Cited by 60Sirtuins and Resveratrol in MedicineExercise and Physiological ResponsesGenetics, Aging, and Longevity in Model Organisms

Modulation of endogenous antioxidant activity by resveratrol and exercise in mouse liver is age dependent

Tung, Bui Thanh, Rodríguez-Bies, Elisabet, Ballesteros-Simarro, Manuel, Motilva, Virginia, Navas, Plácido, López-Lluch, Guillermo·2014·The Journals of Gerontology Series A

Abstract

Aging is a multifactorial process in which oxidative damage plays an important role. Resveratrol (RSV) and exercise delay some of the damages occurring during aging and increase life span and health span. We treated mice at different ages with RSV during 6 months and trained them during the last 6 weeks to determine if RSV and exercise induce changes in endogenous antioxidant activities in liver and if their effects depend on the age of the animal at the beginning of the intervention. Aging was accompanied by the increase in oxidative damage in liver especially affecting the glutathione-dependent system. Both RSV and exercise reversed the effect of aging and maintained high activities of glutathione, glutathione peroxidase, and glutathione transferase activities in old animals. NAD(P)H: quinone acceptor oxidoreductase activity was also increased. Modulation of antioxidant activities was not completely accompanied by changes at the protein level. Whereas glutathione peroxidase 1 protein increased in parallel to the higher activity in old animals, NAD(P)H: quinone acceptor oxidoreductase protein decreased by RSV although the activity was enhanced. Our results indicate that RSV and exercise revert the effect of aging in liver of old animals maintaining higher antioxidant activities and decreasing oxidative damage. Short-term interventions are enough to produce beneficial effects of RSV or exercise at later ages.

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Registry

Crossref · 10.1093/gerona/glt102

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  • If antioxidant enzymes decay during aging, oxidative damage accumulates.

    “if these enzymes decay during aging, as has been found in different models (Rodriguez-Bies et al., 2015; Rodriguez-Bies et al., 2016; Tung et al., 2014; Tung et al., 2015b), oxidative damage accumulates.”

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Authors
Tung, B. T., Rodríguez-Bies, E., Ballesteros-Simarro, M., Motilva, V., Navas, P., & López-Lluch, G.
Affiliations
  • Consejo Superior de Investigaciones Científicas (ES)
  • Universidad de Sevilla (ES)
Venue
The Journals of Gerontology Series A
Published
2013-07-16
Volume
69
Issue
4
Pages
398-409
ISSN
  • 1079-5006 (ISSN-L)
  • 1758-535X
OpenAlex
W2128482561
Cited by
60
References
80
Citations by year
2026: 1 · 2025: 5 · 2024: 4 · 2023: 7 · 2022: 4 · 2021: 4 · 2020: 10 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 3
FWCI
2.17
Type
journal article
Language
en
Open access
closed
Locations
  • The Journals of Gerontology Series A (publishedVersion)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
resveratrol, physical activity, aging, oxidative stress, liver, antioxidant enzymes, glutathione, glutathione peroxidase 1, glutathione S-transferase, age-dependent effects, healthspan, longevity
MeSH terms
Resveratrol, Aging, Animals, Antioxidants, Disease Models, Animal, Liver, Male, Mice, Inbred C57BL, Oxidation-Reduction, Physical Conditioning, Animal, Stilbenes, Mice

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