Cited by 102Congenital Heart Disease StudiesCardiovascular Function and Risk FactorsHemodynamic Monitoring and Therapy

Validation study of the accuracy of echocardiographic measurements of systemic blood flow volume in newborn infants

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Ficial, Benjamim, Finnemore, Anna E., Cox, David J., Broadhouse, Kathryn M., Price, Anthony N., Durighel, Giuliana, Ekitzidou, Georgia, Hajnal, Joseph V. +2 more·2013·Journal of the American Society of Echocardiography

Abstract

BACKGROUND: The echocardiographic assessment of circulatory function in sick newborn infants has the potential to improve patient care. However, measurements are prone to error and have not been sufficiently validated. Phase-contrast magnetic resonance imaging (MRI) provides highly validated measures of blood flow and has recently been applied to the newborn population. The aim of this study was to validate measures of left ventricular output and superior vena caval flow volume in newborn infants. METHODS: Echocardiographic and MRI assessments were performed within 1 working day of each other in a cohort of newborn infants. RESULTS: Examinations were performed in 49 infants with a median corrected gestational age at scan of 34.43 weeks (range, 27.43-40 weeks) and a median weight at scan of 1,880 g (range, 660-3,760 g). Echocardiographic assessment of left ventricular output showed a strong correlation with MRI assessment (R(2) = 0.83; mean bias, -9.6 mL/kg/min; limits of agreement, -79.6 to +60.0 mL/kg/min; repeatability index, 28.2%). Echocardiographic assessment of superior vena caval flow showed a poor correlation with MRI assessment (R(2) = 0.22; mean bias, -13.7 mL/kg/min; limits of agreement, -89.1 to +61.7 mL/kg/min; repeatability index, 68.0%). Calculating superior vena caval flow volume from an axial area measurement and applying a 50% reduction to stroke distance to compensate for overestimation gave a slightly improved correlation with MRI (R(2) = 0.29; mean bias, 2.6 mL/kg/min; limits of agreement, -53.4 to +58.6 mL/kg/min; repeatability index, 54.5%). CONCLUSIONS: Echocardiographic assessment of left ventricular output appears relatively robust in newborn infant. Echocardiographic assessment of superior vena caval flow is of limited accuracy in this population, casting doubt on the utility of the measurement for diagnostic decision making.

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Crossref · 10.1016/j.echo.2013.08.019

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Authors
Ficial, B., Finnemore, A. E., Cox, D. J., Broadhouse, K. M., Price, A. N., Durighel, G., Ekitzidou, G., Hajnal, J. V., Edwards, A. D., & Groves, A. M.
Affiliations
  • University of Verona (IT)
  • King's College London (GB)
  • Imperial College London (GB)
Corresponding author
Groves, Alan M.
Venue
Journal of the American Society of Echocardiography
Publisher
Elsevier BV
Published
2013-12
Volume
26
Issue
12
Pages
1365-1371
ISSN
0894-7317 (ISSN-L)
OpenAlex
W2000595347
Cited by
102
References
41
Citations by year
2026: 5 · 2025: 4 · 2024: 7 · 2023: 12 · 2022: 6 · 2021: 13 · 2020: 10 · 2019: 6 · 2018: 15 · 2017: 6 · 2016: 4 · 2015: 8 · 2014: 6
FWCI
4.37
Type
journal article
Language
en
Open access
Locations
  • Journal of the American Society of Echocardiography (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion, other-oa)
Funders
  • NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
  • National Institute for Health and Care Research
  • British Heart Foundation (FS/11/75/29030)
  • King's College London
  • Sparks (12KCLRTF07)
  • Medical Research Council (MR/K006355/1)
Topics
  • Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
Keywords
neonates, left ventricular output, repeatability
MeSH terms
Blood Volume, Blood Volume Determination, Echocardiography, Female, Heart Ventricles, Humans, Infant, Newborn, Male, Sensitivity and Specificity, Vena Cava, Superior, Reproducibility of Results, Ventricular Function, Left

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