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The vagus nerve modulates BDNF expression and neurogenesis in the hippocampus

O’Leary, Olivia F., Ogbonnaya, Ebere S., Felice, Daniela, Levone, Brunno R., C. Conroy, Lorraine, Fitzgerald, Patrick, Bravo, Javier A., Forsythe, Paul +3 more·2018·European Neuropsychopharmacology
DOI 10.1016/j.euroneuro.2017.12.004
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Abstract

Accumulating evidence suggests that certain gut microbiota have antidepressant-like behavioural effects and that the microbiota can regulate neurogenesis and the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. The precise mechanisms underlying these effects are not yet clear. However, the vagus nerve is one of the primary bidirectional routes of communication between the gut and the brain and thus may represent a candidate mechanism. Yet, relatively little is known about the direct influence of vagus nerve activity on hippocampal function and plasticity. Thus, the aim of the present study was to determine whether constitutive vagus nerve activity contributes to the regulation of neurogenesis and BDNF mRNA expression in the hippocampus. To this end, we examined the impact of subdiaphragmatic vagotomy in adult mice on these parameters. We found that vagotomy decreased BDNF mRNA in all areas of the hippocampus. Vagotomy also reduced the proliferation and survival of newly born cells and decreased the number of immature neurons, particularly those with a more complex dendritic morphology. Taken together, these findings suggest that vagal nerve activity influences neurogenesis and BDNF mRNA expression in the adult hippocampus.

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  • Vagotomy reduces proliferation and survival of newborn cells and decreases the number of immature neurons.

    “Furthermore, vagotomy reduced proliferation and survival of newborn cells, decreased the number of immature neurons (O' Leary et al., 2018)”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as O' Leary et al., 2018

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Authors
O’Leary, O. F., Ogbonnaya, E. S., Felice, D., Levone, B. R., C. Conroy, L., Fitzgerald, P., Bravo, J. A., Forsythe, P., Bienenstock, J., Dinan, T. G., & Cryan, J. F.
Venue
European Neuropsychopharmacology
Publisher
Elsevier BV
Published
2018-02
Volume
28
Issue
2
Pages
307-316
ISSN
0924-977X
DOI
10.1016/j.euroneuro.2017.12.004
Cited by
139
References
11
Language
en
Licence
Funders
  • Science Foundation Ireland
  • Irish Government's National Development Plan (12/RC/2273)
  • Office of Naval Research (N00014-14-1-0787)
  • National Council for Scientific and Technological Development-CNPq of Brazil (249007/2013-4)
  • Mead Johnson
  • Cremo
  • Suntory Wellness
  • Nutricia
  • 4D Pharma

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