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Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women
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“Higher mTORC1/S6K activity in muscle of older mice, rats and humans is associated with sarcopenia 97–101, and in brain is associated with Alzheimer’s disease 101–105.”
From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [98]
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Longitudinal study of muscle strength, quality, and adipose tissue infiltration
Delmonico, M. J., Harris, T. B., Visser, M., Park, S. W., Conroy, M. B., Velasquez-Mieyer, P., Boudreau, R., Manini, T. M., Nevitt, M., Newman, A. B., et al. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28047 · Cited by 1,446
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., Wackerhage, H., Taylor, P. M., & Rennie, M. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2640fje · Cited by 1,211 · cited 2×
“Several researchers reported that aging does not alter basal muscle protein synthesis in men (Cuthbertson et al., 2005; Kumar et al., 2009; Volpi et al., 2001) or women (Chevalier et al., 2011), and that basalmuscle protein synthesis is not affected by sex in young or middle-aged adults (Dreyer et…”
Kumar, V., Selby, A., Rankin, D., Patel, R., Atherton, P., Hildebrandt, W., Williams, J., Smith, K., Seynnes, O., Hiscock, N., et al. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.164483 · Cited by 740 · cited 1×
“Several researchers reported that aging does not alter basal muscle protein synthesis in men (Cuthbertson et al., 2005; Kumar et al., 2009; Volpi et al., 2001) or women (Chevalier et al., 2011), and that basalmuscle protein synthesis is not affected by sex in young or middle-aged adults (Dreyer et…”
Drummond, M. J., Fry, C. S., Glynn, E. L., Dreyer, H. C., Dhanani, S., Timmerman, K. L., Volpi, E., & Rasmussen, B. B. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.163816 · Cited by 439 · cited 1×
“Data from some of the subjectswere reported to address different scientific questions (Dickinson et al., 2011, 2013a, 2013b; Drummond et al., 2008, 2009, 2012; Fry et al., 2010, 2011, 2013; Glynn et al., 2010a, 2010b, 2013; Gundermann et al., 2012; Reidy et al., 2013; Timmerman et al., 2010a,…”
Self-citationGuillet, C., Prod'homme, M., Balage, M., Gachon, P., Giraudet, C., Morin, L., Grizard, J., & Boirie, Y. (2004) · The FASEB Journal · doi:10.1096/fj.03-1341fje · Cited by 412
Fulgoni, V. L. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1554s · Cited by 369 · cited 3×
“There is growing evidence that the protein RDAmay be insufficient for optimal muscle function in the elderly (Volpi et al., 2013) and, on average, older adults eat more than the protein RDA (Fulgoni, 2008).”
Aging impairs contraction-induced human skeletal muscle mtorc1 signaling and protein synthesis
Fry, C. S., Drummond, M. J., Glynn, E. L., Dickinson, J. M., Gundermann, D. M., Timmerman, K. L., Walker, D. K., Dhanani, S., Volpi, E., & Rasmussen, B. B. (2011) · Skeletal Muscle · doi:10.1186/2044-5040-1-11 · Cited by 351
Self-citationHasten, D. L., Pak-Loduca, J., Obert, K. A., & Yarasheski, K. E. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.4.e620 · Cited by 294
Dickinson, J. M., Fry, C. S., Drummond, M. J., Gundermann, D. M., Walker, D. K., Glynn, E. L., Timmerman, K. L., Dhanani, S., Volpi, E., & Rasmussen, B. B. (2011) · The Journal of Nutrition · doi:10.3945/jn.111.139485 · Cited by 282
Self-citationParise, G., Mihic, S., MacLennan, D., Yarasheski, K. E., & Tarnopolsky, M. A. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.3.1041 · Cited by 236 · cited 1×
“…et al., 2011), and that basalmuscle protein synthesis is not affected by sex in young or middle-aged adults (Dreyer et al., 2010; Fujita et al., 2007a; Jahn et al., 1999; Parise et al., 2001; Smith et al., 2009;West et al., 2012) despite the obvious differences inmuscle size betweenmen and women.”
Protein blend ingestion following resistance exercise promotes human muscle protein synthesis
Reidy, P. T., Walker, D. K., Dickinson, J. M., Gundermann, D. M., Drummond, M. J., Timmerman, K. L., Fry, C. S., Borack, M. S., Cope, M. B., Mukherjea, R., et al. (2013) · The Journal of Nutrition · doi:10.3945/jn.112.168021 · Cited by 178
Fasted‐state skeletal muscle protein synthesis after resistance exercise is altered with training
Kim, P. L., Staron, R. S., & Phillips, S. M. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.093708 · Cited by 171
Timmerman, K. L., Lee, J. L., Fujita, S., Dhanani, S., Dreyer, H. C., Fry, C. S., Drummond, M. J., Sheffield-Moore, M., Rasmussen, B. B., & Volpi, E. (2010) · Diabetes · doi:10.2337/db10-0415 · Cited by 149
Self-citationSex-based comparisons of myofibrillar protein synthesis after resistance exercise in the fed state
West, D. W. D., Burd, N. A., Churchward-Venne, T. A., Camera, D. M., Mitchell, C. J., Baker, S. K., Hawley, J. A., Coffey, V. G., & Phillips, S. M. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00170.2012 · Cited by 143
Villareal, D. T., Smith, G. I., Sinacore, D. R., Shah, K., & Mittendorfer, B. (2011) · Obesity · doi:10.1038/oby.2010.110 · Cited by 140 · cited 2×
“While the subjects were obese and lost fat mass with training, that study demonstrates how exercise can affect basal muscle protein synthesis in older adults (Villareal et al., 2011).”
Sexually dimorphic effect of aging on skeletal muscle protein synthesis
Smith, G. I., Reeds, D. N., Hall, A. M., Chambers, K. T., Finck, B. N., & Mittendorfer, B. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-11 · Cited by 105
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Metadata
- Authors
- Markofski, M. M., Dickinson, J. M., Drummond, M. J., Fry, C. S., Fujita, S., Gundermann, D. M., Glynn, E. L., Jennings, K., Paddon-Jones, D., Reidy, P. T., Sheffield-Moore, M., Timmerman, K. L., Rasmussen, B. B., & Volpi, E.
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 65
- Pages
- 1-7
- ISSN
- 0531-5565
- PMC
- PMC4397165
- Cited by
- 155
- References
- 16
- Language
- en
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