Modulation of endogenous antioxidant activity by resveratrol and exercise in mouse liver is age dependent
Abstract
Aging is a multifactorial process in which oxidative damage plays an important role. Resveratrol (RSV) and exercise delay some of the damages occurring during aging and increase life span and health span. We treated mice at different ages with RSV during 6 months and trained them during the last 6 weeks to determine if RSV and exercise induce changes in endogenous antioxidant activities in liver and if their effects depend on the age of the animal at the beginning of the intervention. Aging was accompanied by the increase in oxidative damage in liver especially affecting the glutathione-dependent system. Both RSV and exercise reversed the effect of aging and maintained high activities of glutathione, glutathione peroxidase, and glutathione transferase activities in old animals. NAD(P)H: quinone acceptor oxidoreductase activity was also increased. Modulation of antioxidant activities was not completely accompanied by changes at the protein level. Whereas glutathione peroxidase 1 protein increased in parallel to the higher activity in old animals, NAD(P)H: quinone acceptor oxidoreductase protein decreased by RSV although the activity was enhanced. Our results indicate that RSV and exercise revert the effect of aging in liver of old animals maintaining higher antioxidant activities and decreasing oxidative damage. Short-term interventions are enough to produce beneficial effects of RSV or exercise at later ages.
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If antioxidant enzymes decay during aging, oxidative damage accumulates.
“if these enzymes decay during aging, as has been found in different models (Rodriguez-Bies et al., 2015; Rodriguez-Bies et al., 2016; Tung et al., 2014; Tung et al., 2015b), oxidative damage accumulates.”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Tung et al., 2014
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- Authors
- Tung, B. T., Rodríguez-Bies, E., Ballesteros-Simarro, M., Motilva, V., Navas, P., & López-Lluch, G.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Universidad de Sevilla (ES)
- Venue
- The Journals of Gerontology Series A
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-07-16
- Volume
- 69
- Issue
- 4
- Pages
- 398-409
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2128482561
- Cited by
- 60
- References
- 80
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 7 · 2022: 4 · 2021: 4 · 2020: 10 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 3
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- resveratrol, physical activity, aging, oxidative stress, liver, antioxidant enzymes, glutathione, glutathione peroxidase 1, glutathione S-transferase, age-dependent effects, healthspan, longevity
- MeSH terms
- Resveratrol, Aging, Animals, Antioxidants, Disease Models, Animal, Liver, Male, Mice, Inbred C57BL, Oxidation-Reduction, Physical Conditioning, Animal, Stilbenes, Mice
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