Changes in Synaptic Transmission, Calcium Current, and Neurite Growth by Perfluorinated Compounds Are Dependent on the Chain Length and Functional Group
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Scientific and public concerns on perfluorinated compounds (PFCs) are increasingly growing because of their environmental persistency, bioaccumulation, and extensive distribution throughout the world. Little is known about the effects of PFCs on neural function and the underlying mechanisms. Recent evidence suggests that the toxicological effects of PFCs are closely correlated with their carbon chain lengths. In this present work, the actions of PFCs with varying chain length on cultured rat hippocampal neurons and possible action patterns were examined. Increases in the frequencies of spontaneous miniature postsynaptic current (mPSC) were commonly found in cultured neurons when perfused with PFCs. The increase of mPSC frequency was in proportion to the carbon chain length, and the potency of perfluorinated carboxylates was less pronounced than that of perfluorinated sulfonates. A comparable but less perceptible trend was also found for the amplitudes of voltage-dependent calcium current (I(Ca)). No regular change in pattern was observed for the effects of PFCs on activation and inactivation kinetics of I(Ca). Furthermore, prolonged treatment of PFCs inhibited the neurite growth of neuronsto various degrees. Comparisons between nonfluorinated and perfluorinated analogues demonstrated thatthefluorination in alkyl chain exerts stronger actions on neurons as compared to the surfactant activity. This study shows that PFCs exhibit adverse effects on cultured neurons to various extents, which is dependent on the carbon chain length and functional group attached to the fully fluorinated alkyl chain.
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Perfluorinated sulfonates are more neurotoxic than carboxylates.
“highlight perfluorinated sulfonates as more neurotoxic than carboxylates (Liao et al., 2009; Liu et al., 2011).”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Liao et al., 2009
Disruption of neuronal activities seems to increase with carbon chain length and fluorination level.
“disruption of neuronal activities seems to increase with carbon chain length and fluorination level”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Liao et al., 2009
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- Authors
- Liao, C., Wang, T., Cui, L., Zhou, Q., Duan, S., & Jiang, G.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Jiang, Guibin
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-02-18
- Volume
- 43
- Issue
- 6
- Pages
- 2099-2104
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W2085396811
- Cited by
- 74
- References
- 31
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 4 · 2017: 5 · 2016: 6 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 5
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- green
- ir.rcees.ac.cn
- Licence
- cc-by-nc-nd
- Locations
- Environmental Science & Technology (publishedVersion)
- PubMed (publishedVersion)
- Research Center for Eco-Environmental Sciences OpenIR (Chinese Academy of Sciences) (submittedVersion, cc-by-nc-nd)
- Knowledge Repository of Yantai Institute of Coastal Zone Research, CAS (Yantai Institute of Coastal Zone Research) (submittedVersion)
- Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Fluorine in Organic Chemistry
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- perfluorinated compounds, synaptic transmission, miniature postsynaptic currents, voltage-dependent calcium current, neurite outgrowth, hippocampal neurons, carbon chain length, perfluorinated carboxylic acids, perfluorinated sulfonates, fluorination, neurotoxicity, surfactant activity
- MeSH terms
- Action Potentials, Animals, Calcium, Environmental Pollutants, Hydrocarbons, Fluorinated, Synaptic Transmission, Neurites, Rats, Sprague-Dawley, Rats
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