Sarcopenic obesity and cognitive performance
Open accessAbstract
Background: Sarcopenia and obesity both negatively impact health including cognitive function. Their coexistence, however, can pose an even higher threat likely surpassing their individual effects. We assessed the relationship of sarcopenic obesity with performance on global- and subdomain-specific tests of cognition. Patients and methods: The study was a cross-sectional analysis of data from a series of community-based aging and memory studies. The sample consisted of a total of 353 participants with an average age of 69 years with a clinic visit and valid cognitive (eg, Montreal Cognitive Assessment, animal naming), functional (eg, grip strength, chair stands), and body composition (eg, muscle mass, body mass index, percent body fat) measurements. Results: Sarcopenic obesity was associated with the lowest performance on global cognition (Est. Definition1 =−2.85±1.38, p =0.039), followed by sarcopenia (Est. Definition1 =−1.88±0.79, p =0.017) and obesity (Est. Definition1 =−1.10±0.81, p =0.175) adjusted for sociodemographic factors. The latter, however, did not differ significantly from the comparison group consisting of older adults with neither sarcopenia nor obesity. Subdomain-specific analyses revealed executive function (Est. Definition1 =−1.22±0.46 for sarcopenic obesity; Est. Definition1 =−0.76±0.26 for sarcopenia; Est. Definition1 =−0.52±0.27 for obesity all at p 0.05) and orientation (Est. Definition1 =0.59±0.26 for sarcopenic obesity; Est. Definition1 =−0.36±0.15 for sarcopenia; Est. Definition1 =−0.29±0.15 all but obesity significant at p <0.05) as the individual cognitive skills likely to be impacted. Potential age-specific and depression effects are discussed. Conclusion: Sarcopenia alone and in combination with sarcopenic obesity can be used in clinical practice as indicators of probable cognitive impairment. At-risk older adults may benefit from programs addressing loss of cognitive function by maintaining/improving strength and preventing obesity. Keywords: sarcopenia, obesity, sarcopenic obesity, cognition, cross-sectional studies
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Sarcopenic obesity is an indicator of probable cognitive impairment in the geriatric population.
“A cross-sectional study has evaluated the association between SO and cognitive function in geriatric population, and found that SO is an indicator of probable cognitive impairment (65).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [65]
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The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment
Nasreddine, Z. S., Phillips, N. A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I., Cummings, J. L., & Chertkow, H. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53221.x · Cited by 25,553 · see citing works
Depression and quality of life in older persons: A review
Sivertsen, H., Bjørkløf, G. H., Engedal, K., Selbæk, G., & Helvik, A.-S. (2015) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000437299 · Cited by 14,152 · see citing works
(2000) · PubMed · Cited by 13,173 · see citing works
Obesity : Preventing and managing the global epidemic
Akram, D. S., Astrup, A. V., Atinmo, T., Boissin, J.-L., Bray, G. A., Carroll, K. N., Chitson, P., Chen, C., Dietz, W. H., Hill, J. O., et al. (2000) · Research at the University of Copenhagen (University of Copenhagen) · Cited by 12,945 · see citing works
Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601 · see citing works
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481 · see citing works
Janssen, I., Heymsfield, S. B., & Ross, R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50216.x · Cited by 3,139 · cited 1× · see citing works
“More easily accessible methods to measure MM in the clinical setting including bioelectrical impedance (BIA) were later proposed.(30) More recently, reduced muscle function measured as low MS(31) or low MS and/or poor physical performance were added.”
Newman, A. B., Kupelian, V., Visser, M., Simonsick, E. M., Goodpaster, B. H., Kritchevsky, S. B., Tylavsky, F. A., Rubin, S. M., Harris, T. B., & on Behalf of the Health, A. A. B. C. S. I. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.1.72 · Cited by 1,692 · see citing works
Body Composition in Healthy Aging
BAUMGARTNER, R. N. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06498.x · Cited by 1,078 · see citing works
Sarcopenic obesity: definition, cause and consequences
Stenholm, S., Harris, T. B., Rantanen, T., Visser, M., Kritchevsky, S. B., & Ferrucci, L. (2008) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e328312c37d · Cited by 1,070 · see citing works
Sarcopenia: alternative definitions and associations with lower extremity function
Newman, A. B., Kupelian, V., Visser, M., Simonsick, E., Goodpaster, B., Nevitt, M., Kritchevsky, S. B., Tylavsky, F. A., Rubin, S. M., Harris, T. B., et al. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51534.x · Cited by 981 · see citing works
Sarcopenic obesity: A new category of obesity in the elderly
Zamboni, M., Mazzali, G., Fantin, F., Rossi, A., & Di Francesco, V. (2008) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.10.002 · Cited by 953 · see citing works
Central obesity and increased risk of dementia more than three decades later
Whitmer, R. A., Gustafson, D. R., Barrett-Connor, E., Haan, M. N., Gunderson, E. P., & Yaffe, K. (2008) · Neurology · doi:10.1212/01.wnl.0000306313.89165.ef · Cited by 803 · see citing works
Obesity and neuroinflammation: A pathway to cognitive impairment
Miller, A. A., & Spencer, S. J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.04.001 · Cited by 788 · see citing works
Resistance Training and Executive Functions: A 12-Month Randomized Controlled Trial
Liu-Ambrose, T. (2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.494 · Cited by 775 · see citing works
Smith, E., Hay, P., Campbell, L. V., & Trollor, J. N. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00920.x · Cited by 706 · see citing works
Raji, C. A., Ho, A. J., Parikshak, N., Becker, J. T., López, O. L., Kuller, L. H., Hua, X., Leow, A., Toga, A. W., & Thompson, P. M. (2009) · Human Brain Mapping · doi:10.1002/hbm.20870 · Cited by 692 · see citing works
Elevated body mass index is associated with executive dysfunction in otherwise healthy adults
Gunstad, J., Paul, R. H., Cohen, R. A., Tate, D. F., Spitznagel, M. B., & Gordon, E. (2007) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2006.05.001 · Cited by 668 · see citing works
Insulin effects in muscle and adipose tissue
Dimitriadis, G., Mitrou, P., Lambadiari, V., Maratou, E., & Raptis, S. A. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(11)70014-6 · Cited by 649 · see citing works
Klein, S., Allison, D. B., Heymsfield, S. B., Kelley, D. E., Leibel, R. L., Nonas, C., & Kahn, R. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.5.1197 · Cited by 560 · see citing works
Lemieux, S., Prud'homme, D., Bouchard, C., Tremblay, A., & Despres, J. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.5.685 · Cited by 519 · see citing works
Relation between body mass index and cognitive function in healthy middle-aged men and women
Cournot, M., Marquié, J. C., Ansiau, D., Martinaud, C., Fonds, H., Ferrières, J., & Ruidavets, J. B. (2006) · Neurology · doi:10.1212/01.wnl.0000238082.13860.50 · Cited by 517 · see citing works
Atkins, J. L., Whincup, P. H., Morris, R. W., Lennon, L. T., Papacosta, O., & Wannamethee, S. G. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12652 · Cited by 509 · see citing works
Davison, K. K., Ford, E. S., Cogswell, M. E., & Dietz, W. H. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50508.x · Cited by 435 · see citing works
Body Mass Index in Midlife and Risk of Alzheimer Disease and Vascular Dementia
Whitmer, R., Gunderson, E., Quesenberry, C., Zhou, J., & Yaffe, K. (2007) · Current Alzheimer Research · doi:10.2174/156720507780362047 · Cited by 430 · see citing works
Boyle, P. A., Buchman, A. S., Wilson, R. S., Leurgans, S. E., & Bennett, D. A. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.240 · Cited by 415 · see citing works
Reduced Lean Mass in Early Alzheimer Disease and Its Association With Brain Atrophy
Burns, J. M., Johnson, D. K., Watts, A. S., Swerdlow, R. H., & Brooks, W. M. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.38 · Cited by 400 · see citing works
Obesity, diabetes and cognitive deficit: The Framingham Heart Study
Elias, M. F., Elias, P. K., Sullivan, L. M., Wolf, P. A., & D’Agostino, R. B. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.08.019 · Cited by 395 · see citing works
Accelerated Weight Loss May Precede Diagnosis in Alzheimer Disease
Johnson, D. K., Wilkins, C. H., & Morris, J. C. (2006) · Archives of Neurology · doi:10.1001/archneur.63.9.1312 · Cited by 339 · see citing works
Handgrip Strength and Cognitive Decline in Older Mexican Americans
Alfaro‐Acha, A., Snih, S. A., Raji, M. A., Kuo, Y., Markides, K. S., & Ottenbacher, K. J. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.8.859 · Cited by 288 · see citing works
Cognitive Decline Is Associated with Systemic Oxidative Stress: The EVA Study
Berr, C., Balansard, B., Arnaud, J., Roussel, A., Alpérovitch, A., & EVA Study Group (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb02603.x · Cited by 279 · see citing works
Obesity is linked with lower brain volume in 700 AD and MCI patients
Ho, A. J., Raji, C. A., Becker, J. T., López, O. L., Kuller, L. H., Hua, X., Lee, S., Hibar, D. P., Dinov, I. D., Stein, J. L., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.04.006 · Cited by 204 · see citing works
Fitzgerald, P. B., Srithiran, A., Mendieta, J. B., Daskalakis, Z., Oxley, T. J., Kulkarni, J., & Egan, G. F. (2007) · Human Brain Mapping · doi:10.1002/hbm.20414 · Cited by 190 · see citing works
Hsu, Y., Liang, C., Chou, M.-Y., Liao, M.-C., Lin, Y., Chen, L., & Lo, Y. (2014) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.12221 · Cited by 167 · see citing works
Kuo, H., Jones, R. N., Milberg, W., Tennstedt, S. L., Talbot, L. A., Morris, J. N., & Lipsitz, L. A. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.00522.x · Cited by 158 · see citing works
Body mass index and cognitive decline in a biracial community population
Sturman, M. T., de Leon, C. F. M., Bienias, J. L., Morris, M. C., Wilson, R. S., & Evans, D. A. (2007) · Neurology · doi:10.1212/01.wnl.0000285081.04409.bb · Cited by 119 · see citing works
Sarcopenia and impairment in cognitive and physical performance
Tolea, M. I., & Galvin, J. E. (2015) · Clinical Interventions in Aging · doi:10.2147/cia.s76275 · Cited by 116 · see citing works
Self-citationEisenkölbl, J., Kartasurya, M., & Widhalm, K. (2001) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601184 · Cited by 115 · see citing works
Insulin Resistance in Cognitive Impairment
Geroldi, C., Frisoni, G. B., Paolisso, G., Bandinelli, S., Lamponi, M., Abbatecola, A. M., Zanetti, O. O., Guralnik, J. M., & Ferrucci, L. (2005) · Archives of Neurology · doi:10.1001/archneur.62.7.1067 · Cited by 112 · see citing works
Canon, M. E., & Crimmins, E. M. (2011) · The journal of nutrition health & aging · doi:10.1007/s12603-011-0340-x · Cited by 100 · see citing works
Kilander, L., Nyman, H., Boberg, M., & Lithell, H. (1997) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1997.00196.x · Cited by 77 · see citing works
Levine, M. E., & Crimmins, E. M. (2012) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/826398 · Cited by 75 · see citing works
Alzheimer-type neuropathological changes in morbidly obese elderly individuals
Mrak, R. E. (2009) · Clinical Neuropathology · doi:10.5414/npp28040 · Cited by 65 · see citing works
Screening for dementia in community-based memory clinics.
Sager, M. A., Bp, H., Rue, A. L., & Woodard, J. L. (2006) · PubMed · Cited by 60 · see citing works
Central obesity and increased risk of dementia more than three decades later
Cereda, E., Sacchi, M. C., & Malavazos, A. E. (2009) · Neurology · doi:10.1212/01.wnl.0000343499.72241.ea · Cited by 59 · see citing works
Disability and Depression: Investigating a Complex Relation Using Physical Performance Measures
Yanagita, M., Willcox, B. J., Masaki, K., Chen, R., He, Q., Rodríguez, B. L., Ueshima, H., & Curb, J. D. (2006) · American Journal of Geriatric Psychiatry · doi:10.1097/01.jgp.0000224364.70515.12 · Cited by 53 · see citing works
Quadriceps Strength and Executive Functions in Older Women
Scherder, E., Eggermont, L. H. P., Geuze, R. H., Vis, J., & Verkerke, G. J. (2010) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0b013e3181d3e9f6 · Cited by 28 · see citing works
Miller, D. K., Malmstrom, T. K., Andresen, E. M., Miller, J. P., Herning, M. M., Schootman, M., & Wolinsky, F. D. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln033 · Cited by 25 · see citing works
Neck muscle cross-sectional area, brain volume and cognition in healthy older men; a cohort study
Kilgour, A. H. M., Ferguson, K. J., Gray, C. D., Deary, I. J., Wardlaw, J. M., MacLullich, A. M. J., & Starr, J. M. (2013) · BMC Geriatrics · doi:10.1186/1471-2318-13-20 · Cited by 25 · see citing works
Exercise, Sarcopenia, Cognition, and Mood
Roubenoff, R. (2002) · KARGER eBooks · doi:10.1159/000061864 · Cited by 24 · see citing works
Howard, W. J. (2008) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(08)79122-4 · Cited by 8 · see citing works
Sanderlin, A. H., Alsibai, A., & Bozoki, A. (2015) · Neurology · doi:10.1212/wnl.84.14_supplement.i12-4b · Cited by 2 · see citing works
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- [47]Lezak MD Howieson DB Bigler ED Tranel D Neuropsychological Assessment 5th ed New York Oxford University Press 2012
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Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments
Wang, M., Tan, Y., Shi, Y., Wang, X., Liao, Z., & Wei, P. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00568 · Cited by 231 · see citing works
Zamboni, M., Rubele, S., & Rossi, A. P. (2019) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000519 · Cited by 173 · see citing works
Eating Behavior in Aging and Dementia: The Need for a Comprehensive Assessment
Fostinelli, S., Amicis, R. S. D., Leone, A., Giustizieri, V., Binetti, G. G., Bertoli, S., Battezzati, A., & Cappa, S. F. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.604488 · Cited by 100 · see citing works
Someya, Y., Tamura, Y., Kaga, H., Sugimoto, D., Kadowaki, S., Suzuki, R., Aoki, S., Hattori, N., Motoi, Y., Shimada, K., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.03.017 · Cited by 98 · see citing works
Sui, S. X., Holloway‐Kew, K. L., Hyde, N. K., Williams, L. J., Leach, S., & Pasco, J. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-67251-8 · Cited by 83 · see citing works
Low, S. K., Goh, K. S., Ng, T. P., Ang, S. F., Moh, A. M. C., Wang, J., Ang, K., Subramaniam, T., Sum, C. F., & Lim, S. C. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.10.019 · Cited by 65 · see citing works
Effects of progressive elastic band resistance exercise for aged osteosarcopenic adiposity women
Lee, Y.-H., Lee, P.-H., Lin, L.-F., Liao, C.-D., Liou, T.-H., & Huang, S.-W. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111272 · Cited by 62 · see citing works
Batsis, J. A., Haudenschild, C., Roth, R. M., Gooding, T., Roderka, M. N., Masterson, T. D., Brand, J., Lohman, M. C., & MacKenzie, T. A. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2020.09.008 · Cited by 60 · see citing works
Frailty and Sarcopenia in Older Patients Receiving Kidney Transplantation
Gandolfini, I., Regolisti, G., Bazzocchi, A., Maggiore, U., Palmisano, A., Piotti, G., Fiaccadori, E., & Sabatino, A. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00169 · Cited by 59 · see citing works
Obesity paradox in older sarcopenic adults ― a delay in aging: A systematic review and meta-analysis
Eitmann, S., Mátrai, P., Hegyi, P. J., Balaskó, M., Erőss, B. M., Dorogi, K., & Pétervári, E. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102164 · Cited by 57 · see citing works
Matsushita, T., Nishioka, S., Taguchi, S., Yamanouchi, A., Nakashima, R., & Wakabayashi, H. (2020) · Healthcare · doi:10.3390/healthcare8030255 · Cited by 43 · see citing works
Baad, V. M. A., Bezerra, L. R., de Holanda, N. C. P., dos Santos, A. C. O., da Silva, A. A. M., Bandeira, F., & Cavalcante, T. C. F. (2022) · Obesity Surgery · doi:10.1007/s11695-022-06335-y · Cited by 40 · see citing works
Role of Ultrasonography in Estimating Muscle Mass in Sarcopenic Obesity
Deniz, O., Cruz-Jentoft, A. J., Ayçiçek, G. Ş., Ünsal, P., Eşme, M., Ucar, Y., Bürkük, S., Şendur, A., Doğu, B. B., Cankurtaran, M., et al. (2020) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1830 · Cited by 40 · see citing works
Obesidad sarcopénica: un nuevo reto en la clínica práctica
Ciudin, A., Simó-Servat, A., Palmas-Candia, F. X., & Barahona, M. J. (2020) · Endocrinología Diabetes y Nutrición · doi:10.1016/j.endinu.2020.03.004 · Cited by 39 · see citing works
Zhou, Y., Wang, J., Yao, Q., Jian, Q.-F., & Luo, Z.-P. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.09.920 · Cited by 38 · see citing works
Understanding Sarcopenic Obesity in Terms of Definition and Health Consequences: A Clinical Review
Nezameddin, R., Itani, L., Kreidieh, D., Masri, D. E., Tannir, H., & Ghoch, M. E. (2020) · Current Diabetes Reviews · doi:10.2174/1573399816666200109091449 · Cited by 38 · see citing works
Sarcopenic obesity: A new challenge in the clinical practice
Ciudin, A., Simó-Servat, A., Palmas-Candia, F. X., & Barahona, M. J. (2020) · Endocrinología Diabetes y Nutrición (English ed ) · doi:10.1016/j.endien.2020.03.007 · Cited by 37 · see citing works
Sui, S. X., Balanta‐Melo, J., Pasco, J. A., & Plotkin, L. I. (2022) · Current Osteoporosis Reports · doi:10.1007/s11914-022-00736-9 · Cited by 34 · see citing works
Musculoskeletal effects of obesity and bariatric surgery – a narrative review
de Holanda, N. C. P., Crispim, N., Carlos, I. D. L., Moura, T., Nóbrega, E., & Bandeira, F. A. F. (2022) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000551 · Cited by 33 · see citing works
Effects of exercise-induced apelin on muscle function and cognitive function in aged mice
Kwak, S. E., Cho, S. C., Bae, J. H., Lee, J., Shin, H. E., Di Zhang, D., Lee, Y.-I., & Song, W. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110710 · Cited by 32 · see citing works
Cui, C., Mackey, R. H., Shaaban, C. E., Kuller, L. H., López, O. L., & Sekikawa, A. M. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12125 · Cited by 32 · see citing works
Galvin, J. E., Tolea, M. I., Rosenfeld, A., & Chrisphonte, S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241641 · Cited by 32 · see citing works
Self-citationBooranasuksakul, U., Macdonald, I. A., Stephan, B. C. M., & Siervo, M. (2024) · Journal of the American Nutrition Association · doi:10.1080/27697061.2024.2333310 · Cited by 31 · see citing works
A Modified CAIDE Risk Score as a Screening Tool for Cognitive Impairment in Older Adults
Tolea, M. I., Heo, J., Chrisphonte, S., & Galvin, J. E. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210269 · Cited by 29 · see citing works
Self-citationApelin/APJ system: A novel therapeutic target for locomotor system diseases
Luo, J., Liu, W., Feng, F., & Chen, L. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174286 · Cited by 28 · see citing works
Tou, N. X., Wee, S. L., Pang, B. W. J., Lau, L. K., Jabbar, K. B. A., Seah, W. T., Chen, K. K., & Ng, T. P. (2021) · PLoS ONE · doi:10.1371/journal.pone.0256702 · Cited by 28 · see citing works
Galvin, J. E., Chrisphonte, S., & Chang, L. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215020 · Cited by 26 · see citing works
Self-citationÜnsal, P., Güner, M., Özsürekçi, C., Balli, F., Baş, A. O., Öztürk, Y., Dikmeer, A., Bürkük, S., Koca, M., Balcı, C., et al. (2023) · Nutrition in Clinical Practice · doi:10.1002/ncp.10995 · Cited by 26 · see citing works
Sılay, K., & Öztorun, H. S. (2025) · BMC Geriatrics · doi:10.1186/s12877-025-06105-2 · Cited by 23 · see citing works
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Pilati, I., Slee, A., & Frost, R. (2021) · The Journal of Frailty & Aging · doi:10.14283/jfa.2021.39 · Cited by 22 · see citing works
Daniel, E. V., Kleiman, M. J., & Galvin, J. E. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220959 · Cited by 21 · see citing works
Self-citationLee, H., Seo, H. S., Kim, R. E. Y., Lee, S. K., Lee, Y. H., & Shin, C. (2020) · European Radiology · doi:10.1007/s00330-020-07407-2 · Cited by 21 · see citing works
O’Donovan, G., Sarmiento, O. L., Hessel, P., Terrera, G. M., Duran-Aniotz, C. A., & Ibáñez, A. M. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1011967 · Cited by 20 · see citing works
Phirom, K., Nantakool, S., Chuatrakoon, B., & Rerkasem, K. (2025) · Public Health · doi:10.1016/j.puhe.2025.01.040 · Cited by 18 · see citing works
Kumari, M., & Khanna, A. (2022) · Annals of Geriatric Medicine and Research · doi:10.4235/agmr.22.0081 · Cited by 16 · see citing works
Jung, C., & Mok, J. (2022) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes22058 · Cited by 15 · see citing works
Lim, G., Lee, H., & Lim, Y. (2022) · Biomedicines · doi:10.3390/biomedicines10102529 · Cited by 15 · see citing works
Maheshwari, V., & Basu, S. (2023) · Cureus · doi:10.7759/cureus.49601 · Cited by 14 · see citing works
Cavazzotto, T. G., de Campos, C. D. V., Mazur, C. E., da Silva, D. F., Valério, J. M. S., Vieira, E. R., da Silva, W. C. F. N., & Bonini, J. S. (2022) · Dementia & Neuropsychologia · doi:10.1590/1980-5764-dn-2021-0039 · Cited by 14 · see citing works
Rosano, C., Newman, A. B., Santanasto, A. J., Zhu, X., Goodpaster, B. H., & Miljkovic, I. (2023) · Journal of the American Geriatrics Society · doi:10.1111/jgs.18419 · Cited by 13 · see citing works
Weng, X., Liu, S., Li, M., Zhang, Y., Zhang, Y., Liu, C., Zhu, J., & Hu, H. (2023) · Psychogeriatrics · doi:10.1111/psyg.13015 · Cited by 13 · see citing works
Booranasuksakul, U., Tsintzas, K., Macdonald, I. A., Stephan, B. C. M., & Siervo, M. (2024) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2024.08.017 · Cited by 13 · see citing works
The Vulnerability Index: A weighted measure of dementia and cognitive impairment risk
Kleiman, M. J., & Galvin, J. E. (2021) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12249 · Cited by 13 · see citing works
Self-citationSkeletal muscle adiposity is a novel risk factor for poor cognition in African Caribbean women
Acevedo-Fontánez, A. I., Cvejkus, R., Zmuda, J. M., Kuipers, A. L., Barinas‐Mitchell, E., Sekikawa, A. M., Wheeler, V. W., Rosano, C., & Miljkovic, I. (2023) · Obesity · doi:10.1002/oby.23816 · Cited by 12 · see citing works
Fu, Y., Li, X., Wang, T., Yan, S., Zhang, X., Hu, G., Zhou, J., Wang, Y., Liu, C., Wang, S., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221232 · Cited by 12 · see citing works
Wu, F., Liu, Y., Lin, C.-Y., Haghbin, N., Xia, L., Li, Y., Chen, T., Qiu, H.-N., Jiang, W., Li, J., et al. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-04941-2 · Cited by 11 · see citing works
Peng, L., Xiang, Q., Jia, G., & Yin, R. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1540272 · Cited by 11 · see citing works
Sarcopenic obesity and brain health: A critical appraisal of the current evidence
Booranasuksakul, U., Guan, Z., Macdonald, I. A., Tsintzas, K., Stephan, B. C. M., & Siervo, M. (2025) · Nutrition Bulletin · doi:10.1111/nbu.12725 · Cited by 10 · see citing works
Oporto-Colicoi, V., Sepúlveda-Lara, A., Marzuca-Nassr, G. N., & Sepúlveda, P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262211036 · Cited by 10 · see citing works
Cao, X., Yang, B., & Zhou, J. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1166341 · Cited by 10 · see citing works
Low, S. K., Ng, T. P., Goh, K. S., Moh, A. M. C., Khoo, J., Ang, K., Yap, P. L. K., Cheong, C. Y., Tang, W. E., Lim, Z., et al. (2024) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2023.108672 · Cited by 10 · see citing works
Amini, N., Dupont, J., Lapauw, L., Vercauteren, L., Antonio, L., O’Neill, T. W., Vanderschueren, D., Pendleton, N., Rastrelli, G., Maggi, M., et al. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13229 · Cited by 9 · see citing works
Cognitive performance in relation to metabolic disturbances in patients with COPD
van Beers, M., Gosker, H. R., Janssen, D. J. A., Cleutjens, F. A. H. M., Franssen, F. M. E., van Boxtel, M. P. J., Wouters, E. F. �., Ponds, R., & Schols, A. M. W. J. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.09.029 · Cited by 9 · see citing works
Physical and Cognitive Function Assessment to Predict Postoperative Outcomes of Abdominal Surgery
Ruiz, M., Peña, M., Cohen, A., Ehsani, H., Joseph, B. A., Fain, M. J., Mohler, J. M., & Toosizadeh, N. (2021) · Journal of Surgical Research · doi:10.1016/j.jss.2021.05.018 · Cited by 9 · see citing works
Wagner, P. P., Foesser, D., Chapurlat, R. D., & Szulc, P. (2021) · Calcified Tissue International · doi:10.1007/s00223-021-00926-0 · Cited by 7 · see citing works
Tang, C., Song, Y., Tao, F., Hao, J., Li, Y., Shi, X., Pei, R., & Zeng, B. (2025) · Aging Clinical and Experimental Research · doi:10.1007/s40520-025-03222-1 · Cited by 6 · see citing works
Ishimoto, R., Mutsuzaki, H., Shimizu, Y., Takeuchi, R., Matsumoto, S., & Hada, Y. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13237071 · Cited by 6 · see citing works
Joyce, B. T., Chen, X., Yaffe, K. S., Henkle, B. E., Gao, T., Zheng, Y., Kalhan, R., Washko, G. R., Kunisaki, K. M., Thyagarajan, B., et al. (2022) · The Journals of Gerontology Series A · doi:10.1093/gerona/glac026 · Cited by 6 · see citing works
Fuller‐Thomson, E., Saab, Z., Davison, K., Lin, S., Taler, V., Kobayashi, K. M., & Tong, H. (2020) · The journal of nutrition health & aging · doi:10.1007/s12603-020-1402-8 · Cited by 5 · see citing works
Yitbarek, G. Y., Alty, J., Lawler, K., & Goldberg, L. R. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-076005 · Cited by 5 · see citing works
Sivakumar, J., Chen, Q., Chong, L., Read, M. D., Ward, S. M., Winter, N. N., Sutherland, T., & Hii, M. W. (2024) · ANZ Journal of Surgery · doi:10.1111/ans.19160 · Cited by 5 · see citing works
Vázquez‐Lorente, H., Paz‐Graniel, I., Margara‐Escudero, H. J., Martínez‐González, M. Á., Romaguera, D., Martínez‐Urbistondo, D., Estruch, R., Martín, V., Vidal, J., Fitó, M., et al. (2025) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70158 · Cited by 4 · see citing works
Yao, Z., Wang, J., Zhang, T., Ai, H., Abdelrahman, Z., Wu, X., Wang, D., Chen, F., Zhang, Z., Wang, X., et al. (2024) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2024.100313 · Cited by 4 · see citing works
Association of changes in predicted body composition with subsequent risk of dementia
Kim, S. M., Choi, S., Lee, G., Oh, Y. H., Son, J. S., Ko, A., Kim, J. S., Cho, Y., Keum, N., & Park, S. M. (2024) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.52096 · Cited by 3 · see citing works
Lee, D.-J., Choi, D. K., Kim, J.-G., Kim, W., & Do, H.-K. (2026) · PeerJ · doi:10.7717/peerj.20820 · Cited by 2 · see citing works
The association of obesity and sarcopenia in older adults: Sarcopenic Obesity
Koçyiğit, S. E., Bulut, E. A., Aydın, A. E., & Işık, A. T. (2021) · The Anatolian Journal of General Medical Research · doi:10.5222/terh.2021.49260 · Cited by 2 · see citing works
Agarwal, K., Chorsiya, V., Kaushik, D. K., & Yadav, A. (2022) · Science Talks · doi:10.1016/j.sctalk.2022.100074 · Cited by 2 · see citing works
Öztorun, H. S., Bahşi, R., Turgut, T., Sürmeli, D. M., Coşarderelioğlu, Ç., Atmış, V., Yalçın, A., Aras, S., & Varlı, M. (2022) · European Journal of Geriatrics and Gerontology · doi:10.4274/ejgg.galenos.2022.2022-3-3 · Cited by 1 · see citing works
The Interplay of Sarcopenic Obesity and Mental Health: A Complex Relationship
Cheah, L. J., & Cheah, K. J. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1004582 · Cited by 1 · see citing works
Noguchi, T., Yoshida, Y., Gotoh, K., Nagai, S., Sada, K., Matsuda, N., Suzuki, M., Kudo, A., Miyamoto, S., Ozeki, Y., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115294 · Cited by 1 · see citing works
Lin, C., Wu, H., Yu, N., Liu, Y.-C., & Chien, W. U. C. (2026) · Geriatric Nursing · doi:10.1016/j.gerinurse.2026.103961 · Cited by 1 · see citing works
Zhang, X., Han, W., Li, Y., Yang, P., Jia, Y., Sun, L., Wang, R., Shi, M., Zheng, X., Zhang, Y., et al. (2026) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2026.100879 · Cited by 1 · see citing works
Correlation of sarcopenia and depression: common risk factors and pathogenetic mechanisms
Мамутовна, М. Э., Yafarova, A. A., Sheptulina, A. F., Yakovleva, P. O., & Drapkina, O. M. (2023) · Russian Journal of Preventive Medicine · doi:10.17116/profmed20232611157 · Cited by 1 · see citing works
Sarcopenic obesity - current view
Pekár, M., Pekařová, A., Chovancová, T., & Holéczy, P. (2020) · Vnitřní lékařství · doi:10.36290/vnl.2020.007 · Cited by 1 · see citing works
Förstl, H., & Förstl, S. (2021) · Springer Reference Pflege, Therapie, Gesundheit · doi:10.1007/978-3-662-62426-5_58 · Cited by 1 · see citing works
Sarcopenic Obesity in the Elderly
Naafs, M. A. (2018) · Journal of Physical Fitness Medicine & Treatment in Sports · doi:10.19080/jpfmts.2018.05.555675
Sarcopenia and Cognitive Impairment
Chen, L. (2021) · Wiley eBooks · doi:10.1002/9781119597896.ch13
Förstl, H., & Förstl, S. (2020) · Springer Reference Pflege, Therapie, Gesundheit · doi:10.1007/978-3-662-55793-8_58-1
Slowing phenotype in geriatric patients with sarcopenia, sarcopenic obesity and dyspnea
Sergeeva, V. A., Bulgakova, S. V., Шульпина, Н. Ю., & Chemes, D. V. (2025) · Russian Journal of Geriatric Medicine · doi:10.37586/2686-8636-3-2025-321-331
Yuan, F., Xie, X., Liang, B., Wang, J., Li, J., Xiao, J., Li, H., Yun, Z., Geng, J., Cao, W., et al. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251390874
Çiçek, O., Kars, M. Y., Turgut, Z. İ., Akkar, I., Dogan, M. H., Saglam, M., & Kızılarslanoğlu, M. C. (2026) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/s44411-026-00660-9
Zhang, L., Cao, Y., Zhang, Y., Dai, W., Wu, X., Song, J., Yin, D., & Han, X. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1778293
Nonaka, T., Kenichi, K., Owari, G., Watabe, Y., Takemoto, M., & Nishida, Y. (2026) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-026-02031-1
Booranasuksakul, U., Guan, Z., Pereira, L. R., Tsintzas, K., Macdonald, I. A., Stirling, E., Farzam, S., Donini, L. M., Johnstone, A. M., Sim, M., et al. (2026) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2026.2722926
Kao, H., Chen, T., Lin, C., Li, C.-I., Liu, C.-S., Yang, C., Lin, C., & Lin, C. (2026) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2026.08.056
An, P., Wu, J., Zhang, Y., Shen, Z., Miao, Y., Wu, J., & Li, Q. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1893791
Chen, Y., Ma, K., Meng, Z., Gao, J., & Feng, X. (2026) · Maturitas · doi:10.1016/j.maturitas.2026.109142
Wang, M.-C., Peng, T., Chiou, J., Chen, Y., & Chen, J. (2026) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70395
- Authors
- Tolea, M., Chrisphonte, S., & Galvin, J.
- Affiliations
- Florida Atlantic University (US)
- Corresponding author
- Tolea, Magdalena
- Venue
- Clinical Interventions in Aging
- Publisher
- Informa UK Limited
- Published
- 2018-06
- Volume
- Volume 13
- Pages
- 1111-1119
- ISSN
- 1176-9092 (ISSN-L)
- 1178-1998
- PMC
- PMC5995418
- OpenAlex
- W2806859832
- Cited by
- 90
- References
- 56
- Citations by year
- 2026: 11 · 2025: 10 · 2024: 9 · 2023: 12 · 2022: 14 · 2021: 13 · 2020: 16 · 2019: 3 · 2018: 2
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical Interventions in Aging (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- New York State Department of Health
- Morris and Alma Schapiro Fund
- National Institutes of Health (AG008051)
- National Institute on Aging (P30AG008051, R01AG040211)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- sarcopenic obesity, sarcopenia, obesity, cognitive function, executive function, orientation, older adults, cognitive impairment, grip strength, body composition, muscle mass, Montreal Cognitive Assessment
- MeSH terms
- Aged, Body Composition, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, New York City, Obesity, Body Mass Index, Sarcopenia, Cognitive Dysfunction
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