Effects of exercise-induced apelin on muscle function and cognitive function in aged mice
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In humans and animal models, exercise increases muscle mRNA levels of apelin and possibly serum apelin.
“In both humans and animal models, exercise increases muscle mRNA levels of apelin94 and possibly serum levels of apelin95,96.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [95]
In an animal model, skeletal muscle was a source of apelin secretion that improved muscle function in ageing, supporting apelin as a potential therapy for age-related sarcopenia.
“In an animal model, skeletal muscle95,96 served as a source of apelin secretion, which improved skeletal muscle function in the setting of ageing, supporting the potential of apelin as a therapeutic to combat age-related sarcopenia94–96.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [95]
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Exerkines in health, resilience and disease
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“Skeletal muscle from mice subjected to aerobic exercise (treadmill and ladder) and C2C12 cells treated with the exercise mimetic, forskolin showed increased apelin plasma and mRNA concentrations, respectively [43].”
BackgroundExerkines and long-term synaptic potentiation: Mechanisms of exercise-induced neuroplasticity
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“Current evidence about the role of these exerkines on LTP is mainly derived from studies, in which these exerkines were administered in vitro and subsequent changes in LTP activity (in case of GH, kynurenine, adiponectin, orexinA, ghrelin, and VIP) or BDNF levels (in case of cathepsin-B, apelin, and osteocalcin) were…”
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Self-citationApelin/APJ system: A novel therapeutic target for locomotor system diseases
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Circulating Levels of Apelin, GDF-15 and Sarcopenia: Lack of Association in the MAPT Study
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“To date, several blood-based analytes associated with different pathways involved in muscle tissue metabolism have been proposed as sarcopenia markers but so far, none of them has shown any acceptable predictive ability alone (5).”
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GDF5 as a rejuvenating treatment for age-related neuromuscular failure
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“, 2016), apelin (Kwak et al., 2019) and adiponectin (Dai et al.”
BackgroundExercise, Exerkines, and Sarcopenia
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“Apelin has emerged as a critical myokine involved in maintaining and enhancing skeletal muscle and exerts beneficial effects on cognitive performance during aging [24].”
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Skeletal Muscle as Endocrine Organ
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Global multi-omics analysis of exerkines in progressive treadmill-exercised rodentsPreprint
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Muscle-to-CNS signaling in physiological homeostasis, aging, and disease
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A concise review on the interaction between genes expression/polymorphisms and exercise
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Circulating apelin levels fail to link sarcopenia-related muscle parameters in older adults
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Cross-Platform Transcriptomic Analysis of 40 Human and Rodent Skeletal Muscle Exerkines
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“Its role as an exerkine is known to be mostly related to skeletal muscle of exercised humans and rodents [21,22].”
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“Additionally, apelin regulates muscle mass, function, repair, and regeneration ( Kwak et al., 2019 ; Kwon, Moon & Min, 2020 ).”
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“…of combined endurance and resistance training improves cognitive function in aged mice and upregulates Apelin and BDNF expression in skeletal muscle, serum, and the brain, suggesting that Apelin may act as a key mediator of exercise-induced skeletal muscle–brain axis regulation of cognition [95].”
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- Authors
- Kwak, S. E., Cho, S. C., Bae, J. H., Lee, J., Shin, H. E., Di Zhang, D., Lee, Y.-I., & Song, W.
- Affiliations
- Seoul National University (KR)
- Daegu Gyeongbuk Institute of Science and Technology (KR)
- Corresponding author
- Lee, Yun-Il
- Song, Wook
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 127
- Pages
- 110710
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W2970878132
- Cited by
- 32
- References
- 32
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 5 · 2023: 1 · 2022: 6 · 2021: 3 · 2020: 4
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Seoul National University
- National Research Foundation of Korea (NRF-2013M3A9B6046417, NRF-2013M3A9D5072550, 2013M3A9D5072560, MEST 2011-030135, 2017M3A9D5A01052447)
- Topics
- Health Sciences › Medicine › Pharmacology › Apelin-related biomedical research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Biochemical effects in animals
- Keywords
- apelin, physical activity, aging, muscle function, cognitive function, aged mice, neuroendocrine regulation
- MeSH terms
- Apelin, Aging, Animals, Cognition, Postural Balance, Mice, Inbred C57BL, Motor Activity, Physical Conditioning, Animal, RNA, Messenger, Up-Regulation, Muscle, Skeletal, Maze Learning, Muscle Strength
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