Cited by 244Per- and polyfluoroalkyl substances researchToxic Organic Pollutants ImpactSynthesis and properties of polymers

Decline in Perfluorooctanesulfonate and Other Polyfluoroalkyl Chemicals in American Red Cross Adult Blood Donors, 2000−2006

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Olsen, Geary W., Mair, David C., Church, Timothy R., Ellefson, Mark E., Reagen, William K., Boyd, Theresa M., Herron, Ross M., Medhdizadehkashi, Zahra +4 more·2008·Environmental Science & Technology

Abstract

In 2000, 3M Company, the primary global manufacturer, announced a phase-out of perfluorooctanesulfonyl fluoride (POSF, C8F17SO2F)-based materials after perfluorooctanesulfonate (PFOS, C8F17SO3-) was reported in human populations and wildlife. The purpose of this study was to determine whether PFOS and other polyfluoroalkyl concentrations in plasma samples, collected in 2006 from six American Red Cross adult blood donor centers, have declined compared to nonpaired serum samples from the same locations in 2000-2001. For each location, 100 samples were obtained evenly distributed by age (20-69 years) and sex. Analytes measured, using tandem mass spectrometry, were PFOS, perfluorooctanoate (PFOA), perfluorohexanesulfonate (PFHxS), perfluorobutanesulfonate (PFBS), N-methyl perfluorooctanesulfonamidoacetate (Me-PFOSA-AcOH), and N-ethyl perfluorooctanesulfonamidoacetate (Et-PFOSA-AcOH). The geometric mean plasma concentrations were for PFOS 14.5 ng/mL (95% CI 13.9-15.2), PFOA 3.4 ng/ mL (95% CI 3.3-3.6), and PFHxS 1.5 ng/mL (95% CI 1.4-1.6). The majority of PFBS, Me-PFOSA-AcOH, and Et-PFOSA-AcOH concentrations were less than the lower limit of quantitation. Age- and sex-adjusted geometric means were lower in 2006 (approximately 60% for PFOS, 25% for PFOA, and 30% for PFHxS) than those in 2000-2001. The declines for PFOS and PFHxS are consistent with their serum elimination half-lives and the time since the phase-out of POSF-based materials. The shorter serum elimination half-life for PFOA and its smaller percentage decline than PFOS suggests PFOA concentrations measured in the general population are unlikely to be solely attributed to POSF-based materials. Direct and indirect exposure sources of PFOA could include historic and ongoing electrochemical cell fluorination (ECF) of PFOA, telomer production of PFOA, fluorotelomer-based precursors, and other fluoropoly-mer production.

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Crossref · 10.1021/es800071x

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Authors
Olsen, G. W., Mair, D. C., Church, T. R., Ellefson, M. E., Reagen, W. K., Boyd, T. M., Herron, R. M., Medhdizadehkashi, Z., Nobiletti, J. B., Rios, J. A., Butenhoff, J. L., & Zobel, L. R.
Affiliations
University of Minnesota (US)
Corresponding author
Olsen, Geary W.
Venue
Environmental Science & Technology
Published
2008-05-21
Volume
42
Issue
13
Pages
4989-4995
ISSN
  • 0013-936X (ISSN-L)
  • 1520-5851
OpenAlex
W2081746168
Cited by
244
References
23
Citations by year
2026: 6 · 2025: 4 · 2024: 7 · 2023: 9 · 2022: 8 · 2021: 12 · 2020: 3 · 2019: 8 · 2018: 12 · 2017: 8 · 2016: 7 · 2015: 11 · 2014: 12 · 2013: 14 · 2012: 20
FWCI
25.06
Type
journal article
Language
en
Open access
Locations
  • Environmental Science & Technology (publishedVersion, other-oa)
  • PubMed (publishedVersion)
Funders
U.S. Food and Drug Administration
Topics
  • Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Physical Sciences › Materials Science › Polymers and Plastics › Synthesis and properties of polymers
Keywords
PFOS, perfluorooctanoic acid, PFHxS, perfluorobutanesulfonate, PFOSA, plasma concentration, blood donors, temporal trends
MeSH terms
Adult, Aged, Caprylates, Chromatography, High Pressure Liquid, Environmental Monitoring, Environmental Pollutants, Female, Fluorocarbons, Humans, Male, Middle Aged, Sulfonic Acids, United States, Linear Models, Alkanesulfonic Acids, Tandem Mass Spectrometry

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