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Cited by 15Endometriosis Research and TreatmentOvarian function and disordersGynecological conditions and treatments

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Preoperative serum anti-Müllerian hormone level is a potential predictor of ovarian endometrioma severity and postoperative fertility

Dong, Zhenzhu, An, Jian, Xie, Xi, Wang, Zhenhong, Sun, Pengming·2019·European Journal of Obstetrics & Gynecology and Reproductive Biology
DOI 10.1016/j.ejogrb.2019.06.024
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Abstract

Objective To establish a model for predicting revised American Society of Reproductive Medicine (rASRM) scores before endometrioma surgery based on serum anti-Müllerian hormone (AMH) level and to identify factors that might reliably predict postoperative fertility of women diagnosed with endometrioma. Study design The study population was composed of 134 women with endometrioma, 58 with benign cyst, and 115 with non-ovarian lesion. Preoperative serum AMH level and clinical parameters were compared among three groups. Univariate correlation analyses and multivariate linear regression modeling with a stepwise method were performed for constructing an rASRM scores prediction model. Cox regression analysis was then used to identify predictive variables of spontaneous pregnancy following surgical treatment of endometrioma. Results Preoperative AMH level were significantly lower in the endometrioma group than in the other two groups (p 3.68 ng/ml, HR: 2.383; 95% CI, 1.093-5.197) were independent predictors for postoperative fertility. Conclusion Patients with advanced staged endometriosis tended to have a lower serum AMH level while postoperative infertility was more likely to occur in older patients with a lower level of serum AMH. Thus, timely detection of AMH levels to assess the severity of ovarian endometriosis and possibility for postoperative pregnancy success is necessary to ensure that optimal medical treatment can be provided.

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Metadata

Authors
Dong, Z., An, J., Xie, X., Wang, Z., & Sun, P.
Affiliations
Fujian Medical University (CN)
Corresponding author
Sun, Pengming
ORCID
Venue
European Journal of Obstetrics & Gynecology and Reproductive Biology
Publisher
Elsevier BV
Published
2019-09
Volume
240
Pages
113-120
ISSN
  • 0028-2243 (ISSN-L)
  • 0301-2115
DOI
10.1016/j.ejogrb.2019.06.024
OpenAlex
W2949129368
Cited by
15
References
0
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 1
FWCI
1.67
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • European Journal of Obstetrics & Gynecology and Reproductive Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Natural Science Foundation of Fujian Province, China (2017J01236)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords
anti-Müllerian hormone, endometrioma, endometriosis severity, postoperative fertility, spontaneous conception, CA125, age, prediction model, endometrioma surgery
MeSH terms
Adult, Endometriosis, Female, Fertility, Humans, Ovarian Diseases, Ovary, Postoperative Period, Pregnancy, Prognosis, Severity of Illness Index, Anti-Mullerian Hormone

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