Pre-emptive antinociceptive effects of a synthetic cannabinoid in a model of neuropathic pain
Abstract
The antinociceptive effects of WIN55,212-2, a synthetic cannabinoid, were evaluated in the model of partial sciatic nerve ligation after daily subcutaneous administration of 0.1 mg/kg a week before and two weeks after surgery. Mechanical allodynia and thermal hyperalgesia were evaluated in 46 rats allocated to receive: (1) Vehicle (before surgery)-Vehicle (after surgery); (2) Vehicle-WIN55,212-2; (3) WIN55,212-2-Vehicle; (4) WIN55,212-2-WIN55,212-2; (5) AM251+vehicle; (6) AM251+WIN55,212-2; (7) AM630+vehicle; (8) AM630+WIN55,212-2; (9) Sham receiving vehicle; and (10) Sham receiving WIN55,212-2. The decreased in mechanical allodynia and thermal hyperalgesia by WIN55,212-2 was significantly greater when it was administered during one week before surgery. In conclusion, pre-emptive use of cannabinoids produced greater antinociceptive effects in a model of neuropathic pain and this effect is mediated by cannabinoid CB(1) and CB(2) receptors.
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In the pSNL rat model, the potency of WIN55,212-2 (0.1 mg/kg) in decreasing allodynia and hyperalgesia was significantly greater when administered daily prior to surgery for 7 days and for the following 2 weeks than when administered only 2 weeks post-pSNL.
“In the pSNL rat model, the potency of WIN55,212-2 (0.1 mg/kg) in decreasing allodynia and hyperalgesia was significantly greater when administered daily prior to the surgery for 7 days, and for the following 2 weeks, than when administered only 2 weeks post-pSNL (Guindon et al, 2007).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Guindon et al, 2007
Activation of cannabinoid receptors can prevent the development of pain induced by nerve injury.
“These findings suggest that activation of cannabinoid receptors can prevent the development of pain induced by nerve injury.”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Guindon et al, 2007
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Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside
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Self-citation
- Authors
- Guindon, J., Desroches, J., Dani, M., & Beaulieu, P.
- Affiliations
- Université de Montréal (CA)
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 568
- Issue
- 1-3
- Pages
- 173-176
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2002804792
- Cited by
- 24
- References
- 17
- Citations by year
- 2025: 1 · 2021: 2 · 2019: 1 · 2018: 3 · 2017: 1 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- WIN 55,212-2, synthetic cannabinoids, neuropathic pain, preemptive analgesia, partial sciatic nerve ligation, mechanical allodynia, thermal hyperalgesia, CB1 receptor, CB2 receptor, AM251, AM630, cannabinoid receptor antagonists
- MeSH terms
- Analgesics, Animals, Cannabinoids, Hyperalgesia, Indoles, Male, Morpholines, Naphthalenes, Pain, Piperidines, Pyrazoles, Sciatic Nerve, Rats, Wistar, Sciatic Neuropathy, Receptor, Cannabinoid, CB1, Receptor, Cannabinoid, CB2, Benzoxazines, Rats
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