadan, F., France, J., & Barbeau, W. A. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119923 · Cited by 5
Cunha, O. S., Sousa, M., Almeida, T. C., Guarda, R., & Cruz, A. R. (2025) · Journal of Aggression Maltreatment & Trauma · doi:10.1080/10926771.2025.2555564 · Cited by 5
“…et al., 2022), post-traumatic stress disorder (PTSD) and complex PTSD (Frewen et al., 2019), sleep disturbances (Lee et al., 2020; Vadukapuram et al., 2022), substance use (Leza et al., 2021), antisocial personality disorders (DeLisi et al., 2019), and aggressive behavior (Zhang et al., 2022).”
Campbell, A. C., Pearce, L. A., Willoughby, M., Borschmann, R., Young, J. T., Bruun, A., Sundbery, J., & Kinner, S. A. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-074314 · Cited by 5
Adverse childhood experiences exacerbate peripheral symptoms of autism spectrum disorder in adults
Okumura, K., Takeda, T., Komori, T., Toritsuka, M., Yamamuro, K., Takada, R., Ikehara, M., Kamikawa, K., Noriyama, Y., Nishi, Y., et al. (2024) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13712 · Cited by 7
Estrada, S., & Baskin-sommers, A. R. (2023) · Development and Psychopathology · doi:10.1017/s0954579422001420 · Cited by 5
“Our results add to a body of literature documenting the robust associations among various subtypes of life stress and substance use (Bosk et al., 2021; Leza et al., 2021).”
ResultAdverse childhood experiences and smoking status in children: A systematic review and meta‐analysis
Amiri, S., Taridashti, S., & Khan, M. A. (2024) · Child Abuse Review · doi:10.1002/car.2882 · Cited by 6
Cultural considerations for substance use and substance use disorders among Black men
Bauer, A. G., Bellot, J., Bazan, C., Gilmore, A., Kideys, K., & Cameron, A. (2024) · Bulletin of the Menninger Clinic · doi:10.1521/bumc.2024.88.2.108 · Cited by 5
Understanding Sexual and Gender Minority Substance use through Latent Profiles of Ecological Systems
Scroggs, B., & Love, H. A. (2021) · Substance Abuse · doi:10.1080/08897077.2021.1986769 · Cited by 5
Wu, S., Johnson, S. L., Wolfersteig, W., Díaz, M. J., & Aguilar-Amaya, M. (2022) · BMC Public Health · doi:10.1186/s12889-022-13503-3 · Cited by 7
“However, this is complicated by research suggesting a stronger relationship between ACEs and substance use outcomes for men [29] and supports further attention to understanding mechanisms through which ACEs impact substance use [32].”
BackgroundHarper, C. R., Tan-Schriner, C. U., Royster, J., Morgan, K. L., Burnett, V., Treves-Kagan, S., Bradford, J., Ettman, L., Espinosa, O., & Marziale, E. (2024) · American Journal of Community Psychology · doi:10.1002/ajcp.12741 · Cited by 5
Adverse Childhood Experiences and Prescription Stimulant Use in Adults: A Systematic Review
Beatty, A., Shepard, E., Bickford, E., & Weyandt, L. L. (2024) · Pharmacy · doi:10.3390/pharmacy12020052 · Cited by 4
“Extant research has demonstrated a strong relationship between ACEs and illicit substance use [15,17–19].”
BackgroundInfluentialMigalova, E., Furstova, J., Hasto, J., Tavel, P., & Kascakova, N. (2025) · BMC Psychology · doi:10.1186/s40359-025-03331-6 · Cited by 6
Wang, D., Wang, W., Liao, Y., Zhang, H., Lu, Y., Liu, H., Zhang, Y., Yuan, L., Wu, M., Gao, Y. H., et al. (2025) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-025-02124-7 · Cited by 4
Zou, P., Huang, Z., Zong, X., & Zhang, Q. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106436 · Cited by 5
Jiang, S., Li, X., Jin, C., & Liang, Z. (2025) · Social Science & Medicine · doi:10.1016/j.socscimed.2025.118566 · Cited by 4
Silverstein, S. M., Rivera, J., Gainer, D. M., & Daniulaityte, R. (2023) · SSM - Mental Health · doi:10.1016/j.ssmmh.2022.100185 · Cited by 5
Schwartz, A. N., Galéra, C., Arsandaux, J., Montagni, I., & Tzourio, C. (2024) · International Journal of Behavioral Medicine · doi:10.1007/s12529-023-10256-0 · Cited by 4
Ohio START: An adaption of the National Sobriety Treatment and Recovery Teams model
Dellor, E. D., Allbright-Campos, M., Lee, J. Y., Bunger, A. C., Gadel, F., & Freisthler, B. (2024) · Children and Youth Services Review · doi:10.1016/j.childyouth.2024.107575 · Cited by 4
Sánchez, M., Saavedra, L. M., Lozano, A., Morgan‐López, A. A., & Amaro, H. D. L. A. (2024) · Current Addiction Reports · doi:10.1007/s40429-024-00567-x · Cited by 4
“Strong evidence links exposure to traumatic life events with subsequent SUD, as indicated by disproportionately higher rates of trauma among individuals with SUD [9, 10 •• , 11, 12].”
Metadata
- Authors
- Leza, L., Siria, S., López-Goñi, J. J., & Fernández-Montalvo, J.
- Affiliations
- Universidad Pública de Navarra (UPNA) (ES)
- Venue
- Drug and alcohol dependence
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 221
- Pages
- 108563
- ISSN
- 0376-8716 (ISSN-L)
- OpenAlex
- W3127853237
- Semantic Scholar
- dc7a4fbbfbd932f5cf222f41e88285a778e0ee33
- Cited by
- 305
- References
- 71
- Citations by year
- 2026: 64 · 2025: 62 · 2024: 93 · 2023: 57 · 2022: 21 · 2021: 8
- FWCI
- 5.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Drug and Alcohol Dependence (publishedVersion)
- PubMed (publishedVersion)
- Academica-e (Universidad Pública de Navarra) (submittedVersion, cc-by-nc-nd)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Sociology and Political Science › Child Welfare and Adoption
- Keywords
- adverse childhood experiences, substance use disorders, adolescent substance use
- MeSH terms
- Adverse Childhood Experiences, Adolescent, Adult, Child, Cross-Sectional Studies, Female, Humans, Male, Mental Health, Retrospective Studies, Prevalence, Substance-Related Disorders
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