Ghrelin-Mediated Hippocampal Neurogenesis: Implications for Health and Disease

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Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

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Ghrelin Stimulates Gastric Acid Secretion and Motility in Rats

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Ghrelin controls hippocampal spine synapse density and memory performance

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Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure

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Ghrelin Modulates Brain Activity in Areas that Control Appetitive Behavior

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The vagus nerve modulates BDNF expression and neurogenesis in the hippocampus

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Hippocampal dopamine/DRD1 signaling dependent on the ghrelin receptor

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BDNF in the dentate gyrus is required for consolidation of “pattern-separated” memories.

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A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration

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Ghrelin’s Orexigenic Effect Is Modulated via a Serotonin 2C Receptor Interaction

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Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium.

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Local infusion of ghrelin enhanced hippocampal synaptic plasticity and spatial memory through activation of phosphoinositide 3-kinase in the dentate gyrus of adult rats

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Short-term calorie restriction enhances adult hippocampal neurogenesis and remote fear memory in a Ghsr-dependent manner

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Ghrelin regulates hippocampal neurogenesis in adult mice.

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Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus

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Ghrelin directly stimulates adult hippocampal neurogenesis: implications for learning and memory.

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Characterization of a novel ghrelin cell reporter mouse

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Zif268 / egr1 gene controls the selection, maturation and functional integration of adult hippocampal newborn neurons by learning

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The truncated ghrelin receptor polypeptide (GHS-R1b) is localized in the endoplasmic reticulum where it forms heterodimers with ghrelin receptors (GHS-R1a) to attenuate their cell surface expression

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The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation

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Ghrelin improves left ventricular dysfunction and cardiac cachexia in heart failure

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Cognitive enhancing effects of ghrelin receptor agonists

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The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice

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Multiple signaling pathways mediate ghrelin-induced proliferation of hippocampal neural stem cells

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Proliferative and Protective Effects of Growth Hormone Secretagogues on Adult Rat Hippocampal Progenitor Cells

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Ghrelin and memory: Differential effects on acquisition and retrieval

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Ghrelin administration enhances neurogenesis but impairs spatial learning and memory in adult mice.

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Ghrelin induced memory facilitation implicates nitric oxide synthase activation and decrease in the threshold to promote LTP in hippocampal dentate gyrus

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Pure human butyrylcholinesterase hydrolyzes octanoyl ghrelin to desacyl ghrelin.

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Acyl ghrelin improves cognition, synaptic plasticity deficits and neuroinflammation following amyloid β (Aβ1‐40) administration in mice

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Chronic ghrelin administration restores hippocampal long‐term potentiation and ameliorates memory impairment in rat model of Alzheimer's disease

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Ghrelin Enhances Food Odor Conditioning in Healthy Humans: An fMRI Study

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Exercise Pills: At the Starting Line

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The role of ghrelin-responsive mediobasal hypothalamic neurons in mediating feeding responses to fasting

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Ghrelin increases memory consolidation through hippocampal mechanisms dependent on glutamate release and NR2B-subunits of the NMDA receptor

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Endogenous ghrelin-O-acyltransferase (GOAT) acylates local ghrelin in the hippocampus

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A ghrelin receptor and oxytocin receptor heterocomplex impairs oxytocin mediated signalling

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Ghrelin is required for dietary restriction-induced enhancement of hippocampal neurogenesis: lessons from ghrelin knockout mice

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MK-0677, a Ghrelin Agonist, Alleviates Amyloid Beta-Related Pathology in 5XFAD Mice, an Animal Model of Alzheimer’s Disease

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Central acylated ghrelin improves memory function and hippocampal AMPK activation and partly reverses the impairment of energy and glucose metabolism in rats infused with β-amyloid.

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Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer’s disease mouse model

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Ghrelin-Attenuated Cognitive Dysfunction in Streptozotocin-induced Diabetic Rats

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Ghrelin-induced hippocampal neurogenesis and enhancement of cognitive function are mediated independently of GH/IGF-1 axis: lessons from the spontaneous dwarf rats.

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fMRI Studies of Reward Processing in Adolescent Depression

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Calorie restriction activates new adult born olfactory‐bulb neurones in a ghrelin‐dependent manner but acyl‐ghrelin does not enhance subventricular zone neurogenesis

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The growth hormone secretagogue hexarelin increases cell proliferation in neurogenic regions of the mouse hippocampus

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Ghrelin upregulates the phosphorylation of the GluN2B subunit of the NMDA receptor by activating GHSR1a and Fyn in the rat hippocampus

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The Impact of Ghrelin on the Survival and Efficacy of Dopaminergic Fetal Grafts in the 6-OHDA-Lesioned Rat.

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More than a feeling: sensation from cortical stimulation

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Choosing male or female

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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

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Can dietary patterns prevent cognitive impairment and reduce Alzheimer's disease risk: Exploring the underlying mechanisms of effects

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Hormones and behavior and the integration of brain-body science

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“A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes”

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Acylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease

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Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography

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Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood–brain barrier

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Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson’s Dementia in Humans

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Leptin and ghrelin dynamics: unraveling their influence on food intake, energy balance, and the pathophysiology of type 2 diabetes mellitus

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Ghrelin as a Biomarker of “Immunometabolic Depression” and Its Connection with Dysbiosis

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Expression of the growth hormone secretagogue receptor 1a (GHS‐R1a) in the brain

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Ghrelin and Cancer: Examining the Roles of the Ghrelin Axis in Tumor Growth and Progression

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Role of appetite hormone dysregulation in the cognitive function among patients with bipolar disorder and major depressive disorder

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Beyond Appetite: Acylated Ghrelin As A Learning, Memory and Fear Behavior-modulating Hormone.

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Acylation, a Conductor of Ghrelin Function in Brain Health and Disease

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Metabolic, neuroendocrine and behavioral effects of social defeat in male and female mice using the chronic non-discriminatory social defeat stress model

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Liver-expressed antimicrobial peptide 2 elevation contributes to age-associated cognitive decline

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Ghrelin system in Alzheimer's disease

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miR‑497/MIR497HG inhibits glioma cell proliferation by targeting CCNE1 and the miR‑588/TUSC1 axis

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Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders

Masule, M. V., Rathod, S., Agrawal, Y. O., Patil, C. R., Nakhate, K. T., Ojha, S. K., Goyal, S. N., & Mahajan, U. B. (2022) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2022.100113 · Cited by 14 · see citing works

Ghrelin Mitigates High-Glucose-Induced Oxidative Damage and Apoptosis in Lens Epithelial Cells

Bai, J., Jiang, G., Zhao, M., & Wang, S. (2022) · Journal of Diabetes Research · doi:10.1155/2022/1373533 · Cited by 14 · see citing works

Comparison of the effect of glyphosate and glyphosate-based herbicide on hippocampal neurogenesis after developmental exposure in rats

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The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice

Roberts, L. D., Hornsby, A., Thomas, A., Sassi, M., Kinzett, A., Hsiao, N., David, B. R., Good, M., Wells, T., & Davies, J. (2022) · bioRxiv · doi:10.15252/embr.202357269 · Cited by 11 · see citing works

Study on Improving the Modulatory Effect of Rhythmic Oscillations by Transcranial Magneto-Acoustic Stimulation

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Appetite to learn: An allostatic role for AgRP neurons in the maintenance of energy balance

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Astragaloside IV-mediated inhibition of oxidative stress by upregulation of ghrelin in type 2 diabetes–induced cognitive impairment

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Beyond Hunger: The Structure, Signaling, and Systemic Roles of Ghrelin

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LEAP2 in Physiology—A Narrative Review

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Ghrelin Acylation—A Post-Translational Tuning Mechanism Regulating Adult Hippocampal Neurogenesis

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Nose‐to‐Brain Delivery of Acyl‐Ghrelin Peptide Gold Nanoconjugates for Treatment of Neurodegenerative Diseases

Han, S., Utami, R., Qin, Y., Liam-or, R., Sreedharan, J., Davies, J. S., & Al-Jamal, K. T. (2025) · Small · doi:10.1002/smll.202504517 · Cited by 8 · see citing works

Potential role of ghrelin in neuroprotection and cognitive function: implications for diabetic cognitive impairment

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Therapeutic potential of GHSR-1A antagonism in alcohol dependence, a review

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Ghrelin promotes chronic diabetic wound healing by regulating keratinocyte proliferation and migration through the ERK1/2 pathway

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Exploring the role of acylated ghrelin and gut microbiome in delineating cognitive health in the elderly

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Ghrelin in Depression: A Promising Therapeutic Target

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Elevated Ghrelin Promotes Hippocampal Ghrelin Receptor Defects in Humanized Amyloid-β Knockin Mice During Aging

Tian, J., Du, E., Jia, K., Wang, T.-J., Guo, L., Zigman, J., & Du, H. (2023) · Journal of Alzheimer's Disease · doi:10.3233/jad-231002 · Cited by 1 · see citing works

Ghrelin attenuates drowning injury via dual effects on damage protection and immune repression

Chen, M., Lin, H., Gao, Y., Wang, Z., Li, Y., & Jin, F. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-795 · Cited by 2 · see citing works

The sex-specific relationship of ghrelin and cognition in Chinese han first-episode drug-naive major depressive disorder

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GHSRs in the olfactory bulb suppress food motivation and promote exploration without altering spatial memory in male mice

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Ghrelin Increases Glutamate Release at the Perforant Path‐Dentate Gyrus Granule Cell Synapses by Cross‐Activating Dopamine D 1 Receptors

Oraegbuna, C. S., Hasler, W. A., Chen, X., & Lei, S. (2025) · Journal of Cellular Physiology · doi:10.1002/jcp.70130 · Cited by 1 · see citing works

Nutritional state-dependent changes in subcortical limbic structures in anorexia nervosa are linked to leptin, ghrelin, and neurofilament light

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Expression of Ghrelin Receptor GHS-R1a in the Brain (Mini Review)

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Effects of Exogenous Ghrelin on Feeding, Drinking and Growth Hormone Secretion in African Ostrich Chicks

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