Association between air pollution and lung function growth in southern California children: results from a second cohort
Abstract
A cohort of 1,678 Southern California children, enrolled as fourth graders in 1996, was followed for 4 years to determine whether the growth in lung function of the children was associated with their exposure to ambient air pollutants. These subjects comprised the second cohort of fourth grade children participating in the Children's Health Study. Significant deficits in lung function growth rate were associated with exposure to acid vapor, NO(2), particles with aerodynamic diameter less than 2.5 microm (PM(2.5)), and elemental carbon. For example, the average annual growth rates of maximal midexpiratory flow and forced expiratory volume in 1 second were reduced by approximately 11% (p = 0.005) and 5% (p = 0.03), respectively, across the observed range of acid exposure. Exposure to acid vapor was also associated with reductions in the ratio of maximal midexpiratory flow to forced vital capacity (p = 0.02), whereas exposure to ozone was correlated with reduced growth in peak flow rate (p = 0.006). Larger deficits in lung function growth rate were observed in children who reported spending more time outdoors. These findings provide important replication of our previous findings of an effect of air pollution on lung function growth that were based on the first fourth-grade cohort from the Children's Health Study (Am J Respir Crit Care Med 2000;162:1383-1390).
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Long-term exposures to ozone have been associated with lower lung function and deteriorated or abnormal lung development in children.
“Long-term exposures to ozone have been associated with lower lung function and deteriorated or abnormal lung development in children (31, 32).”
From Ozone pollution: A Major health hazard worldwide (2019) · cites this paper as [32]
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- Authors
- Gauderman, W. J., Gilliland, G. F., Vora, H., Avol, E., Stram, D., McConnell, R., Thomas, D., Lurmann, F., Margolis, H. G., Rappaport, E. B., Berhane, K., & Peters, J. M.
- Affiliations
- University of Southern California (US)
- Department of Preventive Medicine, University of Southern California, Los Angeles; Sonoma Technology Inc., Petaluma; and California Environmental Protection Agency, Sacramento, California
- ORCID
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-07-01
- Volume
- 166
- Issue
- 1
- Pages
- 76-84
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2804108711
- Cited by
- 405
- References
- 25
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 12 · 2023: 10 · 2022: 8 · 2021: 27 · 2020: 16 · 2019: 20 · 2018: 22 · 2017: 20 · 2016: 11 · 2015: 18 · 2014: 11 · 2013: 16 · 2012: 22
- FWCI
- 14.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Keywords
- air pollution, lung function growth, children, ambient air pollutants, nitrogen dioxide, PM2.5, elemental carbon, ozone, forced expiratory volume, Children's Health Study, outdoor time, replication
- MeSH terms
- Air Pollutants, California, Child, Environmental Exposure, Female, Humans, Longitudinal Studies, Lung, Male, Residence Characteristics, Respiratory Mechanics, Linear Models
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