Cited by 176Per- and polyfluoroalkyl substances researchMetabolomics and Mass Spectrometry StudiesPeroxisome Proliferator-Activated Receptors

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Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults

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Chen, Zhanghua, Yang, Tingyu, Walker, Douglas I., Thomas, Duncan C., Qiu, Chenyu, Chatzi, Leda, Alderete, Tanya L., Kim, Jeniffer S., Conti, David V., Breton, Carrie V., Liang, Donghai, Hauser, Elizabeth R., Jones, Dean P., Gilliland, Frank D.·2020·Environment International

DOI 10.1016/j.envint.2020.106091PMC PMC8009052

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Abstract

BACKGROUND: Per- and polyfluoroalkyl substances (PFASs) exposure is ubiquitous among the US population and has been linked to adverse health outcomes including cardiometabolic diseases, immune dysregulation and endocrine disruption. However, the metabolic mechanism underlying the adverse health effect of PFASs exposure is unknown. OBJECTIVE: The aim of this project is to investigate the association between PFASs exposure and altered metabolic pathways linked to increased cardiometabolic risk in young adults. METHODS: A total of 102 young adults with 82% overweight or obese participants were enrolled from Southern California between 2014 and 2017. Cardiometabolic outcomes were assessed including oral glucose tolerance test (OGTT) measures, body fat and lipid profiles. High-resolution metabolomics was used to quantify plasma exposure levels of three PFAS congeners and intensity profiles of the untargeted metabolome. Fasting concentrations of 45 targeted metabolites involved in fatty acid and lipid metabolism were used to verify untargeted metabolomics findings. Bayesian Kernel Machine Regression (BKMR) was used to examine the associations between PFAS exposure mixture and cardiometabolic outcomes adjusting for covariates. Mummichog pathway enrichment analysis was used to explore PFAS-associated metabolic pathways. Moreover, the effect of PFAS exposure on the metabolic network, including metabolomic profiles and cardiometabolic outcomes, was investigated. RESULTS: Higher exposure to perfluorooctanoic acid (PFOA) was associated with higher 30-minute glucose levels and glucose area under the curve (AUC) during the OGTT (p < 0.001). PFAS exposure was also associated with altered lipid pathways, which contributed to the metabolic network connecting PFOA and higher glucose levels following the OGTT. Targeted metabolomics analysis indicated that higher PFOA exposure was associated with higher levels of glycerol (p = 0.006), which itself was associated with higher 30-minute glucose (p = 0.006). CONCLUSIONS: Increased lipolysis and fatty acid oxidation could contribute to the biological mechanisms linking PFAS exposure and impaired glucose metabolism among young adults. Findings of this study warrants future experimental studies and epidemiological studies with larger sample size to replicate.

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Fig. 1. Associations of perfluoroalkyl substances (PFASs) exposure mixture with 30-minute glucose levels and glucose area under the curve (AUC) measured during the oral glucose tolerance test (OGTT). Panels A) and B) present total effects of PFAS exposure mixture on glucose outcomes by quantiles of exposure levels. Panels C) and D) present differences of glucose outcomes in participants with individual PFAS chemical exposure [perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonic acid (PFHxS)] level at 90th percentile to participants with the exposure level at 10th percentile, while conditioned on the other two PFAS chemical exposures both at 50th percentiles across all participants.CC BY-NC-ND · PubMed Central

Fig. 2. Metabolic pathways that are associated with PFAS exposures revealed by the analysis of high-resolution metabolomics data (metabolomic features having coefficients of variation ≤ 0.3 across 5 analytical batches) from fasting and 30-minute post glucose challenge plasma samples using both HILIC positive and C18 negative modes. The horizontal scale indicates the significance levels of pathway enrichment tests conducted by Mummichog software.CC BY-NC-ND · PubMed Central

Fig. 3. Integrated network analysis among PFAS exposures, metabolites with confirmed identity and multiple cardiometabolic outcomes including adiposity measures, oral-glucose tolerance test-derived glucose and insulin measures, insulin resistance index and lipid profiles. Each PFAS exposure, metabolite and outcome variable is treated as a node in the entire network and are plotted using different shapes. Sub-networks are classified by different colors and represent more connections between specific PFAS congener with a group of metabolomic signatures and cardiometabolic outcomes. Panel A presents the network among PFAS exposure, metabolite intensity in fasting plasma samples and cardiometabolic outcomes. Panel B presents the network among PFAS exposure, metabolite intensity in 30-minute post glucose challenge plasma samples and cardiometabolic outcomes. PFAS exposures: PFOA = Perfluorooctanoic acid; PFOS = Perfluorooctane sulfonate; PFHxS = Perfluorohexane sulfonic acid. Metabolites: LysoPC = LysoPC (18:0); FA8:0 = FA 8:0 (Octanoate); FA16:0 = FA 16:0 (Palmitate); FA18:3 = FA 18:3n-3 or n-6 (Linolenic acid); FA18:2 = FA 18:2 (Linoleic acid); FA18:1 = FA 18:1 (Oleic acid); FA18:0 = FA 18:0 (Stearic acid); FA20:4 = FA 20:4 (Arachidonic acid); FA20:3 = FA 20:3 (Homolinoleic acid); Sph = Sphingosine; Cit = Citrulline; Met = Methionine; Glu = Glucose; Man = Mannose/Galactose; Lac = Lactate; Gln = Glutamine; HMG = Hydroxymethylglutarate; KIV = Oxovalerate/Ketoisovalerate. Cardiometabolic outcomes: 30-min GLU = 30-min glucose after OGTT; 2-hr GLU = 2-hour glucose after OGTT; Glu AUC = OGTT glucose area under the curve; Fasting Ins = Fasting insulin; 30-min Ins = 30-min insulin after OGTT; 2-hr Ins = 2-hour insulin after OGTT; Ins AUC = OGTT insulin area under the curve; HFF = Hepatic fat fraction; HOMA-β = Homeostatic model assessment β-cell function; Matsuda = Matsuda index; HOMA-IR = Homeostatic model assessment insulin resistance; SAAT = Subcutaneous adipose tissue; BMI = Body mass index; Body fat % = Body fat percent; VAT = Visceral adipose tissue; VAT/SAAT = VAT-to-SAAT ratio; LDL = Low-density lipoprotein.CC BY-NC-ND · PubMed Central

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Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · cited 3×
“Statistical analysis 1) PFAS association with cardiometabolic outcomes: Triglycerides, VLDL cholesterol, insulin traits, HOMA-IR and Matsuda Index were log transformed to approximate normal distributions.”
MethodInfluential
Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study
Toprak, Ö., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,772
Asymptotic Confidence Intervals for Indirect Effects in Structural Equation Models
Sobel, M. E. (1982) · Sociological Methodology · doi:10.2307/270723 · Cited by 12,810
Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp
Matsuda, M., & DeFronzo, R. A. (1999) · Diabetes Care · doi:10.2337/diacare.22.9.1462 · Cited by 5,621
Proposed minimum reporting standards for chemical analysis: Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI)
Sumner, L. W., Amberg, A., Barrett, D., Beale, M. H., Beger, R., Daykin, C. A., Fan, T. W.-M., Fiehn, O., Goodacre, R., Griffin, J. L., et al. (2007) · Metabolomics · doi:10.1007/s11306-007-0082-2 · Cited by 5,368
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
Newgard, C. B., An, J., Bain, J. R., Muehlbauer, M. J., Stevens, R. D., Lien, L. F., Haqq, A. M., Shah, S. H., Arlotto, M., Slentz, C. A., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.02.002 · Cited by 3,165
A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects
Sunderland, E. M., Hu, X. C., Dassuncao, C., Tokranov, A. K., Wagner, C. C., & Allen, J. G. (2019) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-018-0094-1 · Cited by 2,786
Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures
Bobb, J. F., Valeri, L., Henn, B. C., Christiani, D. C., Wright, R. O., Mazumdar, M., Godleski, J. J., & Coull, B. A. (2014) · Biostatistics · doi:10.1093/biostatistics/kxu058 · Cited by 1,873
Environmental Protection Agency (EPA)
Philander, S. G. (2008) · Sage eBooks · doi:10.4135/9781412963893.n235 · Cited by 1,683

Show all 47 references

Research works printed but not linked: 2

Salihovic, 2018, Identification of metabolic profiles associated with human exposure to perfluoroalkyl substances, J. Expo Sci. Environ. Epidemiol.
Patsouris, 2004, PPARalpha governs glycerol metabolism, J. Clin. Invest., 114, 94, 10.1172/JCI200420468 · DOI

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Sands, M., Zhang, X., Gal, A., Laws, M. J., Spinella, M. J., Erdogan, Z. M., & Irudayaraj, J. (2024) · Environment International · doi:10.1016/j.envint.2024.108556 · Cited by 28
Serum metabolome associated with novel and legacy per- and polyfluoroalkyl substances exposure and thyroid cancer risk: A multi-module integrated analysis based on machine learning
Wang, F., Lin, Y., Qin, L., Zeng, X., Jiang, H., Liang, Y., Wen, S., Li, X., Huang, S., Li, C., et al. (2024) · Environment International · doi:10.1016/j.envint.2024.109203 · Cited by 28
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Hyötyläinen, T., Bodin, J., Duberg, D., Dirven, H. A. A. M., Nygaard, U. C., & Orešič, M. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.721507 · Cited by 27
Associations between Mixture of Perfluoroalkyl Substances and Lipid Profile in a Highly Exposed Adult Community in the Veneto Region
Batzella, E., Jeddi, M. Z., Pitter, G., Russo, F., Fletcher, T., & Canova, C. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191912421 · Cited by 27
Per- and poly-fluoroalkyl substances (PFAS) and human health: a review of exposure routes and potential toxicities across the lifespan
Ly, C. Y. S., Alrazihi, L. A., Wong, S. T., & Wong, S. F. (2025) · Environmental Toxicology and Chemistry · doi:10.1093/etojnl/vgaf172 · Cited by 28
Associations of a Prenatal Serum Per- and Polyfluoroalkyl Substance Mixture with the Cord Serum Metabolome in the HOME Study
Hall, A. M., Fleury, E. S., Papandonatos, G. D., Buckley, J. P., Cecil, K. M., Chen, A., Lanphear, B. P., Yolton, K. A., Walker, D. I., Pennell, K. D., et al. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c07515 · Cited by 24
Fatty Acid Metabolic Impairment in Soil Microbes Induced by PFAS: Dependence on the Fluorocarbon Chain Length, Headgroups, and Ether Attached
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Do perfluoroalkyl substances aggravate the occurrence of obesity-associated glucolipid metabolic disease?
Liu, H., Hu, W., Li, X., Hu, F., Xi, Y., Su, Z., Huang, Y., Liu, B., & Zhang, C. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111724 · Cited by 20
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Ma, X., Cai, D., Chen, Q., Zhu, Z., Zhang, S., Wang, Z., Hu, Z., Shen, H., & Meng, Z. (2024) · Metabolites · doi:10.3390/metabo14070392 · Cited by 24
Impacts of PFAS Exposure on Neurodevelopment: A Comprehensive Literature Review
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Threats of per- and poly-fluoroalkyl pollutants to susceptible populations
Mao, X., Liu, Y., Wei, Y., Li, X., Liu, Y., Su, G., Wang, X., Jia, J., & Yan, B. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.171188 · Cited by 21
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Gebreab, K. Y., Benetti, D. D., Grosell, M., Stieglitz, J. D., & Berry, J. P. (2022) · Ecotoxicology · doi:10.1007/s10646-022-02576-w · Cited by 21
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Wang, Z., Zhang, B., Zhang, J., Xu, S., Dai, Y., Ding, J., Guo, J., Qi, X., Chang, X., Wu, C., et al. (2024) · Environment International · doi:10.1016/j.envint.2024.109037 · Cited by 18
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Kinkade, C. W., Rivera‐Núñez, Z., Thurston, S. W., Kannan, K., Miller, R. K., Brunner, J., Wong, E., Groth, S. W., O’Connor, T. G., & Barrett, E. S. (2023) · Environmental Health · doi:10.1186/s12940-023-01009-3 · Cited by 16
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Idris, O. A., & Erasmus, M. (2024) · Environmental Advances · doi:10.1016/j.envadv.2024.100598 · Cited by 18
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Hussey, M. R., Kornberg, T. G., Sherrick, J. M., Olson, A. M., Kind, J. A., & Pérez, A. L. (2025) · European Journal of Epidemiology · doi:10.1007/s10654-025-01271-4 · Cited by 17
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You, Y., Guan, X., Zhao, H., Wu, T., Wang, C., Xiao, Y., Zhou, Y., Hong, S., Fu, Y., He, M., et al. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.127059 · Cited by 16
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HNF4A as a potential target of PFOA and PFOS leading to hepatic steatosis: Integrated molecular docking, molecular dynamic and transcriptomic analyses
Li, R., Zhang, Z., Xuan, Y., Wang, Y., Zhong, Y., Zhang, L., Zhang, J., Chen, Q., Yu, S., & Yuan, J. (2024) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2024.110867 · Cited by 15
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Rotander, A., Gómez, M. J., Mueller, J. F., Toms, L.-M. L., & Hyötyläinen, T. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.176004 · Cited by 13
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Liver and cardiometabolic markers and conditions in a cross-sectional study of three Australian communities living with environmental per- and polyfluoroalkyl substances contamination
Lazarevic, N., Smurthwaite, K. S., D’Este, C. A., Lucas, R. M., Armstrong, B. K., Clements, A., Trevenar, S. M., Gad, I., Hosking, R., Law, H. D., et al. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115621 · Cited by 12
Association between prenatal exposure to perfluoroalkyl substance mixtures and intrauterine growth restriction risk: A large, nested case–control study in Guangxi, China
Chen, C.-C., Song, Y., Tang, P., Pan, D., Wei, B., Liang, J. L., Sheng, Y., Liao, Q., Huang, D., Liu, S., et al. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115209 · Cited by 11
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Acosta-Tlapalamatl, M., Romo-Gómez, C., Anaya‐Hernández, A., Juárez-Santacruz, L., Gaytán-Oyarzún, J. C., Sandoval, O. A. A., & Garcı́a-Nieto, E. (2022) · Toxics · doi:10.3390/toxics10070380 · Cited by 11
Next generation risk assessment of hair dye HC yellow no. 13: Ensuring protection from liver steatogenic effects
Sepehri, S., Win, D. D., Heymans, A., Goethem, F. V., Rodrigues, R. M., Rogiers, V., & Vanhaecke, T. (2025) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2025.105794 · Cited by 10
In utero exposure to perfluoroalkyl substances and early childhood BMI trajectories: A mediation analysis with neonatal metabolic profiles
Zeng, X., Chen, T., Cui, Y., Zhao, J., Chen, Q., Yu, Z., Zhang, Y., Han, L., Chen, Y., & Zhang, J. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.161504 · Cited by 10
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Sun, S., Xie, Z., Song, X., Wen, S., Yuan, W., Miao, M., Ji, H., & Liang, H. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115751 · Cited by 10
Development, Validation, and Clinical Assessment of a Liquid Chromatography-Tandem Mass Spectrometry Serum Assay for per- and Polyfluoroalkyl Substances (PFAS) Recommended by the National Academies of Science, Engineering, and Medicine (NASEM)
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González-Alvarez, M. E., & Keating, A. F. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116614 · Cited by 9

Authors: Chen, Z., Yang, T., Walker, D. I., Thomas, D. C., Qiu, C., Chatzi, L., Alderete, T. L., Kim, J. S., Conti, D. V., Breton, C. V., Liang, D., Hauser, E. R., Jones, D. P., & Gilliland, F. D.
Affiliations: University of Southern California (US)
Icahn School of Medicine at Mount Sinai (US)
University of Colorado Boulder (US)
Emory University (US)
Duke University (US)
Corresponding author: Chen, Zhanghua
ORCID: Chen, Zhanghua
Yang, Tingyu
Walker, Douglas I.
Thomas, Duncan C.
Qiu, Chenyu
Chatzi, Leda
Alderete, Tanya L.
Kim, Jeniffer S.
Conti, David V.
Breton, Carrie V.
Liang, Donghai
Hauser, Elizabeth R.
Jones, Dean P.
Gilliland, Frank D.
Venue: Environment International
Publisher: Elsevier BV
Published: 2020-12
Volume: 145
Pages: 106091
ISSN: 0160-4120 (ISSN-L)
DOI: 10.1016/j.envint.2020.106091
PMC: PMC8009052
OpenAlex: W3083268731
Cited by: 176
References: 47
Citations by year: 2026: 25 · 2025: 39 · 2024: 33 · 2023: 33 · 2022: 27 · 2021: 18 · 2020: 1
FWCI: 7.29
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Environment International (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
PubMed Central (acceptedVersion, cc-by-nc-nd)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institute of Environmental Health Sciences
U.S. Environmental Protection Agency
Topics: Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: per- and polyfluoroalkyl substances, PFAS exposure, perfluorooctanoic acid, impaired glucose metabolism, lipid metabolism, fatty acid metabolism, glycerol, lipolysis, fatty acid oxidation, cardiometabolic risk, young adults, obesity, oral glucose tolerance test, plasma metabolome
MeSH terms: Bayes Theorem, Environmental Pollutants, Fatty Acids, Fluorocarbons, Glucose, Humans, Lipids, Alkanesulfonic Acids, Lipid Metabolism, Young Adult

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Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults

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