CoChat
Sign Up
Cited by 155

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women

Markofski, Melissa M., Dickinson, Jared M., Drummond, Micah J., Fry, Christopher S., Fujita, Satoshi, Gundermann, David M., Glynn, Erin L., Jennings, Kristofer, Paddon-Jones, Douglas, Reidy, Paul T., Sheffield-Moore, Melinda, Timmerman, Kyle L., Rasmussen, Blake B., Volpi, Elena·2015·Experimental Gerontology
DOI 10.1016/j.exger.2015.02.015PMC PMC4397165
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.exger.2015.02.015

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 16 references

Research works printed but not linked: 51

  1. Balagopal, 1997, Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans, Am. J. Physiol., 273, E790
  2. Bhasin, 2001, Proof of the effect of testosterone on skeletal muscle, J. Endocrinol., 170, 27, 10.1677/joe.0.1700027 · DOI
  3. Campbell, 2001, The recommended dietary allowance for protein may not be adequate for older people to maintain skeletal muscle, J. Gerontol. A Biol. Sci. Med. Sci., 56, M373, 10.1093/gerona/56.6.M373 · DOI · Paper page
  4. Chalé-Rush, 2009, Effects of chronic overload on muscle hypertrophy and mTOR signaling in young adult and aged rats, J. Gerontol. A Biol. Sci. Med. Sci., 64, 1232, 10.1093/gerona/glp146 · DOI
  5. Chevalier, 2011, Protein anabolic responses to a fed steady state in healthy aging, J. Gerontol. A Biol. Sci. Med. Sci., 66, 681, 10.1093/gerona/glr036 · DOI
  6. Dickinson, 2013, Aging differentially affects human skeletal muscle amino acid transporter expression when essential amino acids are ingested after exercise, Clin. Nutr., 32, 273, 10.1016/j.clnu.2012.07.009 · DOI
  7. Dickinson, 2013, Rapamycin does not affect post-absorptive protein metabolism in human skeletal muscle, Metabolism, 62, 144, 10.1016/j.metabol.2012.07.003 · DOI
  8. Dreyer, 2010, Resistance exercise increases leg muscle protein synthesis and mTOR signalling independent of sex, Acta Physiol. (Oxf.), 199, 71, 10.1111/j.1748-1716.2010.02074.x · DOI
  9. Drummond, 2008, Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging, J. Appl. Physiol., 104, 1452, 10.1152/japplphysiol.00021.2008 · DOI
  10. Drummond, 2012, Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults, Am. J. Physiol. Endocrinol. Metab., 302, E1113, 10.1152/ajpendo.00603.2011 · DOI
  11. Ferrando, 1996, Prolonged bed rest decreases skeletal muscle and whole body protein synthesis, Am. J. Physiol., 270, E627
  12. Fok, 2013, Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice, J. Gerontol. A Biol. Sci. Med. Sci., 68, 108, 10.1093/gerona/gls127 · DOI
  13. Fry, 2010, Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men, J. Appl. Physiol., 108, 1199, 10.1152/japplphysiol.01266.2009 · DOI
  14. Fry, 2013, Skeletal muscle autophagy and protein breakdown following resistance exercise are similar in younger and older adults, J. Gerontol. A Biol. Sci. Med. Sci., 68, 599, 10.1093/gerona/gls209 · DOI · Paper page
  15. Fujita, 2006, Effect of insulin on human skeletal muscle protein synthesis is modulated by insulin-induced changes in muscle blood flow and amino acid availability, Am. J. Physiol. Endocrinol. Metab., 291, E745, 10.1152/ajpendo.00271.2005 · DOI
  16. Fujita, 2007, Basal muscle intracellular amino acid kinetics in women and men, Am. J. Physiol. Endocrinol. Metab., 292, E77, 10.1152/ajpendo.00173.2006 · DOI
  17. Fujita, 2007, Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis, J. Appl. Physiol., 103, 903, 10.1152/japplphysiol.00195.2007 · DOI
  18. Fujita, 2009, Essential amino acid and carbohydrate ingestion before resistance exercise does not enhance postexercise muscle protein synthesis, J. Appl. Physiol., 106, 1730, 10.1152/japplphysiol.90395.2008 · DOI · Paper page
  19. Fujita, 2009, Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age-related insulin resistance of muscle protein metabolism, Diabetologia, 52, 1889, 10.1007/s00125-009-1430-8 · DOI · Paper page
  20. Funai, 2006, Age-associated decrease in contraction-induced activation of downstream targets of Akt/mTor signaling in skeletal muscle, Am. J. Physiol. Regul. Integr. Comp. Physiol., 290, R1080, 10.1152/ajpregu.00277.2005 · DOI
  21. Glynn, 2010, Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women, J. Nutr., 140, 1970, 10.3945/jn.110.127647 · DOI · Paper page
  22. Glynn, 2010, Muscle protein breakdown has a minor role in the protein anabolic response to essential amino acid and carbohydrate intake following resistance exercise, Am. J. Physiol. Regul. Integr. Comp. Physiol., 299, R533, 10.1152/ajpregu.00077.2010 · DOI
  23. Glynn, 2013, Addition of carbohydrate or alanine to an essential amino acid mixture does not enhance human skeletal muscle protein anabolism, J. Nutr., 143, 307, 10.3945/jn.112.168203 · DOI · Paper page
  24. Guillet, 2009, Changes in basal and insulin and amino acid response of whole body and skeletal muscle proteins in obese men, J. Clin. Endocrinol. Metab., 94, 3044, 10.1210/jc.2008-2216 · DOI
  25. Gundermann, 2012, Reactive hyperemia is not responsible for stimulating muscle protein synthesis following blood flow restriction exercise, J. Appl. Physiol., 112, 1520, 10.1152/japplphysiol.01267.2011 · DOI
  26. Henderson, 2009, Higher muscle protein synthesis in women than men across the lifespan, and failure of androgen administration to amend age-related decrements, FASEB J., 23, 631, 10.1096/fj.08-117200 · DOI
  27. Jahn, 1999, Tissue composition affects measures of postabsorptive human skeletal muscle metabolism: comparison across genders, J. Clin. Endocrinol. Metab., 84, 1007
  28. Lauretani, 2003, Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia, J. Appl. Physiol. (1985), 95, 1851, 10.1152/japplphysiol.00246.2003 · DOI · Paper page
  29. Li, 2015, Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice, J. Gerontol. A Biol. Sci. Med. Sci., 70, 263, 10.1093/gerona/glu040 · DOI
  30. Li, 2012, Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise, Mech. Ageing Dev., 133, 655, 10.1016/j.mad.2012.09.001 · DOI
  31. Miller, 2006, No effect of menstrual cycle on myofibrillar and connective tissue protein synthesis in contracting skeletal muscle, Am. J. Physiol. Endocrinol. Metab., 290, E163, 10.1152/ajpendo.00300.2005 · DOI · Paper page
  32. Miller, 2013, Calorie restriction does not increase short-term or long-term protein synthesis, J. Gerontol. A Biol. Sci. Med. Sci., 68, 530, 10.1093/gerona/gls219 · DOI
  33. Morris, 2015, Genetic analysis of TOR complex gene variation with human longevity: a nested case–control study of American men of Japanese ancestry, J. Gerontol. A Biol. Sci. Med. Sci., 70, 133, 10.1093/gerona/glu021 · DOI
  34. Parkington, 2004, Contraction-mediated mTOR, p70S6k, and ERK1/2 phosphorylation in aged skeletal muscle, J. Appl. Physiol. (1985), 97, 243, 10.1152/japplphysiol.01383.2003 · DOI
  35. Smith, 2008, Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65–80 year old men and women, PLoS One, 3, e1875, 10.1371/journal.pone.0001875 · DOI · Paper page
  36. Smith, 2008, Physical activity by elderly patients undergoing inpatient rehabilitation is low: an observational study, Aust. J. Physiother., 54, 209, 10.1016/S0004-9514(08)70028-X · DOI
  37. Smith, 2009, No major sex differences in muscle protein synthesis rates in the postabsorptive state and during hyperinsulinemia–hyperaminoacidemia in middle-aged adults, J. Appl. Physiol., 107, 1308, 10.1152/japplphysiol.00348.2009 · DOI · Paper page
  38. Smith, 2012, Muscle protein synthesis response to exercise training in obese, older men and women, Med. Sci. Sports Exerc., 10.1249/MSS.0b013e3182496a41 · DOI
  39. Timmerman, 2010, Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling, J. Clin. Endocrinol. Metab., 95, 3848, 10.1210/jc.2009-2696 · DOI
  40. Timmerman, 2012, A moderate acute increase in physical activity enhances nutritive flow and the muscle protein anabolic response to mixed nutrient intake in older adults, Am. J. Clin. Nutr., 95, 1403, 10.3945/ajcn.111.020800 · DOI
  41. Tremblay, 2005, Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability, Diabetes, 54, 2674, 10.2337/diabetes.54.9.2674 · DOI · Paper page
  42. Volpi, 2000, The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly, J. Clin. Endocrinol. Metab., 85, 4481
  43. Volpi, 2001, Basal muscle amino acid kinetics and protein synthesis in healthy young and older men, JAMA, 286, 1206, 10.1001/jama.286.10.1206 · DOI
  44. Volpi, 2013, Is the optimal level of protein intake for older adults greater than the recommended dietary allowance?, J. Gerontol. A Biol. Sci. Med. Sci., 68, 677, 10.1093/gerona/gls229 · DOI
  45. Walker, 2011, Exercise, amino acids, and aging in the control of human muscle protein synthesis, Med. Sci. Sports Exerc., 43, 2249, 10.1249/MSS.0b013e318223b037 · DOI
  46. Welle, 1993, Myofibrillar protein synthesis in young and old men, Am. J. Physiol., 264, E693
  47. Welle, 1995, Myofibrillar protein synthesis in young and old human subjects after three months of resistance training, Am. J. Physiol., 268, E422
  48. Yarasheski, 1993, Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women, Am. J. Physiol., 265, E210
  49. Yarasheski, 1999, Resistance exercise training increases mixed muscle protein synthesis rate in frail women and men >/=76yr old, Am. J. Physiol., 277, E118
  50. Yu, 2014, Rapamycin and dietary restriction induce metabolically distinctive changes in mouse liver, J. Gerontol. A Biol. Sci. Med. Sci.
  51. Zhang, 2014, Rapamycin extends life and health in C57BL/6 mice, J. Gerontol. A Biol. Sci. Med. Sci., 69, 119, 10.1093/gerona/glt056 · DOI

Cited by

Sorted by citations

Metadata

Authors
Markofski, M. M., Dickinson, J. M., Drummond, M. J., Fry, C. S., Fujita, S., Gundermann, D. M., Glynn, E. L., Jennings, K., Paddon-Jones, D., Reidy, P. T., Sheffield-Moore, M., Timmerman, K. L., Rasmussen, B. B., & Volpi, E.
Venue
Experimental Gerontology
Publisher
Elsevier BV
Published
2015-05
Volume
65
Pages
1-7
ISSN
0531-5565
DOI
10.1016/j.exger.2015.02.015
PMC
PMC4397165
Cited by
155
References
16
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review