Extracellular vesicles in renal tissue damage and regeneration

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

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Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

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Extracellular vesicles: biology and emerging therapeutic opportunities

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Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles

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Exosomes: Extracellular organelles important in intercellular communication

Mathivanan, S., Ji, H. L., & Simpson, R. J. (2010) · Journal of Proteomics · doi:10.1016/j.jprot.2010.06.006 · Cited by 2,539 · see citing works

Standardization of sample collection, isolation and analysis methods in extracellular vesicle research

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Regulation of immune responses by extracellular vesicles

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Identification and proteomic profiling of exosomes in human urine

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Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

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Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

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A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

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Shedding microvesicles: artefacts no more

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Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

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Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery

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Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper

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A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

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ExoCarta: A Web-Based Compendium of Exosomal Cargo

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Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

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The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

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Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

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Mesenchymal Stem Cell-Derived Microvesicles Protect Against Acute Tubular Injury

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Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial

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Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study

Zaborowski, M. P., Balaj, L., Breakefield, X. O., & Lai, C. P. (2015) · BioScience · doi:10.1093/biosci/biv084 · Cited by 1,272 · see citing works

Cell-produced α-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

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MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease

Kordelas, L., Rebmann, V., Ludwig, A., Radtke, S., Ruesing, J., Doeppner, T. R., Epple, M., Horn, P., Beelen, D. W., & Giebel, B. (2014) · Leukemia · doi:10.1038/leu.2014.41 · Cited by 1,086 · see citing works

Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes

Crescitelli, R., Lässer, C., Szabó, T. G., Kittel, Á., Eldh, M., Dianzani, I., Buzás, E. I., & Lötvall, J. O. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.20677 · Cited by 996 · see citing works

Endothelial progenitor cell–derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA

Deregibus, M. C., Cantaluppi, V., Calogero, R., Iacono, M. L., Tetta, C., Biancone, L., Bruno, S., Bussolati, B., & Camussi, G. (2007) · Blood · doi:10.1182/blood-2007-03-078709 · Cited by 977 · see citing works

Human saliva, plasma and breast milk exosomes contain RNA: Uptake by macrophages

Lässer, C., Seyed Alikhani, V., Ekström, K., Eldh, M., Torregrosa Paredes, P., Bossios, A., Sjöstrand, M., Gabrielsson, S., Lötvall, J., & Valadi, H. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-9 · Cited by 899 · see citing works

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

Lai, C. P., Mardini, O., Ericsson, M., Prabhakar, S., Maguire, C. A., Chen, J. W., Tannous, B. A., & Breakefield, X. O. (2014) · ACS Nano · doi:10.1021/nn404945r · Cited by 894 · see citing works

Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury

Gatti, S., Bruno, S., Deregibus, M. C., Sordi, A., Cantaluppi, V., Tetta, C., & Camussi, G. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfr015 · Cited by 814 · see citing works

Molecular lipidomics of exosomes released by PC-3 prostate cancer cells

Llorente, A., Skotland, T., Sylvänne, T., Kauhanen, D., Róg, T., Orłowski, A., Vattulainen, I., Ekroos, K., & Sandvig, K. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.04.011 · Cited by 771 · see citing works

Body fluid derived exosomes as a novel template for clinical diagnostics

Keller, S., Ridinger, J., Rupp, A.-K., Janssen, J. W. G., & Altevogt, P. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-86 · Cited by 752 · see citing works

A Protocol for Exosome Isolation and Characterization: Evaluation of Ultracentrifugation, Density-Gradient Separation, and Immunoaffinity Capture Methods

Greening, D. W., Xu, R., Ji, H. L., Tauro, B. J., & Simpson, R. J. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2550-6_15 · Cited by 723 · see citing works

A comprehensive overview of exosomes as drug delivery vehicles — Endogenous nanocarriers for targeted cancer therapy

Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Pilgaard, L., Moos, T., & Duroux, M. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.04.005 · Cited by 704 · see citing works

Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR

Al-Nedawi, K. N. I., Meehan, B., Kerbel, R. S., ALLISON, A. C., & Rak, J. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804543106 · Cited by 666 · see citing works

Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro

Zhou, Y., Xu, H., Xu, W., Wang, B., Wu, H., Tao, Y., Zhang, B., Wang, M., Mao, F., Yan, Y., et al. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt194 · Cited by 647 · see citing works

Methods of isolating extracellular vesicles impact down-stream analyses of their cargoes

Taylor, D. D., & Shah, S. (2015) · Methods · doi:10.1016/j.ymeth.2015.02.019 · Cited by 634 · see citing works

Microvesicles Derived from Mesenchymal Stem Cells Enhance Survival in a Lethal Model of Acute Kidney Injury

Bruno, S., Grange, C., Collino, F., Deregibus, M. C., Cantaluppi, V., Biancone, L., Tetta, C., & Camussi, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033115 · Cited by 613 · see citing works

Microvesicles Derived from Adult Human Bone Marrow and Tissue Specific Mesenchymal Stem Cells Shuttle Selected Pattern of miRNAs

Collino, F., Deregibus, M. C., Bruno, S., Sterpone, L., Aghemo, G., Viltono, L., Tetta, C., & Camussi, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011803 · Cited by 608 · see citing works

Nontemplated Nucleotide Additions Distinguish the Small RNA Composition in Cells from Exosomes

Koppers‐Lalic, D., Hackenberg, M., Bijnsdorp, I. V., van Eijndhoven, M. A. J., Sadek, P., Sie, D., Zini, N., Middeldorp, J. M., Ylstra, B., de Menezes, R. X., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.027 · Cited by 589 · see citing works

Dedifferentiation and Proliferation of Surviving Epithelial Cells in Acute Renal Failure

Bonventre, J. V. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000067652.51441.21 · Cited by 587 · see citing works

Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease

Lai, R. C., Chen, T. S., & Lim, S. K. (2011) · Regenerative Medicine · doi:10.2217/rme.11.35 · Cited by 553 · see citing works

Exosomes as intercellular signalosomes and pharmacological effectors

Record, M., Subra, C., Silvente‐Poirot, S., & Poirot, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.02.011 · Cited by 539 · see citing works

Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia–reperfusion injury by microRNA-dependent reprogramming of resident renal cells

Cantaluppi, V., Gatti, S., Medica, D., Figliolini, F., Bruno, S., Deregibus, M. C., Sordi, A., Biancone, L., Tetta, C., & Camussi, G. (2012) · Kidney International · doi:10.1038/ki.2012.105 · Cited by 535 · see citing works

Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids

Wang, Q., Zhuang, X., Mu, J., Deng, Z., Jiang, H., Zhang, L., Xiang, X., Wang, B., Yan, J., Miller, D., et al. (2013) · Nature Communications · doi:10.1038/ncomms2886 · Cited by 528 · see citing works

Extracellular Membrane Vesicles as a Mechanism of Cell-to-Cell Communication: Advantages and Disadvantages

Turturici, G., Tinnirello, R., Sconzo, G., & Geraci, F. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00228.2013 · Cited by 483 · see citing works

Immune Surveillance Properties of Human NK Cell-Derived Exosomes

Lugini, L., Cecchetti, S., Huber, V., Luciani, F., Macchia, G., Spadaro, F., Paris, L., Abalsamo, L., Colone, M., Molinari, A., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101988 · Cited by 455 · see citing works

Exosomal Fetuin-A identified by proteomics: A novel urinary biomarker for detecting acute kidney injury

Zhou, H., Pisitkun, T., Aponte, A. M., Yuen, P. S. T., Hoffert, J. D., Yasuda, H., Hu, X., Chawla, L. S., Shen, R., Knepper, M. A., et al. (2006) · Kidney International · doi:10.1038/sj.ki.5001874 · Cited by 446 · see citing works

The therapeutic potential of mesenchymal stem cell‐derived extracellular vesicles

Katsuda, T., Kosaka, N., Takeshita, F., & Ochiya, T. (2013) · PROTEOMICS · doi:10.1002/pmic.201200373 · Cited by 425 · see citing works

TGF-β1–Containing Exosomes from Injured Epithelial Cells Activate Fibroblasts to Initiate Tissue Regenerative Responses and Fibrosis

Borges, F. T., Melo, S. A., Özdemir, B. C., Kato, N., Revuelta, I., Miller, C. A., Gattone, V. H., LeBleu, V. S., & Kalluri, R. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012101031 · Cited by 420 · see citing works

Proteomic Analysis of Microvesicles Derived from Human Mesenchymal Stem Cells

Kim, H.-S., Choi, D., Yun, S. J., Choi, S., Kang, J. W., Jung, J. W., Hwang, D., Kim, K. P., & Kim, D. (2011) · Journal of Proteome Research · doi:10.1021/pr200682z · Cited by 398 · see citing works

Tumour-derived microvesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes

Baj‐Krzyworzeka, M., Szatanek, R., Węglarczyk, K., Baran, J., Urbanowicz, B., Brański, P., Ratajczak, M. Z., & Zembala, M. (2005) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-005-0075-9 · Cited by 397 · see citing works

EVpedia: a community web portal for extracellular vesicles research

Kim, D.-K., Lee, J., Kim, S. R., Choi, D., Yoon, Y. J., Kim, J. H., Go, G., Nhung, D., Hong, K., Jang, S. C., et al. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu741 · Cited by 393 · see citing works

CD24 is a marker of exosomes secreted into urine and amniotic fluid

Keller, S., Rupp, C., Stoeck, A., Runz, S., Fogel, M., Lugert, S., Hager, H. D., Abdel‐Bakky, M. S., Gutwein, P., & Altevogt, P. (2007) · Kidney International · doi:10.1038/sj.ki.5002486 · Cited by 372 · see citing works

Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism

Potolicchio, I., Carven, G. J., Xu, X., Stipp, C., Riese, R. J., Stern, L. J., & Santambrogio, L. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2237 · Cited by 365 · see citing works

Biodistribution of mesenchymal stem cell-derived extracellular vesicles in a model of acute kidney injury monitored by optical imaging

Grange, C., Tapparo, M., Bruno, S., Chatterjee, D., Quesenberry, P. J., Tetta, C., & Camussi, G. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1663 · Cited by 362 · see citing works

Exosomes: Vehicles for the Transfer of Toxic Proteins Associated with Neurodegenerative Diseases?

Bellingham, S. A., Guo, B. B., Coleman, B. M., & Hill, A. F. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00124 · Cited by 355 · see citing works

Transfer of Growth Factor Receptor mRNA Via Exosomes Unravels the Regenerative Effect of Mesenchymal Stem Cells

Tomasoni, S., Longaretti, L., Rota, C., Morigi, M., Conti, S., Gotti, E., Capelli, C., Introna, M., Remuzzi, G., & Benigni, A. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0266 · Cited by 340 · see citing works

Characterization of PKD Protein-Positive Exosome-Like Vesicles

Hogan, M. C., Manganelli, L., Woollard, J. R., Masyuk, A. I., Masyuk, T. V., Tammachote, R., Huang, B. Q., Leontovich, A. A., Beito, T. G., Madden, B. J., et al. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008060564 · Cited by 329 · see citing works

Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential

Lopatina, T., Bruno, S., Tetta, C., Kalinina, N., Porta, M., & Camussi, G. (2014) · Cell Communication and Signaling · doi:10.1186/1478-811x-12-26 · Cited by 308 · see citing works

MicroRNA and mRNA cargo of extracellular vesicles from porcine adipose tissue-derived mesenchymal stem cells

Eirin, A., Riester, S. M., Zhu, X. Y., Tang, H. R., Evans, J. M., O’Brien, D. R., van Wijnen, A. J., & Lerman, L. O. (2014) · Gene · doi:10.1016/j.gene.2014.08.041 · Cited by 293 · see citing works

Bone Marrow-Derived Mesenchymal Stem Cells Repaired but Did Not Prevent Gentamicin-Induced Acute Kidney Injury through Paracrine Effects in Rats

Reis, L. A., Borges, F. T., Simões, M. D. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044092 · Cited by 277 · see citing works

Microvesicles derived from human Wharton’s Jelly mesenchymal stromal cells ameliorate renal ischemia-reperfusion injury in rats by suppressing CX3CL1

Zou, X., Zhang, G., Cheng, Z., Deming, Y., Du, T., Ju, G., Miao, S., Liu, G., Lu, M., & Zhu, Y. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt428 · Cited by 271 · see citing works

Exosomes secreted by human urine-derived stem cells could prevent kidney complications from type I diabetes in rats

Jiang, Z.-Z., Liu, Y., Niu, X., Yin, J., Hu, B., Guo, S., Fan, Y., Wang, Y., & Wang, N. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0287-2 · Cited by 271 · see citing works

Exosomes induce and reverse monocrotaline-induced pulmonary hypertension in mice

Aliotta, J. M., Pereira, M. G., Wen, S., et al. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw054 · Cited by 249 · see citing works

AKI Recovery Induced by Mesenchymal Stromal Cell-Derived Extracellular Vesicles Carrying MicroRNAs

Collino, F., Bruno, S., Incarnato, D., Dettori, D., Neri, F., Provero, P., Pomatto, M. A. C., Oliviero, S., Tetta, C., Quesenberry, P. J., et al. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014070710 · Cited by 248 · see citing works

Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Angiogenesis: Potencial Clinical Application

Merino-González, C., Zuñiga, F. A., Escudero, C., Ormazábal, V., Reyes, C., Nova‐Lamperti, E., Salomón, C., & Aguayo, C. R. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00024 · Cited by 237 · see citing works

Extracellular Vesicles: Evolving Factors in Stem Cell Biology

Nawaz, M., Fatima, F., Vallabhaneni, K. C., Penfornis, P., Valadi, H., Ekström, K. M., Kholia, S., Whitt, J. D., Fernandes, J. D., Pochampally, R. R., et al. (2015) · Stem Cells International · doi:10.1155/2016/1073140 · Cited by 225 · see citing works

Human Embryonic Mesenchymal Stem Cell-Derived Conditioned Medium Rescues Kidney Function in Rats with Established Chronic Kidney Disease

van Koppen, A., Joles, J. A., van Balkom, B. W. M., Lim, S. K., de Kleijn, D. P. V., Giles, R. H., & Verhaar, M. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038746 · Cited by 204 · see citing works

Bone marrow stem cells‐derived microvesicles protect against renal injury in the mouse remnant kidney model

He, J., Wang, Y., Sun, S. W., Yu, M.-N., WANG, C., Pei, X., Zhu, B. L., Wu, J., & Zhao, W. (2012) · Nephrology · doi:10.1111/j.1440-1797.2012.01589.x · Cited by 201 · see citing works

Urinary extracellular vesicles and the kidney: biomarkers and beyond

Salih, M., Zietse, R., & Hoorn, E. J. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00128.2014 · Cited by 186 · see citing works

Extracellular vesicles – vehicles that spread cancer genes

Rak, J. W., & Guha, A. (2012) · BioEssays · doi:10.1002/bies.201100169 · Cited by 184 · see citing works

Exosomal transmission of functional aquaporin 2 in kidney cortical collecting duct cells

Street, J. M., Birkhoff, W. A. J., Menzies, R. I., Webb, D. J., Bailey, M. A., & Dear, J. W. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.220277 · Cited by 174 · see citing works

The secretome of mesenchymal stromal cells: Role of extracellular vesicles in immunomodulation

Bruno, S., Deregibus, M. C., & Camussi, G. (2015) · Immunology Letters · doi:10.1016/j.imlet.2015.06.007 · Cited by 153 · see citing works

Extracellular Vesicles Released from Mesenchymal Stromal Cells Modulate miRNA in Renal Tubular Cells and Inhibit ATP Depletion Injury

Lindoso, R. S., Collino, F., Bruno, S., Araujo, D. S., Sant’Anna, J. F., Tetta, C., Provero, P., Quesenberry, P. J., Vieyra, A. R., Einicker‐Lamas, M., et al. (2014) · Stem Cells and Development · doi:10.1089/scd.2013.0618 · Cited by 144 · see citing works

Horizontal transfer of RNA and proteins between cells by extracellular microvesicles: 14 years later

Ratajczak, M. Z., & Ratajczak, J. (2016) · Clinical and Translational Medicine · doi:10.1186/s40169-016-0087-4 · Cited by 143 · see citing works

Microvesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Tubular Epithelial Cell Dedifferentiation and Growth via Hepatocyte Growth Factor Induction

Ju, G., Cheng, J., Zhong, L., Wu, S., Zou, X., Zhang, G., Gu, D., Miao, S., Zhu, Y., Sun, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121534 · Cited by 141 · see citing works

Massively Parallel Sequencing of Human Urinary Exosome/Microvesicle RNA Reveals a Predominance of Non-Coding RNA

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Exosomal transfer from human renal proximal tubule cells to distal tubule and collecting duct cells

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