Odd-numbered perfluorocarboxylates predominate over perfluorooctanoic acid in serum samples from Japan, Korea and Vietnam
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Perfluorooctanoic acid (PFOA) has recently attracted attention as a potential health risk following environmental contamination. However, information detailing exposure to perfluorinated carboxylic acids (PFCAs) other than PFOA is limited. We measured the concentrations of PFCAs (from perfluorohexanoic acid to perfluorotetradecanoic acid) in serum samples obtained from patients in Japan (Sendai, Takayama, Kyoto and Osaka) between 2002 and 2009, Korea (Busan and Seoul) between 1994 and 2008 and Vietnam (Hanoi) in 2007/2008. Total PFCA levels (geometric mean) were increased from 8.9 ng mL(-1) to 10.3 ng mL(-1) in Japan; from 7.0 ng mL(-1) to 9.2 ng mL(-1) in Korea; and were estimated at 4.7 ng mL(-1) in Vietnam. PFCAs of greater length than PFOA were significantly increased in Sendai, Takayama and Kyoto, Japan, and levels of long-chain PFCAs exceeded PFOA levels in serum. Among these PFCAs, perfluoroundecanoic acid (PFUnDA) was the predominant component (28.5%), followed by perfluorononanoic acid (PFNA 17.5%), perfluorodecanoic acid (PFDA 7.9%), perfluorotridecanoic acid (PFTrDA 6.1%) and perfluorododecanoic acid (PFDoDA 1.8%). Odd-numbered PFCAs (PFNA, PFUnDA and PFTrDA) were also observed in Korea and Vietnam and their presence increased significantly in Korea between 1994 and 2007/2008. The proportion of long-chain PFCAs in serum was relatively high compared to reports in Western countries. Further investigations into the sources and exposure routes are needed to predict the future trajectory of these serum PFCA levels.
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The other Canadian sediment study in Lake Ontario showed significantly increasing trends before and after the change points (in 1979 and 1987) in two separate cores (stations 1004 and 1034).
“The other Canadian sediment study in Lake Ontario [90] showed significantly increasing trends before and after the change points (in 1979 and 1987) in two separate cores (stations 1004 and 1034).”
In a third core (station 1046) from the Canadian Lake Ontario study no change point was detected.
“In a third core (station 1046) from this Canadian study [90] no change point was detected.”
For PFOA in abiotic samples, independent change point analysis revealed change points for sediment cores in three separate studies in Canada/USA, China and Japan.
“For PFOA in abiotic samples, the independent change point analysis revealed change points (Additional file 7, Figure S17) for sediment cores in three separate studies in Canada/USA [90], China [64] and Japan [3].”
For the two cores in the Canada/USA study where change points were identified (stations 1004 and 1034), statistically significant increasing trends were observed before and after the change points (in 1979 and 1988, respectively).
“For the two cores in the Canada/USA study [90] where change points were identified (stations 1004 and 1034), statistically significant increasing trends were observed before and after the change points (in 1979 and 1988, respectively).”
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Self-citationAssociations between exposure to perfluoroalkyl substances and birth outcomes: A meta-analysis
Yang, Z., Liu, H., Yang, Q., Chen, X., Li, W., Leng, J., & Tang, N. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.132909 · Cited by 23 · see citing works
Per- and polyfluoroalkyl substances: toxicokinetics, exposure and health risks.
Fujii, Y., & Harada, K. H. (2025) · Journal of Toxicological Sciences · doi:10.2131/jts.50.97 · Cited by 23 · see citing works
Self-citationKu, M.-S., Pan, W., Huang, Y., Hsieh, W., Hsu, Y., Chen, P., & Liu, C.-Y. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119183 · Cited by 20 · see citing works
Fujii, Y., Kato, Y., Miyatake, M., Akeda, S., Nagata, S., Ando, J., Kido, K., Ohta, C., Koga, N., Harada, K. H., et al. (2024) · Environment International · doi:10.1016/j.envint.2024.108685 · Cited by 20 · see citing works
Self-citationFujii, Y., Harada, K. H., Nakamura, T., Kato, Y., Ohta, C., Koga, N., Kimura, O., Endo, T., Koizumi, A., & Haraguchi, K. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114369 · Cited by 17 · see citing works
Self-citationSoleman, S. R., Li, M., Fujitani, T., & Harada, K. H. (2023) · Environmental Health and Preventive Medicine · doi:10.1265/ehpm.22-00302 · Cited by 16 · see citing works
Self-citationHu, X., Gong, S., He, Q., Wu, J., & Li, N. (2023) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2023.117289 · Cited by 16 · see citing works
Perfluorinated carboxylic acids discharged from the Yodo River Basin, Japan
Niisoe, T., Senevirathna, L., Harada, K. H., Fujii, Y., Hitomi, T., Kobayashi, H., Yan, J., Zhao, C., Oshima, M., & Koizumi, A. (2015) · Chemosphere · doi:10.1016/j.chemosphere.2015.05.060 · Cited by 16 · see citing works
Self-citationWang, Z., Yang, W., Xu, M., Li, B. Y., Chen, M., Hu, J., Wu, P., & Wu, W. (2024) · Scientific Reports · doi:10.1038/s41598-024-75210-w · Cited by 12 · see citing works
Tsai, W.-J., Hsieh, W., Chen, P., & Liu, C.-Y. (2024) · Toxics · doi:10.3390/toxics12120876 · Cited by 12 · see citing works
Shin, E., Jeong, Y., Barghi, M., Seo, S.-H., Kwon, S. Y., & Chang, Y. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115306 · Cited by 12 · see citing works
Plasma perfluoroalkyl substances and breast cancer risk in Brazilian women: a case–control study
Itoh, H., Harada, K. H., Hamada, G. S., Lyu, Z., Fujitani, T., Sassa, M. H., Yamaji, T., Tsugane, S., & Iwasaki, M. (2025) · Environmental Health · doi:10.1186/s12940-025-01168-5 · Cited by 9 · see citing works
Self-citationBirth cohorts in Asia: The importance, advantages, and disadvantages of different-sized cohorts.
Kishi, R., Araki, A., Minatoya, M., Itoh, S., Goudarzi, H., & Miyashita, C. (2018) · Science of the Total Environment · doi:10.1016/j.scitotenv.2017.08.268 · Cited by 8 · see citing works
Fujii, Y., Shibata, Y., Tokuda, Y., Ito, Y., Kudo, N., & Harada, K. H. (2025) · Chemosphere · doi:10.1016/j.chemosphere.2025.144508 · Cited by 8 · see citing works
Self-citationA review of human exposure to PFAS: substantial contribution from seafood
Fujii, Y., & Harada, K. H. (2025) · Environmental Health and Preventive Medicine · doi:10.1265/ehpm.25-00002 · Cited by 8 · see citing works
Self-citationPersistent Toxic Substances in Vietnam: A Review of Environmental Contamination and Human Exposure
Minh, N. H., Anh, D. H., Tran, T. M., Anh, H. Q., Mai, P. T. N., Nam, V. D., Viet, P. H., & Minh, T. B. (2016) · ACS symposium series · doi:10.1021/bk-2016-1243.ch003 · Cited by 7 · see citing works
Chae, H., Choi, J. Y., Jeon, H., Kim, W., Park, N.-Y., Lee, I., Moon, H.-B., Kho, Y., & Choi, K. (2025) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2025.114644 · Cited by 5 · see citing works
Fujii, Y., Harada, K. H., Kobayashi, H., Haraguchi, K., & Koizumi, A. (2020) · Toxics · doi:10.3390/toxics8020023 · Cited by 5 · see citing works
Self-citationZhao, Y., Hu, S., Jin, H.-B., Fan, C.-B., Liao, K., Zhang, S.-Z., & Xue, J. (2024) · Toxics · doi:10.3390/toxics12100764 · Cited by 3 · see citing works
Liu, B.-L., Ma, X., Li, J., Liu, S., & Yu, Y. (2025) · Journal of Environmental Science · doi:10.1016/j.jes.2025.06.048 · Cited by 2 · see citing works
Harada, K. H., Lyu, Z., Zhu, J., Zou, X., & Fujii, Y. (2025) · Comprehensive analytical chemistry · doi:10.1016/bs.coac.2025.01.004 · Cited by 2 · see citing works
Self-citationSornsil, D., & Harada, K. H. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c02042 · Cited by 1 · see citing works
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Human exposures to per- and polyfluoroalkyl substances (PFAS) and their biomonitoring
Harada, K. H., & Fujii, Y. (2026) · Journal of Environmental Chemistry · doi:10.5985/jec.36.s44
Self-citationFukuman, Y., Honda, M., & Nagato, E. G. (2026) · Atmospheric Pollution Research · doi:10.1016/j.apr.2026.103075
- Authors
- Harada, K. H., Hitomi, T., Niisoe, T., Takanaka, K., Kamiyama, S., Watanabe, T., Moon, C.-S., Yang, H.-R., Hung, N. N., & Koizumi, A.
- Affiliations
- Kyoto University (JP)
- Takayama Red Cross Hospital (JP)
- Tohoku Bunkyo University (JP)
- Catholic University of Pusan (KR)
- Hanoi Medical University (VN)
- Corresponding author
- Koizumi, Akio
- Venue
- Environment International
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 37
- Issue
- 7
- Pages
- 1183-1189
- ISSN
- 0160-4120 (ISSN-L)
- OpenAlex
- W1966810141
- Cited by
- 78
- References
- 37
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 3 · 2020: 7 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 10 · 2015: 7 · 2014: 5 · 2013: 2 · 2012: 4
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Environment International (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Kyoto University Research Information Repository (Kyoto University) (submittedVersion)
- Funders
- Ministry of Health, Labour and Welfare (H21-Food-003)
- Örebro Universitet
- Japan Society for the Promotion of Science (23590739, 23590740)
- Japan Science and Technology Agency (1300001)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Fluorine in Organic Chemistry
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- perfluorinated carboxylic acids, perfluorooctanoic acid, perfluoroundecanoic acid, perfluorononanoic acid, perfluorodecanoic acid, perfluorododecanoic acid, human exposure, environmental contamination, Japan, Korea, Vietnam
- MeSH terms
- Adult, Aged, Caproates, Caprylates, Carboxylic Acids, Cities, Decanoic Acids, Environmental Exposure, Environmental Pollutants, Female, Fluorocarbons, Humans, Japan, Male, Middle Aged, Vietnam, Republic of Korea
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