Cited by 37Mitochondrial Function and PathologyAdipose Tissue and MetabolismMuscle Physiology and Disorders

Adaptations of Skeletal Muscle Mitochondria to Obesity, Exercise, and Polyunsaturated Fatty Acids

Chen, Phoebe B., Yang, Jason S., Park, Yeonhwa·2018·Lipids

Abstract

Mitochondria intricately modulate their energy production through the control of mitochondrial adaptation (mitochondrial biogenesis, fusion, and/or fission) to meet energy demands. Nutrient overload may result in dysregulated mitochondrial biogenesis, morphology toward mitochondrial fragmentation, and oxidative stress in the skeletal muscle. In addition, physical activity and diet components influence mitochondrial function. Exercise may stimulate mitochondrial biogenesis and promote mitochondrial fusion/fission in the skeletal muscle. Moreover, some dietary fatty acids, such as n‐3 polyunsaturated fatty acids and conjugated linoleic acid, have been identified to positively regulate mitochondrial adaptation in the skeletal muscle. This review discusses the association of mitochondrial impairments and obesity, and presents an overview of various mechanisms of which exercise training and mitochondrial nutrients promote mitochondrial function in the skeletal muscle.

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Crossref · 10.1002/lipd.12037

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89 of 89 references verified0 citation errors · 0 not checkable

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Authors
Chen, P. B., Yang, J. S., & Park, Y.
Affiliations
University of Massachusetts Amherst (US)
Venue
Lipids
Publisher
Wiley
Published
2018-03
Volume
53
Issue
3
Pages
271-278
ISSN
  • 0024-4201 (ISSN-L)
  • 1558-9307
OpenAlex
W2801779130
Cited by
37
References
89
Citations by year
2026: 2 · 2025: 2 · 2024: 13 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 4
FWCI
0.32
Type
journal article
Language
en
Open access
closed
Locations
  • Lipids (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Food and Agriculture
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
skeletal muscle mitochondria, mitochondrial biogenesis, mitochondrial fusion, mitochondrial fission, mitochondrial fragmentation, obesity, exercise training, polyunsaturated fatty acids, omega-3 fatty acids, conjugated linoleic acid, oxidative stress, mitochondrial function
MeSH terms
Adaptation, Physiological, Animals, Organelle Biogenesis, Dietary Fats, Energy Metabolism, Gene Expression Regulation, Humans, Mitochondria, Muscle, Obesity, Exercise, Fatty Acids, Omega-3, Oxidative Stress, Muscle, Skeletal, Mitochondrial Proteins, Linoleic Acids, Conjugated

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