Cited by 28Apelin-related biomedical researchNeuropeptides and Animal PhysiologyBiochemical effects in animals

Apelin/APJ system: A novel therapeutic target for locomotor system diseases

Luo, Jingshun, Liu, Wei, Feng, Fen, Chen, Linxi·2021·European Journal of Pharmacology

Abstract

Apelin is an endogenous ligand of G protein-coupled receptor APJ. Apelin/APJ system is widely expressed in abundant tissues, especially bone, joint and muscle tissue. This review focus on the effects of apelin/APJ system on locomotor system. An increasing number of evidence suggests that apelin/APJ system plays a crucial role in many physiological and pathological processes of locomotor system. Physiologically, apelin/APJ system promotes bone formation, muscle metabolism and skeletal muscle production. Pathologically, apelin/APJ system exacerbates osteoarthritis pathogenesis, whereas it alleviates osteoporosis. Besides, the level of apelin expression is regulated by different training modes, including continuous aerobic exercise, high-intensity interval training and resistance exercises. More importantly, exercise-induced apelin may be a potent pharmacological agent for the treatment of diseases and the regulation of physiological processes. Considering the pleiotropic effects of apelin on locomotor system, apelin/APJ system may be an important therapeutic target for locomotor system diseases.

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Crossref · 10.1016/j.ejphar.2021.174286

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  • Myokines that affect bone include apelin, myostatin, irisin, IL-6, IL-7 and BAIBA.

    “Noted myokines affecting the bone include apelin166, myostatin61, irisin167, IL-6 (REF.168), IL-7 (REF.60) and BAIBA59 (Supplementary Table 1).”

    From Exerkines in health, resilience and disease (2022) · cites this paper as [166]

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Authors
Luo, J., Liu, W., Feng, F., & Chen, L.
Affiliations
  • University of South China (CN)
  • Central South University (CN)
  • Shaoyang University (CN)
Corresponding author
  • Feng, Fen
  • Chen, Linxi
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
2021-09
Volume
906
Pages
174286
ISSN
0014-2999 (ISSN-L)
OpenAlex
W3177381405
Cited by
28
References
128
Citations by year
2026: 4 · 2025: 12 · 2024: 7 · 2023: 2 · 2022: 3
FWCI
0.38
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (81973326)
  • Natural Science Foundation of Hunan Province (2019JJ40255)
Topics
  • Health Sciences › Medicine › Pharmacology › Apelin-related biomedical research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Physiology › Biochemical effects in animals
Keywords
apelin, APJ receptor, musculoskeletal system, osteoarthritis, osteoporosis, bone formation, skeletal muscle metabolism, physical activity, high-intensity interval training, resistance training, aerobic exercise, therapeutic target
MeSH terms
Apelin, Apelin Receptors, Animals, Disease Models, Animal, Humans, Musculoskeletal Diseases, Signal Transduction, Molecular Targeted Therapy

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