TH1 and TH2 cell polarization increases with aging and is modulated by zinc supplementation
Open accessAbstract
Elderly subjects suffer from increased levels of activated T cells and a TH1/TH2 imbalance. Zinc deficiency of the aged is correlated with decreased cell-mediated immune responses. The association of age and zinc adjustment with the amounts of TH1 (CCR5+) and TH2 (CCR4+) cell populations in healthy aged old donors enrolled in the European ZINCAGE project was examined. Old and nonagenarian individuals revealed increased TH1, TH2 cell numbers and a decreased TH2/TH1 ratio in comparison to young individuals. The differences between TH2/TH1 ratios of young and old/nonagenarians arose from young females. Adjusted zinc status led to enhanced TH2 and TH1 amounts in fresh whole blood and thawed cells of aged donors whereas increased HLA-DR+ expression and a generally lower CCR5 expression was observed on thawed PBMC. In conclusion, aging is associated with an increase in T helper cell polarization, and changes in TH2/TH1 subsets are more obvious in women than in men. Advanced healthy aging is accompanied by TH cell polarization, too. Moderate zinc supplementation in vivo alters TH proportions. Longer zinc treatment will give more insight into the beneficial effect of zinc on T helper cell modulation.
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- Authors
- Uciechowski, P., Kahmann, L., Plümäkers, B., Malavolta, M., Mocchegiani, E., Dedoussis, G., Herbein, G., Jajte, J., Fulop, T., & Rink, L.
- Affiliations
- Universitätsklinikum Aachen (DE)
- Istituto Nazionale di Riposo e Cura per Anziani (IT)
- Harokopio University of Athens (GR)
- Université de Franche-Comté (FR)
- Medical University of Lodz (PL)
- Corresponding author
- Rink, Lothar
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 43
- Issue
- 5
- Pages
- 493-498
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W2136526212
- Cited by
- 97
- References
- 36
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 7 · 2021: 6 · 2020: 1 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 12 · 2013: 8 · 2012: 6
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- HAL (submittedVersion, other-oa)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- T helper cell polarization, Th1/Th2 imbalance, aging, zinc supplementation, zinc deficiency, CCR5, CCR4, HLA-DR, peripheral blood mononuclear cells, sex differences, healthy aging, nonagenarians, immunosenescence
- MeSH terms
- Aged, Aged, 80 and over, Aging, Female, Humans, Lymphocyte Activation, Male, Trace Elements, Zinc, T-Lymphocyte Subsets, Th1 Cells, Th2 Cells, Dietary Supplements, Receptors, CCR4, Receptors, CCR6
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