Involvement of IL-1β in acute stress-induced worsening of cerebral ischaemia in rats
Abstract
Stress is known to be one of the risk factors of stroke. Most of the knowledge on the effects of stress on cerebrovascular disease in humans is restricted to catecholamines and glucocorticoids effects on blood pressure and/or development of atherosclerosis. However, few experimental studies have examined the possible mechanisms by which stress may affect stroke outcome. We have used an acute stress protocol consisting of the exposure of male Fischer rats to an acute, single exposure immobilisation protocol (6 h) prior to permanent middle cerebral artery occlusion (MCAO), and we have found that stress worsens behavioural and neurological outcomes and increased infarct size after MCAO. The possible regulatory role of the TNFalpha and IL-1beta was studied by looking at the release of these cytokines in brain. The results of the present study showed an increase in IL-1beta release in cerebral cortex after exposure to acute stress. Brain levels of IL-1beta are also higher in previously stressed MCAO rats than in MCAO animals without stress. Pharmacological blockade of IL-1beta with an antibody anti-IL-1beta led to a decrease in the infarct size as well as in neurological and behavioural deficits after MCAO. In summary, our results indicate that IL-1beta, but not TNFalpha, accounts at least partly for the worsening of MCAO consequences in brain of rats exposed to acute stress.
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Prior acute stress worsens stroke damage by increasing IL-1β levels in the postischemic cortex.
“As evidence, prior acute stress worsens stroke damage by increasing IL-1β levels in the postischemic cortex (Caso et al., 2007).”
From The Stressed CNS: When Glucocorticoids Aggravate Inflammation (2009) · cites this paper as Caso et al., 2007
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Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke
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- Authors
- Caso, J. R., Moro, M. A., Lorenzo, P., Lizasoain, I., & Leza, J. C.
- Affiliations
- Universidad Complutense de Madrid (ES)
- Venue
- European Neuropsychopharmacology
- Publisher
- Elsevier BV
- Published
- 2007-09
- Volume
- 17
- Issue
- 9
- Pages
- 600-607
- ISSN
- 0924-977X (ISSN-L)
- OpenAlex
- W2153342338
- Cited by
- 84
- References
- 52
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 7 · 2021: 8 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 9 · 2012: 5
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- IL-1β, acute stress, cerebral ischemia, middle cerebral artery occlusion, stroke, infarct size, TNF-α, neuroinflammation, neurological deficit, behavioural deficits
- MeSH terms
- Animals, Antibodies, Behavior, Animal, Brain Ischemia, Corticosterone, Disease Models, Animal, Injections, Intraventricular, Male, Neurologic Examination, Rats, Inbred F344, Stress, Psychological, Time Factors, Tumor Necrosis Factor-alpha, Brain Infarction, Rats, Interleukin-1beta
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