Interventions to improve adherence to antipsychotic medication in patients with schizophrenia–A review of the past decade

Barkhof, E.; Meijer, C.J.; de Sonneville, L.M.J.; Linszen, D.H.; de Haan, L.

doi:10.1016/j.eurpsy.2011.02.005

Cited by 183Medication Adherence and ComplianceSchizophrenia research and treatmentPsychotherapy Techniques and Applications

Interventions to improve adherence to antipsychotic medication in patients with schizophrenia–A review of the past decade

Barkhof, E., Meijer, C.J., de Sonneville, L.M.J., Linszen, D.H., de Haan, L.·2012·European Psychiatry

DOI 10.1016/j.eurpsy.2011.02.005

Open this paper in CoChat — free account

Abstract

Objective: Nonadherence to antipsychotic medication is highly prevalent in patients with schizophrenia and has a deleterious impact on the course of the illness. This review seeks to determine the interventions that were examined in the past decade to improve adherence rates. Method: The literature between 2000 and 2009 was searched for randomized controlled trials which compared a psychosocial intervention with another intervention or with treatment as usual in patients with schizophrenia. Results: Fifteen studies were identified, with a large heterogeneity in design, adherence measures and outcome variables. Interventions that offered more sessions during a longer period of time, and especially those with a continuous focus on adherence, seem most likely to be successful, as well as pragmatic interventions that focus on attention and memory problems. The positive effects of adapted forms of Motivational Interviewing found in earlier studies, such as compliance therapy, have not been confirmed. Conclusion: Nonadherence remains a challenging problem in schizophrenia. The heterogeneity of factors related to nonadherence calls for individually tailored approaches to promote adherence. More evidence is required to determine the effects of specific interventions.

Integrity signals

Registry

Crossref · 10.1016/j.eurpsy.2011.02.005

Cites

119 of 119 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Non-adherence contributes enormously to poor health outcome and needs substantial work to improve treatment outcomes.
“Non-adherence contributes enormously to poor health outcome and needs substantial work to improve treatment outcomes [80].”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [80]

Motivational interviewing: preparing people for change.
Miller, W. R., & Rollnick, S. (2002) · Cited by 7,002 · see citing works
Selective publication of antidepressant trials and its influence on apparent efficacy
Turner, E. H., Matthews, A. M., Linardatos, E., Tell, R. A., & Rosenthal, R. (2008) · New England Journal of Medicine · doi:10.1056/nejmsa065779 · Cited by 2,435 · see citing works
Alternative to Mental Hospital Treatment: I. Conceptual Model, Treatment Program, and Clinical Evaluation
Stein, L. I. (1980) · Archives of General Psychiatry · doi:10.1001/archpsyc.1980.01780170034003 · Cited by 1,902 · see citing works
Sociobehavioral Determinants of Compliance with Health and Medical Care Recommendations
Becker, M. H., & Maiman, L. A. (1975) · Medical Care · doi:10.1097/00005650-197501000-00002 · Cited by 1,584 · see citing works
Prevalence of and Risk Factors for Medication Nonadherence in Patients With Schizophrenia: A Comprehensive Review of Recent Literature
Lacro, J. P., Dunn, L. B., Dolder, C. R., Leckband, S. G., & Jeste, D. V. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n1007 · Cited by 1,383 · cited 4× · see citing works
“Also, general beliefs and attitudes towards health and taking medication, based on previous experiences, cultural factors and socioeconomic status, are associated with adherence [56].”
BackgroundResultInfluential
Predictors of Relapse Following Response From a First Episode of Schizophrenia or Schizoaffective Disorder
Robinson, D., Woerner, M. G., Alvir, J. M. J., Bilder, R., Goldman, R., Geisler, S., Koreen, A., Sheitman, B., Chakos, M., Mayerhoff, D., et al. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.3.241 · Cited by 1,327 · see citing works
Determinants of Medication Compliance in Schizophrenia: Empirical and Clinical Findings
Fenton, W. S., Blyler, C. R., & HEINSSEN, R. K. (1997) · Schizophrenia Bulletin · doi:10.1093/schbul/23.4.637 · Cited by 944 · see citing works
Family Psychoeducation, Social Skills Training, and Maintenance Chemotherapy in the Aftercare Treatment of Schizophrenia
Hogarty, G. E. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800070019003 · Cited by 917 · see citing works
The Schizophrenia Patient Outcomes Research Team (PORT): Updated Treatment Recommendations 2003
Lehman, A. F., Kreyenbuhl, J. A., Buchanan, R. W., Dickerson, F., Dixon, L. B., Goldberg, R., Green-Paden, L. D., Tenhula, W. N., Boerescu, D. A., Tek, C., et al. (2004) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007071 · Cited by 758 · see citing works
Compliance With Medication Regimens for Mental and Physical Disorders
Cramer, J. A., & Rosenheck, R. (1998) · Psychiatric Services · doi:10.1176/ps.49.2.196 · Cited by 725 · see citing works
The Expert Consensus Guideline Series
Velligan, D. I., Weiden, P. J., Sajatovic, M., Scott, J. L., Carpenter, D., Ross, R., & Docherty, J. P. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.7090su1cj · Cited by 692 · see citing works
Cost of Relapse in Schizophrenia
Weiden, P. J., & Olfson, M. (1995) · Schizophrenia Bulletin · doi:10.1093/schbul/21.3.419 · Cited by 665 · see citing works
Compliance therapy in psychotic patients: randomised controlled trial
Kemp, R., Hayward, P., Applewhaite, G., Everitt, B. J., & David, A. S. (1996) · BMJ · doi:10.1136/bmj.312.7027.345 · Cited by 633 · see citing works
The expert consensus guideline series: adherence problems in patients with serious and persistent mental illness.
Velligan, D. I., Weiden, P. J., Sajatovic, M., Scott, J. L., Carpenter, D., Ross, R., & Docherty, J. P. (2009) · PubMed · Cited by 625 · see citing works
Partial Compliance and Risk of Rehospitalization Among California Medicaid Patients With Schizophrenia
Weiden, P. J., Kozma, C., Grogg, A., & Locklear, J. (2004) · Psychiatric Services · doi:10.1176/appi.ps.55.8.886 · Cited by 621 · see citing works
A randomised multicentre trial of integrated versus standard treatment for patients with a first episode of psychotic illness
Petersen, L., Jeppesen, P., Thorup, A. A. E., Abel, M.-B., Øhlenschlæger, J., Christensen, T. Ø., Krarup, G., Jørgensen, P., & Nordentoft, M. (2005) · BMJ · doi:10.1136/bmj.38565.415000.e01 · Cited by 599 · see citing works
Family Management in the Prevention of Morbidity of Schizophrenia
Falloon, I. R. H. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790320059008 · Cited by 587 · see citing works
Why Do Schizophrenic Patients Refuse to Take Their Drugs?
Putten, T. V. (1974) · Archives of General Psychiatry · doi:10.1001/archpsyc.1974.01760130049008 · Cited by 578 · see citing works
Multiple-Family Groups and Psychoeducation in the Treatment of Schizophrenia
McFarlane, W. R. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950200069016 · Cited by 559 · see citing works
The Role of the Therapeutic Alliance in the Treatment of Schizophrenia: Relationship to Course and Outcome
Frank, A. F. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810150028006 · Cited by 552 · see citing works
Interventions to Improve Medication Adherence in Schizophrenia
Zygmunt, A., Olfson, M., Boyer, C. A., & Mechanic, D. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1653 · Cited by 541 · see citing works
Randomised controlled trial of compliance therapy
Kemp, R., Kirov, G., Everitt, B. J., Hayward, P., & David, A. S. (1998) · The British Journal of Psychiatry · doi:10.1192/bjp.172.5.413 · Cited by 525 · see citing works
Relapse Prevention in Schizophrenia With New-Generation Antipsychotics: A Systematic Review and Exploratory Meta-Analysis of Randomized, Controlled Trials
Leucht, S., Barnes, T. R. E., Kissling, W., Engel, R. R., Correll, C. U., & Kane, J. M. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.7.1209 · Cited by 518 · see citing works
Family Psychoeducation, Social Skills Training, and Maintenance Chemotherapy in the Aftercare Treatment of Schizophrenia
Hogarty, G. E. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810280056008 · Cited by 510 · see citing works
The Community Management of Schizophrenia
Tarrier, N., Barrowclough, C., Vaughn, C. E., Bamrah, J., Porceddu, K., Watts, S., & Freeman, H. L. (1988) · The British Journal of Psychiatry · doi:10.1192/bjp.153.4.532 · Cited by 465 · see citing works
Neuroleptic Withdrawal in Schizophrenic Patients
Gilbert, P. L. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950150005001 · Cited by 434 · see citing works
Overview of patient compliance with medication dosing: a literature review.
Rn, G. (1984) · PubMed · Cited by 422 · see citing works
A Controlled Trial of Social Intervention in the Families of Schizophrenic Patients: Two Year Follow-up
Leff, J., Kuipers, L., Berkowitz, R., & Sturgeon, D. (1985) · The British Journal of Psychiatry · doi:10.1192/bjp.146.6.594 · Cited by 399 · see citing works
Family-Based Intervention for Schizophrenic Patients in China: A Randomised Controlled Trial
Xiong, W., Phillips, M. R., Hu, X., Wang, R., Dai, Q., Kleinman, J., & Kleinman, A. (1994) · British Journal of Psychiatry · doi:10.1192/bjp.165.2.239 · Cited by 341 · see citing works
Should we pay the patient? Review of financial incentives to enhance patient compliance
Giuffrida, A., & Torgerson, D. J. (1997) · BMJ · doi:10.1136/bmj.315.7110.703 · Cited by 337 · see citing works
The metabolic effects of antipsychotic medications
Newcomer, J. W., & Haupt, D. W. (2006) · The Canadian Journal of Psychiatry · doi:10.1177/070674370605100803 · Cited by 315 · see citing works
Defining and Assessing Adherence to Oral Antipsychotics: A Review of the Literature
Velligan, D. I., Lam, Y.-W. F., Glahn, D. C., Barrett, J. A., Maples, N. J., Ereshefsky, L., & Miller, A. L. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbj075 · Cited by 310 · see citing works
Relapse and Rehospitalization During Maintenance Treatment of Schizophrenia
Schooler, N. R. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830170079011 · Cited by 298 · see citing works
Predictors of medication discontinuation by patients with first-episode schizophrenia and schizoaffective disorder
Robinson, D. G., Woerner, M. G., Alvir, J. M. J., Bilder, R. M., Hinrichsen, G. A., & Lieberman, J. A. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00312-7 · Cited by 290 · see citing works
A Trial of Family Therapy v. a Relatives Group for Schizophrenia
Leff, J., Berkowitz, R., Shavit, N., STRACHAN, A. M., Glass, I. B., & Vaughn, C. E. (1989) · The British Journal of Psychiatry · doi:10.1192/bjp.154.1.58 · Cited by 287 · see citing works
A two-year prospective study of treatment compliance in patients with schizophrenia
Buchanan, A. W. (1992) · Psychological Medicine · doi:10.1017/s0033291700038228 · Cited by 287 · see citing works
Three-Year Trials of Personal Therapy Among Schizophrenic Patients Living With or Independent of Family, I: Description of Study and Effects on Relapse Rates
Hogarty, G. E., Kornblith, S. J., Greenwald, D. P., DiBarry, A. L., Cooley, S., Ulrich, R. F., Carter, M., & Flesher, S. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.11.1504 · Cited by 272 · see citing works
Drug Refusal in Schizophrenia and the Wish to Be Crazy
Putten, T. V. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770120047004 · Cited by 259 · see citing works
Insight and the Clinical Outcome of Schizopheric Patients
McEvoy, J. P., Freter, S. H., EVERETT, G., Geller, J. L., Appelbaum, P. S., Apperson, L. J., & Roth, L. H. (1989) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198901000-00008 · Cited by 253 · see citing works
Relationships Among Subjective and Objective Measures of Adherence to Oral Antipsychotic Medications
Velligan, D. I., Wang, M., Diamond, P. M., Glahn, D. C., Castillo, D., Bendle, S., Lam, Y. W. F., Ereshefsky, L., & Miller, A. L. (2007) · Psychiatric Services · doi:10.1176/ps.2007.58.9.1187 · Cited by 250 · see citing works
Assertive Case Management in Three CMHCs: A Controlled Study
Bond, G. R., Miller, L. D., Krumwied, R. D., & Ward, R. S. (1988) · Psychiatric Services · doi:10.1176/ps.39.4.411 · Cited by 237 · see citing works
Interventions to Improve Antipsychotic Medication Adherence: Review of Recent Literature
Dolder, C. R., Lacro, J. P., Leckband, S. G., & Jeste, D. V. (2003) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000085413.08426.41 · Cited by 236 · see citing works
Epidemiology, clinical consequences, and psychosocial treatment of nonadherence in schizophrenia.
Leucht, S., & Heres, S. (2006) · PubMed · Cited by 226 · see citing works
Treatment, expressed emotion and relapse in recent onset schizophrenic disorders
Linszen, D. H., Dingemans, P. M. A. J., van der Does, W. A. J., Nugter, A., Scholte, P., Lenior, R., Vanier, C., & Goldstein, M. J. (1996) · Psychological Medicine · doi:10.1017/s0033291700034723 · Cited by 223 · see citing works
Self-citation
Compliance therapy: a randomised controlled trial in schizophrenia
O’Donnell, C. P., Donohoe, G. J., Sharkey, L., Owens, N., Migone, M., Harries, R., Kinsella, A., Larkin, C., & O'Callaghan, E. (2003) · BMJ · doi:10.1136/bmj.327.7419.834 · Cited by 219 · see citing works
Medication noncompliance in schizophrenia: codification and update.
Young, J. L., Zonana, H. V., & Shepler, L. (1986) · PubMed · Cited by 198 · see citing works
Effectiveness of psychoeducational intervention for rural Chinese families experiencing schizophrenia
Ran, M., Xiang, M., Chan, C., Leff, J., Simpson, P., Huang, M., Shan, Y.-H., & Li, S. (2003) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-003-0601-z · Cited by 195 · see citing works
Adherence therapy for people with schizophrenia
Gray, R. J., Leese, M., Bindman, J. P., Becker, T. M., Burti, L., David, A. S., Gournay, K., Kikkert, M., Koeter, M. W. J., Puschner, B., et al. (2006) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.105.019489 · Cited by 194 · see citing works
Three-Year Trials of Personal Therapy Among Schizophrenic Patients Living With or Independent of Family, II: Effects on Adjustment of Patients
Hogarty, G. E., Greenwald, D. P., Ulrich, R. F., Kornblith, S. J., DiBarry, A. L., Cooley, S., Carter, M., & Flesher, S. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.11.1514 · Cited by 190 · see citing works
A Trial of Family Therapy versus a Relatives' Group for Schizophrenia
Leff, J., Berkowitz, R., Shavit, N., STRACHAN, A. M., Glass, I. B., & Vaughn, C. (1990) · The British Journal of Psychiatry · doi:10.1192/bjp.157.4.571 · Cited by 184 · see citing works
Cognitive predictors of medication adherence among middle-aged and older outpatients with schizophrenia
Jeste, S., Patterson, T. L., Palmer, B. W., Dolder, C. R., Goldman, S., & Jeste, D. V. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00314-6 · Cited by 183 · see citing works
Adherence to antipsychotic medications.
Perkins, D. O. (1999) · PubMed · Cited by 176 · see citing works
Effect of Patient Education on Medication Compliance
Seltzer, A., Roncari, I., & Garfinkel, P. E. (1980) · The Canadian Journal of Psychiatry · doi:10.1177/070674378002500807 · Cited by 175 · see citing works
Randomised-control trial of family intervention for 78 first-episode male schizophrenic patients. An 18-month study in Suzhou, Jiangsu.
Zhang, M., Wang, M., Li, J., & Phillips, M. R. (1994) · PubMed · Cited by 172 · see citing works
The Use of Individually Tailored Environmental Supports to Improve Medication Adherence and Outcomes in Schizophrenia
Velligan, D. I., Diamond, P. M., Mintz, J., Maples, N. J., Li, X., Zeber, J. E., Ereshefsky, L., Lam, Y.-W. F., Castillo, D., & Miller, A. L. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm111 · Cited by 168 · see citing works
Medication Nonadherence and Treatment Outcome in Patients With Schizophrenia or Schizoaffective Disorder With Suboptimal Prior Response
Lindenmayer, J., Liu‐Seifert, H., Kulkarni, P. M., Kinon, B. J., Stauffer, V. L., Edwards, S., Chen, L., Adams, D. H., Ascher‐Svanum, H., Buckley, P. F., et al. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04221 · Cited by 162 · see citing works
Evaluation of a psychoeducation program for Chinese clients with schizophrenia and their family caregivers
Chan, S. W., Yip, B., Tso, S., Cheng, B.-S., & Tam, W. (2008) · Patient Education and Counseling · doi:10.1016/j.pec.2008.08.028 · Cited by 162 · see citing works
A Controlled Study of Education About Drug Treatment in Schizophrenia
Macpherson, R., Jerrom, B., & Hughes, A. (1996) · The British Journal of Psychiatry · doi:10.1192/bjp.168.6.709 · Cited by 160 · see citing works
Do fixed-dose combination pills or unit-of-use packaging improve adherence? A systematic review.
CONNOR, J. L., Rafter, N., & Rodgers, A. (2004) · Europe PMC (PubMed Central) · Cited by 155 · see citing works
Randomised-Control Trial of Family Intervention for 78 First-Episode Male Schizophrenic Patients
Zhang, M., Wang, M., Li, J., & Phillips, M. R. (1994) · The British Journal of Psychiatry · doi:10.1192/s0007125000293045 · Cited by 147 · see citing works
Relapse and rehospitalization: comparing oral and depot antipsychotics.
Schooler, N. R. (2003) · PubMed · Cited by 141 · see citing works
Medication Compliance and Health Education Among Outpatients With Chronic Mental Disorders
Kelly, G. R., & Scott, J. E. (1990) · Medical Care · doi:10.1097/00005650-199012000-00006 · Cited by 139 · see citing works
Psychoeducational psychotherapy for schizophrenic patients and their key relatives or care‐givers: results of a 2‐year follow‐up
Buchkremer, G., Klingberg, S., Holle, R., Mönking, H. S., & Hornung, W. P. (1997) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1997.tb09951.x · Cited by 139 · see citing works
Teaching Medication Management Skills to Schizophrenic Patients
Eckman, T. A., Liberman, R. P., Phipps, C. C., & Blair, K. E. (1990) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199002000-00006 · Cited by 136 · see citing works
ITAREPS: Information Technology Aided Relapse Prevention Programme in Schizophrenia
Španiel, F., Vohlídka, P., Hrdlička, J., Kožený, J., Novák, T., Motlová, L. B., Cermak, J. K., Bednařík, J., Novák, D., & Höschl, C. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.09.005 · Cited by 135 · see citing works
Validity of Electronically Monitored Medication Adherence and Conventional Adherence Measures in Schizophrenia
Byerly, M., Thompson, A. K., Carmody, T. J., Bugno, R., Erwin, T., Kashner, M. T., & Rush, A. J. (2007) · Psychiatric Services · doi:10.1176/ps.2007.58.6.844 · Cited by 134 · see citing works
Immigrant Families Coping with Schizophrenia Behavioural Family Intervention v. Case Management with a Low-Income Spanish-Speaking Population
Telles, C., Karno, M., Mintz, J., Paz, G. G., Arias, M., Tucker, D., & López, S. R. (1995) · The British Journal of Psychiatry · doi:10.1192/bjp.167.4.473 · Cited by 134 · see citing works
Adherence to Conventional and Atypical Antipsychotics After Hospital Discharge
Díaz, E., Neuse, E. C., Sullivan, M. C., Pearsall, R., & Woods, S. W. (2004) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v65n0311 · Cited by 127 · see citing works
The Impact of Education Groups for People with Schizophrenia on Social Functioning and Quality of Life
Atkinson, J. M., Coia, D. A., Gilmour, W. H., & Harper, J. P. (1996) · The British Journal of Psychiatry · doi:10.1192/bjp.168.2.199 · Cited by 127 · see citing works
Compliance with treatment in schizophrenia: a drug intervention program in a developing country
Salleh, M. R., & Yahya, H. M. (1995) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1995.tb09790.x · Cited by 125 · see citing works
Effects of a mutual support group for families of Chinese people with schizophrenia: 18-month follow-up
Chien, W. T., Chan, S. W., & Thompson, D. R. (2006) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.105.008375 · Cited by 125 · see citing works
Assertive community treatment and reference groups: An evaluation of their effectiveness for young adults with serious mental illness and substance abuse problems.
Bond, G. R., McDonel, E. C., Miller, L. D., & Salyers, M. P. (1991) · Psychosocial Rehabilitation Journal · doi:10.1037/h0095785 · Cited by 125 · see citing works
Untitled work
(2008) · PubMed · Cited by 124 · see citing works
Patient and relative education in community psychiatry: a randomized controlled trial regarding its effectiveness
Merinder, L. B., Viuff, A. G., Laugesen, H., Clemmensen, K., Misfelt, S., & Espensen, B. (1999) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s001270050146 · Cited by 123 · see citing works
The efficacy of a consumer case management team: 2-year outcomes of a randomized trial
Solomon, P., & Draine, J. (2006) · The Journal of Mental Health Administration · doi:10.1007/bf02518754 · Cited by 116 · see citing works
The efficacy of SMS text messages to compensate for the effects of cognitive impairments in schizophrenia
Pijnenborg, G. H. M., Withaar, F. K., Brouwer, W., Timmerman, M. E., van den Bosch, R. J., & Evans, J. J. (2009) · British Journal of Clinical Psychology · doi:10.1348/014466509x467828 · Cited by 108 · see citing works
Neuroleptic compliance among chronic schizophrenic outpatients: An intervention outcome report.
Boczkowski, J. A., Zeichner, A., & DeSanto, N. (1985) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.53.5.666 · Cited by 108 · see citing works
Effect of a medication management training package for nurses on clinical outcomes for patients with schizophrenia
Gray, R. J., Wykes, T., Edmonds, M., Leese, M., & Gournay, K. (2004) · The British Journal of Psychiatry · doi:10.1192/bjp.185.2.157 · Cited by 106 · see citing works
The evaluation of case management services with the chronically mentally ill
Modrcin, M. J., Rapp, C. A., & Poertner, J. (1988) · Evaluation and Program Planning · doi:10.1016/0149-7189(88)90043-2 · Cited by 104 · see citing works
A Controlled Evaluation of Psychoeducational Family Intervention in a Rural Chinese Community
Xiang, M., Ran, M., & Li, S. (1994) · British Journal of Psychiatry · doi:10.1192/bjp.165.4.544 · Cited by 102 · see citing works
Family education for people with schizophrenia in Beijing, China
Li, Z., & Arthur, D. (2005) · The British Journal of Psychiatry · doi:10.1192/bjp.187.4.339 · Cited by 102 · see citing works
Medication Self-Management: A preliminary report on an intervention to improve medication compliance
Hayward, P. (1995) · Journal of Mental Health · doi:10.1080/09638239550037343 · Cited by 101 · see citing works
Assertive community treatment and medication compliance in the homeless mentally ill
Dixon, L. B., Weiden, P. J., Torres, M., & Lehman, A. F. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.9.1302 · Cited by 98 · see citing works
Using A Pharmacy-Based Intervention To Improve Antipsychotic Adherence Among Patients With Serious Mental Illness
Valenstein, M. M., Kavanagh, J., Lee, T. A., Reilly, P., Dalack, G. W., Grabowski, J., Smelson, D. A., Ronis, D. L., Ganoczy, D. A., Woltmann, E. M., et al. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp121 · Cited by 91 · see citing works
Association Between Type of Medication Instruction and Patients' Knowledge, Side Effects, and Compliance
Brown, C., Wright, R. G., & Christensen, D. B. (1987) · Psychiatric Services · doi:10.1176/ps.38.1.55 · Cited by 88 · see citing works
Operation Outreach: Intensive Case Management for Severely Psychiatrically Disabled Adults
Bush, C. T., Langford, M. W., Rosen, P., & Gott, W. (1990) · Psychiatric Services · doi:10.1176/ps.41.6.647 · Cited by 85 · see citing works
Habitual prospective memory in schizophrenia
Elvevåg, B., Maylor, E. A., & Gilbert, A. L. (2003) · BMC Psychiatry · doi:10.1186/1471-244x-3-9 · Cited by 83 · see citing works
Clinical evaluation of negative symptoms in schizophrenia
Möller, H. (2007) · European Psychiatry · doi:10.1016/j.eurpsy.2007.03.010 · Cited by 83 · see citing works
Providing the safety net: Case management for people with a serious mental illness.
Ford, R. A. (1995) · Journal of Mental Health · doi:10.1080/09638239550037893 · Cited by 82 · see citing works
Neuroleptic compliance among chronic schizophrenic outpatients: An intervention outcome report.
Boczkowski, J. A., Zeichner, A., & DeSanto, N. (1985) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.53.5.666 · Cited by 81 · see citing works
Causes of Neuroleptic Noncompliance
Weiden, P. J., Shaw, E., & Mann, J. J. (1986) · Psychiatric Annals · doi:10.3928/0048-5713-19861001-07 · Cited by 80 · see citing works
Psychoeducational training for schizophrenic patients: background, procedure and empirical findings
Hornung, W. P., Kieserg, A., Feldmann, R., & Buchkremer, G. (1996) · Patient Education and Counseling · doi:10.1016/s0738-3991(96)00918-4 · Cited by 78 · see citing works
An RCT of adherence therapy for people with schizophrenia in Chiang Mai, Thailand
von Bormann, S. M., Robson, D., Gournay, K., & Gray, R. J. (2007) · Journal of Clinical Nursing · doi:10.1111/j.1365-2702.2007.01786.x · Cited by 78 · see citing works
Evaluation of an instructional program for improving medication compliance for chronically mentally ill outpatients
Azrin, N. H., & Teichner, G. A. (1998) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(98)00036-9 · Cited by 76 · see citing works
Non-Compliance With Treatment in Patients Suffering From Schizophrenia: a Study To Evaluate Possible Contributing Factors
Agarwal, M., Sharma, V. K., Kishore Kumar, K. V., & Lowe, D. (1998) · International Journal of Social Psychiatry · doi:10.1177/002076409804400202 · Cited by 76 · see citing works
Family Characteristics, Substance Abuse, and Hospitalization Patterns of Patients With Schizophrenia
Kashner, T. M., Rader, L. E., Rodell, D. E., Beck, C. M., Rodell, L., & Muller, K. (1991) · Psychiatric Services · doi:10.1176/ps.42.2.195 · Cited by 72 · see citing works
Subjective Experience and Dopamine D 2 Receptor Occupancy in Patients Treated with Antipsychotics: Clinical Implications
de Haan, L., Lavalaye, J., van Bruggen, M., van Nimwegen, L. J. M., Booij, J., van Amelsvoort, T., & LINSZEN, D. H. (2004) · The Canadian Journal of Psychiatry · doi:10.1177/070674370404900503 · Cited by 69 · see citing works
Self-citation
Collaboration with drug treatment by schizophrenic patients with and without psychoeducational training: results of a 1‐year follow‐up
Hornung, W. P., Klingberg, S., Feldmann, R., Schonauer, K., & Mönking, H. S. (1998) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1998.tb09990.x · Cited by 68 · see citing works
Cluster randomised controlled trials
Sedgwick, P. M. (2012) · BMJ · doi:10.1136/bmj.e4654 · Cited by 62 · see citing works
Money for medication: financial incentives to improve medication adherence in assertive outreach
Claassen, D., Fakhoury, W. K. H., Ford, R. A., & Priebe, S. (2006) · Psychiatric Bulletin · doi:10.1192/pb.31.1.4 · Cited by 61 · see citing works
A Comparison of Two Crisis Housing Alternatives to Psychiatric Hospitalization
Bond, G. R., Witheridge, T. F., Wasmer, D., Dincin, J., McRae, S. A., Mayes, J., & Ward, R. S. (1989) · Psychiatric Services · doi:10.1176/ps.40.2.177 · Cited by 58 · see citing works
A Randomized Clinical Trial of Inpatient Family Intervention: VI. Mediating Variables and Outcome
Glick, I. D., Clarkin, J. F., Haas, G. L., SPENCER, J. H., & CHEN, C. L. (1991) · Family Process · doi:10.1111/j.1545-5300.1991.00085.x · Cited by 55 · see citing works
Telenursing Intervention Increases Psychiatric Medication Adherence in Schizophrenia Outpatients
Beebe, L. H., Smith, K., Crye, C., Addonizio, C., Strunk, D. J., Martin, W., & Poche, J. (2008) · Journal of the American Psychiatric Nurses Association · doi:10.1177/1078390308318750 · Cited by 52 · see citing works
Educating patients about psychiatric medications: Failure to enhance compliance.
Streicker, S. K., Amdur, M. A., & Dincin, J. (1986) · Psychosocial Rehabilitation Journal · doi:10.1037/h0099155 · Cited by 51 · see citing works
Depot Neuroleptic Therapy: Clinical Considerations
Gary, J. R., & Martha, E. A. (1995) · The Canadian Journal of Psychiatry · doi:10.1177/070674379504003s02 · Cited by 49 · see citing works
Guideline Implementation and Patient-Tailoring Strategies to Improve Medication Adherence for Schizophrenia
Hudson, T. J., Owen, R. R., Thrush, C. R., Armitage, T. L., & Thapa, P. B. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0110 · Cited by 45 · see citing works
Collaboration in outpatient antipsychotic drug treatment: Analysis of potentially influencing factors
Klingberg, S., Schneider, S., Wittorf, A., Buchkremer, G., & Wiedemann, G. (2008) · Psychiatry Research · doi:10.1016/j.psychres.2007.07.027 · Cited by 43 · see citing works
Financial incentives to improve adherence to anti-psychotic maintenance medication in non-adherent patients - a cluster randomised controlled trial (FIAT)
Priebe, S., Burton, A., Ashby, D., Ashcroft, R. E., Burns, T., David, A. S., Eldridge, S. M., Firn, M., Knapp, M. R. J., & McCabe, R. (2009) · BMC Psychiatry · doi:10.1186/1471-244x-9-61 · Cited by 40 · see citing works
Psychosocial interventions for schizophrenia
Razali, S. M. (2000) · Journal of Mental Health · doi:10.1080/jmh.9.3.283.289 · Cited by 35 · see citing works
The Influence of Group Therapy on Schizophrenia
Malm, U. (1982) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1982.tb00288.x · Cited by 34 · see citing works
Two modes of case management: Assessing their impact
Sands, R. G., & Cnaan, R. A. (1994) · Community Mental Health Journal · doi:10.1007/bf02189062 · Cited by 32 · see citing works
A Preliminary Trial of Adherence-Coping-Education (ACE) Therapy for Early Psychosis
Uzenoff, S. R., Perkins, D. O., Hamer, R. M., Wiesen, C., & Penn, D. L. (2008) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0b013e31817d01a5 · Cited by 32 · see citing works
Psychosocial interventions for schizophrenia
Salleh, M. R., Ismail, H. C., Khan, A. N., & Subramaniam, M. (2000) · Journal of Mental Health · doi:10.1080/713680246 · Cited by 32 · see citing works
Effects of Integrated Treatment on Antipsychotic Medication Adherence in a Randomized Trial in Recent-Onset Schizophrenia
Morken, G., Gråwe, R. W., & Widen, J. H. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0409 · Cited by 30 · see citing works
Does patient education enhance compliance with clozapine? A preliminary investigation
Gray, R. J. (2000) · Journal of Psychiatric and Mental Health Nursing · doi:10.1046/j.1365-2850.2000.00299.x · Cited by 27 · see citing works
An evaluation of a medication management training programme for community mental health professionals; service user level outcomes
Harris, N., Lovell, K., Day, J., & Roberts, C. (2008) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2008.10.010 · Cited by 27 · see citing works
Implementation and effectiveness of a bed reduction project
Bigelow, D. A., McFarland, B. H., Gareau, M. J., & Young, D. J. (1991) · Community Mental Health Journal · doi:10.1007/bf00752815 · Cited by 21 · see citing works
Self Medication Among Psychiatric Patients and Adherence After Discharge
Battle, E. H., Halliburton, A., & Wallston, K. A. (1982) · Journal of Psychosocial Nursing and Mental Health Services · doi:10.3928/0279-3695-19820501-05 · Cited by 20 · see citing works
Psychosocial Treatment
Herz, M. I. (1996) · Psychiatric Annals · doi:10.3928/0048-5713-19960801-11 · Cited by 13 · see citing works

Flagged first, then by citations

Sorted by citations

Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis
Semahegn, A., Torpey, K., Manu, A., Assefa, N., Tesfaye, G., & Ankomah, A. (2020) · Systematic Reviews · doi:10.1186/s13643-020-1274-3 · Cited by 555 · see citing works
Non-adherence to medication in patients with psychotic disorders: epidemiology, contributing factors and management strategies
Kane, J. M., Kishimoto, T., & Correll, C. U. (2013) · World Psychiatry · doi:10.1002/wps.20060 · Cited by 520 · see citing works
A systematic review of factors influencing adherence to antipsychotic medication in schizophrenia-spectrum disorders
Sendt, K.-V., Tracy, D. K., & Bhattacharyya, S. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2014.11.002 · Cited by 245 · see citing works
Medication adherence in schizophrenia
Acosta, F. J. (2012) · World Journal of Psychiatry · doi:10.5498/wjp.v2.i5.74 · Cited by 215 · see citing works
The efficacy and safety of once-daily quetiapine extended release in patients with schizophrenia switched from other antipsychotics: an open-label study in Chinese population
Pan, P., Lee, M., & Yeh, C. (2015) · BMC Psychiatry · doi:10.1186/s12888-014-0378-5 · Cited by 159 · see citing works
A short message service (SMS)-based strategy for enhancing adherence to antipsychotic medication in schizophrenia
Montes, J. M. G., Medina, E., Gómez-Beneyto, M., & Mauriño, J. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.07.034 · Cited by 140 · see citing works
Medication adherence in patients with schizophrenia
Phan, S. V. (2016) · The International Journal of Psychiatry in Medicine · doi:10.1177/0091217416636601 · Cited by 117 · see citing works
Technological Interventions for Medication Adherence in Adult Mental Health and Substance Use Disorders: A Systematic Review
Steinkamp, J., Goldblatt, N. P., Borodovsky, J. T., LaVertu, A. E., Kronish, I. M., Marsch, L. A., & Schuman‐Olivier, Z. (2018) · JMIR Mental Health · doi:10.2196/12493 · Cited by 106 · see citing works
Predictors of medication adherence among patients with severe psychiatric disorders: findings from the baseline assessment of a randomized controlled trial (Tecla)
Stentzel, U., van den Berg, N., Schulze, L. N., Schwaneberg, T., Radicke, F., Langosch, J. M., Freyberger, H. J., Hoffmann, W. U., & Grabe, H. J. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1737-4 · Cited by 91 · see citing works
Internet- and mobile-based aftercare and relapse prevention in mental disorders: A systematic review and recommendations for future research
Hennemann, S., Farnsteiner, S., & Sander, L. (2018) · Internet Interventions · doi:10.1016/j.invent.2018.09.001 · Cited by 86 · see citing works
Psychotropic medication non-adherence and associated factors among adult patients with major psychiatric disorders: a protocol for a systematic review
Semahegn, A., Torpey, K., Manu, A., Assefa, N., Tesfaye, G., & Ankomah, A. (2018) · Systematic Reviews · doi:10.1186/s13643-018-0676-y · Cited by 85 · see citing works
A qualitative study of experiences with and perceptions regarding long-acting injectable antipsychotics: part II-physician perspectives.
Iyer, S., Banks, N., Roy, M.-A., Tibbo, P., Williams, R., Manchanda, R., Chue, P., & Malla, A. (2013) · The Canadian Journal of Psychiatry · doi:10.1177/088740341305805s04 · Cited by 81 · see citing works
Lay health supporters aided by mobile text messaging to improve adherence, symptoms, and functioning among people with schizophrenia in a resource-poor community in rural China (LEAN): A randomized controlled trial
Xu, D. R., Xiao, S., He, H., Caine, E. D., Gloyd, S. S., Simoni, J. M., Hughes, J. P., Nie, J., Lin, M., He, W., et al. (2019) · PLoS Medicine · doi:10.1371/journal.pmed.1002785 · Cited by 81 · see citing works
Using the theory of planned behavior to improve treatment adherence in Mexican Americans with schizophrenia.
Kopelowicz, A. J., Zárate, R., Wallace, C. J., Liberman, R. P., Lopez, S. R., & Mintz, J. (2015) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0039346 · Cited by 77 · see citing works
A systematic review of service-user reasons for adherence and nonadherence to neuroleptic medication in psychosis
Wade, M., Tai, S., Awenat, Y. F., & Haddock, G. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.10.009 · Cited by 69 · see citing works
The Effect of Motivational Interviewing on Medication Adherence and Hospitalization Rates in Nonadherent Patients with Multi-Episode Schizophrenia
Barkhof, E., Meijer, C. J., de Sonneville, L. M. J., LINSZEN, D. H., & de Haan, L. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt138 · Cited by 64 · see citing works
Self-citation
A Qualitative Study of Experiences with and Perceptions regarding Long-Acting Injectable Antipsychotics: Part I—Patient Perspectives
Iyer, S. N., Banks, N., Roy, M., Tibbo, P. G., Williams, R., Manchanda, R., Chue, P. S., & MALLA, A. K. (2013) · The Canadian Journal of Psychiatry · doi:10.1177/088740341305805s03 · Cited by 58 · see citing works
Improving Medication Adherence With Telemedicine for Adults With Severe Mental Illness
Schulze, L. N., Stentzel, U., Leipert, J., Schulte, J., Langosch, J. M., Freyberger, H. J., Hoffmann, W. U., Grabe, H. J., & van den Berg, N. (2019) · Psychiatric Services · doi:10.1176/appi.ps.201800286 · Cited by 57 · see citing works
The effectiveness of psychoeducational family intervention for patients with schizophrenia in a 14-year follow-up study in a Chinese rural area
Ran, M., Chan, C., Ng, S., Guo, L., & Xiang, M. (2015) · Psychological Medicine · doi:10.1017/s0033291715000197 · Cited by 52 · see citing works
Is adherence therapy an effective adjunct treatment for patients with schizophrenia spectrum disorders? A systematic review and meta-analysis
Gray, R. J., Bressington, D. T., Ivanecka, A., Hardy, S., Jones, M., Schulz, M., von Bormann, S., White, J., Anderson, K. H., & Chien, W. T. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-0801-1 · Cited by 52 · see citing works
Patterns of Adherence to Oral Atypical Antipsychotics Among Patients Diagnosed with Schizophrenia
MacEwan, J. P., Forma, F. M., Shafrin, J. T., Hatch, A., Lakdawalla, D. N., & Lindenmayer, J. (2016) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2016.22.11.1349 · Cited by 52 · see citing works
Is Elevated Neutrophil Count and Neutrophil-to-Lymphocyte Ratio a Cause or Consequence of Schizophrenia?—A Scoping Review
Sandberg, A. A., Steen, V. M., & Torsvik, A. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.728990 · Cited by 48 · see citing works
Measuring Medication Adherence in Patients With Schizophrenia: An Integrative Review
Bright, C. E. (2016) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2016.09.003 · Cited by 42 · see citing works
Comparing cognitive functions in medication adherent and non-adherent patients with schizophrenia
El-Missiry, A., Elbatrawy, A. N., Missiry, M. E., Moneim, D. A., Ali, R., & Essawy, H. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.09.006 · Cited by 42 · see citing works
Modeling Determinants of Medication Attitudes and Poor Adherence in Early Nonaffective Psychosis: Implications for Intervention
Drake, R. J., Nordentoft, M., Haddock, G., Arango, C., Fleischhacker, W. W., Glenthøj, B., Leboyer, M., Leucht, S., Leweke, M., McGuire, P., et al. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv015 · Cited by 42 · see citing works
Attitudes of European physicians towards the use of long-acting injectable antipsychotics
Patel, M. X., Bent‐Ennakhil, N., Sapin, C., di Nicola, S., Loze, J.-Y., Nylander, A.-G., & Heres, S. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02530-2 · Cited by 40 · see citing works
A qualitative study of medication adherence amongst people with schizophrenia
Clifford, L., Crabb, S., Turnbull, D. A., Hahn, L. A., & Galletly, C. A. (2020) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2020.06.002 · Cited by 39 · see citing works
Development and Feasibility Testing of a Smartphone Intervention to Improve Adherence to Antipsychotic Medications
Kreyenbuhl, J. A., Record, E. J., Himelhoch, S. S., Charlotte, M., Palmer-Bacon, J., Dixon, L. B., Medoff, D. R., & Li, L. (2016) · Clinical Schizophrenia & Related Psychoses · doi:10.3371/csrp.krre.070816 · Cited by 39 · see citing works
Patient Experiences of Autonomy and Coercion While Receiving Legal Leverage in Forensic Assertive Community Treatment
Lamberti, J. S., Russ, A. J., Cerulli, C., Weisman, R. L., Jacobowitz, D. B., & Williams, G. C. (2014) · Harvard Review of Psychiatry · doi:10.1097/01.hrp.0000450448.48563.c1 · Cited by 36 · see citing works
Prospective memory predicts medication management ability and correlates with non-adherence to medications in individuals with clinically stable schizophrenia
Lam, J. W. S., Lui, S. S. Y., Wang, Y., Chan, R. C. K., & Cheung, E. F. C. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.04.010 · Cited by 34 · see citing works
The effect of motivational interviews on treatment adherence and insight levels of patients with schizophrenia: A randomized controlled study
Ertem, M., & Duman, Z. Ç. (2018) · Perspectives In Psychiatric Care · doi:10.1111/ppc.12301 · Cited by 34 · see citing works
Randomized controlled trial of the effects of nursing care based on a telephone intervention for medication adherence in schizophrenia
Uslu, E., & Buldukoğlu, K. (2019) · Perspectives In Psychiatric Care · doi:10.1111/ppc.12376 · Cited by 32 · see citing works
Nonadherence after hospital discharge in patients with schizophrenia or schizoaffective disorder: A six-month naturalistic follow-up study
Vega, D., Acosta, F. J., & Saavedra, P. (2021) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2021.152240 · Cited by 37 · see citing works
An exploratory, open-label, randomized trial comparing risperidone long-acting injectable with oral antipsychotic medication in the treatment of early psychosis.
Malla, A., Chue, P., Jordan, G., Stip, E., Koczerginski, D., Milliken, H., Joseph, A., Williams, R., Adams, B., Manchanda, R., et al. (2016) · Clinical Schizophrenia & Related Psychoses · doi:10.3371/csrp.mach.061213 · Cited by 30 · see citing works
The Effect of Group Psychoeducation Program on Medication Adherence in Patients with Bipolar Mood Disorders: a Randomized Controlled Trial
Rahmani, F., Ebrahimi, H., Ranjbar, F., Razavi, S. S., & Asghari, E. (2016) · Journal of Caring Sciences · doi:10.15171/jcs.2016.030 · Cited by 30 · see citing works
Does adherence therapy improve medication adherence among patients with schizophrenia? A systematic review
Hegedüs, A., & Kozel, B. (2014) · International Journal of Mental Health Nursing · doi:10.1111/inm.12089 · Cited by 30 · see citing works
Short-term clinical stability and lack of insight are associated with a negative attitude towards antipsychotic treatment at discharge in patients with schizophrenia and bipolar disorder
Mauriño, J., Medina, Salvà, Ampudia, & Larumbe (2012) · Patient Preference and Adherence · doi:10.2147/ppa.s34345 · Cited by 30 · see citing works
The effectiveness of a nursing discharge programme to improve medication adherence and patient satisfaction in the psychiatric intensive care unit
Virgolesi, M., Pucciarelli, G., Colantoni, A. M., D'Andrea, F., Donato, B. D., Giorgi, F., Landi, L., Salustri, E., Turci, C., & Proietti, M. G. (2017) · Journal of Clinical Nursing · doi:10.1111/jocn.13776 · Cited by 29 · see citing works
Improving adherence to pharmacological treatment for schizophrenia: a systematic assessment
Curto, M., Fazio, F., Ulivieri, M., Navari, S., Lionetto, L., & Baldessarini, R. J. (2021) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2021.1882996 · Cited by 29 · see citing works
A review of behavioral tailoring strategies for improving medication adherence in serious mental illness
Kreyenbuhl, J. A., Record, E. J., & Palmer-Bacon, J. (2016) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2016.18.2/jkreyenbuhl · Cited by 26 · see citing works
Mobile phone text message reminders: Measuring preferences of people with antipsychotic medication
Kauppi, K., Kannisto, K. A., Hätönen, H. M., Anttila, M., Löyttyniemi, E., Adams, C. E., & Valimaki, M. A. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.07.044 · Cited by 25 · see citing works
Schizophrenia in the Netherlands: Continuity of Care with Better Quality of Care for Less Medical Costs
van der Lee, A., de Haan, L., & Beekman, A. T. F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157150 · Cited by 25 · see citing works
Reasons associated with treatment non-adherence in schizophrenia in a Pakistan cohort
Ahmad, I., Khalily, M. T., & Hallahan, B. P. (2017) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2017.07.024 · Cited by 25 · see citing works
Motivational Interviewing–Based Compliance/Adherence Therapy Interventions to Improve Psychiatric Symptoms of People With Severe Mental Illness: Meta-Analysis
Wong‐Anuchit, C., Chantamit-O-Pas, C., Schneider, J. K., & Mills, A. C. (2018) · Journal of the American Psychiatric Nurses Association · doi:10.1177/1078390318761790 · Cited by 25 · see citing works
Time to Treatment Discontinuation in German Patients with Schizophrenia: Long-Acting Injectables versus Oral Antipsychotics
Mahlich, J., Olbrich, K., Wilk, A., Wimmer, A., & Wolff‐Menzler, C. (2020) · Clinical Drug Investigation · doi:10.1007/s40261-020-00990-8 · Cited by 24 · see citing works
Barriers to medication adherence for rural patients with mental disorders in eastern China: a qualitative study
Chai, X., Liu, Y., Mao, Z., & Li, S. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03144-y · Cited by 24 · see citing works
Transdermal delivery of second-generation antipsychotics for management of schizophrenia; disease overview, conventional and nanobased drug delivery systems
El-Tokhy, F. S., Abdel-Mottaleb, M. M. A., El-Ghany, E. A., & Geneidi, A. S. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.102104 · Cited by 23 · see citing works
The motivation paradox: higher psychosocial problem levels in severely mentally ill patients are associated with less motivation for treatment
Mulder, C. L., Jochems, E. C., & Kortrijk, H. E. (2013) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-013-0779-7 · Cited by 22 · see citing works
Coercion in psychiatry: the importance of extramural factors
Andersen, K., & Nielsen, B. (2016) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2016.1190401 · Cited by 22 · see citing works
Adherence to Antipsychotic Medication and Quality of Life in Latin-American Patients Diagnosed with Schizophrenia
Caqueo‐Urízar, A., Alfonso Urzúa, M., Mena‐Chamorro, P., Fond, G. B., & Boyer, L. (2020) · Patient Preference and Adherence · doi:10.2147/ppa.s265312 · Cited by 22 · see citing works
Effects of the Nursing Psychoeducation Program on the Acceptance of Medication and Condition-Specific Knowledge of Patients with Schizophrenia
Matsuda, M., & Kohno, A. (2016) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2016.03.008 · Cited by 21 · see citing works
Telephone-delivered psychosocial interventions targeting key health priorities in adults with a psychotic disorder: systematic review
Baker, A., Turner, A., Beck, A. K., Berry, K., Haddock, G., Kelly, P. J., & Bucci, S. (2018) · Psychological Medicine · doi:10.1017/s0033291718001125 · Cited by 21 · see citing works
Changing the Drug Delivery System: Does it Add to Non-Compliance Ramifications Control? A Simulation Study on the Pharmacokinetics and Pharmacodynamics of Atypical Antipsychotic Drug
Elkomy, M. H. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12040297 · Cited by 21 · see citing works
Impact of Psychoeducation on Knowledge of and Attitude Toward Medications in Clients With Schizophrenia and Schizoaffective Disorders
Choe, K., Sung, B. J., Kang, Y., & Yoo, S. Y. (2015) · Perspectives In Psychiatric Care · doi:10.1111/ppc.12106 · Cited by 19 · see citing works
Attitudes and Willingness to Accept Long-Acting Injections for Patients With Schizophrenia in Beijing: A Cross-Sectional Investigation Based on Samples From the Communities
Zhu, J., Chen, Y., Lu, W., Huang, Q., Li, B., Xu, Y., Xi, R., & Jin, L. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.770276 · Cited by 19 · see citing works
Effect of adding individualized occupational therapy to standard care on rehospitalization of patients with schizophrenia: A 2‐year prospective cohort study
Shimada, T., Ohori, M., Inagaki, Y., Shimooka, Y., Ishihara, I., Sugimura, N., Tanaka, S., & Kobayashi, M. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12858 · Cited by 19 · see citing works
Effects of Social Support on Medication Adherence Among Patients with Schizophrenia: Serial Multiple Mediation Model
Jiang, N., Jin, W., Fu, Z., Cao, H., Zheng, H., Wang, Q., Zhang, Q., Ju, K., & Wang, J. (2024) · Patient Preference and Adherence · doi:10.2147/ppa.s460210 · Cited by 18 · see citing works
Cost-Effectiveness of Financial Incentives to Promote Adherence to Depot Antipsychotic Medication: Economic Evaluation of a Cluster-Randomised Controlled Trial
Henderson, C., Knapp, M. R. J., Yeeles, K., Bremner, S. A., Eldridge, S. M., David, A. S., O’Connell, N., Burns, T., & Priebe, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138816 · Cited by 18 · see citing works
Randomized trial of a brief peer support intervention for individuals with schizophrenia transitioning from hospital to community
Kidd, S. A., Mutschler, C., Lichtenstein, S., Yan, S., Virdee, G., Blair, F., Mihalakakos, G., Mckinney, C. D., Collins, A. A., Guimond, T. H., et al. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.03.019 · Cited by 17 · see citing works
Mobile.net: Mobile Telephone Text Messages to Encourage Adherence to Medication and to Follow up With People With Psychosis: Methods and Protocol for a Multicenter Randomized Controlled Two-Armed Trial
Valimaki, M. A., Hätönen, H. M., & Adams, C. E. (2012) · JMIR Research Protocols · doi:10.2196/resprot.2136 · Cited by 17 · see citing works
Pharmacy Students’ Reflections on an Experiential Learning Visit to a Psychiatric Hospital
Keating, D., McWilliams, S., Hynes-Ryan, C., Clarke, M., & Strawbridge, J. (2019) · American Journal of Pharmaceutical Education · doi:10.5688/ajpe6784 · Cited by 17 · see citing works
Tecla: a telephone- and text-message based telemedical concept for patients with severe mental health disorders – study protocol for a controlled, randomized, study
Stentzel, U., Grabe, H. J., Strobel, L. N., Penndorf, P., Langosch, J. M., Freyberger, H. J., Hoffmann, W. U., & van den Berg, N. (2015) · BMC Psychiatry · doi:10.1186/s12888-015-0659-7 · Cited by 16 · see citing works
Effects of a Story Character’s Goal Achievement
Lee, T. K., & Shapiro, M. A. (2015) · Communication Research · doi:10.1177/0093650215608236 · Cited by 16 · see citing works
Treatment adherence rates across different psychiatric disorders and settings: findings from a large patient cohort
Girone, N., Cocchi, M., Achilli, F., Grechi, E., Vicentini, C., Benatti, B., Vismara, M. E. M., Priori, A., & Dell’Osso, B. M. (2024) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000557 · Cited by 15 · see citing works
Factors associated with adherence over time to antipsychotic drug treatment
Ngui, A. N., Vasiliadis, H., & Tempier, R. (2013) · Clinical Epidemiology and Global Health · doi:10.1016/j.cegh.2013.11.001 · Cited by 15 · see citing works
Targets, attitudes, and goals of psychiatrists treating patients with schizophrenia: key outcome drivers, role of quality of life, and place of long-acting antipsychotics
Fagiolini, A. M., de Bartolomeis, A., Vaggi, M., & Vampini, C. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s96214 · Cited by 15 · see citing works
All-cause hospitalization and associated costs in patients with schizophrenia or bipolar disorder initiating long-acting injectable antipsychotics
Yan, T., Greene, M., Chang, E. Y., Hartry, A., Touya, M., & Broder, M. S. (2017) · Current Medical Research and Opinion · doi:10.1080/03007995.2017.1395733 · Cited by 15 · see citing works
Method for Increased Treatment Adherence in Mental Disorders: Adherence Therapy
Dıkeç, G. (2015) · Journal of Psychiatric Nursing · doi:10.5505/phd.2015.69875 · Cited by 15 · see citing works
Clinical and Functional Outcome of Assertive Outreach for Patients With Schizophrenic Disorder: Results of a Quasi-Experimental Controlled Trial
Kästner, D., Büchtemann, D., Warnke, I., Radisch, J., Baumgardt, J., Giersberg, S., Köpke, K.-H., Moock, J., Kawohl, W., & Wulf Rössler, A. (2015) · European Psychiatry · doi:10.1016/j.eurpsy.2015.04.003 · Cited by 14 · see citing works
Attitude Towards Drug Therapy in a Community Mental Health Center Evaluated by the Drug Attitude Inventory
Lorenzo, R. D., Perrone, D., Montorsi, A., Balducci, J., Rovesti, S., & Ferri, P. (2020) · Patient Preference and Adherence · doi:10.2147/ppa.s251993 · Cited by 14 · see citing works
Identification of Risk Factors to Predict the Occurrences of Relapses in Individuals with Schizophrenia Spectrum Disorder in Iran
Davarinejad, O., Majd, T. M., Golmohammadi, F., Mohammadi, P., Radmehr, F., Alikhani, M., Motaei, T., Moradinazar, M., Brühl, A. B., Bahmani, D. S., et al. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18020546 · Cited by 14 · see citing works
The Personal Antipsychotic Choice Index
van Dijk, F. A., de Wit, I. E., Blankers, M., Sommer, I. E., & de Haan, L. (2017) · Pharmacopsychiatry · doi:10.1055/s-0043-116854 · Cited by 13 · see citing works
The Impact of Paliperidone Palmitate on Hospitalization in Patients with Schizophrenia: A Retrospective Mirror-image Study
Oh, S.-Y., Jon, D., Hong, H. J., Hong, N., Yi, J.-S., Roh, D. D., & Jung, M. H. (2019) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2019.17.4.531 · Cited by 13 · see citing works
The case for prescribing PrEP in community mental health settings
Sudler, A., Cournos, F., Arnold, E. A., Koester, K. A., Riano, N. S., Dilley, J., Liu, A., & Mangurian, C. V. (2021) · The Lancet HIV · doi:10.1016/s2352-3018(20)30273-3 · Cited by 13 · see citing works
Comparative Effectiveness of Second Generation Long-acting Injectable Antipsychotics Based on Nationwide Database Research in Hungary: An Update
Takács, P., Kunovszki, P., Timtschenko, V., Fehér, L., Balázs, T., Hegyi, R., Czobor, P., & Bitter, I. (2022) · Schizophrenia Bulletin Open · doi:10.1093/schizbullopen/sgac013 · Cited by 12 · see citing works
Predictors of Difficulty in Medication Intake in Europe: a Cross-country Analysis Based on SHARE
de Figueiredo, D. M. P., Teixeira, L., Poveda, V., Paúl, C., Santos‐Silva, A., & Costa, E. M. (2016) · Aging and Disease · doi:10.14336/ad.2015.0925 · Cited by 12 · see citing works
Interventions for improving adherence to psychological treatments for common mental disorders: a systematic review
Biswal, B., Gandhi, Y., Singla, D. R., Velleman, R. D. B., Zhou, B., Fernandes, L., Patel, V., Prina, M. A., Sequeira, M., Garg, A., et al. (2024) · Cambridge Prisms Global Mental Health · doi:10.1017/gmh.2024.94 · Cited by 13 · see citing works
Effectiveness of Adherence Therapy for People With Schizophrenia in Turkey: A Controlled Study
Dıkeç, G., & Kutlu, Y. (2015) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2015.11.009 · Cited by 11 · see citing works
Prescription patterns in psychiatric compulsory care: polypharmacy and high-dose antipsychotics
Kaikoushi, K., Karanikola, M. N. K., Middleton, N., Bella, E., & Chatzittofis, A. (2021) · BJPsych Open · doi:10.1192/bjo.2021.982 · Cited by 11 · see citing works
Pharmacy practice and continuing professional development in low and middle income countries (LMICs)
Chan, A. H. Y., Darwish, R. M., Shamim, S., & Babar, Z. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819378-5.00007-6 · Cited by 11 · see citing works
A randomized controlled trial of an acceptance-based, insight-inducing medication adherence therapy (AIM-AT) for adults with early-stage psychosis
Chien, W. T., Chong, Y. Y., Bressington, D., & McMaster, C. W. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.116046 · Cited by 10 · see citing works
“…psychological distress (e.g., negative perceptions of medication use, poor insight into the illness) with illness self-management skills in early-stage psychosis can reduce rates of medication non-adherence and illness self-care (Barkhof et al., 2012; Cahaya et al., 2022; Hsieh et al., 2023).”
Theoretical Approaches to Enhancing Motivation for Adherence to Antidepressant Medications
Hamrin, V., Sinclair, V. G., & Gardner, V. (2016) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2016.09.004 · Cited by 10 · see citing works
Post-discharge medication adherence in schizophrenia
Yalamova, I. (2016) · Archives of Psychiatry and Psychotherapy · doi:10.12740/app/60513 · Cited by 10 · see citing works
Does Non-Adherence Increase Treatment Costs in Schizophrenia?
Pennington, M., & McCrone, P. (2018) · PharmacoEconomics · doi:10.1007/s40273-018-0652-3 · Cited by 10 · see citing works
Prevalence of metabolic syndrome and its associated factors in first‐treatment drug‐naïve schizophrenia patients: A large‐scale cross‐sectional study
Hu, S., Liu, X., Zhang, Y., & Ma, J. (2024) · Early Intervention in Psychiatry · doi:10.1111/eip.13565 · Cited by 9 · see citing works
Predictors of long-acting injectable antipsychotic treatment discontinuation in outpatients with schizophrenia: relevance of the Drug Attitude Inventory-10
Tatini, L., D’Anna, G., Pietrini, F., Calligaris, E., Ballerini, A., & Ricca, V. (2021) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000359 · Cited by 9 · see citing works
The feasibility and acceptability study of a positive psychology group intervention for people with severe psychiatric conditions
Valiente, C., Espinosa, R., Contreras, A., Trucharte, A., Caballero, R., & Peinado, V. (2021) · The Journal of Positive Psychology · doi:10.1080/17439760.2021.1871940 · Cited by 9 · see citing works
Improving Adherence in Hospitalized Patients Diagnosed With Schizophrenia: An Integrative One-on-One Intervention
Dahan, S., Behrbalk, P., Stolovy, T., & Greenberger, C. (2016) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2016.03.002 · Cited by 9 · see citing works
Effectiveness of antipsychotic medication in patients with schizophrenia in a real world retrospective observational study in Ethiopia
Kelebie, M. A., Kibralew, G., Tadesse, G., Rtbey, G., Aderaw, M., Endeshaw, W., Belachew, M., Muche, M., Getnet, D., & Fentahun, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-85832-3 · Cited by 8 · see citing works
Antipsychotic Polypharmacy and High-Dose Antipsychotics in Involuntary Patients: a Seven-Year Audit of Discharge Prescriptions in an Acute Care Unit
Martinho, S., Poças, A., Simões, M., & Laureano, C. (2020) · Psychiatric quarterly · doi:10.1007/s11126-020-09762-1 · Cited by 6 · see citing works
Testing the hypothesis of subtypes of nonadherence in schizophrenia and schizoaffective disorder: A prospective study
Vega, D., Acosta, F. J., & Saavedra, P. (2020) · World Journal of Psychiatry · doi:10.5498/wjp.v10.i11.260 · Cited by 8 · see citing works
Examining a Digital Health Approach for Advancing Schizophrenia Illness Self-Management and Provider Engagement: Protocol for a Feasibility Trial
Kidd, S. A., McKenzie, K. J., Wang, W., Agrawal, S., & Voineskos, A. N. (2020) · JMIR Research Protocols · doi:10.2196/24736 · Cited by 8 · see citing works
Adherence to Medication Regimen in Patients with Severe and Chronic Psychiatric Disorders: A Qualitative Study
Zarea, K., Moghadam, M. F., & Hakim, A. (2016) · Issues in Mental Health Nursing · doi:10.1080/01612840.2016.1239147 · Cited by 8 · see citing works
Promoting Medication Adherence Among Psychiatric Patients With a History of Nonadherence: A Clinical Practice Improvement Program
XIA, X. S., Poremski, D., UBANA, R. L., & Ravichandran, N. (2020) · Journal of Psychiatric Practice · doi:10.1097/pra.0000000000000482 · Cited by 7 · see citing works
Evaluation of nonadherence to treatment among patients with schizophrenia attending psychosocial care centers in the south region of Brazil
Viveiros, C. P., Tatar, C. R., dos Santos, D. V. D., Stefanello, S., & Nisihara, R. (2020) · Trends in Psychiatry and Psychotherapy · doi:10.1590/2237-6089-2019-0072 · Cited by 7 · see citing works
Rising co-payments coincide with unwanted effects on continuity of healthcare for patients with schizophrenia in the Netherlands
van der Lee, A. P. M., de Haan, L., & Beekman, A. T. F. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222046 · Cited by 7 · see citing works
Motivational Interviewing in Patients with Acute Psychosis: A Feasibility Study
Panchalingam, J., Horisberger, R., Corda, C., Kleisner, N., Krasnoff, J., Burrer, A., Spiller, T. R., Edkins, V., Seifritz, E., & Homan, P. (2025) · Schizophrenia Bulletin Open · doi:10.1093/schizbullopen/sgaf004 · Cited by 6 · see citing works
Does the frequency of administration of long acting injectable antipsychotics impact psychiatric outcomes and adverse effects: A systematic review and meta-analysis
Ting, E., Kamalvand, S., Shang, D., Siskind, D. J., & Kisely, S. R. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.12.004 · Cited by 6 · see citing works
Predictors of persistence in patients with schizophrenia treated with aripiprazole once-monthly long-acting injection in the Spanish clinical practice: a retrospective, observational study
Olivares, J. M., González-Pinto, A. M., & Páramo, M. (2021) · European Psychiatry · doi:10.1192/j.eurpsy.2021.23 · Cited by 6 · see citing works
Factors associated with early response to olanzapine and clinical and functional outcomes of early responders treated for schizophrenia in the People’s Republic of China
Stensland, M. D., Ye, W., Montgomery, W., KADZIOLA, Z. A., Liu, L., Xue, H. B., & Treuer, T. (2014) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s59468 · Cited by 6 · see citing works

Interventions to Improve Antipsychotic Medication Adherence: Review of Recent Literature
Dolder, C. R., Lacro, J. P., Leckband, S. G., & Jeste, D. V. (2003) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000085413.08426.41 · Cited by 236 · see citing works
Interventions to Improve Medication Adherence in Schizophrenia
Zygmunt, A., Olfson, M., Boyer, C. A., & Mechanic, D. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1653 · Cited by 541 · see citing works
A review of Motivational Interviewing to enhance adherence to antipsychotic medication in patients with schizophrenia: Evidence and recommendations
Drymalski, W. M., & Campbell, T. C. (2008) · Journal of Mental Health · doi:10.1080/09638230802052161 · Cited by 23 · see citing works
Non-Pharmacological Strategies to Enhance Adherence and Continuity of Care in Schizophrenia
Vita, A., Barlati, S., & Sacchetti, E. (2013) · Springer eBooks · doi:10.1007/978-88-470-2679-7_3 · Cited by 5 · see citing works
Effects of motivational interviewing‐based adherence therapy for schizophrenia spectrum disorders: a randomized controlled trial
Chien, W. T., Mui, J. H., Cheung, E. F., & Gray, R. (2015) · Trials · doi:10.1186/s13063-015-0785-z · Cited by 80 · see citing works

Authors: Barkhof, E., Meijer, C. J., de Sonneville, L. M. J., Linszen, D. H., & de Haan, L.
Affiliations: Amsterdam UMC Location University of Amsterdam (NL)
Corresponding author: Barkhof, E.
ORCID: Meijer, C.J.
Venue: European Psychiatry
Publisher: Cambridge University Press (CUP)
Published: 2012-01
Volume: 27
Issue: 1
Pages: 9-18
ISSN: 0924-9338 (ISSN-L)
1778-3585
DOI: 10.1016/j.eurpsy.2011.02.005
OpenAlex: W2013847807
Cited by: 183
References: 118
Citations by year: 2026: 4 · 2025: 9 · 2024: 9 · 2023: 6 · 2022: 7 · 2021: 17 · 2020: 22 · 2019: 8 · 2018: 17 · 2017: 9 · 2016: 28 · 2015: 23 · 2014: 7 · 2013: 11 · 2012: 6
FWCI: 1.10
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified, 3027 d)
Locations: European Psychiatry (publishedVersion)
PubMed (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Topics: Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Keywords: antipsychotic adherence, schizophrenia, psychosocial interventions, non-compliance, motivational interviewing, usual care
MeSH terms: Humans, Schizophrenia, Schizophrenic Psychology, Antipsychotic Agents, Medication Adherence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Interventions to improve adherence to antipsychotic medication in patients with schizophrenia–A review of the past decade

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks