Cited by 419Cannabis and Cannabinoid ResearchPain Mechanisms and TreatmentsIon Channels and Receptors

Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models

Zhang, Ji, Hoffert, Cyrla, Vu, Huy Khang, Groblewski, Thierry, Ahmad, Sultan, O'Donnell, Dajan·2003·European Journal of Neuroscience

Abstract

Cannabinoids have been considered for some time as potent therapeutic agents in chronic pain management. Central and systemic administration of natural, synthetic and endogenous cannabinoids produce antinociceptive and antihyperalgesic effects in both acute and chronic animal pain models. Although much of the existing data suggest that the analgesic effects of cannabinoids are mediated via neuronal CB1 receptors, there is increasing evidence to support a role for peripheral CB2 receptors, which are expressed preferentially on immune cells. As yet, little is known about the central contribution of CB2 in neuropathic pain states. We report here that chronic pain models associated with peripheral nerve injury, but not peripheral inflammation, induce CB2 receptor expression in a highly restricted and specific manner within the lumbar spinal cord. Moreover, the appearance of CB2 expression coincides with the appearance of activated microglia.

Integrity signals

Registry

Crossref · 10.1046/j.1460-9568.2003.02704.x

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Zhang, J., Hoffert, C., Vu, H. K., Groblewski, T., Ahmad, S., & O'Donnell, D.
Affiliations
AstraZeneca (Canada) (CA)
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2003-06
Volume
17
Issue
12
Pages
2750-2754
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
OpenAlex
W2045531190
Cited by
419
References
28
Citations by year
2026: 8 · 2025: 11 · 2024: 8 · 2023: 11 · 2022: 19 · 2021: 11 · 2020: 19 · 2019: 9 · 2018: 10 · 2017: 17 · 2016: 11 · 2015: 16 · 2014: 11 · 2013: 17 · 2012: 14
FWCI
14.57
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
CB2 receptor, cannabinoid receptors, neuropathic pain, chronic pain, spinal cord, microglial activation, peripheral nerve injury, inflammatory pain, lumbar spinal cord, cannabinoid analgesia
MeSH terms
Animals, Antigens, Neoplasm, Antigens, Surface, Blood Proteins, Disease Models, Animal, Freund's Adjuvant, Glial Fibrillary Acidic Protein, Immunohistochemistry, Inflammation, Male, Membrane Glycoproteins, Membrane Proteins, Pain, Receptors, Drug, RNA, Messenger, Spinal Cord Injuries, Time Factors, Antigens, CD, Gene Expression, Rats, Sprague-Dawley, In Situ Hybridization, Microglia, CD11 Antigens, Sciatic Neuropathy, Avian Proteins, Receptors, Cannabinoid, Receptor, Cannabinoid, CB2, Rats, Basigin, Ectodysplasins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review