Treatment adherence in schizophrenia: A patient-level meta-analysis of combined CATIE and EUFEST studies
Open accessAbstract
The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) obtained a sample of 1493 chronic schizophrenia patients. The European First Episode Schizophrenia Trial (EUFEST) studied a sample of 498 patients. We have combined these two samples to study the predictors and correlates of adherence to treatment. Here we report on adherence to pharmacological treatment at the six and twelve month assessments of these trials with a combined subsample of 1154 schizophrenia patients. Individual patients׳ data were used for analyses. We used logistic regression to examine the effects of substance use, akathisia, parkinsonism, dyskinesia, hostility, and insight on pharmacological adherence. The results showed that reduced adherence to pharmacological treatment was associated with substance use (p=0.0003), higher levels of hostility (p=0.0002), and impaired insight (p<0.0001). Furthermore, poor adherence to study medication was associated with earlier discontinuation in the combined data. The clinical implications of the results point to the importance of routine assessments and interventions to address patients׳ insight and comorbid substance use and the establishment of therapeutic alliance.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Poor insight predicts medication discontinuation and less adherence over time.
“Examining the relationship of insight and adherence over time, Zhou et al 31 found that poor insight was predictive of medication discontinuation at one-year follow-up.”
From Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments (2018) · cites this paper as [32]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378 · see citing works
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
(1998) · PubMed · Cited by 10,216 · see citing works
Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia
Lieberman, J. A., Stroup, T. S., McEvoy, J. P., Swartz, M. S., Rosenheck, R. A., Perkins, D. O., Keefe, R. S. E., Davis, S. M., Davis, C. E., Lebowitz, B. D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051688 · Cited by 5,892 · see citing works
The mini international neuropsychiatric interview
Lecrubier, Y., Sheehan, D. V., Hergueta, T., & Weiller, E. (1998) · European Psychiatry · doi:10.1016/s0924-9338(99)80239-9 · Cited by 5,882 · see citing works
A RATING SCALE FOR EXTRAPYRAMIDAL SIDE EFFECTS
Simpson, G. M., B., M., B., G., Angus, J. W. S., P., F. R. C., & M., D. P. (1970) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1970.tb02066.x · Cited by 3,265 · see citing works
Multiple imputation of discrete and continuous data by fully conditional specification
van Buuren, S. (2007) · Statistical Methods in Medical Research · doi:10.1177/0962280206074463 · Cited by 2,827 · see citing works
A Rating Scale for Drug-Induced Akathisia
Barnes, T. R. E. (1989) · The British Journal of Psychiatry · doi:10.1192/bjp.154.5.672 · Cited by 2,179 · see citing works
Flexible Imputation of Missing Data
van Buuren, S. (2012) · doi:10.1201/b11826 · Cited by 2,022 · see citing works
Lacro, J. P., Dunn, L. B., Dolder, C. R., Leckband, S. G., & Jeste, D. V. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n1007 · Cited by 1,383 · cited 3× · see citing works
“The other eight studies demonstrated little or no association (Lacro et al., 2002).”
BackgroundResultAssessment of insight in psychosis
AMADOR, X. F., Strauss, D. H., Yale, S. A., FLAUM, M. M., Endicott, J., & Gorman, J. M. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.6.873 · Cited by 1,100 · see citing works
Kahn, R. S., Fleischhacker, W. W., Boter, H., Davidson, M., Vergouwe, Y., Keet, I. P., Gheorghe, M. D., Rybakowski, J. K., Galderisi, S., Libiger, J., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60486-9 · Cited by 1,088 · see citing works
Self-citationCompliance therapy in psychotic patients: randomised controlled trial
Kemp, R., Hayward, P., Applewhaite, G., Everitt, B. J., & David, A. S. (1996) · BMJ · doi:10.1136/bmj.312.7027.345 · Cited by 633 · see citing works
Violence and Severe Mental Illness: The Effects of Substance Abuse and Nonadherence to Medication
Swartz, M. S., Swanson, J. W., Hiday, V. A., Borum, R., Wagner, H. R., & Burns, B. J. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.2.226 · Cited by 628 · see citing works
Velligan, D. I., Weiden, P. J., Sajatovic, M., Scott, J. L., Carpenter, D., Ross, R., & Docherty, J. P. (2009) · PubMed · Cited by 625 · see citing works
Weiden, P. J., Kozma, C., Grogg, A., & Locklear, J. (2004) · Psychiatric Services · doi:10.1176/appi.ps.55.8.886 · Cited by 621 · see citing works
Why Do Schizophrenic Patients Refuse to Take Their Drugs?
Putten, T. V. (1974) · Archives of General Psychiatry · doi:10.1001/archpsyc.1974.01760130049008 · Cited by 578 · see citing works
Predictors of Noncompliance in Patients With Schizophrenia
Perkins, D. O. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n1206 · Cited by 546 · see citing works
Insight in Schizophrenia. Its Relationship to Acute Psychopathology
McEvoy, J. P., Apperson, L. J., Appelbaum, P. S., Ortlip, P., Brecosky, J., Hammill, K., Geller, J. L., & Roth, L. H. (1989) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198901000-00007 · Cited by 528 · see citing works
Ascher‐Svanum, H., Faries, D. E., Zhu, B., Ernst, F. R., Swartz, M. S., & Swanson, J. W. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0317 · Cited by 485 · see citing works
Medication adherence of individuals with a first episode of psychosis
Coldham, E. L., Addington, J., & Addington, D. E. (2002) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2002.02437.x · Cited by 415 · see citing works
Robinson, D. G., Woerner, M. G., Alvir, J. M. J., Bilder, R. M., Hinrichsen, G. A., & Lieberman, J. A. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00312-7 · Cited by 290 · see citing works
Abnormal Involuntary Movement Scale
Marks, W. J. (2010) · doi:10.1017/cbo9780511763281.014 · Cited by 271 · see citing works
Mohamed, S., Rosenheck, R., McEvoy, J., Swartz, M., Stroup, S., & Lieberman, J. A. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn067 · Cited by 258 · see citing works
Relationships Among Subjective and Objective Measures of Adherence to Oral Antipsychotic Medications
Velligan, D. I., Wang, M., Diamond, P. M., Glahn, D. C., Castillo, D., Bendle, S., Lam, Y. W. F., Ereshefsky, L., & Miller, A. L. (2007) · Psychiatric Services · doi:10.1176/ps.2007.58.9.1187 · Cited by 250 · see citing works
Abnormal Involuntary Movement Scale (AIMS).
(1988) · PubMed · Cited by 237 · see citing works
Insight in Schizophrenia: Involvement of Self-Reflection Networks?
van der Meer, L., de Vos, A. E., Stiekema, A. P. M., Pijnenborg, G. H. M., van Tol, M., Nolen, W. A., David, A. S., & Aleman, A. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs122 · Cited by 221 · see citing works
Velligan, D. I., Weiden, P. J., Sajatovic, M., Scott, J. L., Carpenter, D. P., ROSS, R. W., & Docherty, J. P. (2010) · Journal of Psychiatric Practice · doi:10.1097/01.pra.0000388626.98662.a0 · Cited by 180 · see citing works
The St. Hans Rating Scale for extrapyramidal syndromes: reliability and validity
Gerlach, J., Korsgaard, S., Clemmesen, P., Lauersen, A. ‐. L., Magelund, G., Noring, U., Povlsen, U. J., Bech, P., & Casey, D. E. (1993) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1993.tb03366.x · Cited by 166 · see citing works
Perkins, D. O., Johnson, J. L., Hamer, R. M., Zipursky, R. B., Keefe, R. S. E., Centorrhino, F., Green, A. I., Glick, I. D., Kahn, R. S., & Sharma, T. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2005.10.016 · Cited by 164 · see citing works
Self-citationLindenmayer, J., Liu‐Seifert, H., Kulkarni, P. M., Kinon, B. J., Stauffer, V. L., Edwards, S., Chen, L., Adams, D. H., Ascher‐Svanum, H., Buckley, P. F., et al. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04221 · Cited by 162 · see citing works
Self-citationAscher‐Svanum, H., Zhu, B., Faries, D. E., Lacro, J. P., & Dolde, C. R. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0715 · Cited by 147 · see citing works
Swartz, M. S., Wagner, H. R., Swanson, J. W., Stroup, T. S., McEvoy, J. P., Canive, J. M., Miller, D. D., Reimherr, F., McGee, M., Khan, A., et al. (2006) · Journal of Nervous & Mental Disease · doi:10.1097/01.nmd.0000202575.79453.6e · Cited by 146 · see citing works
Swartz, M. S., Swanson, J. W., Hiday, V. A., Borum, R., Wagner, H. R., & Burns, B. J. (1998) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s001270050213 · Cited by 141 · see citing works
Rettenbacher, M. A., Hofer, A., Eder, U., Hummer, M., Kemmler, G., Weiss, E. M., & Fleischhacker, W. (2004) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v65n0908 · Cited by 126 · see citing works
Self-citationPsychopharmacology: Perspectives on Medication Adherence and Atypical Antipsychotic Medications
Velligan, D. I., Lam, F., Ereshefsky, L., & Miller, A. L. (2003) · Psychiatric Services · doi:10.1176/appi.ps.54.5.665 · Cited by 105 · see citing works
Hofer, A., Rettenbacher, M. A., Widschwendter, C. G., Kemmler, G., Hummer, M., & Fleischhacker, W. W. (2005) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-005-0633-3 · Cited by 88 · see citing works
Self-citationAdherence to Atypical Antipsychotic Treatment Among Newly Treated Patients
Cooper, D., Moisan, J., & Grégoire, J. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0601 · Cited by 88 · see citing works
Risk profiles for non‐adherence to antipsychotic medications
McCann, T. V., BOARDMAN, G., Clark, E., & Lu, L. (2008) · Journal of Psychiatric and Mental Health Nursing · doi:10.1111/j.1365-2850.2008.01277.x · Cited by 67 · see citing works
Gäebel, W., Riesbeck, M., von Wilmsdorff, M., Burns, T., Derks, E. M., Kahn, R. S., Wulf Rössler, A., & Fleischhacker, W. W. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.02.001 · Cited by 63 · see citing works
Self-citationImproving Treatment Adherence in Your Patients with Schizophrenia
Cañas, F., Alptekın, K., Azorin, J. M., Dubois, V., Emsley, R. A., Garcı́a, A. G., Gorwood, P. A. P. M., Haddad, P. M., Naber, D., Olivares, J. M., et al. (2013) · Clinical Drug Investigation · doi:10.1007/s40261-012-0047-8 · Cited by 50 · see citing works
Substance Abuse and the Management of Medication Nonadherence in Schizophrenia
Wilk, J. E., Marcus, S. C., West, J. C., Countis, L., Hall, R., Regier, D. A., & Olfson, M. (2006) · The Journal of Nervous and Mental Disease · doi:10.1097/01.nmd.0000221289.54911.63 · Cited by 48 · see citing works
Hofer, A., Rettenbacher, M. A., Edlinger, M., Kemmler, G., Widschwendter, C. G., & Fleischhacker, W. W. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.01087.x · Cited by 40 · see citing works
Self-citationExtrapyramidal symptoms during treatment of first schizophrenia episode: Results from EUFEST
RYBAKOWSKI, J. K., Vansteelandt, K., Remlinger-Molenda, A., Fleischhacker, W. W., Kahn, R. S., & Peuskens, J. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.07.001 · Cited by 34 · see citing works
Self-citationChan, S. K. W., Hui, C. L. M., Wong, G. H. Y., Lee, E. H. M., Chang, W. C., & Chen, E. Y. H. (2013) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000000068 · Cited by 25 · see citing works
Czobor, P., Volavka, J., Derks, E. M., Bitter, I., Libiger, J., Kahn, R. S., & Fleischhacker, W. W. (2013) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3182856886 · Cited by 17 · see citing works
Self-citationEffectiveness of antipsychotics: is the CATIE trial a tsunami?
Stip, É., & Anselmo, K. (2007) · PubMed · Cited by 13 · see citing works
Drug and alcohol trajectories among adults with schizophrenia: Data from the CATIE study
Dorn, R. A. V., Desmarais, S. L., Tueller, S., Jolley, J. M., Johnson, K. L., & Swartz, M. S. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.05.006 · Cited by 6 · see citing works
Flagged first, then by citations
1 of the 49 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Velligan DI Weiden PJ Sajatovic M Scott J Carpenter D Ross R Docherty JP The expert consensus guideline series: adherence problems in patients with serious and persistent mental illness. J. Clin. Psychiatry 2009b 70 Suppl. 4 S1 S46 19686636
Cited by
Sorted by citations
Barnes, T. R. E., Drake, R., Paton, C., Cooper, S. J., Deakin, J. F. W., Ferrier, I. N., Gregory, C. J., Haddad, P. M., Howes, O. D., Jones, I. R., et al. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119889296 · Cited by 607 · see citing works
Adherence to Antipsychotic Medication in Bipolar Disorder and Schizophrenic Patients
García, S., Martínez‐Cengotitabengoa, M., López-Zurbano, S., Zorrilla, E. P., López‐Mahía, P., Vieta, E., & González-Pinto, A. M. (2016) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000523 · Cited by 363 · see citing works
Lysaker, P. H., Pattison, M. L., Leonhardt, B. L., Phelps, S., & Vohs, J. L. (2018) · World Psychiatry · doi:10.1002/wps.20508 · Cited by 247 · see citing works
Carbon, M., Kane, J. M., Leucht, S., & Correll, C. U. (2018) · World Psychiatry · doi:10.1002/wps.20579 · Cited by 214 · see citing works
Insight and medication adherence in schizophrenia: An analysis of the CATIE trial
Kim, J., Ozzoude, M., Nakajima, S., Shah, P., Caravaggio, F., Iwata, Y., Luca, V. D., Graff‐Guerrero, A., & Gerretsen, P. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.05.011 · Cited by 138 · see citing works
Barriers to the Use of Long-Acting Injectable Antipsychotics in the Management of Schizophrenia
Parellada, E., & Bioque, M. (2016) · CNS Drugs · doi:10.1007/s40263-016-0350-7 · Cited by 89 · see citing works
Is It Possible to Predict the Future in First-Episode Psychosis?
Suvisaari, J., Mantere, O., Keinänen, J., Mäntylä, T. J. S., Rikandi, E., Lindgren, M., Kieseppä, T., & Raij, T. T. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00580 · Cited by 88 · see citing works
Tielman, M. L., Neerincx, M. A., van Meggelen, M., Franken, I., & Brinkman, W.-P. (2018) · Technology and Health Care · doi:10.3233/thc-170899 · Cited by 63 · see citing works
“therapist alliance is related to adherence [32,33].”
BackgroundOwie, G. O., Olotu, S. O., & James, B. O. (2018) · Trends in Psychiatry and Psychotherapy · doi:10.1590/2237-6089-2017-0077 · Cited by 49 · see citing works
Zisman‐Ilani, Y., Shern, D. L., Deegan, P. E., Kreyenbuhl, J. A., Dixon, L. B., Drake, R. E., Torrey, W. C., Mishra, M. K., Gorbenko, K. O., & Elwyn, G. J. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1707-x · Cited by 46 · see citing works
Resistance is not futile: treatment-refractory schizophrenia – overview, evaluation and treatment
Faden, J., & Citrome, L. (2018) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2018.1543409 · Cited by 46 · see citing works
Self-citationIngestible Sensors and Medication Adherence: Focus on Use in Serious Mental Illness
Alipour, A., Gabrielson, S. W., & Patel, P. B. (2020) · Pharmacy · doi:10.3390/pharmacy8020103 · Cited by 45 · see citing works
Prevalence of and Risk Factors for Extrapyramidal Side Effects of Antipsychotics
Misdrahi, D., Tessier, A., Daubigney, A., Meissner, W. G., Schürhoff, F., Boyer, L., Godin, O., Bulzacka, E., Aouizerate, B., Andrianarisoa, M., et al. (2019) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.18m12246 · Cited by 43 · see citing works
Decriminalizing mental illness: specialized policing responses
Dempsey, C., Quanbeck, C., Bush, C., & Kruger, K. (2019) · CNS Spectrums · doi:10.1017/s1092852919001640 · Cited by 43 · see citing works
A qualitative study of medication adherence amongst people with schizophrenia
Clifford, L., Crabb, S., Turnbull, D. A., Hahn, L. A., & Galletly, C. A. (2020) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2020.06.002 · Cited by 39 · see citing works
Tang, C. T., Chua, E. C., Chew, Q. H., He, Y., Si, T., Chiu, H. F. K., Xiang, Y., Kato, T. A., Kanba, S., Shinfuku, N., et al. (2020) · Asia-Pacific Psychiatry · doi:10.1111/appy.12393 · Cited by 39 · see citing works
Mervis, J., Vohs, J. L., & Lysaker, P. H. (2022) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2022.2049757 · Cited by 37 · see citing works
Citrome, L. (2015) · Expert Review of Clinical Pharmacology · doi:10.1586/17512433.2016.1121809 · Cited by 37 · see citing works
Self-citationOlagunju, A. T., Clark, S. R., & Baune, B. T. (2019) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867419837358 · Cited by 33 · see citing works
Treatment Compliance in the Long-Term Paranoid Schizophrenia Telemedicine Study
Krzystanek, M., Krysta, K., & Skałacka, K. (2017) · Journal of Technology in Behavioral Science · doi:10.1007/s41347-017-0016-4 · Cited by 31 · see citing works
The impact of self-stigmatization on medication attitude in schizophrenia patients
Feldhaus, T., Falke, S., von Gruchalla, L., Maisch, B., Uhlmann, C., Bock, E., & Lencer, R. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.01.012 · Cited by 30 · see citing works
Long-Acting Injectable Atypical Antipsychotic Use in Adolescents: An Observational Study
Fortea, A., Ilzarbe, D., Espinosa, L., Solerdelcoll, M., de Castro, C., Oriolo, G., Sugranyes, G., & Baeza, I. (2018) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2017.0096 · Cited by 31 · see citing works
Volavka, J., Dorn, R. A. V., Citrome, L., Kahn, R. S., Fleischhacker, W. W., & Czobor, P. (2015) · European Psychiatry · doi:10.1016/j.eurpsy.2015.10.003 · Cited by 30 · see citing works
Self-citationLeijala, J., Kampman, O., Suvisaari, J., & Eskelinen, S. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03037-0 · Cited by 29 · see citing works
Citrome, L., & Volavka, J. (2021) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000275 · Cited by 28 · see citing works
Self-citationImproving adherence to pharmacological treatment for schizophrenia: a systematic assessment
Curto, M., Fazio, F., Ulivieri, M., Navari, S., Lionetto, L., & Baldessarini, R. J. (2021) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2021.1882996 · Cited by 29 · see citing works
Johnson, K. L., Desmarais, S. L., Tueller, S., Grimm, K. J., Swartz, M. S., & Dorn, R. A. V. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.09.039 · Cited by 27 · see citing works
Rezansoff, S. N., Moniruzzaman, A., Fazel, S., Procyshyn, R. M., & Somers, J. M. (2016) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-016-1259-7 · Cited by 26 · see citing works
Joshi, K., Lafeuille, M., Kamstra, R. L., Tiggelaar, S., Lefèbvre, P., Kim, E., Yue, Y. G., & Tandon, N. (2017) · Journal of Comparative Effectiveness Research · doi:10.2217/cer-2017-0043 · Cited by 25 · see citing works
Clozapine augmentation strategies
Roerig, J. L. (2019) · Mental Health Clinician · doi:10.9740/mhc.2019.11.336 · Cited by 25 · see citing works
Kim, J., Plitman, E., Nakajima, S., Alshehri, Y., Iwata, Y., Chung, J. K., Caravaggio, F., Menon, M., Blumberger, D. M., Pollock, B. G., et al. (2019) · European Psychiatry · doi:10.1016/j.eurpsy.2019.06.007 · Cited by 21 · see citing works
Arango, C., Buitelaar, J. K., Correll, C. U., Díaz‐Caneja, C. M., Figueira, M. L., Fleischhacker, W. W., Marcotulli, D., Parellada, M., & Vitiello, B. (2022) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2022.04.005 · Cited by 21 · see citing works
Self-citationAdherence, insight and disability in paranoid schizophrenia
García‐Cabeza, I., Díaz‐Caneja, C. M., Bruna, M. M. O., & Portugal, E. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.09.021 · Cited by 21 · see citing works
How long should antipsychotic treatment be continued after a single episode of schizophrenia?
Emsley, R. A., Kilian, S., & Phahladira, L. S. (2016) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000249 · Cited by 20 · see citing works
Beebe, L. H., Smith, K., & Phillips, C. (2016) · Issues in Mental Health Nursing · doi:10.1080/01612840.2016.1214855 · Cited by 20 · see citing works
Smith, R. L., Tveito, M., Kyllesø, L., Jukić, M. M., Ingelman‐Sundberg, M., Andreassen, O. A., & Molden, E. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.06.007 · Cited by 20 · see citing works
Beebe, L. H., Smith, K., & Phillips, C. (2017) · Journal of Psychosocial Nursing and Mental Health Services · doi:10.3928/02793695-20170119-04 · Cited by 19 · see citing works
Baeza, I., Fortea, A., Ilzarbe, D., & Sugranyes, G. (2023) · Pediatric Drugs · doi:10.1007/s40272-023-00558-x · Cited by 18 · see citing works
Treatment-resistant schizophrenia: challenges and implications for clinical practice.
Šagud, M. (2015) · PubMed · Cited by 18 · see citing works
García‐Pérez, L., Linertová, R., Serrano-Pérez, P., Trujillo‐Martín, M. M., Rodríguez‐Rodríguez, L., Valcárcel‐Nazco, C., & del Pino‐Sedeño, T. (2020) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651501.2020.1782434 · Cited by 18 · see citing works
Güney, E., Alnıak, İ., & Erkıran, M. (2020) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2020.102068 · Cited by 17 · see citing works
Medication nonadherence among South American patients with schizophrenia
Caqueo‐Urízar, A., Alfonso Urzúa, M., Fond, G. B., & Boyer, L. (2017) · Patient Preference and Adherence · doi:10.2147/ppa.s144961 · Cited by 16 · see citing works
Ishigooka, J., Nakagome, K., Ohmori, T., Iwata, N., Inada, K., Iga, J., Kishi, T., Fujita, K., Kikuchi, Y. S., Shichijo, T., et al. (2021) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13304 · Cited by 15 · see citing works
Poor Insight in Schizophrenia Patients in China: a Meta-Analysis of Observational Studies
Li, W., Zhang, H.-H., Wang, Y., Zhang, L., Ungvari, G. S., Cheung, T. C. C., & Xiang, Y. (2020) · Psychiatric Quarterly · doi:10.1007/s11126-020-09786-7 · Cited by 15 · see citing works
Beebe, L. H., Smith, K., & Phillips, C. (2016) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2016.01.010 · Cited by 15 · see citing works
The Effect of Therapeutic Alliance on Attitudes Toward Psychiatric Medications in Schizophrenia
Lim, M., Li, Z., Xie, H., Tan, B., & Lee, J. (2021) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001449 · Cited by 14 · see citing works
The debate regarding maintenance treatment with antipsychotic drugs in schizophrenia
Davidson, M. (2018) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2018.20.3/mdavidson · Cited by 14 · see citing works
The Psychosocial Impact of Insight Paradox and Internalized Stigma in Chronic Psychotic Disorders
García, J. J. M., Hodann-Caudevilla, R. M., Castaño, A. G., Garrido, S. A., Tischhauser, R. D., Rada, Á. P., & Salom, R. (2025) · Behavioral Sciences · doi:10.3390/bs15040410 · Cited by 15 · see citing works
Schandrin, A., Norton, J. L., Raffard, S., Aouizerate, B., Berna, F. S., Brunel, L., Chéreau, I., d’Amato, T., Denizot, H., Dubertret, C., et al. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.07.029 · Cited by 13 · see citing works
Brahim, L. O., Hanganu, C., & Gros, C. P. (2019) · Journal of the American Psychiatric Nurses Association · doi:10.1177/1078390319878773 · Cited by 12 · see citing works
Roux, P., Faivre, N., Urbach, M., Aouizerate, B., Brunel, L., Capdevielle, D., Chéreau, I., Dubertret, C., Dubreucq, J., Fond, G. B., et al. (2023) · Schizophrenia Research · doi:10.1016/j.schres.2022.12.037 · Cited by 12 · see citing works
Khosravani, V., Sharifibastan, F., Aghaeimazraji, M., Berk, M., & Ardestani, S. M. S. (2024) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2024.107087 · Cited by 12 · see citing works
Self-reported treatment adherence among psychiatric in- and outpatients
Karpov, B., Joffe, G., Aaltonen, K. I., Oksanen, J., Suominen, K. H., Melartin, T. K., Baryshnikov, I., Koivisto, M., Heikkinen, M. E., & Isometsä, E. T. (2018) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2018.1538387 · Cited by 12 · see citing works
Davidson, M., & Carpenter, W. T. (2023) · Schizophrenia Bulletin · doi:10.1093/schbul/sbad145 · Cited by 10 · see citing works
Misdrahi, D., Dupuy, M., Dansou, Y., Boyer, L., Berna, F. S., Capdevielle, D., Chéreau, I., Coulon, N., d’Amato, T., Dubertret, C., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02640-x · Cited by 11 · see citing works
Exploring Hidden Issues in the Use of Antipsychotic Polypharmacy in the Treatment of Schizophrenia
Kim, J., Pae, C., Han, C., Bahk, W., Lee, S.-J., Patkar, A. A., & Masand, P. S. (2021) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2021.19.4.600 · Cited by 11 · see citing works
Cuevas, C. D. L., & de León, J. (2020) · Patient Preference and Adherence · doi:10.2147/ppa.s242693 · Cited by 11 · see citing works
Smithnaraseth, A., Seeherunwong, A., Panitrat, R., & Tipayamongkholgul, M. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-03001-4 · Cited by 10 · see citing works
Kim, J., Song, J., Kambari, Y., Plitman, E., Shah, P., Iwata, Y., Caravaggio, F., Brown, E. E., Nakajima, S., Chakravarty, M. M., et al. (2023) · Schizophrenia · doi:10.1038/s41537-023-00347-y · Cited by 9 · see citing works
Dahan, S., Behrbalk, P., Stolovy, T., & Greenberger, C. (2016) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2016.03.002 · Cited by 9 · see citing works
Aguglia, A., Fusar‐Poli, L., Amerio, A., Placenti, V., Concerto, C., Martinotti, G., Carrà, G., Bartoli, F., D’Agostino, A., Serafini, G., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.784366 · Cited by 8 · see citing works
Iasevoli, F., Fagiolini, A. M., Formato, M. V., Prinzivalli, E., Giordano, S., Balletta, R., Luca, V. D., & de Bartolomeis, A. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.01.015 · Cited by 7 · see citing works
Accuracy of self-reported adherence and therapeutic drug monitoring in a psychiatric emergency ward
Brasso, C., Cisotto, M., Ghirardini, C., Pennazio, F., Villari, V., & Rocca, P. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.114214 · Cited by 7 · see citing works
Insight's level in borderline personality disorder, questioning consciousness
Martin, S. S., Graziani, P., & Del-Monte, J. (2020) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2020.100045 · Cited by 7 · see citing works
Poor insight and self-disorders in schizophrenia: an empirical study
Nilsson, L. S., Nordgaard, J., Henriksen, M. G., Parnas, J., & Rasmussen, A. R. (2025) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-025-02035-7 · Cited by 6 · see citing works
Calhoun, S. (2018) · Journal of Forensic Psychiatry and Psychology · doi:10.1080/14789949.2018.1477976 · Cited by 6 · see citing works
Daniell, K., Kim, J., Iwata, Y., Caravaggio, F., Brown, E. E., Remington, G. J., Agid, O., Graff‐Guerrero, A., & Gerretsen, P. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.10.016 · Cited by 6 · see citing works
Falkai, P., Schennach, R., Lincoln, T. M., Schaub, A., & Hasan, A. (2016) · Springer eBooks · doi:10.1007/978-3-642-45028-0_64-1 · Cited by 6 · see citing works
Gil‐Berrozpe, G. J., Peralta, V., Sánchez-Torres, A. M., Moreno-Izco, L., de Jalón, E. G., Peralta, D., Janda, L., Cuesta, M. J., Ballesteros, A., Hernández, R., et al. (2023) · Schizophrenia Research · doi:10.1016/j.schres.2022.12.046 · Cited by 6 · see citing works
Stockbridge, E. L., Webb, N. J., Dhakal, E., Garg, M., Loethen, A. D., Miller, T. L., & Nandy, K. (2021) · BMC Health Services Research · doi:10.1186/s12913-020-06045-0 · Cited by 6 · see citing works
Medication non-adherence in re-admitted patients at a psychiatry hospital: A qualitative study
Zwide, G. E., Dewet, Z. T., & Sokudela, F. B. (2025) · South African Journal of Psychiatry · doi:10.4102/sajpsychiatry.v31i0.2345 · Cited by 5 · see citing works
Joshi, K., Rao, S., & Mehta, S. C. (2025) · Cureus · doi:10.7759/cureus.86258 · Cited by 5 · see citing works
Stabell, L. A., Johnsen, E., Kroken, R. A., Løberg, E., Blindheim, A. A., Joa, I., Reitan, S. K., Rettenbacher, M. A., Munk‐Jørgensen, P., & Gjestad, R. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04981-9 · Cited by 5 · see citing works
Clinical and psychological correlates of insight dimensions in patients with early psychosis
Kam, T. K., Lui, T. T., Lau, F. C., Chan, S. K. W., Lee, E. H. M., Hui, C. L. M., Suen, Y. N., Lui, S. S. Y., Chen, E. Y. H., & Chang, W. C. (2021) · Early Intervention in Psychiatry · doi:10.1111/eip.13191 · Cited by 4 · see citing works
Introspective accuracy for substance use across a year of treatment for first episode psychosis
Mervis, J., Fischer, J., Cooper, S. E., Deckert, A. C., Lysaker, P. H., MacDonald, A. W., & Meyer-Kalos, P. (2021) · Schizophrenia Research Cognition · doi:10.1016/j.scog.2021.100200 · Cited by 4 · see citing works
Long-Acting Injectable Antipsychotics in the Treatment of Schizophrenia: Practical Considerations
Kverno, K. S., & Rozenberg, I. (2021) · Journal of Psychosocial Nursing and Mental Health Services · doi:10.3928/02793695-20210611-04 · Cited by 4 · see citing works
Investing in a Research Workforce With Personal Experience of Serious Mental Illness
Kimhy, D., Jones, N., & Dixon, L. B. (2022) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2022.2026 · Cited by 4 · see citing works
Shilbayeh, S. A. R., Aldosari, F. N., Al-Sahabi, W., Al-Saif, M., Al-Najjar, A. H., & Albogami, N. (2023) · Indian Journal of Pharmaceutical Education and Research · doi:10.5530/ijper.57.3.111 · Cited by 4 · see citing works
Song, J., Carmona-Torres, E., Kambari, Y., Chavez, S., Ueno, F., Koizum, T., Amaev, A., Abdolizadeh, A., Luca, V. D., Blumberger, D. M., et al. (2025) · Schizophrenia · doi:10.1038/s41537-024-00536-3 · Cited by 3 · see citing works
Beebe, L. H. (2017) · Medical & Clinical Reviews · doi:10.21767/2471-299x.1000048 · Cited by 3 · see citing works
Falkai, P., Schennach, R., Lincoln, T. M., Schaub, A., & Hasan, A. (2017) · Springer eBooks · doi:10.1007/978-3-662-49295-6_64 · Cited by 3 · see citing works
Adherence to Pharmacological Treatment Among Patients with Schizophrenia
Abdulkareem, M., & Mahmood, H. (2022) · Iraqi National Journal of Medicine · doi:10.37319/iqnjm.4.1.4 · Cited by 3 · see citing works
Recovery-Oriented Psychopharmacological Interventions in Schizophrenia
Mallet, J., Strat, Y. L., Dubertret, C., & Gorwood, P. A. P. M. (2022) · Comprehensive approach to psychiatry · doi:10.1007/978-3-030-98301-7_9 · Cited by 3 · see citing works
Adherencia a la medicación antipsicótica en pacientes indígenas con esquizofrenia
Caqueo‐Urízar, A., Escuela de Psicología y Filosofía, U. D. T., Alfonso Urzúa, M., Miranda‐Castillo, C., Irarrázaval, M., Escuela de Psicología, U. C. D. N., de Sociología, P. U. C. D. C. I., & Instituto Milenio para la Investigación en Depresión y Personalidad, S. (2016) · Salud Mental · doi:10.17711/sm.0185-3325.2016.035 · Cited by 3 · see citing works
The Challenge of Nonadherence in Schizophrenia
Lawrence, R. E., & Dixon, L. B. (2019) · Springer eBooks · doi:10.1007/978-3-030-12665-0_4 · Cited by 3 · see citing works
Liu, Z., Chen, W., Wang, X. Q., Huang, J., Gou, M., Han, H., Wang, J. P., Wang, D.-H., Chen, S., Xie, T., et al. (2026) · Schizophrenia Bulletin · doi:10.1093/schbul/sbag009 · Cited by 2 · see citing works
Suicidal risk in patients with aggression in schizophrenia: a systematic review
Bravve, L. V., Kaydan, M. A., & Kostyuk, G. P. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1560699 · Cited by 2 · see citing works
Long-acting Injectable Antipsychotics and Stigma: Some Considerations and Future Perspectives
Natale, A., Fusar‐Poli, L., Amerio, A., Escelsior, A., Serafini, G., Aguglia, E., Amore, M., & Aguglia, A. (2023) · Current Pharmaceutical Design · doi:10.2174/1381612829666230406102039 · Cited by 2 · see citing works
Kishi, T., Yoshimura, R., Matsuda, Y., Sakuma, K., & Iwata, N. (2020) · Pharmacopsychiatry · doi:10.1055/a-1096-1266 · Cited by 2 · see citing works
What Do Patients Want? Patient Satisfaction and Treatment Engagement
Webb, A. E., & Gearing, R. E. (2020) · doi:10.1002/9781119129530.ch2 · Cited by 2 · see citing works
Pseudo-Resistant Schizophrenia: Non-Adherence to Treatment
Kim, H., & Lee, S. J. (2020) · Korean Journal of Schizophrenia Research · doi:10.16946/kjsr.2020.23.2.51 · Cited by 1 · see citing works
Alisauskiene, R., Johnsen, E., Gjestad, R., Kroken, R. A., Jørgensen, H. A., & Løberg, E. (2021) · Substance Use & Misuse · doi:10.1080/10826084.2021.1958858 · Cited by 1 · see citing works
Leon-Morales, D., Navarro, J. B., Lamarca, M., González‐Higueras, F., Torres, P., Cid, J., Capell, E. F., Birulés, I., Ochoa, S., Vidal, C., et al. (2025) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2025.1655885 · Cited by 1 · see citing works
Song, J., Kim, J., Carmona-Torres, E., Kambari, Y., Ueno, F., Koizumi, T., Iwata, Y., Amaev, A., Luca, V. D., Blumberger, D. M., et al. (2026) · Schizophrenia Bulletin · doi:10.1093/schbul/sbag022 · Cited by 1 · see citing works
Hussein, F., Mohamed, H. S. I., & Eweida, R. S. (2019) · doi:10.7176/jep/10-1-13 · Cited by 1 · see citing works
Improving Treatment Adherence in Schizophrenia
El-Mallakh, P. L., & Findlay, L. (2016) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-016-0074-9 · Cited by 1 · see citing works
Progress in Schizophrenia Research and Treatment
(2020) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.18310 · Cited by 1 · see citing works
Psychopharmacology of Violent Behavior Among People with Severe Mental Disorders
Citrome, L., & Volavka, J. (2019) · Comprehensive approach to psychiatry · doi:10.1007/978-3-030-33188-7_14
Self-citationАлександровна, Г. А. (2021) · Сибирский вестник психиатрии и наркологии · doi:10.26617/1810-3111-2021-1(110)-13-18
Nonadherence and Mental Health Treatment in Homeless Populations
Hargrave, R., & Noufi, P. E. (2021) · Springer eBooks · doi:10.1007/978-3-030-70135-2_11
- Authors
- Czobor, P., Van Dorn, R. A., Citrome, L., Kahn, R. S., Fleischhacker, W. W., & Volavka, J.
- Affiliations
- Semmelweis University (HU)
- New York Medical College (US)
- Innsbruck Medical University (AT)
- New York University (US)
- Corresponding author
- Czobor, Pál
- Venue
- European Neuropsychopharmacology
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 25
- Issue
- 8
- Pages
- 1158-1166
- ISSN
- 0924-977X (ISSN-L)
- PMC
- PMC4860611
- OpenAlex
- W2125320544
- Cited by
- 112
- References
- 49
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 2 · 2023: 10 · 2022: 6 · 2021: 16 · 2020: 16 · 2019: 11 · 2018: 13 · 2017: 8 · 2016: 11 · 2015: 3
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Semmelweis University Repository (Semmelweis University) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Funders
- Bristol-Myers Squibb
- National Institute of Mental Health (R01MH093426)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- medication adherence, schizophrenia, antipsychotic drugs, substance use, hostility, insight, akathisia, parkinsonism, dyskinesia, drug discontinuation, therapeutic relationship, predictors of adherence
- MeSH terms
- Assessment of Medication Adherence, Humans, Schizophrenia, Schizophrenic Psychology, Antipsychotic Agents, Randomized Controlled Trials as Topic, Drug Monitoring, Medication Adherence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
