Resveratrol primes the effects of physical activity in old mice
Open accessAbstract
Decrease in muscle mass and performance with ageing is one of the main factors of frailty in the elderly. Maintenance of muscle performance by involving in physical activities is essential to increase independence and quality of life among elderly. The use of natural compounds with ergogenic activity in old people would increase the effect of moderate exercises in the maintenance of physiological muscle capacity. Resveratrol (RSV), a polyphenol found in walnuts, berries and grapes, shows this ergogenic activity. By using young, mature and old mice as models, we have found that RSV improves muscle performance in mature and old animals but not in young animals. Without showing significant effect by itself, RSV primed the effect of exercise by increasing endurance, coordination and strength in old animals. This effect was accompanied by a higher protection against oxidative damage and an increase in mitochondrial mass. RSV increased catalase and superoxide dismutase protein levels in muscle and primed exercise to reverse the decrease in their activities during ageing. Furthermore, RSV increased the level of mitochondrial mass markers such as cytochrome C, mitochondrial transcription factor A and nuclear respiratory factor-1 in muscle in exercised animals. Our results indicate that RSV can be considered an ergogenic compound that helps maintain muscle performance during ageing and subsequently reduces frailty and increases muscle performance in old individuals practising moderate exercise.
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If antioxidant enzymes decay during aging, oxidative damage accumulates.
“if these enzymes decay during aging, as has been found in different models (Rodriguez-Bies et al., 2015; Rodriguez-Bies et al., 2016; Tung et al., 2014; Tung et al., 2015b), oxidative damage accumulates.”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Rodriguez-Bies et al., 2016
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Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity
López-Lluch, G. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.12.005 · Cited by 103 · see citing works
“If ROS production is balanced with antioxidant enzymes, oxidative damage did not occur, but if these enzymes decay during aging, as has been found in different models (Rodriguez-Bies et al., 2015; Rodriguez-Bies et al., 2016; Tung et al., 2014; Tung et al., 2015b), oxidative damage accumulates.”
BackgroundSelf-citation
- Authors
- Rodríguez-Bies, E., Tung, B. T., Navas, P., & López-Lluch, G.
- Affiliations
- Instituto de Salud Carlos III (ES)
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2016-08-04
- Volume
- 116
- Issue
- 6
- Pages
- 979-988
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2481696776
- Cited by
- 40
- References
- 51
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 12 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 1
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Ministerio de Ciencia e Innovación
- Agencia Española de Cooperación Internacional para el Desarrollo
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- resveratrol, physical activity, aging, muscle performance, frailty, oxidative damage, mitochondrial mass, catalase, superoxide dismutase, cytochrome c, TFAM, NRF1, polyphenols, aged mice
- MeSH terms
- Resveratrol, Aging, Animals, Anti-Inflammatory Agents, Non-Steroidal, Male, Mice, Inbred C57BL, Mitochondria, Physical Conditioning, Animal, Physical Endurance, Stilbenes, Lipid Peroxidation, Muscle, Skeletal, Mice
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