Brain-based classification of negative social bias in adolescents with nonsuicidal self-injury: Findings from simulated online social interaction
Open accessAbstract
BACKGROUND: Interpersonal stress and perceived rejection have been clinically observed as common triggers of nonsuicidal self-injury (NSSI), with self-injury behavior regulating both affective and social experiences. We investigated whether the subjective interpretation of social interaction in a simulated online environment might be biased in the NSSI group, and the brain mechanisms underlying the experience. METHODS: Thirty female adolescent patients with NSSI and thirty female age-matched controls were investigated in this case-control study. In our novel task that simulates interaction on current social media platforms, participants indicated whether they liked or disliked pictures of other players during a functional magnetic resonance imaging (fMRI) scan. Participants also viewed positive and negative feedback directed toward them by others. The task also assessed the subjective effects of the social interaction. Finally, subjects underwent a separate facial electromyography session, which measured facial expressions processing. OUTCOMES: Behaviorally, the NSSI group showed a negative bias in processing social feedback from others. A multi-voxel pattern analysis (MVPA) identified brain regions that robustly classified NSSI subjects and controls. Regions in which mutual activity contributed to the classification included dorsomedial prefrontal cortex and subgenual anterior cingulate cortex, a region implicated in mood control. In the NSSI group, multi-voxel classification scores correlated with behavioral sensitivity to negative feedback from others. Results remained significant after controlling for medication, symptoms of depression, and symptoms of borderline personality disorder. INTERPRETATION: This study identified behavioral and neural signatures of adolescents with NSSI during social interaction in a simulated social media environment. These findings highlight the importance of understanding social information processing in this clinical population and can potentially advance treatment approaches.
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Relative to depressed adolescents, depressed self-injurers show increased activation in medial PFC, ventrolateral PFC, and parahippocampus during exclusion versus inclusion trials, suggesting self-injurers may view social exclusion more negatively.
“Relative to depressed adolescents, depressed self-injurers show increased activation in the medial PFC, ventrolateral PFC, and parahippocampus during exclusion versus inclusion trials; suggesting that self-injurers may view social exclusion more negatively (88) (c.f., (89)).”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [89]
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Neural correlates associated with suicide and nonsuicidal self-injury in youth
Auerbach, R. P., Pagliaccio, D., Allison, G. O., Alqueza, K. L., & Alonso, M. F. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.06.002 · Cited by 204 · see citing works
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- Authors
- Perini, I., Gustafsson, P. A., Hamilton, J. P., Kämpe, R., Mayo, L. M., Heilig, M., & Zetterqvist, M.
- Affiliations
- Linköping University (SE)
- Corresponding author
- Perini, Irene
- ORCID
- Venue
- EClinicalMedicine
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 13
- Pages
- 81-90
- ISSN
- 2589-5370 (ISSN-L)
- PMC
- PMC6733998
- OpenAlex
- W2954401043
- Cited by
- 53
- References
- 43
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 7 · 2023: 8 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 1
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- EClinicalMedicine (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DiVA (Linkoping University) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Swedish Research Council (538-2013-7434)
- Östergötland County (LIO-535931, LIO-520131)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Psychology › Social Psychology › Death Anxiety and Social Exclusion
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- non-suicidal self-injury, adolescents, social rejection, social bias, social media, brain classification, multi-voxel pattern analysis, dorsomedial prefrontal cortex, subgenual anterior cingulate cortex, facial expression processing, interpersonal stress
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